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ANDREEFF, MICHAEL
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Academic Article Use of granulocyte colony-stimulating factor before, during, and after fludarabine plus cytarabine induction therapy of newly diagnosed acute myelogenous leukemia or myelodysplastic syndromes: comparison with fludarabine plus cytarabine without granulocyte colony-stimulating factor.
Academic Article A 3-day schedule of fludarabine in previously treated chronic lymphocytic leukemia.
Academic Article Influenza among hospitalized adults with leukemia.
Academic Article Expression of Bcl-2-related genes in normal and AML progenitors: changes induced by chemotherapy and retinoic acid.
Academic Article Respiratory syncytial virus pneumonia in hospitalized adult patients with leukemia.
Academic Article Concomitant inhibition of MDM2 and Bcl-2 protein function synergistically induce mitochondrial apoptosis in AML.
Academic Article Bystander transfer of functional human CD40 ligand from gene-modified fibroblasts to B-chronic lymphocytic leukemia cells.
Academic Article Sorafenib induces apoptosis of AML cells via Bim-mediated activation of the intrinsic apoptotic pathway.
Academic Article Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax).
Academic Article Engraftment of acute myeloid leukemia in NOD/SCID mice is independent of CXCR4 and predicts poor patient survival.
Academic Article Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction.
Academic Article Correlation between CXCR4 and homing or engraftment of acute myelogenous leukemia.
Academic Article The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces caspase-dependent and -independent apoptosis in acute myelogenous leukemia.
Academic Article Comparison of the efficiency of transduction of leukemic cells by fiber-modified adenoviruses.
Academic Article MEK inhibition enhances ABT-737-induced leukemia cell apoptosis via prevention of ERK-activated MCL-1 induction and modulation of MCL-1/BIM complex.
Academic Article HDAC inhibition by SNDX-275 (Entinostat) restores expression of silenced leukemia-associated transcription factors Nur77 and Nor1 and of key pro-apoptotic proteins in AML.
Academic Article Selective depletion of a minor subpopulation of B-chronic lymphocytic leukemia cells is followed by a delayed but progressive loss of bulk tumor cells and disease regression.
Academic Article High incidence of IDH mutations in acute myeloid leukaemia with cuplike nuclei.
Academic Article Treatment of myelodysplastic syndromes with AML-type chemotherapy.
Academic Article Fludarabine plus doxorubicin in previously treated chronic lymphocytic leukemia.
Academic Article Fluorescent in situ hybridization and cytogenetic studies of trisomy 12 in chronic lymphocytic leukemia.
Academic Article Preliminary results of treatment with filgrastim for relapse of leukemia and myelodysplasia after allogeneic bone marrow transplantation.
Academic Article High incidence of monosomy 18 in lymphoid malignancies that have bone marrow and peripheral blood involvement.
Academic Article Acute lymphoblastic leukemia following preleukemic syndromes in adults.
Academic Article Autologous antileukemic immune response induced by chronic lymphocytic leukemia B cells expressing the CD40 ligand and interleukin 2 transgenes.
Academic Article Selection of chronic lymphocytic leukemia binding peptides.
Academic Article An in vivo propagated human acute myeloid leukemia expressing ABCA3.
Academic Article Responses to human CD40 ligand/human interleukin-2 autologous cell vaccine in patients with B-cell chronic lymphocytic leukemia.
Academic Article Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia.
Concept Precursor Cell Lymphoblastic Leukemia-Lymphoma
Concept Leukemia, T-Cell
Concept Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Concept Leukemia, Erythroblastic, Acute
Concept Leukemia, B-Cell
Concept Leukemia, Myelomonocytic, Chronic
Concept Leukemia, Myeloid, Accelerated Phase
Concept Leukemia, Monocytic, Acute
Concept Myeloid-Lymphoid Leukemia Protein
Concept Leukemia, Promyelocytic, Acute
Concept Leukemia, Experimental
Concept Leukemia, Lymphoid
Concept Leukemia, Myelomonocytic, Acute
Concept Leukemia, Myeloid
Concept Leukemia
Concept Leukemia, Myeloid, Acute
Concept Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Concept Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Concept Leukemia, Biphenotypic, Acute
Concept Leukemia, Lymphocytic, Chronic, B-Cell
Concept Leukemia, Prolymphocytic
Concept Leukemia, Myeloid, Chronic-Phase
Concept Graft vs Leukemia Effect
Academic Article Connective tissue growth factor regulates adipocyte differentiation of mesenchymal stromal cells and facilitates leukemia bone marrow engraftment.
Academic Article Proteomic profiling identifies distinct protein patterns in acute myelogenous leukemia CD34+CD38- stem-like cells.
Academic Article Apoptosis repressor with caspase recruitment domain is regulated by MAPK/PI3K and confers drug resistance and survival advantage to AML.
Academic Article Case series of patients with acute myeloid leukemia receiving hypomethylation therapy and retrospectively found to have IDH1 or IDH2 mutations.
Academic Article Final report of phase II study of sorafenib, cytarabine and idarubicin for initial therapy in younger patients with acute myeloid leukemia.
Academic Article Evaluation of apoptosis induction by concomitant inhibition of MEK, mTOR, and Bcl-2 in human acute myelogenous leukemia cells.
Academic Article Subpopulations of normal peripheral blood and bone marrow cells express a functional multidrug resistant phenotype.
Academic Article Flow cytometric analysis of cytokinetics of L3-acute lymphoblastic leukemia/lymphoma.
Academic Article High incidence of disseminated intravascular coagulation during remission induction of adult patients with acute lymphoblastic leukemia.
Academic Article Acute lymphoblastic leukemia in adults.
Academic Article Prognostic value of DNA/RNA flow cytometry in myeloblastic and lymphoblastic leukemia in adults: RNA content and S-phase predict remission duration and survival in multi-variate analysis.
Academic Article Use of prognostic factors in deciding therapy for adult acute lymphoblastic leukemia: new approaches at Memorial Sloan-Kettering Cancer Center (MSKCC).
Academic Article Etoposide as an in vitro purging agent for the treatment of acute leukemias and lymphomas in conjunction with autologous bone marrow transplantation.
Academic Article Detection of luxol-fast-blue positive cells in human promyelocytic leukemia cell line HL-60.
Academic Article Induction of in vitro proliferation and maturation of human aneuploid myelogenous leukemic cells.
Academic Article Recognition of central nervous system leukemia by flow cytometry.
Academic Article Effect of very high-dose thymidine infusions on leukemia and lymphoma patients.
Academic Article Changes of cellular markers during differentiation of HL-60 promyelocytes to macrophages as induced by T lymphocyte conditioned medium.
Academic Article Allogeneic blood stem cell transplantation for refractory leukemia and lymphoma: potential advantage of blood over marrow allografts.
Academic Article Flow cytometry. Clinical and research applications in hematologic malignancies.
Academic Article Graft-versus-leukemia effect after allogeneic bone marrow transplantation for chronic lymphocytic leukemia.
Academic Article Sensitivity of combined DNA/immunophenotype flow cytometry for the detection of low levels of aneuploid lymphoblastic leukemia cells in bone marrow.
Academic Article Phase I study of mitoxantrone plus etoposide with multidrug blockade by SDZ PSC-833 in relapsed or refractory acute myelogenous leukemia.
Academic Article Expression of CD95(FAS) by gene transfer does not sensitize K562 to Fas-killing.
Academic Article CECA-cyclophosphamide, etoposide, carboplatin and cytosine arabinoside--a new salvage regimen for relapsed or refractory acute myelogenous leukemia.
Academic Article Multilineage involvement of Philadelphia chromosome positive acute lymphoblastic leukemia.
Academic Article Caspase 2 and caspase 3 protein levels as predictors of survival in acute myelogenous leukemia.
Academic Article PML/RARalpha, a fusion protein in acute promyelocytic leukemia, prevents growth factor withdrawal-induced apoptosis in TF-1 cells.
Academic Article Proteasome inhibitors induce apoptosis in glucocorticoid-resistant chronic lymphocytic leukemic lymphocytes.
Academic Article Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia.
Academic Article Liposomal Bcl-2 antisense oligonucleotides enhance proliferation, sensitize acute myeloid leukemia to cytosine-arabinoside, and induce apoptosis independent of other antiapoptotic proteins.
Academic Article Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia.
Academic Article Cytokine expression of T cells in chronic myeloid leukemia.
Academic Article The anti-apoptotic genes Bcl-X(L) and Bcl-2 are over-expressed and contribute to chemoresistance of non-proliferating leukaemic CD34+ cells.
Academic Article Phase II study of fludarabine, cytarabine (Ara-C), cyclophosphamide, cisplatin and GM-CSF (FACPGM) in patients with Richter's syndrome or refractory lymphoproliferative disorders.
Academic Article A randomized trial of liposomal daunorubicin and cytarabine versus liposomal daunorubicin and topotecan with or without thalidomide as initial therapy for patients with poor prognosis acute myelogenous leukemia or myelodysplastic syndrome.
Academic Article Synthetic triterpenoids activate a pathway for apoptosis in AML cells involving downregulation of FLIP and sensitization to TRAIL.
Academic Article Regulation and targeting of antiapoptotic XIAP in acute myeloid leukemia.
Academic Article PKC alpha mediates chemoresistance in acute lymphoblastic leukemia through effects on Bcl2 phosphorylation.
Academic Article Changes associated with the development of resistance to imatinib (STI571) in two leukemia cell lines expressing p210 Bcr/Abl protein.
Academic Article Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells.
