"Leukotriene B4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990)
| Descriptor ID |
D007975
|
| MeSH Number(s) |
D10.251.355.255.100.450.411 D10.251.355.310.166.887.411 D23.469.050.175.450.415
|
| Concept/Terms |
Leukotriene B4- Leukotriene B4
- Leukotriene B-4
- B-4, Leukotriene
- Leukotriene B 4
- LTB4
|
Below are MeSH descriptors whose meaning is more general than "Leukotriene B4".
Below are MeSH descriptors whose meaning is more specific than "Leukotriene B4".
This graph shows the total number of publications written about "Leukotriene B4" by people in this website by year, and whether "Leukotriene B4" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1995 | 1 | 0 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2005 | 1 | 1 | 2 |
| 2007 | 0 | 1 | 1 |
| 2008 | 2 | 0 | 2 |
| 2009 | 1 | 1 | 2 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Leukotriene B4" by people in Profiles.
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Evaluation of Acebilustat, a Selective Inhibitor of Leukotriene B4 Biosynthesis, for Treatment of Outpatients With Mild-Moderate Coronavirus Disease 2019: A Randomized, Double-Blind, Placebo-Controlled Phase 2 Trial. Clin Infect Dis. 2023 07 26; 77(2):186-193.
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Mast Cell-Dependent CD8+ T-cell Recruitment Mediates Immune Surveillance of Intestinal Tumors in ApcMin/+ Mice. Cancer Immunol Res. 2018 03; 6(3):332-347.
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Effects of the experimental subarachnoid hemorrhage on the eicosanoid receptors in nicotine-induced contraction of the rat basilar artery. J Stroke Cerebrovasc Dis. 2013 Nov; 22(8):1258-62.
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Randomized trial of zileuton for treatment of COPD exacerbations requiring hospitalization. COPD. 2011 Feb; 8(1):21-9.
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Pomegranate fruit extract impairs invasion and motility in human breast cancer. Integr Cancer Ther. 2009 Sep; 8(3):242-53.
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Measurement of tumor necrosis factor-alpha, leukotriene B4, and interleukin 8 in the exhaled breath condensate in patients with acute exacerbations of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2009; 4:79-86.
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Phosphorylation of 5-lipoxygenase at ser523 by protein kinase A determines whether pioglitazone and atorvastatin induce proinflammatory leukotriene B4 or anti-inflammatory 15-epi-lipoxin a4 production. J Immunol. 2008 Sep 01; 181(5):3515-23.
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Zyflamend reduces LTB4 formation and prevents oral carcinogenesis in a 7,12-dimethylbenz[alpha]anthracene (DMBA)-induced hamster cheek pouch model. Carcinogenesis. 2008 Nov; 29(11):2182-9.
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Critical role for polar residues in coupling leukotriene B4 binding to signal transduction in BLT1. J Biol Chem. 2007 Mar 30; 282(13):10005-10017.
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Simultaneous inhibition of COX-2 and 5-LOX activities augments growth arrest and death of premalignant and malignant human lung cell lines. J Exp Ther Oncol. 2007; 6(3):183-92.