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Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment.
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Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment.
Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment. Blood. 2012 Sep 27; 120(13):2679-89.
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PubMed
subject areas
Animals
Antibiotics, Antineoplastic
Antineoplastic Combined Chemotherapy Protocols
Apoptosis
Blotting, Western
Bone Marrow
Cell Proliferation
Coculture Techniques
Flow Cytometry
Humans
Indoles
Leukemia, Experimental
Leukemia, Myeloid, Acute
Mechanistic Target of Rapamycin Complex 1
Mechanistic Target of Rapamycin Complex 2
Mice
Mice, SCID
Multiprotein Complexes
Phosphorylation
Protein Array Analysis
Protein Kinase Inhibitors
Purines
Real-Time Polymerase Chain Reaction
Receptors, CXCR4
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger
Signal Transduction
Sirolimus
TOR Serine-Threonine Kinases
authors with profiles
MICHAEL ANDREEFF
HAGOP M KANTARJIAN
STEVEN M KORNBLAU
MARINA KONOPLEVA
KEITH A BAGGERLY
ZHIHONG ZENG