Academic Article A novel ring-substituted diindolylmethane,1,1-bis[3'-(5-methoxyindolyl)]-1-(p-t-butylphenyl) methane, inhibits extracellular signal-regulated kinase activation and induces apoptosis in acute myelogenous leukemia.
Academic Article Indole-3-carbinol suppresses NF-kappaB and IkappaBalpha kinase activation, causing inhibition of expression of NF-kappaB-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells.
Academic Article A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells.
Academic Article Bcl2 phosphorylation and active PKC alpha are associated with poor survival in AML.
Academic Article Antileukemic activity of shepherdin and molecular diversity of hsp90 inhibitors.
Academic Article MEK blockade converts AML differentiating response to retinoids into extensive apoptosis.
Academic Article Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML.
Academic Article MicroRNA gene expression during retinoic acid-induced differentiation of human acute promyelocytic leukemia.
Academic Article Targeting the leukemia microenvironment.
Academic Article Triterpenoids display single agent anti-tumor activity in a transgenic mouse model of chronic lymphocytic leukemia and small B cell lymphoma.
Academic Article CDDO induces granulocytic differentiation of myeloid leukemic blasts through translational up-regulation of p42 CCAAT enhancer binding protein alpha.
Academic Article Anti-myeloma effect of homoharringtonine with concomitant targeting of the myeloma-promoting molecules, Mcl-1, XIAP, and beta-catenin.
Academic Article Ceramide promotes apoptosis in chronic myelogenous leukemia-derived K562 cells by a mechanism involving caspase-8 and JNK.
Academic Article Triptolide induces cell death independent of cellular responses to imatinib in blast crisis chronic myelogenous leukemia cells including quiescent CD34+ primitive progenitor cells.
Academic Article MicroRNA 29b functions in acute myeloid leukemia.
Academic Article Simultaneous activation of p53 and inhibition of XIAP enhance the activation of apoptosis signaling pathways in AML.
Academic Article Physiological hypoxia promotes lipid raft and PI3K-dependent activation of MAPK 42/44 in leukemia cells.
Academic Article Chemoimmunotherapy with a modified hyper-CVAD and rituximab regimen improves outcome in de novo Philadelphia chromosome-negative precursor B-lineage acute lymphoblastic leukemia.
Academic Article XIAP antisense oligonucleotide (AEG35156) achieves target knockdown and induces apoptosis preferentially in CD34+38- cells in a phase 1/2 study of patients with relapsed/refractory AML.
Academic Article Low expression of PP2A regulatory subunit B55a is associated with T308 phosphorylation of AKT and shorter complete remission duration in acute myeloid leukemia patients.
Academic Article Treatment of FLT3-ITD-positive acute myeloid leukemia relapsing after allogeneic stem cell transplantation with sorafenib.
Academic Article Role of stromal microenvironment in nonpharmacological resistance of CML to imatinib through Lyn/CXCR4 interactions in lipid rafts.
Academic Article Activation of apoptosis signaling eliminates CD34+ progenitor cells in blast crisis CML independent of response to tyrosine kinase inhibitors.
Academic Article Concomitant inhibition of DNA methyltransferase and BCL-2 protein function synergistically induce mitochondrial apoptosis in acute myelogenous leukemia cells.
Academic Article BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model of AML by targeting primitive LSK and progenitor cells.
Academic Article Implications of the miR-10 family in chemotherapy response of NPM1-mutated AML.
Academic Article The protein phosphatase 2A regulatory subunit B55a is a modulator of signaling and microRNA expression in acute myeloid leukemia cells.
Academic Article SL-401 and SL-501, targeted therapeutics directed at the interleukin-3 receptor, inhibit the growth of leukaemic cells and stem cells in advanced phase chronic myeloid leukaemia.
Academic Article T-cell-depleted autologous marrow fails to prevent acute graft-versus-host disease after allogeneic marrow transplantation for lymphoblastic lymphoma.
Academic Article Comparison of in vivo and in vitro effects of granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients with acute myeloid leukemia.
Academic Article Effect of tamoxifen on cell lines displaying the multidrug-resistant phenotype.
Academic Article Detection of bcr-abl fusion in chronic myelogeneous leukemia by in situ hybridization.
Academic Article Kinetic rationale for cytokine-induced recruitment of myeloblastic leukemia followed by cycle-specific chemotherapy in vitro.
Academic Article Colony-stimulating factors (rhG-CSF, rhGM-CSF, rhIL-3, and BCGF) recruit myeloblastic and lymphoblastic leukemic cells and enhance the cytotoxic effects of cytosine-arabinoside.
Academic Article Idarubicin in acute leukemia: results of US trials.
Academic Article Distinct antigen expression related to DNA ploidy in a case of biphenotypic leukemia.
Academic Article Prognostic factors in acute lymphoblastic leukemia in adults: the Memorial Hospital experience.
Academic Article Cell differentiation effects of 2'-fluoro-1-beta-D-arabinofuranosyl pyrimidines in HL-60 cells.
Academic Article Childhood CML in blastic stage: an analysis of cell markers and cell kinetics.
Academic Article Heterogeneity of cell lineages in L3 leukemias.
Academic Article Serum LDH values in childhood acute leukemias and non-Hodgkin's lymphoma.
Academic Article Thymidine as a kinetic and biochemical modulator of 1-beta-D-arabinofuranosylcytosine in human acute nonlymphocytic leukemia.
Academic Article Discrimination of human leukemia subtypes by flow cytometric analysis of cellular DNA and RNA.
Academic Article Combination of hematopoietic growth factors containing IL-3 induce acute myeloid leukemia cell sensitization to cycle specific and cycle non-specific drugs.
Academic Article Granulocyte-colony stimulating factor, granulocyte-macrophage colony stimulating factor, PIXY-321, stem cell factor, interleukin-3, and interleukin-7: receptor binding and effects on clonogenic proliferation in acute lymphoblastic leukemia.
Academic Article Analysis of CD7 expression in acute myelogenous leukemia: martingale residual plots combined with 'optimal' cutpoint analysis reveals absence of prognostic significance.
Academic Article Idarubicin cardiotoxicity: a retrospective study in acute myeloid leukemia and myelodysplasia.
Academic Article Epidemiology of influenza A virus infection in patients with acute or chronic leukemia.
Academic Article Phase II study of interleukin-6 in patients with smoldering relapse of acute myelogenous leukemia.
Academic Article Lack of effect of 2-chlorodeoxyadenosine therapy in patients with chronic lymphocytic leukemia refractory to fludarabine therapy.
Academic Article Dose-escalation trial of M195 labeled with iodine 131 for cytoreduction and marrow ablation in relapsed or refractory myeloid leukemias.
Academic Article Soluble FAS (CD95) is not elevated in the serum of patients with myeloid leukemias, myeloproliferative and myelodysplastic syndromes.
Academic Article A new series of vitamin D analogs is highly active for clonal inhibition, differentiation, and induction of WAF1 in myeloid leukemia.
Academic Article Semi-automated PCR method for quantitating MDR1 expression.
Academic Article Use of leukemic dendritic cells for the generation of antileukemic cellular cytotoxicity against Philadelphia chromosome-positive chronic myelogenous leukemia.
Academic Article 2-Chlorodeoxyadenosine therapy for idiopathic hypereosinophilic syndrome.
Academic Article Minimal residual disease in acute myelogenous leukaemia and myelodysplastic syndromes: a follow-up of patients in clinical remission.
Academic Article High remission rate, short remission duration in patients with refractory anemia with excess blasts (RAEB) in transformation (RAEB-t) given acute myelogenous leukemia (AML)-type chemotherapy in combination with granulocyte-CSF (G-CSF).
Academic Article Induction of death (CD95/FAS), activation and adhesion (CD54) molecules on blast cells of acute myelogenous leukemias by TNF-alpha and IFN-gamma.
Academic Article Cellular pharmacology of mitoxantrone in p-glycoprotein-positive and -negative human myeloid leukemic cell lines.
Academic Article Elevated levels of biologically active soluble CD40 ligand in the serum of patients with chronic lymphocytic leukaemia.
Academic Article Comparison of referring and tertiary cancer center physician's diagnoses in patients with leukemia.
Academic Article Phase I study of taxol in refractory acute myelogenous leukemias using a weekly schedule.
Academic Article Bryostatin and CD40-ligand enhance apoptosis resistance and induce expression of cell survival genes in B-cell chronic lymphocytic leukaemia.
Academic Article Cell-surface exposure of phosphatidylserine correlates with the stage of fludarabine-induced apoptosis in chronic lymphocytic leukemia and expression of apoptosis-regulating genes.
Academic Article Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias.
Academic Article Human A1 expression in acute myeloid leukemia and its relationship to Bcl-2 expression.
Academic Article Expression of apoptosis proteins in chronic myelogenous leukemia: associations and significance.
Academic Article Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia.
Academic Article Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins.
Academic Article Functional blocks in caspase activation pathways are common in leukemia and predict patient response to induction chemotherapy.
Academic Article A method for functional evaluation of caspase activation pathways in intact lymphoid cells using electroporation-mediated protein delivery and flow cytometric analysis.
Academic Article Results of triple therapy with interferon-alpha, cytarabine, and homoharringtonine, and the impact of adding imatinib to the treatment sequence in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in early chronic phase.
Academic Article Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias.
Academic Article PML-RARalpha is associated with leptin-receptor induction: the role of mesenchymal stem cell-derived adipocytes in APL cell survival.
Academic Article The mitogen-activated protein kinase signaling module as a therapeutic target in hematologic malignancies.
