Combinatorial targeting of XPO1 and FLT3 exerts synergistic anti-leukemia effects through induction of differentiation and apoptosis in FLT3-mutated acute myeloid leukemias: from concept to clinical trial.

Combinatorial targeting of XPO1 and FLT3 exerts synergistic anti-leukemia effects through induction of differentiation and apoptosis in FLT3-mutated acute myeloid leukemias: from concept to clinical trial. Haematologica. 2018 10; 103(10):1642-1653.

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subject areas

Animals
Antineoplastic Combined Chemotherapy Protocols
Apoptosis
Cell Line, Tumor
Dose-Response Relationship, Drug
Female
fms-Like Tyrosine Kinase 3
Humans
Hydrazines
Karyopherins
Leukemia, Myeloid, Acute
Male
Mice
Mutation
Receptors, Cytoplasmic and Nuclear
Triazoles

authors with profiles

MICHAEL ANDREEFF
NAVAL DAVER