"Ephrin-A4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A GLYCOINOSITOL PHOSPHOLIPID MEMBRANE ANCHOR containing ephrin found in variety of adult tissue such as KIDNEY; LUNG; COLON and OVARY. During embryonic development, ephrin-A4 is expressed in the HIPPOCAMPUS and CEREBRAL CORTEX. It binds preferentially to ephA receptors (EPH FAMILY RECEPTORS) with the exception of the EPHA1 RECEPTOR.
| Descriptor ID |
D036385
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| MeSH Number(s) |
D12.644.276.500.400 D12.776.395.550.448.330 D12.776.467.500.400 D12.776.543.287.400 D12.776.543.484.500.330 D12.776.543.550.418.330 D23.529.500.400
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| Concept/Terms |
Ephrin-A4- Ephrin-A4
- Ephrin A4
- LERK-4 Protein
- LERK 4 Protein
- LERK-4
- EPLG4
- Epl4 Protein
|
Below are MeSH descriptors whose meaning is more general than "Ephrin-A4".
Below are MeSH descriptors whose meaning is more specific than "Ephrin-A4".
This graph shows the total number of publications written about "Ephrin-A4" by people in this website by year, and whether "Ephrin-A4" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2019 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Ephrin-A4" by people in Profiles.
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Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation. Nat Commun. 2021 05 13; 12(1):2788.
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First-in-human, phase I study of PF-06647263, an anti-EFNA4 calicheamicin antibody-drug conjugate, in patients with advanced solid tumors. Int J Cancer. 2019 10 01; 145(7):1798-1808.
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The genes encoding the eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4, Epl4) are clustered on human chromosome 1 and mouse chromosome 3. Genomics. 1996 Apr 15; 33(2):277-82.