Academic Article A Phase I and pharmacokinetic study of VNP40101M, a novel sulfonylhydrazine alkylating agent, in patients with refractory leukemia.
Academic Article Fludarabine and mitoxantrone for patients with chronic lymphocytic leukemia.
Academic Article Peroxisome proliferator-activated receptor gamma and retinoid X receptor ligands are potent inducers of differentiation and apoptosis in leukemias.
Academic Article Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia.
Academic Article The novel triterpenoid CDDO-Me suppresses MAPK pathways and promotes p38 activation in acute myeloid leukemia cells.
Academic Article MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy.
Academic Article Beyond single pathway inhibition: MEK inhibitors as a platform for the development of pharmacological combinations with synergistic anti-leukemic effects.
Academic Article Pharmacodynamics of cytarabine alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trial.
Academic Article Vaccination with leukemia cells expressing cell-surface-associated GM-CSF blocks leukemia induction in immunocompetent mice.
Academic Article Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells.
Academic Article Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia.
Academic Article Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias.
Academic Article Overexpression of CXCR4 predicts adverse overall and event-free survival in patients with unmutated FLT3 acute myeloid leukemia with normal karyotype.
Academic Article ERK1/2 phosphorylation is an independent predictor of complete remission in newly diagnosed adult acute lymphoblastic leukemia.
Academic Article Novel role of HDAC inhibitors in AML1/ETO AML cells: activation of apoptosis and phagocytosis through induction of annexin A1.
Academic Article Apoptosis-based dual molecular targeting by INNO-406, a second-generation Bcr-Abl inhibitor, and ABT-737, an inhibitor of antiapoptotic Bcl-2 proteins, against Bcr-Abl-positive leukemia.
Academic Article ABT-737 is a useful component of combinatory chemotherapies for chronic myeloid leukaemias with diverse drug-resistance mechanisms.
Academic Article Synthetic triterpenoids have cytotoxicity in pediatric acute lymphoblastic leukemia cell lines but cytotoxicity is independent of induced ceramide increase in MOLT-4 cells.
Academic Article PPARgamma-active triterpenoid CDDO enhances ATRA-induced differentiation in APL.
Academic Article MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia.
Academic Article CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells.
Academic Article Inhibition of mitochondrial metabolism by methyl-2-cyano-3,12-dioxooleana-1,9-diene-28-oate induces apoptotic or autophagic cell death in chronic myeloid leukemia cells.
Academic Article The dual PI3 kinase/mTOR inhibitor PI-103 prevents p53 induction by Mdm2 inhibition but enhances p53-mediated mitochondrial apoptosis in p53 wild-type AML.
Academic Article HOX expression patterns identify a common signature for favorable AML.
Academic Article Functional proteomic profiling of AML predicts response and survival.
Academic Article Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML.
Academic Article Phase I/II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia.
Academic Article The elusive chronic myeloid leukemia stem cell: does it matter and how do we eliminate it?
Academic Article Expression of ARC (apoptosis repressor with caspase recruitment domain), an antiapoptotic protein, is strongly prognostic in AML.
Academic Article Targeting PKC-mediated signal transduction pathways using enzastaurin to promote apoptosis in acute myeloid leukemia-derived cell lines and blast cells.
Academic Article Functional implications of microRNAs in acute myeloid leukemia by integrating microRNA and messenger RNA expression profiling.
Academic Article Phosphorylated CXCR4 is associated with poor survival in adults with B-acute lymphoblastic leukemia.
Academic Article Pronounced hypoxia in models of murine and human leukemia: high efficacy of hypoxia-activated prodrug PR-104.
Academic Article Therapeutic potential of MEK inhibition in acute myelogenous leukemia: rationale for "vertical" and "lateral" combination strategies.
Academic Article Survivin is highly expressed in CD34(+)38(-) leukemic stem/progenitor cells and predicts poor clinical outcomes in AML.
Academic Article A randomized controlled trial of an intensive insulin regimen in patients with hyperglycemic acute lymphoblastic leukemia.
Academic Article Effects of PPAR? Ligands on Leukemia.
Academic Article Molecular characterization of de novo Philadelphia chromosome-positive acute myeloid leukemia.
Academic Article Mechanisms of apoptosis induction by simultaneous inhibition of PI3K and FLT3-ITD in AML cells in the hypoxic bone marrow microenvironment.
Academic Article Salvage therapy using FLT3 inhibitors may improve long-term outcome of relapsed or refractory AML in patients with FLT3-ITD.
Academic Article Phase 2 study of azacytidine plus sorafenib in patients with acute myeloid leukemia and FLT-3 internal tandem duplication mutation.
Academic Article XIAP downregulation promotes caspase-dependent inhibition of proteasome activity in AML cells.
Academic Article Clofarabine, idarubicin, and cytarabine (CIA) as frontline therapy for patients =60 years with newly diagnosed acute myeloid leukemia.
Academic Article Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute myeloid leukemia.
Academic Article Synergistic targeting of AML stem/progenitor cells with IAP antagonist birinapant and demethylating agents.
Academic Article Preclinical and early clinical evaluation of the oral AKT inhibitor, MK-2206, for the treatment of acute myelogenous leukemia.
Academic Article SPARC promotes leukemic cell growth and predicts acute myeloid leukemia outcome.
Academic Article The coexistence of acute myeloblastic leukemia and diffuse histiocytic lymphoma in the same patient as demonstrated by multiparameter analysis.
Academic Article Retinoids and cancer therapy.
Academic Article Clinical implications of decreased retinoblastoma protein expression in acute myelogenous leukemia.
Academic Article Proliferation of hematopoietic cells is accompanied by suppressed expression of heat shock protein 70.
Academic Article The phosphorylation of retinoblastoma gene product in human myeloid leukemia cells during the cell cycle.
Academic Article Recombinant human granulocyte-macrophage colony-stimulating factor in combination with standard induction chemotherapy in de novo acute myeloid leukemia.
Academic Article Results of a randomized trial comparing idarubicin and cytosine arabinoside with daunorubicin and cytosine arabinoside in adult patients with newly diagnosed acute myelogenous leukemia.
Academic Article A study of multidrug resistance and cell kinetics in a child with near-haploid acute lymphoblastic leukemia.
Academic Article Detection of central nervous system relapse in acute leukemia by multiparameter flow cytometry of DNA, RNA, and CALLA.
Academic Article Implications of 'cell kill' for the treatment of acute myelogenous leukemia: can the cure rate be increased?
Academic Article Comparative trial of cytarabine and thioguanine in combination with amsacrine or daunorubicin in patients with untreated acute nonlymphocytic leukemia: results of the L-16M protocol.
Academic Article Idarubicin in acute leukemia: results of studies at Memorial Sloan-Kettering Cancer Center.
Academic Article A cause-specific hazard rate analysis of prognostic factors among 199 adults with acute lymphoblastic leukemia: the Memorial Hospital experience since 1969.
Academic Article Cellular ras oncogene expression and cell cycle measured by flow cytometry in hematopoietic cell lines.
Academic Article Cell kinetics of leukemia.
Academic Article [Oncogens and cancer. Review and a new method for measuring the gene expression in relation to the cell cycle].
Academic Article Multiparameter flow cytometry. Part II. application in hematology.
Academic Article Bone marrow biopsy instead of 'marrow juice' for cell kinetic analysis. Comparison of bone marrow biopsy and aspiration material.
Academic Article Flow cytometry in clinical cancer research.
Academic Article Cell survival kinetics in peripheral blood and bone marrow during total body irradiation for marrow transplantation.
Academic Article Lymphoblastic neoplasia in a homosexual patient with Kaposi's sarcoma.
Academic Article [Pro and con: Aggressive or conventional treatment of chronic myelogenous leukemia. Arguments in favor of aggressive treatment].
Academic Article [Summary: Therapy of chronic myelogenous leukemia--prognosis].
Academic Article Acute myeloblastic leukemia following non-Hodgkin lymphoma in an adolescent. A report of a case with preleukemic syndrome, and review of the literature.
Academic Article Bone marrow cell count per cubic millimeter bone marrow: a new parameter for quantitating therapy-induced cytoreduction in acute leukemia.
Academic Article Cell kinetics in acute leukemia: a critical reevaluation based on new data.
Academic Article Quantitation of chemotherapy-induced cytoreduction in acute leukemia.
Academic Article A pilot study of the biologic and therapeutic effects of granulocyte colony-stimulating factor (filgrastim) in patients with acute myelogenous leukemia.
Academic Article Retinoic acid-induced expression of CD38 antigen in myeloid cells is mediated through retinoic acid receptor-alpha.
Academic Article Expression of MDR1 by normal bone marrow cells and its implication for leukemic hematopoiesis.
Academic Article Interleukin-3 priming in acute myeloid leukaemia patients.
Academic Article Homoharringtonine therapy induces responses in patients with chronic myelogenous leukemia in late chronic phase.
Academic Article Chromosome 17 numerical abnormalities in 55 patients with non-Hodgkin's lymphoma: a fluorescence in situ hybridization study.
Academic Article Growth-factor stimulation reveals two mechanisms of retinoblastoma gene inactivation in human myelogenous leukemia cells.
Academic Article Cell cycle-related shifts in subcellular localization of BCR: association with mitotic chromosomes and with heterochromatin.
Academic Article Low incidence of MDR1 expression in acute promyelocytic leukaemia.
