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Phase I/II study of the hypoxia-activated prodrug PR104 in refractory/relapsed acute myeloid leukemia and acute lymphoblastic leukemia.
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Phase I/II study of the hypoxia-activated prodrug PR104 in refractory/relapsed acute myeloid leukemia and acute lymphoblastic leukemia.
Phase I/II study of the hypoxia-activated prodrug PR104 in refractory/relapsed acute myeloid leukemia and acute lymphoblastic leukemia. Haematologica. 2015 Jul; 100(7):927-34.
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PubMed
subject areas
Adult
Aged
Anemia
Antigens, Neoplasm
Antineoplastic Agents, Alkylating
Biomarkers
Bone Marrow
Carbonic Anhydrase IX
Carbonic Anhydrases
Enterocolitis
Female
Gene Expression
Humans
Hypoxia
Hypoxia-Inducible Factor 1, alpha Subunit
Leukemia, Myeloid, Acute
Male
Middle Aged
Neutropenia
Nitrogen Mustard Compounds
Nitroimidazoles
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Prodrugs
Recurrence
Remission Induction
Thrombocytopenia
authors with profiles
MICHAEL ANDREEFF
CARLOS E BUESO-RAMOS
HAGOP M KANTARJIAN
PETER F THALL
STEVEN M KORNBLAU
MARINA KONOPLEVA
SERGEJ NAUMOVICH KONOPLEV
ELIAS JOSEPH JABBOUR
GAUTAM BORTHAKUR
TAPAN MAHENDRA KADIA
NAVEEN PEMMARAJU
NAVAL DAVER