"Leukotrienes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of biologically active compounds derived from arachidonic acid by oxidative metabolism through the 5-lipoxygenase pathway. They participate in host defense reactions and pathophysiological conditions such as immediate hypersensitivity and inflammation. They have potent actions on many essential organs and systems, including the cardiovascular, pulmonary, and central nervous system as well as the gastrointestinal tract and the immune system.
| Descriptor ID |
D015289
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| MeSH Number(s) |
D10.251.355.255.100.450 D10.251.355.310.166.887 D23.469.050.175.450
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Leukotrienes".
Below are MeSH descriptors whose meaning is more specific than "Leukotrienes".
This graph shows the total number of publications written about "Leukotrienes" by people in this website by year, and whether "Leukotrienes" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2006 | 1 | 1 | 2 |
| 2007 | 1 | 1 | 2 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 1 | 2 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Leukotrienes" by people in Profiles.
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Leukotrienes, a potential target for Covid-19. Prostaglandins Leukot Essent Fatty Acids. 2020 10; 161:102174.
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Targeting lipid mediators in asthma: time for reappraisal. Curr Opin Pulm Med. 2019 01; 25(1):121-127.
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Leukotriene enhanced allergic lung inflammation through induction of chemokine production. Clin Exp Med. 2015 Aug; 15(3):233-44.
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Montelukast suppresses epithelial to mesenchymal transition of bronchial epithelial cells induced by eosinophils. Biochem Biophys Res Commun. 2014 Jul 04; 449(3):351-6.
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Biologic mechanisms of environmental tobacco smoke in children with poorly controlled asthma: results from a multicenter clinical trial. J Allergy Clin Immunol Pract. 2013 Mar; 1(2):172-80.
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Pranlukast attenuates ischemia-like injury in endothelial cells via inhibiting reactive oxygen species production and nuclear factor-kappaB activation. J Cardiovasc Pharmacol. 2009 Jan; 53(1):77-85.
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Inflammation resolved by retinoid X receptor-mediated inactivation of leukotriene signaling pathways. FASEB J. 2008 Feb; 22(2):538-47.
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Heterogeneity in response to asthma medications. Curr Opin Allergy Clin Immunol. 2007 Apr; 7(2):185-9.
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GRKs and arrestins: regulators of migration and inflammation. J Leukoc Biol. 2006 Dec; 80(6):1214-21.
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Cysteinyl leukotriene levels in esophageal mucosal biopsies of children with eosinophilic inflammation: are they all the same? Am J Gastroenterol. 2006 May; 101(5):1125-8.