Academic Article Use of retroviral markers to identify efficacy of purging and origin of relapse following autologous bone marrow and peripheral blood cell transplantation in indolent B cell neoplasms (follicular non-Hodgkin's lymphoma or chronic lymphocytic leukemia (CLL) patients).
Academic Article Consensus review of the clinical utility of DNA flow cytometry in neoplastic hematopathology.
Academic Article Combination treatment of acute myeloblastic leukemia with rhGM-CSF and standard induction chemotherapy.
Academic Article Induction of differentiation in myeloid leukemia cell lines and acute promyelocytic leukemia cells by liposomal all-trans-retinoic acid.
Academic Article Quantitative expression of proliferating cell nuclear antigen by western blot (PCNAWB) in peripheral blasts correlates with remission induction in patients with acute myelogenous leukemia.
Academic Article Myeloid markers in adult acute lymphocytic leukemia. Correlations with patient and disease characteristics and with prognosis.
Academic Article Topotecan, a topoisomerase I inhibitor, is active in the treatment of myelodysplastic syndrome and chronic myelomonocytic leukemia.
Academic Article Clinical and laboratory studies of 2-chlorodeoxyadenosine +/- cytosine arabinoside for relapsed or refractory acute myelogenous leukemia in adults.
Academic Article Disseminated intravascular coagulation in adult acute lymphoblastic leukemia: frequent complications with fibrinogen levels less than 100 mg/dl.
Academic Article Protease activation is required for glucocorticoid-induced apoptosis in chronic lymphocytic leukemic lymphocytes.
Academic Article Differential induction of apoptosis by fludarabine monophosphate in leukemic B and normal T cells in chronic lymphocytic leukemia.
Academic Article Ratio of bcl-xshort to bcl-xlong is different in good- and poor-prognosis subsets of acute myeloid leukemia.
Academic Article Overexpression of Bax gene sensitizes K562 erythroleukemia cells to apoptosis induced by selective chemotherapeutic agents.
Academic Article Humanized M195 monoclonal antibody conjugated to recombinant gelonin: an anti-CD33 immunotoxin with antileukemic activity.
Academic Article Ligation of cell surface CD38 protein with agonistic monoclonal antibody induces a cell growth signal in myeloid leukemia cells.
Academic Article Expression and function of leptin receptor isoforms in myeloid leukemia and myelodysplastic syndromes: proliferative and anti-apoptotic activities.
Academic Article Randomized phase II study of fludarabine + cytosine arabinoside + idarubicin +/- all-trans retinoic acid +/- granulocyte colony-stimulating factor in poor prognosis newly diagnosed acute myeloid leukemia and myelodysplastic syndrome.
Academic Article Quantitation of minimal residual disease in acute myelogenous leukemia and myelodysplastic syndromes in complete remission by molecular cytogenetics of progenitor cells.
Academic Article Sequential homoharringtonine and interferon-alpha in the treatment of early chronic phase chronic myelogenous leukemia.
Academic Article Use of peripheral blood blasts vs bone marrow blasts for diagnosis of acute leukemia.
Academic Article Treatment of Philadelphia chromosome-positive early chronic phase chronic myelogenous leukemia with daily doses of interferon alpha and low-dose cytarabine.
Academic Article Functional expression of TRAIL by lymphoid and myeloid tumour cells.
Academic Article Expression of bcr-abl mRNA in individual chronic myelogenous leukaemia cells as determined by in situ amplification.
Academic Article Cytokine-regulated expression of survivin in myeloid leukemia.
Academic Article Thiotepa, busulfan, and cyclophosphamide as a preparative regimen for allogeneic transplantation for advanced myelodysplastic syndrome and acute myelogenous leukemia.
Academic Article Donor lymphocyte apheresis for adoptive immunotherapy compared with blood stem cell apheresis.
Academic Article Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia.
Academic Article Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia.
Academic Article Imatinib mesylate for Philadelphia chromosome-positive, chronic-phase myeloid leukemia after failure of interferon-alpha: follow-up results.
Academic Article Independent prognostic significance of day 21 cytogenetic findings in newly-diagnosed acute myeloid leukemia or refractory anemia with excess blasts.
Academic Article Results of decitabine (5-aza-2'deoxycytidine) therapy in 130 patients with chronic myelogenous leukemia.
Academic Article Caspase-independent cell death in AML: caspase inhibition in vitro with pan-caspase inhibitors or in vivo by XIAP or Survivin does not affect cell survival or prognosis.
Academic Article Treatment of Philadelphia chromosome-positive acute lymphocytic leukemia with hyper-CVAD and imatinib mesylate.
Academic Article Expression of inducible Bcl-X(S) in myeloid leukemia: compensatory upregulation of Bcl-X(L) and Bcl-2 prevents apoptosis and chemosensitization.
Academic Article Quantitative single cell determination of ERK phosphorylation and regulation in relapsed and refractory primary acute myeloid leukemia.
Academic Article Leukotriene B4 receptor inhibitor LY293111 induces cell cycle arrest and apoptosis in human anaplastic large-cell lymphoma cells via JNK phosphorylation.
Academic Article Regulation of survivin expression through Bcr-Abl/MAPK cascade: targeting survivin overcomes imatinib resistance and increases imatinib sensitivity in imatinib-responsive CML cells.
Academic Article Development of a conditional in vivo model to evaluate the efficacy of small molecule inhibitors for the treatment of Raf-transformed hematopoietic cells.
Academic Article Guggulsterones induce apoptosis and differentiation in acute myeloid leukemia: identification of isomer-specific antileukemic activities of the pregnadienedione structure.
Academic Article Triapine and cytarabine is an active combination in patients with acute leukemia or myelodysplastic syndrome.
Academic Article Targeting Hsp90 by 17-AAG in leukemia cells: mechanisms for synergistic and antagonistic drug combinations with arsenic trioxide and Ara-C.
Academic Article Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia.
Academic Article Simultaneous activation of multiple signal transduction pathways confers poor prognosis in acute myelogenous leukemia.
Academic Article Studying the right cell in acute myelogenous leukemia: dynamic changes of apoptosis and signal transduction pathway protein expression in chemotherapy resistant ex-vivo selected "survivor cells".
Academic Article Tetra-O-methyl nordihydroguaiaretic acid inhibits growth and induces death of leukemia cells independent of Cdc2 and survivin.
Academic Article Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5.
Academic Article MicroRNAs and noncoding RNAs in hematological malignancies: molecular, clinical and therapeutic implications.
Academic Article TGF-beta receptor kinase inhibitor LY2109761 reverses the anti-apoptotic effects of TGF-beta1 in myelo-monocytic leukaemic cells co-cultured with stromal cells.
Academic Article Potential role of sorafenib in the treatment of acute myeloid leukemia.
Academic Article A phase I study of the pan bcl-2 family inhibitor obatoclax mesylate in patients with advanced hematologic malignancies.
Academic Article Stabilization and activation of p53 downregulates mTOR signaling through AMPK in mantle cell lymphoma.
Academic Article Cyclin-dependent kinase 1 inhibitor RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AML.
Academic Article Inhibition of KSP by ARRY-520 induces cell cycle block and cell death via the mitochondrial pathway in AML cells.
Academic Article Blockade of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase and murine double minute synergistically induces Apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim.
Academic Article 1,25-dihydroxyvitamin D3 enhances the apoptotic activity of MDM2 antagonist nutlin-3a in acute myeloid leukemia cells expressing wild-type p53.
Academic Article The novel tryptamine derivative JNJ-26854165 induces wild-type p53- and E2F1-mediated apoptosis in acute myeloid and lymphoid leukemias.
Academic Article p53 activation of mesenchymal stromal cells partially abrogates microenvironment-mediated resistance to FLT3 inhibition in AML through HIF-1a-mediated down-regulation of CXCL12.
Academic Article MRx102, a triptolide derivative, has potent antileukemic activity in vitro and in a murine model of AML.
Academic Article Prognostic significance of alterations in IDH enzyme isoforms in patients with AML treated with high-dose cytarabine and idarubicin.
Academic Article Regulation of HIF-1a signaling and chemoresistance in acute lymphocytic leukemia under hypoxic conditions of the bone marrow microenvironment.
Academic Article Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment.
Academic Article Safety and pharmacokinetics of the antisense oligonucleotide (ASO) LY2181308 as a single-agent or in combination with idarubicin and cytarabine in patients with refractory or relapsed acute myeloid leukemia (AML).
Academic Article CXCR4 downregulation of let-7a drives chemoresistance in acute myeloid leukemia.
Academic Article Phase I/II trial of nanomolecular liposomal annamycin in adult patients with relapsed/refractory acute lymphoblastic leukemia.
Academic Article PI3K inhibitor GDC-0941 enhances apoptotic effects of BH-3 mimetic ABT-737 in AML cells in the hypoxic bone marrow microenvironment.
Academic Article BH3 profiling discriminates response to cytarabine-based treatment of acute myelogenous leukemia.
Academic Article Targeting connective tissue growth factor (CTGF) in acute lymphoblastic leukemia preclinical models: anti-CTGF monoclonal antibody attenuates leukemia growth.
Academic Article Reciprocal leukemia-stroma VCAM-1/VLA-4-dependent activation of NF-?B mediates chemoresistance.
Academic Article Tyrosine kinase inhibitors induce mesenchymal stem cell-mediated resistance in BCR-ABL+ acute lymphoblastic leukemia.
Academic Article Different sensitivity of chromatin to acid denaturation in quiescent and cycling cells as revealed by flow cytometry.
Academic Article Surface marker analysis and flow cytometric studies of acute nonlymphocytic leukemias in children and young adults.
