"Thymine DNA Glycosylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that removes THYMINE and URACIL bases mispaired with GUANINE through hydrolysis of their N-glycosidic bond. These mispaired nucleotides generally occur through the hydrolytic DEAMINATION of 5-METHYLCYTOSINE to thymine.
| Descriptor ID |
D044502
|
| MeSH Number(s) |
D08.811.074.249.750 D08.811.277.450.430.099.750
|
| Concept/Terms |
Thymine DNA Glycosylase- Thymine DNA Glycosylase
- DNA Glycosylase, Thymine
- Glycosylase, Thymine DNA
- Thymine Glycol Glycosylase
- Glycol Glycosylase, Thymine
- Glycosylase, Thymine Glycol
- G-T Mismatch-Specific Thymine DNA Glycosylase
- G T Mismatch Specific Thymine DNA Glycosylase
- Thymine Glycol DNA Glycosylase
|
Below are MeSH descriptors whose meaning is more general than "Thymine DNA Glycosylase".
Below are MeSH descriptors whose meaning is more specific than "Thymine DNA Glycosylase".
This graph shows the total number of publications written about "Thymine DNA Glycosylase" by people in this website by year, and whether "Thymine DNA Glycosylase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Thymine DNA Glycosylase" by people in Profiles.
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Active DNA demethylation promotes cell fate specification and the DNA damage response. Science. 2022 12 02; 378(6623):983-989.
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Mutations in the DNMT3A DNA methyltransferase in acute myeloid leukemia patients cause both loss and gain of function and differential regulation by protein partners. J Biol Chem. 2019 03 29; 294(13):4898-4910.
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Minimal role of base excision repair in TET-induced global DNA demethylation in HEK293T cells. Epigenetics. 2015; 10(11):1006-13.
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DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45. Cell. 2008 Dec 26; 135(7):1201-12.
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Envisioning the molecular choreography of DNA base excision repair. Curr Opin Struct Biol. 1999 Feb; 9(1):37-47.