"Leukotriene D4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of the biologically active principles of SRS-A. It is generated from LEUKOTRIENE C4 after partial hydrolysis of the peptide chain, i.e., cleavage of the gamma-glutamyl portion. Its biological actions include stimulation of vascular and nonvascular smooth muscle, and increases in vascular permeability. (From Dictionary of Prostaglandins and Related Compounds, 1990)
| Descriptor ID |
D017998
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| MeSH Number(s) |
D10.251.355.255.100.450.855.461 D10.251.355.310.166.887.855.461 D23.469.050.175.450.725.415
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Leukotriene D4".
Below are MeSH descriptors whose meaning is more specific than "Leukotriene D4".
This graph shows the total number of publications written about "Leukotriene D4" by people in this website by year, and whether "Leukotriene D4" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 |
| 2001 | 1 | 0 | 1 |
| 2002 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
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Below are the most recent publications written about "Leukotriene D4" by people in Profiles.
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Pranlukast attenuates ischemia-like injury in endothelial cells via inhibiting reactive oxygen species production and nuclear factor-kappaB activation. J Cardiovasc Pharmacol. 2009 Jan; 53(1):77-85.
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Leukotriene pathways and in vitro adenotonsillar cell proliferation in children with obstructive sleep apnea. Chest. 2009 May; 135(5):1142-1149.
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[Cysteinyl leukotriene receptor 1 antagonist pranlukast modulates differentiation of SK-N-SH cells]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2007 03; 36(2):123-8.
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Cysteinyl leukotrienes and leukotriene B mediate vasoconstriction to arginine vasopressin in rat basilar artery. Clin Exp Pharmacol Physiol. 2005 Dec; 32(12):1027-33.
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Gamma-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D(4) formation in vivo. Am J Pathol. 2002 Aug; 161(2):481-90.
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Disruption of gamma-glutamyl leukotrienase results in disruption of leukotriene D(4) synthesis in vivo and attenuation of the acute inflammatory response. Mol Cell Biol. 2001 Aug; 21(16):5389-95.
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Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist. Mol Pharmacol. 2000 Dec; 58(6):1601-8.
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Leukotriene D4 and cystinyl-bis-glycine metabolism in membrane-bound dipeptidase-deficient mice. Proc Natl Acad Sci U S A. 1998 Apr 28; 95(9):4859-63.