"Self Tolerance" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The normal lack of the ability to produce an immunological response to autologous (self) antigens. A breakdown of self tolerance leads to autoimmune diseases. The ability to recognize the difference between self and non-self is the prime function of the immune system.
| Descriptor ID |
D017634
|
| MeSH Number(s) |
G12.535.425.800
|
| Concept/Terms |
Self Tolerance- Self Tolerance
- Self Tolerances
- Tolerance, Self
- Tolerances, Self
|
Below are MeSH descriptors whose meaning is more general than "Self Tolerance".
Below are MeSH descriptors whose meaning is more specific than "Self Tolerance".
This graph shows the total number of publications written about "Self Tolerance" by people in this website by year, and whether "Self Tolerance" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 1 | 0 | 1 |
| 2003 | 0 | 1 | 1 |
| 2011 | 1 | 1 | 2 |
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Below are the most recent publications written about "Self Tolerance" by people in Profiles.
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CD4(+) T cell anergy prevents autoimmunity and generates regulatory T cell precursors. Nat Immunol. 2016 Mar; 17(3):304-14.
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NKG2D ligation relieves 2B4-mediated NK-cell self-tolerance in mice. Eur J Immunol. 2014 Jun; 44(6):1802-13.
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Immune regulation through mitochondrion-dependent dendritic cell death induced by T regulatory cells. J Immunol. 2011 Dec 01; 187(11):5684-92.
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The absence of immunoglobulin D B cell receptor-mediated signals promotes the production of autoantibodies and exacerbates glomerulonephritis in murine lupus. Clin Exp Immunol. 2011 May; 164(2):227-35.
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Autoimmune hepatitis and antigen-specific T regulatory cells: when can we send in the regulators? Hepatology. 2011 Feb; 53(2):385-8.
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Lymphotoxin pathway-directed, autoimmune regulator-independent central tolerance to arthritogenic collagen. J Immunol. 2006 Jul 01; 177(1):290-7.
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Impaired thymic negative selection causes autoimmune graft-versus-host disease. Blood. 2003 Jul 15; 102(2):429-35.
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Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs. J Clin Invest. 2001 Mar; 107(5):555-64.