"Uracil-DNA Glycosidase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the HYDROLYSIS of the N-glycosidic bond between sugar phosphate backbone and URACIL residue during DNA synthesis.
| Descriptor ID |
D051981
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| MeSH Number(s) |
D08.811.074.249.875
|
| Concept/Terms |
Uracil-DNA Glycosidase- Uracil-DNA Glycosidase
- Glycosidase, Uracil-DNA
- Uracil DNA Glycosidase
- Ura-DNA Glycosidase
- Glycosidase, Ura-DNA
- Ura DNA Glycosidase
- Uracil-DNA Glycosylase
- Glycosylase, Uracil-DNA
- Uracil DNA Glycosylase
- DNA Glycosylase, Uracil
- Glycosylase, Uracil DNA
- Uracil N-Glycosidase
- N-Glycosidase, Uracil
- Uracil N Glycosidase
- Uracil N-Glycosylase
- N-Glycosylase, Uracil
- Uracil N Glycosylase
- Ung DNA Glycosylase
- DNA Glycosylase, Ung
- Glycosylase, Ung DNA
- Ura-DNA Glycosylase
- Glycosylase, Ura-DNA
- Ura DNA Glycosylase
|
Below are MeSH descriptors whose meaning is more general than "Uracil-DNA Glycosidase".
Below are MeSH descriptors whose meaning is more specific than "Uracil-DNA Glycosidase".
This graph shows the total number of publications written about "Uracil-DNA Glycosidase" by people in this website by year, and whether "Uracil-DNA Glycosidase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 2 | 2 |
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Below are the most recent publications written about "Uracil-DNA Glycosidase" by people in Profiles.
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Uracil-DNA glycosylase of murine gammaherpesvirus 68 binds cognate viral replication factors independently of its catalytic residues. mSphere. 2023 10 24; 8(5):e0027823.
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Divergent structures of Mammalian and gammaherpesvirus uracil DNA glycosylases confer distinct DNA binding and substrate activity. DNA Repair (Amst). 2023 Aug; 128:103515.
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An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation. Prog Biophys Mol Biol. 2021 08; 163:143-159.
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Combinatorial Loss of the Enzymatic Activities of Viral Uracil-DNA Glycosylase and Viral dUTPase Impairs Murine Gammaherpesvirus Pathogenesis and Leads to Increased Recombination-Based Deletion in the Viral Genome. mBio. 2018 10 30; 9(5).
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High UDG and BRCA1 expression is associated with adverse outcome in patients with pemetrexed treated non-small cell lung Cancer. Lung Cancer. 2018 12; 126:48-54.
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Absence of the uracil DNA glycosylase of murine gammaherpesvirus 68 impairs replication and delays the establishment of latency in vivo. J Virol. 2015 Mar; 89(6):3366-79.
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Combining H/D exchange mass spectroscopy and computational docking reveals extended DNA-binding surface on uracil-DNA glycosylase. Nucleic Acids Res. 2012 Jul; 40(13):6070-81.
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Homeostatic regulation of base excision repair by a p53-induced phosphatase: linking stress response pathways with DNA repair proteins. Cell Cycle. 2004 Nov; 3(11):1363-6.
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The p53-induced oncogenic phosphatase PPM1D interacts with uracil DNA glycosylase and suppresses base excision repair. Mol Cell. 2004 Aug 27; 15(4):621-34.
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Altered patterns of gene expression distinguishing ascending aortic aneurysms from abdominal aortic aneurysms: complementary DNA expression profiling in the molecular characterization of aortic disease. J Thorac Cardiovasc Surg. 2003 Aug; 126(2):344-57; discission 357.