Academic Article Hexamethylene bisacetamide in myelodysplastic syndrome and acute myelogenous leukemia: a phase II clinical trial with a differentiation-inducing agent.
Academic Article Autologous bone marrow transplantation for acute myelogenous leukemia using 4-hydroperoxycyclophosphamide and VP-16 purged bone marrow.
Academic Article Importance of long-term follow-up in evaluating treatment regimens for adults with acute lymphoblastic leukemia.
Academic Article DNA and RNA analysis by flow cytometry of the leukemia in AKR mice.
Academic Article Common acute lymphoblastic leukemia characterized by four different DNA stemlines with heterogeneity in RNA content, antigen expression and sensitivity to chemotherapy.
Academic Article DNA and RNA determination in 111 cases of childhood acute lymphoblastic leukaemia (ALL) by flow cytometry: correlation of FAB classification with DNA stemline and proliferation.
Academic Article Prognostic significance of terminal deoxynucleotidyl transferase activity in acute nonlymphoblastic leukemia.
Academic Article Acute non-lymphoblastic leukemia after treatment of nodular lymphoma with human leukocyte interferon.
Academic Article [Comparison of the therapeutic efficacity of 2 induction protocols in acute myeloid leukemia using exact quantification of bone marrow cellularity].
Academic Article Non-T, non-B acute lymphoblastic leukemia (L3) with t(8;22) and two 14q+ chromosomes.
Academic Article Characterization of hematologic malignancies by flow cytometry.
Academic Article A knowledge-based system for the interpretation of flow cytometry data in leukemias and lymphomas.
Academic Article Acanthamoeba meningoencephalitis after bone marrow transplantation.
Academic Article Flow cytometric determination of the multidrug-resistant phenotype in acute leukemia.
Academic Article Severe toxicity limits intensification of induction therapy for acute lymphoblastic leukemia.
Academic Article Activation of p21WAF1/Cip1 expression by a temperature-sensitive mutant of human p53 does not lead to apoptosis.
Academic Article CD30 ligand is expressed on resting normal and malignant human B lymphocytes.
Academic Article The novel anthracycline annamycin is not affected by P-glycoprotein-related multidrug resistance: comparison with idarubicin and doxorubicin in HL-60 leukemia cell lines.
Academic Article Flt3 ligand stimulates proliferation and inhibits apoptosis of acute myeloid leukemia cells: regulation of Bcl-2 and Bax.
Academic Article Low and maximally phosphorylated levels of the retinoblastoma protein confer poor prognosis in newly diagnosed acute myelogenous leukemia: a prospective study.
Academic Article Telomerase activity in human acute myelogenous leukemia: inhibition of telomerase activity by differentiation-inducing agents.
Academic Article Apoptosis. Molecules and mechanisms.
Academic Article Simultaneous homoharringtonine and interferon-alpha in the treatment of patients with chronic-phase chronic myelogenous leukemia.
Academic Article Phase I trial and correlative laboratory studies of bryostatin 1 (NSC 339555) and high-dose 1-B-D-arabinofuranosylcytosine in patients with refractory acute leukemia.
Academic Article Mechanisms of drug resistance in AML.
Academic Article Experience with alemtuzumab plus rituximab in patients with relapsed and refractory lymphoid malignancies.
Academic Article Effects of the proteasome inhibitor, bortezomib, on apoptosis in isolated lymphocytes obtained from patients with chronic lymphocytic leukemia.
Academic Article Spontaneous migration of acute promyelocytic leukemia cells beneath cultured bone marrow adipocytes with matched expression of the major histocompatibility complex.
Academic Article Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells.
Academic Article Single-agent liposomal all-trans retinoic acid can cure some patients with untreated acute promyelocytic leukemia: an update of The University of Texas M. D. Anderson Cancer Center Series.
Academic Article Phase I/II study of the mammalian target of rapamycin inhibitor everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies.
Academic Article Regulation and targeting of Eg5, a mitotic motor protein in blast crisis CML: overcoming imatinib resistance.
Academic Article Activation of integrin-linked kinase is a critical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells.
Academic Article Mitogen-activated protein kinase kinase inhibition enhances nuclear proapoptotic function of p53 in acute myelogenous leukemia cells.
Academic Article The warburg effect in leukemia-stroma cocultures is mediated by mitochondrial uncoupling associated with uncoupling protein 2 activation.
Academic Article MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1.
Academic Article Therapeutic targeting of microenvironmental interactions in leukemia: mechanisms and approaches.
Academic Article Phase I/II trial of AEG35156 X-linked inhibitor of apoptosis protein antisense oligonucleotide combined with idarubicin and cytarabine in patients with relapsed or primary refractory acute myeloid leukemia.
Academic Article Selective FLT3 inhibitor FI-700 neutralizes Mcl-1 and enhances p53-mediated apoptosis in AML cells with activating mutations of FLT3 through Mcl-1/Noxa axis.
Academic Article Apoptosis in leukemias: regulation and therapeutic targeting.
Academic Article Role of peroxisome proliferator-activated receptor-gamma and its coactivator DRIP205 in cellular responses to CDDO (RTA-401) in acute myelogenous leukemia.
Academic Article The organic arsenic derivative GMZ27 induces PML-RARa-independent apoptosis in myeloid leukemia cells.
Academic Article Prognostic impact and targeting of CRM1 in acute myeloid leukemia.
Academic Article CXC chemokine receptor 4 expression, CXC chemokine receptor 4 activation, and wild-type nucleophosmin are independently associated with unfavorable prognosis in patients with acute myeloid leukemia.
Academic Article Apoptosis repressor with caspase recruitment domain modulates second mitochondrial-derived activator of caspases mimetic-induced cell death through BIRC2/MAP3K14 signalling in acute myeloid leukaemia.
Academic Article Treatment of de novo acute myelogenous leukemia with recombinant granulocyte macrophage-colony-stimulating factor in combination with standard induction chemotherapy: effect of granulocyte macrophage-colony-stimulating factor on white blood cell counts.
Academic Article Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid).
Academic Article Hematopoietic colony-stimulating factors.
Academic Article The PML gene encodes a phosphoprotein associated with the nuclear matrix.
Academic Article Minimal residual disease in hematologic malignancies.
Academic Article A phase I-II study of high-dose thiotepa, busulfan and cyclophosphamide as a preparative regimen for allogeneic marrow transplantation.
Academic Article Analysis of chimerism following allogeneic bone marrow transplantation by fluorescent-in-situ hybridization.
Academic Article The prognostic impact of BCL2 protein expression in acute myelogenous leukemia varies with cytogenetics.
Academic Article Topotecan and cytarabine is an active combination regimen in myelodysplastic syndromes and chronic myelomonocytic leukemia.
Academic Article BAX and PKCalpha modulate the prognostic impact of BCL2 expression in acute myelogenous leukemia.
Academic Article CD38 in hematopoietic malignancies.
Academic Article Autocrine cell suicide in a Burkitt lymphoma cell line (Daudi) induced by interferon alpha: involvement of tumor necrosis factor as ligand for the CD95 receptor.
Academic Article Proliferation and apoptosis in acute and chronic leukemias and myelodysplastic syndrome.
Academic Article Up-regulation of MDR1 and induction of doxorubicin resistance by histone deacetylase inhibitor depsipeptide (FK228) and ATRA in acute promyelocytic leukemia cells.
Academic Article Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia.
Academic Article PML-RARalpha and AML1-ETO translocations are rarely associated with methylation of the RARbeta2 promoter.
Academic Article Differential tumor suppressor properties and transforming growth factor-beta responsiveness of p57KIP2 in leukemia cells with aberrant p57KIP2 promoter DNA methylation.
Academic Article Mutant FLT3: a direct target of sorafenib in acute myelogenous leukemia.
Academic Article Concomitant inhibition of Mdm2-p53 interaction and Aurora kinases activates the p53-dependent postmitotic checkpoints and synergistically induces p53-mediated mitochondrial apoptosis along with reduced endoreduplication in acute myelogenous leukemia.
Academic Article CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure.
Academic Article Phase I study of sorafenib in patients with refractory or relapsed acute leukemias.
Academic Article Decreased sensitivity of 17p-deleted chronic lymphocytic leukemia cells to a small molecule BCL-2 antagonist ABT-737.
Academic Article Ink4a and Arf are crucial factors in the determination of the cell of origin and the therapeutic sensitivity of Myc-induced mouse lymphoid tumor.
Academic Article Differential impact of structurally different anti-diabetic drugs on proliferation and chemosensitivity of acute lymphoblastic leukemia cells.
Academic Article GM-CSF in combination with cytotoxic chemotherapy in AML patients.
Academic Article Surface immunoglobulin light chain expression in pre-B cell leukemias.
Academic Article Current status of treatment of acute leukemia in adults: an overview of the Memorial experience and review of literature.
Academic Article Biosynthesis of ferritin subunits from different cell lines of HL-60 human promyelocytic leukaemia cells and the release of acidic isoferritin-inhibitory activity against normal granulocyte-macrophage progenitor cells.
Academic Article Mitochondrial uncoupling and the reprograming of intermediary metabolism in leukemia cells.
Academic Article Reversal of acquired drug resistance in FLT3-mutated acute myeloid leukemia cells via distinct drug combination strategies.
Academic Article The effect of calcium channel blockers on the outcome of acute myeloid leukemia.
Academic Article Treatment with FLT3 inhibitor in patients with FLT3-mutated acute myeloid leukemia is associated with development of secondary FLT3-tyrosine kinase domain mutations.
