"Forkhead Box Protein O3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A forkhead box transcription factor and transcriptional activator which triggers type 1 programmed cell death (APOPTOSIS) in the absence of APOPTOSIS INHIBITING PROTEINS, including neuronal cell death induced by OXIDATIVE STRESS. It recognizes and binds to the DNA sequence 5'-(AG)TAAA(TC)A-3' and also functions in post-transcriptional regulation of the c-MYC PROTO-ONCOGENE.
| Descriptor ID |
D000071316
|
| MeSH Number(s) |
D12.776.260.950.249.125 D12.776.930.977.249.125
|
| Concept/Terms |
Forkhead Box Protein O3- Forkhead Box Protein O3
- Forkhead in Rhabdomyosarcoma-Like 1 Protein
- Forkhead in Rhabdomyosarcoma Like 1 Protein
- FOXO3 Protein
- Protein, FOXO3
|
Below are MeSH descriptors whose meaning is more general than "Forkhead Box Protein O3".
Below are MeSH descriptors whose meaning is more specific than "Forkhead Box Protein O3".
This graph shows the total number of publications written about "Forkhead Box Protein O3" by people in this website by year, and whether "Forkhead Box Protein O3" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2009 | 0 | 2 | 2 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 3 | 3 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 2 | 2 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 2 | 2 |
| 2016 | 1 | 0 | 1 |
| 2018 | 2 | 0 | 2 |
| 2019 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
| 2025 | 1 | 1 | 2 |
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Below are the most recent publications written about "Forkhead Box Protein O3" by people in Profiles.
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Metformin induces FOXO3-dependent fetal hemoglobin production in human primary erythroid cells. Blood. 2018 07 19; 132(3):321-333.
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High-density and very-low-density lipoprotein?have opposing roles in regulating tumor-initiating cells and sensitivity to radiation in inflammatory breast cancer. Int J Radiat Oncol Biol Phys. 2015 Apr 01; 91(5):1072-80.
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FoxO transcription factors promote AKT Ser473 phosphorylation and renal tumor growth in response to pharmacologic inhibition of the PI3K-AKT pathway. Cancer Res. 2014 Mar 15; 74(6):1682-93.
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Caspase-independent cell death is involved in the negative effect of EGF receptor inhibitors on cisplatin in non-small cell lung cancer cells. Clin Cancer Res. 2013 Feb 15; 19(4):845-54.
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Methylation by Set9 modulates FoxO3 stability and transcriptional activity. Aging (Albany NY). 2012 Jul; 4(7):462-79.
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FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage. Nat Commun. 2012; 3:1000.
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Behavioral stress-induced activation of FoxO3a in the cerebral cortex of mice. Biol Psychiatry. 2012 Apr 01; 71(7):583-92.
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FOXO3a-Dependent Mechanism of E1A-Induced Chemosensitization. Cancer Res. 2011 Nov 01; 71(21):6878-87.
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Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation. Oncogene. 2012 Mar 22; 31(12):1546-57.
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Resveratrol up-regulates SIRT1 and inhibits cellular oxidative stress in the diabetic milieu: mechanistic insights. J Nutr Biochem. 2012 Jul; 23(7):699-705.