"SRS-A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of LEUKOTRIENES; (LTC4; LTD4; and LTE4) that is the major mediator of BRONCHOCONSTRICTION; HYPERSENSITIVITY; and other allergic reactions. Earlier studies described a "slow-reacting substance of ANAPHYLAXIS" released from lung by cobra venom or after anaphylactic shock. The relationship between SRS-A leukotrienes was established by UV which showed the presence of the conjugated triene. (From Merck Index, 11th ed)
| Descriptor ID |
D013189
|
| MeSH Number(s) |
D10.251.355.255.100.450.855 D10.251.355.310.166.887.855 D23.469.050.175.450.725
|
| Concept/Terms |
SRS-A- SRS-A
- Slow Reacting Substance of Anaphylaxis
|
Below are MeSH descriptors whose meaning is more general than "SRS-A".
Below are MeSH descriptors whose meaning is more specific than "SRS-A".
This graph shows the total number of publications written about "SRS-A" by people in this website by year, and whether "SRS-A" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 0 | 1 |
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Below are the most recent publications written about "SRS-A" by people in Profiles.
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Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist. Mol Pharmacol. 2000 Dec; 58(6):1601-8.
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Modulation of human marrow haematopoiesis by leucotrienes in vitro. Br J Haematol. 1988 Jul; 69(3):321-7.
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Leukotriene D4 increases extravascular lung water in the dog. Circ Shock. 1987; 21(2):121-8.
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Pharmacological action of FPL 55712 on canine cerebral arterial segments. Acta Neurochir (Wien). 1985; 74(1-2):81-3.
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Effect of trimetoquinol analogs for antagonism of endoperoxide/thromboxane A2-mediated responses in human platelets and rat aorta. J Pharmacol Exp Ther. 1985 Jan; 232(1):1-9.