Academic Article Investigational FMS-like tyrosine kinase 3 inhibitors in treatment of acute myeloid leukemia.
Academic Article Platelets promote mitochondrial uncoupling and resistance to apoptosis in leukemia cells: a novel paradigm for the bone marrow microenvironment.
Academic Article Phase I/II trial of the combination of midostaurin (PKC412) and 5-azacytidine for patients with acute myeloid leukemia and myelodysplastic syndrome.
Academic Article Single-cell mass cytometry reveals intracellular survival/proliferative signaling in FLT3-ITD-mutated AML stem/progenitor cells.
Academic Article Phase I/II study of the hypoxia-activated prodrug PR104 in refractory/relapsed acute myeloid leukemia and acute lymphoblastic leukemia.
Academic Article Leukemia cell mobilization with G-CSF plus plerixafor during busulfan-fludarabine conditioning for allogeneic stem cell transplantation.
Academic Article Antileukemia activity of the novel peptidic CXCR4 antagonist LY2510924 as monotherapy and in combination with chemotherapy.
Academic Article Inhibition of Mcl-1 with the pan-Bcl-2 family inhibitor (-)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia.
Academic Article Improvement in clinical outcome of FLT3 ITD mutated acute myeloid leukemia patients over the last one and a half decade.
Academic Article Mitochondrial Profiling of Acute Myeloid Leukemia in the Assessment of Response to Apoptosis Modulating Drugs.
Academic Article Synergistic effects of p53 activation via MDM2 inhibition in combination with inhibition of Bcl-2 or Bcr-Abl in CD34+ proliferating and quiescent chronic myeloid leukemia blast crisis cells.
Academic Article MDM2 Inhibitor, Nutlin 3a, Induces p53 Dependent Autophagy in Acute Leukemia by AMP Kinase Activation.
Academic Article Preclinical activity of the novel B-cell-specific Moloney murine leukemia virus integration site 1 inhibitor PTC-209 in acute myeloid leukemia: Implications for leukemia therapy.
Academic Article Implementation of a Pan-Genomic Approach to Investigate Holobiont-Infecting Microbe Interaction: A Case Report of a Leukemic Patient with Invasive Mucormycosis.
Academic Article Phosphorylation of GSK3a/? correlates with activation of AKT and is prognostic for poor overall survival in acute myeloid leukemia patients.
Academic Article MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199.
Academic Article Mixed-phenotype acute leukemia (MPAL) exhibits frequent mutations in DNMT3A and activated signaling genes.
Academic Article DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia.
Academic Article TGF-?-Neutralizing Antibody 1D11 Enhances Cytarabine-Induced Apoptosis in AML Cells in the Bone Marrow Microenvironment.
Academic Article Results of the Phase I Trial of RG7112, a Small-Molecule MDM2 Antagonist in Leukemia.
Academic Article The Dual MEK/FLT3 Inhibitor E6201 Exerts Cytotoxic Activity against Acute Myeloid Leukemia Cells Harboring Resistance-Conferring FLT3 Mutations.
Academic Article Biguanides sensitize leukemia cells to ABT-737-induced apoptosis by inhibiting mitochondrial electron transport.
Academic Article Improvement in clinical outcome of FLT3 ITD mutated acute myeloid leukemia patients over the last one and a half decade
Academic Article MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199
Academic Article Combined targeting of BCL-2 and BCR-ABL tyrosine kinase eradicates chronic myeloid leukemia stem cells
Academic Article Higher levels of expression of BCL-2 and BCL-XL in poor prognosis monosomy 5 and monosomy 7} acute myeloid leukemia (AML) cells than in good prognosis (inversion 16 and translocation 8;21) aml cells
Academic Article The dual MEK/FLT3 inhibitor E6201 exerts cytotoxic activity against acute myeloid leukemia cells harboring resistance-conferring FLT3 Mutations
Academic Article Targeting survivin in leukemia
Academic Article DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia
Academic Article Kinetic and biochemical modulation of pyrimidine antimetabolites in therapy of acute leukemia
Academic Article Phase I/II study of the hypoxia-activated prodrug PR104 in refractory/relapsed acute myeloid leukemia and acute lymphoblastic leukemia
Academic Article Dual tel-abl fusion in a PH-negative chronic myeloid leukemia patient
Academic Article Preclinical activity of the novel B-cell-specific Moloney murine leukemia virus integration site 1 inhibitor PTC-209 in acute myeloid leukemia
Academic Article Chemotherapy of acute non-lymphocytic leukemia - new cell kinetic determinants
Academic Article Leukemia cell mobilization with G-CSF plus plerixafor during busulfan-fludarabine conditioning for allogeneic stem cell transplantation
Academic Article Mitochondrial uncoupling and the reprograming of intermediary metabolism in leukemia cells
Academic Article Targeting autophagy to overcome chemoresistance in acute myleogenous leukemia
Academic Article MDM2 inhibitor, Nutlin 3a, induces p53 dependent autophagy in acute leukemia by AMP kinase activation
Academic Article Quantitation of therapy induced cytoreduction in acute myeloblastic leukemia (AML)
Academic Article Mesenchymal stem cells (MSC) as carriers of hologically active molecules in cancer and leukemia therapy
Academic Article Clofarabine Plus Low-Dose Cytarabine Is as Effective as and Less Toxic Than Intensive Chemotherapy in Elderly AML Patients
Academic Article Synergistic effects of p53 activation via MDM2 inhibition in combination with inhibition of Bcl-2 or Bcr-Abl in CD34+ proliferating and quiescent chronic myeloid leukemia blast crisis cells
Academic Article Inihibition of PI3K by LY294002 promotes apoptosis and dephosphorylates bad in myeloid leukemias
Academic Article Mixed-phenotype acute leukemia (MPAL) exhibits frequent mutations in DNMT3A and activated signaling genes
Academic Article Comparison of the therapeutic efficacy of two induction regimens for acute myelocytic leukemia (AML) by accurate quantitation of bone marrow cellularity
Academic Article High Expression of Human Homologue of Murine Double Minute 4 and the Short Splicing Variant, HDM4-S, in Bone Marrow in Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome
Academic Article Peripheral blood blast clearance is an independent prognostic factor for survival and response to acute myeloid leukemia induction chemotherapy
Academic Article New directions in the biology and therapy of chronic myeloid leukemia
Academic Article Non B- non T acute lymphoblastic leukemia (ALL)
Academic Article Photothermolysis by laser-induced microbubbles generated around gold nanorod clusters selectively formed in leukemia cells
Academic Article Results of the phase i trial of RG7112, a small-molecule MDM2 antagonist in leukemia
Academic Article Anti-apoptotic ARC protein confers chemoresistance by controlling leukemia-microenvironment interactions through a NFκB/IL1β signaling network
Academic Article Treatment of Newly-Diagnosed AML with idarubicin + ARA-C
Academic Article Targeted therapy of acute myeloid leukemia
Academic Article Platelets promote mitochondrial uncoupling and resistance to apoptosis in leukemia cells
Academic Article Hypoxia-activated prodrug TH-302 targets hypoxic bone marrow niches in preclinical leukemia models
Academic Article Biguanides sensitize leukemia cells to ABT-737-induced apoptosis by inhibiting mitochondrial electron transport
Academic Article Current status of treatment of acute leukemia in adults
Academic Article Phosphorylation of GSK3α/β correlates with activation of AKT and is prognostic for poor overall survival in acute myeloid leukemia patients
Academic Article Treatment of philadelphia chromosome positive (ph +) chronic myelogenous leukemia in blast crisis and ph + acute leukemia with high dose cytosine arabinoside (HDARAC)
Academic Article Mitochondrial profiling of acute myeloid leukemia in the assessment of response to apoptosis modulating drugs
Academic Article Photothermal therapy of acute leukemia cells in the near-infrared region using gold nanorods CD-33 conjugates
Academic Article Pharmacological activation of wild-type p53 in the therapy of leukemia
Academic Article Buparlisib, a PI3K inhibitor, demonstrates acceptable tolerability and preliminary activity in a phase I trial of patients with advanced leukemias
Academic Article Bone marrow niche-mediated survival of leukemia stem cells in acute myeloid leukemia
Academic Article Treatment of Newly-Diagnosed AML with Idarubicin + ARA-C
Academic Article Iap family of proteins as therapeutic targets for acute myeloid leukemia
Academic Article AML-induced osteogenic differentiation in mesenchymal stromal cells supports leukemia growth.
Academic Article Laser nanothermolysis of human leukemia cells using functionalized plasmonic nanoparticles.
Academic Article Combination of galectin inhibitor GCS-100 and BH3 mimetics eliminates both p53 wild type and p53 null AML cells.
Academic Article Clofarabine Plus Low-Dose Cytarabine Is as Effective as and Less Toxic Than Intensive Chemotherapy in Elderly AML Patients.
Academic Article ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies.
Academic Article Anti-apoptotic ARC protein confers chemoresistance by controlling leukemia-microenvironment interactions through a NF?B/IL1? signaling network.
Academic Article Hypoxia-Activated Prodrug TH-302 Targets Hypoxic Bone Marrow Niches in Preclinical Leukemia Models.
Academic Article High Expression of Human Homologue of Murine Double Minute 4 and the Short Splicing?Variant, HDM4-S, in Bone Marrow in?Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome.
Academic Article Phase I study of evofosfamide, an investigational hypoxia-activated prodrug, in patients with advanced leukemia.
