"Clonal Anergy" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Functional inactivation of T- or B-lymphocytes rendering them incapable of eliciting an immune response to antigen. This occurs through different mechanisms in the two kinds of lymphocytes and can contribute to SELF TOLERANCE.
| Descriptor ID |
D017635
|
| MeSH Number(s) |
G12.535.425.100
|
| Concept/Terms |
Clonal Anergy- Clonal Anergy
- Anergies, Clonal
- Anergy, Clonal
- Clonal Anergies
|
Below are MeSH descriptors whose meaning is more general than "Clonal Anergy".
Below are MeSH descriptors whose meaning is more specific than "Clonal Anergy".
This graph shows the total number of publications written about "Clonal Anergy" by people in this website by year, and whether "Clonal Anergy" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Clonal Anergy" by people in Profiles.
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Local and Systemic CD4+ T Cell Exhaustion Reverses with Clinical Resolution of Pulmonary Sarcoidosis. J Immunol Res. 2017; 2017:3642832.
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CD4(+) T cell anergy prevents autoimmunity and generates regulatory T cell precursors. Nat Immunol. 2016 Mar; 17(3):304-14.
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Arthritogenic self-reactive CD4+ T cells acquire an FR4hiCD73hi anergic state in the presence of Foxp3+ regulatory T cells. J Immunol. 2012 Jan 01; 188(1):170-81.
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IFN-? induces the proliferation of CD4+CD25+Foxp3+ regulatory T cells through upregulation of GITRL on dendritic cells in the treatment of multiple sclerosis. J Neuroimmunol. 2012 Jan 18; 242(1-2):39-46.
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CD25+Foxp3+ regulatory T cells facilitate CD4+ T cell clonal anergy induction during the recovery from lymphopenia. J Immunol. 2006 May 15; 176(10):5880-9.
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Efficient CD28 signalling leads to increases in the kinase activities of the TEC family tyrosine kinase EMT/ITK/TSK and the SRC family tyrosine kinase LCK. Biochem J. 1998 Mar 15; 330 ( Pt 3):1123-8.
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Co-stimulation via CD28 induces activation of a refractory subset of MRL-lpr/lpr T lymphocytes. Int Immunol. 1993 Nov; 5(11):1451-60.