"Forkhead Box Protein O3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A forkhead box transcription factor and transcriptional activator which triggers type 1 programmed cell death (APOPTOSIS) in the absence of APOPTOSIS INHIBITING PROTEINS, including neuronal cell death induced by OXIDATIVE STRESS. It recognizes and binds to the DNA sequence 5'-(AG)TAAA(TC)A-3' and also functions in post-transcriptional regulation of the c-MYC PROTO-ONCOGENE.
Descriptor ID |
D000071316
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MeSH Number(s) |
D12.776.260.950.249.125 D12.776.930.977.249.125
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Concept/Terms |
Forkhead Box Protein O3- Forkhead Box Protein O3
- Forkhead in Rhabdomyosarcoma-Like 1 Protein
- Forkhead in Rhabdomyosarcoma Like 1 Protein
- FOXO3 Protein
- Protein, FOXO3
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Below are MeSH descriptors whose meaning is more general than "Forkhead Box Protein O3".
Below are MeSH descriptors whose meaning is more specific than "Forkhead Box Protein O3".
This graph shows the total number of publications written about "Forkhead Box Protein O3" by people in this website by year, and whether "Forkhead Box Protein O3" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2002 | 0 | 1 | 1 |
2003 | 0 | 1 | 1 |
2005 | 0 | 2 | 2 |
2007 | 0 | 4 | 4 |
2008 | 0 | 7 | 7 |
2009 | 0 | 5 | 5 |
2010 | 0 | 12 | 12 |
2011 | 0 | 7 | 7 |
2012 | 0 | 3 | 3 |
2013 | 0 | 7 | 7 |
2014 | 0 | 3 | 3 |
2015 | 1 | 6 | 7 |
2016 | 2 | 0 | 2 |
2017 | 1 | 1 | 2 |
2018 | 3 | 1 | 4 |
2019 | 1 | 0 | 1 |
2021 | 1 | 1 | 2 |
2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Forkhead Box Protein O3" by people in Profiles.
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FOXO Transcription Factors Are Required for Normal Somatotrope Function and Growth. Endocrinology. 2022 02 01; 163(2).
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FoxO3 deficiency in cortical astrocytes leads to impaired lipid metabolism and aggravated amyloid pathology. Aging Cell. 2021 08; 20(8):e13432.
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FoxO1 is required for physiological cardiac hypertrophy induced by exercise but not by constitutively active PI3K. Am J Physiol Heart Circ Physiol. 2021 04 01; 320(4):H1470-H1485.
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Chitinase 1 regulates pulmonary fibrosis by modulating TGF-?/SMAD7 pathway via TGFBRAP1 and FOXO3. Life Sci Alliance. 2019 06; 2(3).
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ROR?t-Expressing Tregs Drive the Growth of Colitis-Associated Colorectal Cancer by Controlling IL6 in Dendritic Cells. Cancer Immunol Res. 2018 09; 6(9):1082-1092.
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Metformin induces FOXO3-dependent fetal hemoglobin production in human primary erythroid cells. Blood. 2018 07 19; 132(3):321-333.
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FoxO3 an important player in fibrogenesis and therapeutic target for idiopathic pulmonary fibrosis. EMBO Mol Med. 2018 02; 10(2):276-293.
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Suppression of Activated FOXO Transcription Factors in the Heart Prolongs Survival in a Mouse Model of Laminopathies. Circ Res. 2018 03 02; 122(5):678-692.
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Gain-of-function mutant p53 promotes the oncogenic potential of head and neck squamous cell carcinoma cells by targeting the transcription factors FOXO3a and FOXM1. Oncogene. 2018 03; 37(10):1279-1292.
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Rational combination therapy with PARP and MEK inhibitors capitalizes on therapeutic liabilities in RAS mutant cancers. Sci Transl Med. 2017 05 31; 9(392).