Academic Article Bone marrow niche-mediated survival of leukemia stem cells in acute myeloid leukemia: Yin and Yang.
Academic Article Treatment of Philadelphia Chromosome Positive (Ph +) Chronic Myelogenous Leukemia in Blast Crisis and Ph + Acute Leukemia with High Dose Cytosine Arabinoside (HDARAC).
Academic Article The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.
Academic Article Atg7 suppression enhances chemotherapeutic agent sensitivity and overcomes stroma-mediated chemoresistance in acute myeloid leukemia.
Academic Article Pharmacological activation of wild-type p53 in the therapy of leukemia.
Academic Article MLN0128, a novel mTOR kinase inhibitor, disrupts survival signaling and triggers apoptosis in AML and AML stem/ progenitor cells.
Academic Article Peripheral blood blast clearance is an independent prognostic factor for survival and response to acute myeloid leukemia induction chemotherapy.
Academic Article Persistence of minimal residual disease assessed by multiparameter flow cytometry is highly prognostic in younger patients with acute myeloid leukemia.
Academic Article FZR1 loss increases sensitivity to DNA damage and consequently promotes murine and human B-cell acute leukemia.
Academic Article Relapse risk and survival in patients with FLT3 mutated acute myeloid leukemia undergoing stem cell transplantation.
Academic Article Focal Adhesion Kinase as a Potential Target in AML and MDS.
Academic Article Jab1/Csn5-Thioredoxin Signaling in Relapsed Acute Monocytic Leukemia under Oxidative Stress.
Academic Article Targeting autophagy to overcome chemoresistance in acute myleogenous leukemia.
Academic Article Bone Marrow Adipocytes Facilitate Fatty Acid Oxidation Activating AMPK and a Transcriptional Network Supporting Survival of Acute Monocytic Leukemia Cells.
Academic Article Targeting FLT3-ITD signaling mediates ceramide-dependent mitophagy and attenuates drug resistance in AML.
Academic Article Combined targeting of BCL-2 and BCR-ABL tyrosine kinase eradicates chronic myeloid leukemia stem cells.
Academic Article Buparlisib, a PI3K inhibitor, demonstrates acceptable tolerability and preliminary activity in a phase I trial of patients with advanced leukemias.
Academic Article Long-term outcome of acute promyelocytic leukemia treated with all-trans-retinoic acid, arsenic trioxide, and gemtuzumab.
Academic Article Antileukemia Efficacy and Mechanisms of Action of SL-101, a Novel Anti-CD123 Antibody Conjugate, in Acute Myeloid Leukemia.
Academic Article The novel BMI-1 inhibitor PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells.
Academic Article Combined targeting of STAT3 and STAT5: a novel approach to overcome drug resistance in chronic myeloid leukemia.
Academic Article High-throughput profiling of signaling networks identifies mechanism-based combination therapy to eliminate microenvironmental resistance in acute myeloid leukemia.
Academic Article Vosaroxin in combination with decitabine in newly diagnosed older patients with acute myeloid leukemia or high-risk myelodysplastic syndrome.
Academic Article More than 1 TP53 abnormality is a dominant characteristic of pure erythroid leukemia.
Academic Article A phase 1 clinical trial of single-agent selinexor in acute myeloid leukemia.
Academic Article Combined inhibition of ?-catenin and Bcr-Abl synergistically targets tyrosine kinase inhibitor-resistant blast crisis chronic myeloid leukemia blasts and progenitors in vitro and in vivo.
Academic Article A phase 1/2 study of chemosensitization with plerixafor plus G-CSF in relapsed or refractory acute myeloid leukemia.
Academic Article Single-Cell Mass Cytometry of Acute Myeloid Leukemia and Leukemia Stem/Progenitor Cells.
Academic Article Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy.
Academic Article Anexelekto/MER tyrosine kinase inhibitor ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanisms.
Academic Article Tumor Trp53 status and genotype affect the bone marrow microenvironment in acute myeloid leukemia.
Academic Article Anti-leukemia activity of NSC-743380 in SULT1A1-expressing acute myeloid leukemia cells is associated with inhibitions of cFLIP expression and PI3K/AKT/mTOR activities.
Academic Article Distinct protein signatures of acute myeloid leukemia bone marrow-derived stromal cells are prognostic for patient survival.
Academic Article Treated secondary acute myeloid leukemia: a distinct high-risk subset of AML with adverse prognosis.
Academic Article Disruption of Wnt/?-Catenin Exerts Antileukemia Activity and Synergizes with FLT3 Inhibition in FLT3-Mutant Acute Myeloid Leukemia.
Academic Article MYC protein expression is an important prognostic factor in acute myeloid leukemia.
Academic Article Discovery and functional implications of a miR-29b-1/miR-29a cluster polymorphism in acute myeloid leukemia.
Academic Article Role of MSC-derived galectin 3 in the AML microenvironment.
Academic Article Outcomes with lower intensity therapy in TP53-mutated acute myeloid leukemia.
Academic Article Predictive Gene Signatures Determine Tumor Sensitivity to MDM2 Inhibition.
Academic Article Clearance of Somatic Mutations at Remission and the Risk of Relapse in Acute Myeloid Leukemia.
Academic Article Integrative genomic analysis of adult mixed phenotype acute leukemia delineates lineage associated molecular subtypes.
Academic Article A phase II study of omacetaxine mepesuccinate for patients with higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia after failure of hypomethylating agents.
Academic Article Low-level expression of SAMHD1 in acute myeloid leukemia (AML) blasts correlates with improved outcome upon consolidation chemotherapy with high-dose cytarabine-based regimens.
Academic Article Efficacy, Safety, and Biomarkers of Response to Azacitidine and Nivolumab in Relapsed/Refractory Acute Myeloid Leukemia: A Nonrandomized, Open-Label, Phase II Study.
Academic Article Initial Report of a Phase I Study of LY2510924, Idarubicin, and Cytarabine in Relapsed/Refractory Acute Myeloid Leukemia.
Academic Article Combinatorial targeting of XPO1 and FLT3 exerts synergistic anti-leukemia effects through induction of differentiation and apoptosis in FLT3-mutated acute myeloid leukemias: from concept to clinical trial.
Academic Article NSG-S mice for acute myeloid leukemia, yes. For myelodysplastic syndrome, no.
Academic Article Sorafenib Combined with 5-azacytidine in Older Patients with Untreated FLT3-ITD Mutated Acute Myeloid Leukemia.
Academic Article The distribution of T-cell subsets and the expression of immune checkpoint receptors and ligands in patients with newly diagnosed and relapsed acute myeloid leukemia.
Academic Article Inhibition of FAO in AML co-cultured with BM adipocytes: mechanisms of survival and chemosensitization to cytarabine.
Academic Article Randomized trial of ibrutinib vs ibrutinib plus rituximab in patients with chronic lymphocytic leukemia.
Grant Combined inhibition of CXCR4 and FLT3-ITD signaling in acute myeloid leukemia
Grant THE THERAPY OF AML
Grant Anti-Leukemic Activity of the Novel Triterpeniod CDDO
Grant CYTOKINE/CHEMOTHERAPY COMBINATIONS IN MYELOID LEUKEMIA
Grant Plerixafor/G-CSF with Sorafenib for Acute Myelogenous Leukemia with FLT3-ITD Muta
Grant CELL BIOLOGY AND PHARMACOKINETICS OF LOW-DOSE ARA-C
Grant FUNCTION OF QUIESCENT CELLS IN PEDIATRIC LEUKEMIA
Academic Article An ARC-Regulated IL1?/Cox-2/PGE2/?-Catenin/ARC Circuit Controls Leukemia-Microenvironment Interactions and Confers Drug Resistance in AML.
Academic Article BETP degradation simultaneously targets acute myelogenous leukemia stem cells and the microenvironment.
Academic Article Janus kinase 2 variants associated with the transformation of myeloproliferative neoplasms into acute myeloid leukemia.
Academic Article Osteogenic niche in the regulation of normal hematopoiesis and leukemogenesis.
Academic Article Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality.
Concept Promyelocytic Leukemia Protein
Concept Myeloid Cell Leukemia Sequence 1 Protein
Academic Article Concomitant targeting of BCL2 with venetoclax and MAPK signaling with cobimetinib in acute myeloid leukemia models.
Academic Article LGALS3 is connected to CD74 in a previously unknown protein network that is associated with poor survival in patients with AML.
Academic Article Imipridone ONC212 activates orphan G protein-coupled receptor GPR132 and integrated stress response in acute myeloid leukemia.
Academic Article Prognostic significance of baseline FLT3-ITD mutant allele level in acute myeloid leukemia treated with intensive chemotherapy with/without sorafenib.
Academic Article Combined inhibition of MDM2 and BCR-ABL1 tyrosine kinase targets chronic myeloid leukemia stem/progenitor cells in a murine model.
Academic Article LAM-003, a new drug for treatment of tyrosine kinase inhibitor-resistant FLT3-ITD-positive AML.
Academic Article Outcomes of older patients with NPM1-mutated AML: current treatments and the promise of venetoclax-based regimens.
Academic Article Clinical value of event-free survival in acute myeloid leukemia.
Academic Article Combinatorial Inhibition of Focal Adhesion Kinase and BCL-2 Enhances Antileukemia Activity of Venetoclax in Acute Myeloid Leukemia.
Academic Article Outcomes of relapsed or refractory acute myeloid leukemia after frontline hypomethylating agent and venetoclax regimens.
Academic Article LGALS1 acts as a pro-survival molecule in AML.
