"Forkhead Box Protein L2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A forkhead box transcription factor that is expressed in the developing eyelid and during very early development of the gonad, prior to sex determination. It is essential for development of the ovary and inhibits SOX9 TRANSCRIPTION FACTOR to prevent differentiation to testes. It also induces APOPTOSIS in ovarian cells. Mutations in the FOXL2 gene are associated with BLEPHAROPHIMOSIS; Ptosis, and Epicanthus inversus (BPES with ovarian failure).
| Descriptor ID |
D000074842
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| MeSH Number(s) |
D12.776.260.950.249.032 D12.776.930.977.249.032
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Forkhead Box Protein L2".
Below are MeSH descriptors whose meaning is more specific than "Forkhead Box Protein L2".
This graph shows the total number of publications written about "Forkhead Box Protein L2" by people in this website by year, and whether "Forkhead Box Protein L2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2013 | 0 | 2 | 2 |
| 2020 | 1 | 1 | 2 |
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Below are the most recent publications written about "Forkhead Box Protein L2" by people in Profiles.
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Gain-of-Function Chromatin Remodeling Activity of Oncogenic FOXL2C134W Reprograms Glucocorticoid Receptor Occupancy to Drive Granulosa Cell Tumors. Cancer Res. 2025 Mar 03; 85(5):875-893.
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The clinical efficacy and safety of single-agent pembrolizumab in patients with recurrent granulosa cell tumors of the ovary: a case series from a phase II basket trial. Invest New Drugs. 2021 06; 39(3):829-835.
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Increased FOXL2 expression alters uterine structures and functions?. Biol Reprod. 2020 10 29; 103(5):951-965.
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Sex Cord Tumor With Annular Tubules-Like Histologic Pattern in Adult Granulosa Cell Tumor: Case Report of a Hitherto Unreported Morphologic Variant. Int J Surg Pathol. 2021 Jun; 29(4):433-437.
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Conditional Deletion of FOXL2 and SMAD4 in Gonadotropes of Adult Mice Causes Isolated FSH Deficiency. Endocrinology. 2018 07 01; 159(7):2641-2655.
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Clinical, radiologic, and genetic features in blepharophimosis, ptosis, and epicanthus inversus syndrome in the Indian population. Invest Ophthalmol Vis Sci. 2013 Apr 26; 54(4):2985-91.
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Microhomology-mediated mechanisms underlie non-recurrent disease-causing microdeletions of the FOXL2 gene or its regulatory domain. PLoS Genet. 2013; 9(3):e1003358.
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Impaired fertility and FSH synthesis in gonadotrope-specific Foxl2 knockout mice. Mol Endocrinol. 2013 Mar; 27(3):407-21.
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The ovary: basic biology and clinical implications. J Clin Invest. 2010 Apr; 120(4):963-72.
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Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation. Cell. 2009 Dec 11; 139(6):1130-42.