Hydroxyeicosatetraenoic Acids
"Hydroxyeicosatetraenoic Acids" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Eicosatetraenoic acids substituted in any position by one or more hydroxy groups. They are important intermediates in a series of biosynthetic processes leading from arachidonic acid to a number of biologically active compounds such as prostaglandins, thromboxanes, and leukotrienes.
| Descriptor ID |
D006893
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| MeSH Number(s) |
D10.251.355.255.100.300 D10.251.355.310.166.550
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Hydroxyeicosatetraenoic Acids".
Below are MeSH descriptors whose meaning is more specific than "Hydroxyeicosatetraenoic Acids".
This graph shows the total number of publications written about "Hydroxyeicosatetraenoic Acids" by people in this website by year, and whether "Hydroxyeicosatetraenoic Acids" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 1 | 1 | 2 |
| 2008 | 1 | 0 | 1 |
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Below are the most recent publications written about "Hydroxyeicosatetraenoic Acids" by people in Profiles.
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Glutamine activates peroxisome proliferator-activated receptor-? in intestinal epithelial cells via 15-S-HETE and 13-OXO-ODE: a novel mechanism. Am J Physiol Gastrointest Liver Physiol. 2011 Sep; 301(3):G547-54.
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Pomegranate fruit extract impairs invasion and motility in human breast cancer. Integr Cancer Ther. 2009 Sep; 8(3):242-53.
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Gamma tocopherol upregulates the expression of 15-S-HETE and induces growth arrest through a PPAR gamma-dependent mechanism in PC-3 human prostate cancer cells. Nutr Cancer. 2009; 61(5):649-62.
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Expression of CYP4A1 in U251 human glioma cell induces hyperproliferative phenotype in vitro and rapidly growing tumors in vivo. J Pharmacol Exp Ther. 2008 Oct; 327(1):10-9.
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Simultaneous inhibition of COX-2 and 5-LOX activities augments growth arrest and death of premalignant and malignant human lung cell lines. J Exp Ther Oncol. 2007; 6(3):183-92.
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15-Lipoxygenase-2 gene regulation by its product 15-(S)-hydroxyeicosatetraenoic acid through a negative feedback mechanism that involves peroxisome proliferator-activated receptor gamma. Oncogene. 2006 Sep 28; 25(44):6015-25.
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Inverse relationship between 15-lipoxygenase-2 and PPAR-gamma gene expression in normal epithelia compared with tumor epithelia. Neoplasia. 2005 Mar; 7(3):280-93.
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Evaluation of targeted arterial delivery of the branched chain fatty acid 12-methyltetradecanoic acid as a novel therapy for solid tumors. J Exp Ther Oncol. 2005; 5(1):55-68.
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Inhibition of proliferation of PC3 cells by the branched-chain fatty acid, 12-methyltetradecanoic acid, is associated with inhibition of 5-lipoxygenase. Prostate. 2003 Jun 01; 55(4):281-91.
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Aberrant arachidonic acid metabolism in esophageal adenocarcinogenesis, and the effects of sulindac, nordihydroguaiaretic acid, and alpha-difluoromethylornithine on tumorigenesis in a rat surgical model. Carcinogenesis. 2002 Dec; 23(12):2095-102.