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TODD M LINK

TitleAssistant Professor
InstitutionMD Anderson
DepartmentGenomic Medicine
Address1881 East Road
Houston TX 77054-3005
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Brosey CA, Link TM, Shen R, Moiani D, Burnett K, Hura GL, Jones DE, Tainer JA. Chemical screening by time-resolved X-ray scattering to discover allosteric probes. Nat Chem Biol. 2024 Sep; 20(9):1199-1209. PMID: 38671223; PMCID: PMC11358040.
      Citations:    Fields:    Translation:HumansCells
    2. Lee D, Huntoon K, Wang Y, Kang M, Lu Y, Jeong SD, Link TM, Gallup TD, Qie Y, Li X, Dong S, Schrank BR, Grippin AJ, Antony A, Ha J, Chang M, An Y, Wang L, Jiang D, Li J, Koong AC, Tainer JA, Jiang W, Kim BYS. Synthetic cationic helical polypeptides for the stimulation of antitumour innate immune pathways in antigen-presenting cells. Nat Biomed Eng. 2024 May; 8(5):593-610. PMID: 38641710; PMCID: PMC11162332.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Ye Z, Xu S, Shi Y, Cheng X, Zhang Y, Roy S, Namjoshi S, Longo MA, Link TM, Schlacher K, Peng G, Yu D, Wang B, Tainer JA, Ahmed Z. GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer. Nat Commun. 2024 Mar 08; 15(1):2132. PMID: 38459011; PMCID: PMC10923831.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    4. Aitken MJL, Malaney P, Zhang X, Herbrich SM, Chan L, Benitez O, Rodriguez AG, Ma H, Jacamo R, Duan R, Link TM, Kornblau SM, Kanagal-Shamanna R, Bueso-Ramos CE, Post SM. Heterogeneous nuclear ribonucleoprotein K is overexpressed in acute myeloid leukemia and causes myeloproliferation in mice via altered Runx1 splicing. NAR Cancer. 2022 Dec; 4(4):zcac039. PMID: 36518526; PMCID: PMC9732523.
      Citations: 2     
    5. Moiani D, Link TM, Brosey CA, Katsonis P, Lichtarge O, Kim Y, Joachimiak A, Ma Z, Kim IK, Ahmed Z, Jones DE, Tsutakawa SE, Tainer JA. An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2. Methods Enzymol. 2021; 661:407-431. PMID: 34776222; PMCID: PMC8474023.
      Citations: 2     Fields:    Translation:HumansCells
    6. Brosey CA, Houl JH, Katsonis P, Balapiti-Modarage LPF, Bommagani S, Arvai A, Moiani D, Bacolla A, Link T, Warden LS, Lichtarge O, Jones DE, Ahmed Z, Tainer JA. Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors. Prog Biophys Mol Biol. 2021 08; 163:171-186. PMID: 33636189; PMCID: PMC7901392.
      Citations: 16     Fields:    Translation:HumansCells
    7. Pisaneschi F, Lin YH, Leonard PG, Satani N, Yan VC, Hammoudi N, Raghavan S, Link TM, K Georgiou D, Czako B, Muller FL. The 3S Enantiomer Drives Enolase Inhibitory Activity in SF2312 and Its Analogues. Molecules. 2019 Jul 09; 24(13). PMID: 31324042; PMCID: PMC6651268.
      Citations: 1     Fields:    Translation:Cells
    8. Chan WK, Horvath TD, Tan L, Link T, Harutyunyan KG, Pontikos MA, Anishkin A, Du D, Martin LA, Yin E, Rempe SB, Sukharev S, Konopleva M, Weinstein JN, Lorenzi PL. Glutaminase Activity of L-Asparaginase Contributes to Durable Preclinical Activity against Acute Lymphoblastic Leukemia. Mol Cancer Ther. 2019 09; 18(9):1587-1592. PMID: 31209181; PMCID: PMC6726508.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    9. Ishizawa J, Zarabi SF, Davis RE, Halgas O, Nii T, Jitkova Y, Zhao R, St-Germain J, Heese LE, Egan G, Ruvolo VR, Barghout SH, Nishida Y, Hurren R, Ma W, Gronda M, Link T, Wong K, Mabanglo M, Kojima K, Borthakur G, MacLean N, Ma MCJ, Leber AB, Minden MD, Houry W, Kantarjian H, Stogniew M, Raught B, Pai EF, Schimmer AD, Andreeff M. Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality. Cancer Cell. 2019 05 13; 35(5):721-737.e9. PMID: 31056398; PMCID: PMC6620028.
      Citations: 79     Fields:    Translation:HumansAnimalsCells
    10. Leonard PG, Satani N, Maxwell D, Lin YH, Hammoudi N, Peng Z, Pisaneschi F, Link TM, Lee GR, Sun D, Prasad BAB, Di Francesco ME, Czako B, Asara JM, Wang YA, Bornmann W, DePinho RA, Muller FL. SF2312 is a natural phosphonate inhibitor of enolase. Nat Chem Biol. 2016 Dec; 12(12):1053-1058. PMID: 27723749; PMCID: PMC5110371.