Academic Article MDM2 inhibition: an important step forward in cancer therapy.
Academic Article Phase 1 study of combinatorial sorafenib, G-CSF, and plerixafor treatment in relapsed/refractory, FLT3-ITD-mutated acute myelogenous leukemia patients.
Academic Article Survivorship in AML - a landmark analysis on the outcomes of acute myelogenous leukemia patients after maintaining complete remission for at least 3 years.
Academic Article 10-day decitabine with venetoclax for newly diagnosed intensive chemotherapy ineligible, and relapsed or refractory acute myeloid leukaemia: a single-centre, phase 2 trial.
Academic Article First Report of Sorafenib in Patients With Acute Myeloid Leukemia Harboring Non-Canonical FLT3 Mutations.
Academic Article Outcomes with sequential FLT3-inhibitor-based therapies in patients with AML.
Academic Article Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics.
Academic Article Prognostic and therapeutic impacts of mutant TP53 variant allelic frequency in newly diagnosed acute myeloid leukemia.
Academic Article Publisher Correction: Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics.
Academic Article Venetoclax with decitabine vs intensive chemotherapy in acute myeloid leukemia: A propensity score matched analysis stratified by risk of treatment-related mortality.
Academic Article BL-8040 CXCR4 antagonist is safe and demonstrates antileukemic activity in combination with cytarabine for the treatment of relapsed/refractory acute myelogenous leukemia: An open-label safety and efficacy phase 2a study.
Academic Article Bone marrow stromal cells induce an ALDH+ stem cell-like phenotype and enhance therapy resistance in AML through a TGF-?-p38-ALDH2 pathway.
Academic Article Targeting MCL-1 dysregulates cell metabolism and leukemia-stroma interactions and resensitizes acute myeloid leukemia to BCL-2 inhibition.
Academic Article Phase 2 study of lenalidomide maintenance for patients with high-risk acute myeloid leukemia in remission.
Academic Article Patterns of Resistance Differ in Patients with Acute Myeloid Leukemia Treated with Type I versus Type II FLT3 inhibitors.
Academic Article Loss of expression of both miR-15/16 loci in CML transition to blast crisis.
Academic Article High-throughput proteomic profiling reveals mechanisms of action of AMG925, a dual FLT3-CDK4/6 kinase inhibitor targeting AML and AML stem/progenitor cells.
Academic Article Prognostic value of measurable residual disease after venetoclax and decitabine in acute myeloid leukemia.
Academic Article A phase I/II study of the combination of quizartinib with azacitidine or low-dose cytarabine for the treatment of patients with acute myeloid leukemia and myelodysplastic syndrome.
Academic Article Author Correction: Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics.
Academic Article Venetoclax Combined With FLAG-IDA Induction and Consolidation in Newly Diagnosed and Relapsed or Refractory Acute Myeloid Leukemia.
Academic Article DNA-PK inhibitor peposertib enhances p53-dependent cytotoxicity of DNA double-strand break inducing therapy in acute leukemia.
Academic Article Therapeutic implications of menin inhibition in acute leukemias.
Academic Article Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML.
Academic Article A phase 1b/2 study of azacitidine with PD-L1 antibody avelumab in relapsed/refractory acute myeloid leukemia.
Academic Article Outcomes in patients with newly diagnosed TP53-mutated acute myeloid leukemia with or without venetoclax-based therapy.
Academic Article Menin inhibition decreases Bcl-2 and synergizes with venetoclax in NPM1/FLT3-mutated AML.
Academic Article Venetoclax enhances T cell-mediated antileukemic activity by increasing ROS production.
Academic Article Exogenous mitochondrial transfer and endogenous mitochondrial fission facilitate AML resistance to OxPhos inhibition.
Academic Article Single-cell polyfunctional proteomics of CD4 cells from patients with AML predicts responses to anti-PD-1-based therapy.
Academic Article Predictors of outcomes in adults with acute myeloid leukemia and KMT2A rearrangements.
Academic Article BCL-2 Inhibitor ABT-737 Effectively Targets Leukemia-Initiating Cells with Differential Regulation of Relevant Genes Leading to Extended Survival in a NRAS/BCL-2 Mouse Model of High Risk-Myelodysplastic Syndrome.
Academic Article Value of measurable residual disease monitoring in patients with acute promyelocytic leukemia in the era of frontline 'chemotherapy-free' therapy.
Academic Article AXL/MERTK inhibitor ONO-7475 potently synergizes with venetoclax and overcomes venetoclax resistance to kill FLT3-ITD acute myeloid leukemia.
Academic Article Targeting the NOTCH1-MYC-CD44 axis in leukemia-initiating cells in T-ALL.
Academic Article Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia.
Academic Article Maximal Activation of Apoptosis Signaling by Cotargeting Antiapoptotic Proteins in BH3 Mimetic-Resistant AML and AML Stem Cells.
Academic Article Correction: Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia.
Academic Article Efficacy and safety of enasidenib and azacitidine combination in patients with IDH2 mutated acute myeloid leukemia and not eligible for intensive chemotherapy.
Academic Article A multi-arm phase Ib/II study designed for rapid, parallel evaluation of novel immunotherapy combinations in relapsed/refractory acute myeloid leukemia.
Academic Article Beyond BCL-2 Inhibition in Acute Myloid Leukemia: Other Approaches to Leverage the Apoptotic Pathway.
Academic Article Hypomethylating agent and venetoclax with FLT3 inhibitor "triplet" therapy in older/unfit patients with FLT3 mutated AML.
Academic Article Correction to: MicroRNA gene expression during retinoic acid-induced differentiation of human acute promyelocytic leukemia.
Academic Article Venetoclax combined with FLAG-IDA induction and consolidation in newly diagnosed acute myeloid leukemia.
Academic Article Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia.
Academic Article Transgenic Expression of IL15 Retains CD123-Redirected T Cells in a Less Differentiated State Resulting in Improved Anti-AML Activity in Autologous AML PDX Models.
Academic Article Phase II Study of Venetoclax Added to Cladribine Plus Low-Dose Cytarabine Alternating With 5-Azacitidine in Older Patients With Newly Diagnosed Acute Myeloid Leukemia.
Academic Article Clinical and molecular profiling of AML patients with chromosome 7 or 7q deletions in the context of TP53 alterations and venetoclax treatment.
Academic Article A phase two study of high dose blinatumomab in Richter's syndrome.
Academic Article Venetoclax and idasanutlin in relapsed/refractory AML: a nonrandomized, open-label phase 1b trial.
Academic Article Clinical outcomes associated with NPM1 mutations in patients with relapsed or refractory AML.
Academic Article Azacitidine plus venetoclax in patients with high-risk myelodysplastic syndromes or chronic myelomonocytic leukaemia: phase 1 results of a single-centre, dose-escalation, dose-expansion, phase 1-2 study.
Academic Article Concomitant targeting of FLT3 and BTK overcomes FLT3 inhibitor resistance in acute myeloid leukemia through the inhibition of autophagy.
Academic Article Inhibition of menin, BCL-2, and FLT3 combined with a hypomethylating agent cures NPM1/FLT3-ITD/-TKD mutant acute myeloid leukemia in a patient-derived xenograft model.
Academic Article Targeting Unc51-like Autophagy Activating Kinase 1 (ULK1) Overcomes Adaptive Drug Resistance in Acute Myelogenous Leukemia.
Academic Article The multi-kinase inhibitor CG-806 exerts anti-cancer activity against acute myeloid leukemia by co-targeting FLT3, BTK, and Aurora kinases.
Academic Article Early mortality in acute myeloid leukemia with KMT2A rearrangement is associated with high risk of bleeding and disseminated intravascular coagulation.
Academic Article Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics.
Academic Article Mitophagy Promotes Resistance to BH3 Mimetics in Acute Myeloid Leukemia.
Academic Article Co-targeting BCL-XL and BCL-2 by PROTAC 753B eliminates leukemia cells and enhances efficacy of chemotherapy by targeting senescent cells.
Academic Article FLT3 inhibitors upregulate CXCR4 and E-selectin ligands via ERK suppression in AML cells and CXCR4/E-selectin inhibition enhances anti-leukemia efficacy of FLT3-targeted therapy in AML.
Academic Article Molecular Mechanisms of Ferroptosis and Updates of Ferroptosis Studies in Cancers and Leukemia.
Academic Article Correction: Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics.
Academic Article A phase 1/2 study of azacitidine, venetoclax and pevonedistat in newly diagnosed secondary AML and in MDS or CMML after failure of hypomethylating agents.
Academic Article Epichaperome inhibition targets TP53-mutant AML and AML stem/progenitor cells.
Academic Article A Phase I study of Milademetan (DS3032b) in combination with low dose cytarabine with or without venetoclax in acute myeloid leukemia: Clinical safety, efficacy, and correlative analysis.
Academic Article Cigarette smoke exposure accelerates AML progression in FLT3-ITD models.
Academic Article ABCC1 and glutathione metabolism limit the efficacy of BCL-2 inhibitors in acute myeloid leukemia.
Academic Article Enhanced TP53 reactivation disrupts MYC transcriptional program and overcomes venetoclax resistance in acute myeloid leukemias.
Academic Article Mitochondrial regulation of GPX4 inhibition-mediated ferroptosis in acute myeloid leukemia.
Academic Article Correction: Mitochondrial regulation of GPX4 inhibition-mediated ferroptosis in acute myeloid leukemia.
Academic Article Combination of dasatinib and venetoclax in newly diagnosed chronic phase chronic myeloid leukemia.
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