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Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality.
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Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality.
Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality. Cancer Cell. 2019 05 13; 35(5):721-737.e9.
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PubMed
subject areas
Animals
Cell Line, Tumor
Cell Survival
Crystallography, X-Ray
Drug Screening Assays, Antitumor
Endopeptidase Clp
Female
HCT116 Cells
HEK293 Cells
Heterocyclic Compounds, 4 or More Rings
Humans
Imidazoles
Leukemia, Myeloid, Acute
Mice
Mitochondria
Models, Molecular
Point Mutation
Protein Conformation
Proteolysis
Pyridines
Pyrimidines
Tumor Suppressor Protein p53
Xenograft Model Antitumor Assays
authors with profiles
MICHAEL ANDREEFF
GAUTAM BORTHAKUR
TODD M LINK
HAGOP M KANTARJIAN