      Citations: 37     Fields:    Translation:HumansCells
    11. Campbell JC, Kim JJ, Li KY, Huang GY, Reger AS, Matsuda S, Sankaran B, Link TM, Yuasa K, Ladbury JE, Casteel DE, Kim C. Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II. J Biol Chem. 2016 Mar 11; 291(11):5623-5633. PMID: 26769964; PMCID: PMC4786703.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    12. Mandal PK, Morlacchi P, Knight JM, Link TM, Lee GR, Nurieva R, Singh D, Dhanik A, Kavraki L, Corry DB, Ladbury JE, McMurray JS. Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity. J Med Chem. 2015 Nov 25; 58(22):8970-84. PMID: 26506089; PMCID: PMC5109833.
      Citations: 14     Fields:    Translation:AnimalsCells
    13. Munoz WA, Lee M, Miller RK, Ahmed Z, Ji H, Link TM, Lee GR, Kloc M, Ladbury JE, McCrea PD. Plakophilin-3 catenin associates with the ETV1/ER81 transcription factor to positively modulate gene activity. PLoS One. 2014; 9(1):e86784. PMID: 24475179; PMCID: PMC3903613.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    14. Robinson KE, Orans J, Kovach AR, Link TM, Brennan RG. Mapping Hfq-RNA interaction surfaces using tryptophan fluorescence quenching. Nucleic Acids Res. 2014 Feb; 42(4):2736-49. PMID: 24288369; PMCID: PMC3936774.
      Citations: 39     Fields:    Translation:Cells
    15. Schumacher MA, Min J, Link TM, Guan Z, Xu W, Ahn YH, Soderblom EJ, Kurie JM, Evdokimov A, Moseley MA, Lewis K, Brennan RG. Role of unusual P loop ejection and autophosphorylation in HipA-mediated persistence and multidrug tolerance. Cell Rep. 2012 Sep 27; 2(3):518-25. PMID: 22999936; PMCID: PMC4831868.
      Citations: 17     Fields:    Translation:Cells
    16. Link TM, Valentin-Hansen P, Brennan RG. Structure of Escherichia coli Hfq bound to polyriboadenylate RNA. Proc Natl Acad Sci U S A. 2009 Nov 17; 106(46):19292-7. PMID: 19889981; PMCID: PMC2773200.
      Citations: 187     Fields:    Translation:Cells
    17. Amen M, Espinoza HM, Cox C, Liang X, Wang J, Link TM, Brennan RG, Martin JF, Amendt BA. Chromatin-associated HMG-17 is a major regulator of homeodomain transcription factor activity modulated by Wnt/beta-catenin signaling. Nucleic Acids Res. 2008 Feb; 36(2):462-76. PMID: 18045789; PMCID: PMC2241859.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    18. Brennan RG, Link TM. Hfq structure, function and ligand binding. Curr Opin Microbiol. 2007 Apr; 10(2):125-33. PMID: 17395525.
      Citations: 195     Fields:    Translation:HumansCells
    19. Sakamaki T, Casimiro MC, Ju X, Quong AA, Katiyar S, Liu M, Jiao X, Li A, Zhang X, Lu Y, Wang C, Byers S, Nicholson R, Link T, Shemluck M, Yang J, Fricke ST, Novikoff PM, Papanikolaou A, Arnold A, Albanese C, Pestell R. Cyclin D1 determines mitochondrial function in vivo. Mol Cell Biol. 2006 Jul; 26(14):5449-69. PMID: 16809779; PMCID: PMC1592725.
      Citations: 94     Fields:    Translation:HumansAnimalsCells
    20. Van Lanen SG, Kinzie SD, Matthieu S, Link T, Culp J, Iwata-Reuyl D. tRNA modification by S-adenosylmethionine:tRNA ribosyltransferase-isomerase. Assay development and characterization of the recombinant enzyme. J Biol Chem. 2003 Mar 21; 278(12):10491-9. PMID: 12533518.
      Citations: 13     Fields:    Translation:Cells
    21. Albanese C, Reutens AT, Bouzahzah B, Fu M, D'Amico M, Link T, Nicholson R, Depinho RA, Pestell RG. Sustained mammary gland-directed, ponasterone A-inducible expression in transgenic mice. FASEB J. 2000 May; 14(7):877-84. PMID: 10783141.
      Citations: 13     Fields:    Translation:Animals
    22. Chen XY, Link TM, Schramm VL. Ricin A-chain: kinetics, mechanism, and RNA stem-loop inhibitors. Biochemistry. 1998 Aug 18; 37(33):11605-13. PMID: 9708998.
      Citations: 25     Fields:    
    23. Link T, Chen XY, Niu LH, Schramm VL. A hypothesis to explain the substrate reactivity of ribosomal and stem-loop RNA with ricin A-chain. Toxicon. 1996 Nov-Dec; 34(11-12):1317-24. PMID: 9027988.
      Citations: 1     Fields:    Translation:HumansCells
    24. Structural basis of cyclic nucleotide selectivity in cGMP-dependent Protein Kinase II. Journal of Biological Chemistry. 291:5623-5633.
    25. Inhibition of ricin by an rna stem-loop containing a ribo-oxycarbonium mimic. FASEB Journal. 10.
    26. The transition state for RNA depurination by ricin a-chain. FASEB Journal. 11.
    27. Organic Preparations and Procedures International. 26:696-701.
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