"SMN Complex Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A complex of proteins that assemble the SNRNP CORE PROTEINS into a core structure that surrounds a highly conserved RNA sequence found in SMALL NUCLEAR RNA. They are found localized in the GEMINI OF COILED BODIES and in the CYTOPLASM. The SMN complex is named after the Survival of Motor Neuron Complex Protein 1, which is a critical component of the complex.
| Descriptor ID |
D055532
|
| MeSH Number(s) |
D12.776.157.725.875 D12.776.580.922 D12.776.664.962.875
|
| Concept/Terms |
SMN Complex Proteins- SMN Complex Proteins
- Gemin Proteins
- Survival of Motor Neuron Complex Proteins
- Gem-Associated Proteins
- Gem Associated Proteins
Gemin4 Protein- Gemin4 Protein
- Gemin-4 Protein
- Gemin 4 Protein
- Component of Gems 4 Protein
Gemin7 Protein- Gemin7 Protein
- Protein, Gemin7
- Gemin-7 Protein
- Gemin 7 Protein
- Protein, Gemin-7
Gemin8 Protein- Gemin8 Protein
- Gemin-8 Protein
- Gemin 8 Protein
- FAM51A1 Protein
Gemin2 Protein- Gemin2 Protein
- Survival of Motor Neuron Protein-Interacting Protein 1
- Survival of Motor Neuron Protein Interacting Protein 1
- Gemin-2 Protein
- Gemin 2 Protein
|
Below are MeSH descriptors whose meaning is more general than "SMN Complex Proteins".
Below are MeSH descriptors whose meaning is more specific than "SMN Complex Proteins".
This graph shows the total number of publications written about "SMN Complex Proteins" by people in this website by year, and whether "SMN Complex Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 2 | 2 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "SMN Complex Proteins" by people in Profiles.
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A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II. Nat Commun. 2022 09 16; 13(1):5453.
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Fam118B, a newly identified component of Cajal bodies, is required for Cajal body formation, snRNP biogenesis and cell viability. J Cell Sci. 2014 May 01; 127(Pt 9):2029-39.
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Crystal structure of TDRD3 and methyl-arginine binding characterization of TDRD3, SMN and SPF30. PLoS One. 2012; 7(2):e30375.
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The human centromeric survival motor neuron gene (SMN2) rescues embryonic lethality in Smn(-/-) mice and results in a mouse with spinal muscular atrophy. Hum Mol Genet. 2000 Feb 12; 9(3):333-9.
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A single nucleotide difference that alters splicing patterns distinguishes the SMA gene SMN1 from the copy gene SMN2. Hum Mol Genet. 1999 Jul; 8(7):1177-83.
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Intragenic telSMN mutations: frequency, distribution, evidence of a founder effect, and modification of the spinal muscular atrophy phenotype by cenSMN copy number. Am J Hum Genet. 1998 Dec; 63(6):1712-23.
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Diagnosis of spinal muscular atrophy in an SMN non-deletion patient using a quantitative PCR screen and mutation analysis. J Med Genet. 1998 Aug; 35(8):674-6.
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Identification of proximal spinal muscular atrophy carriers and patients by analysis of SMNT and SMNC gene copy number. Am J Hum Genet. 1997 Jun; 60(6):1411-22.
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An 11 base pair duplication in exon 6 of the SMN gene produces a type I spinal muscular atrophy (SMA) phenotype: further evidence for SMN as the primary SMA-determining gene. Hum Mol Genet. 1996 Nov; 5(11):1727-32.