"Dynamins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of high molecular weight GTP phosphohydrolases that play a direct role in vesicle transport. They associate with microtubule bundles (MICROTUBULES) and are believed to produce mechanical force via a process linked to GTP hydrolysis. This enzyme was formerly listed as EC 3.6.1.50.
| Descriptor ID |
D034281
|
| MeSH Number(s) |
D08.811.277.040.330.200 D12.776.220.600.450.200 D12.776.543.990.400
|
| Concept/Terms |
GTPase-Deficient Dynamin- GTPase-Deficient Dynamin
- Dynamin, GTPase-Deficient
- GTPase Deficient Dynamin
- Dynamin, Alanine44 Substituted With Lysine
- Dynamin, Mutated Form, K44A
- Dynamin K44A
|
Below are MeSH descriptors whose meaning is more general than "Dynamins".
Below are MeSH descriptors whose meaning is more specific than "Dynamins".
This graph shows the total number of publications written about "Dynamins" by people in this website by year, and whether "Dynamins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2006 | 1 | 1 | 2 |
| 2009 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 2 | 2 |
| 2013 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 0 | 2 | 2 |
| 2019 | 2 | 0 | 2 |
| 2020 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Dynamins" by people in Profiles.
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DLK-dependent axonal mitochondrial fission drives degeneration after axotomy. Nat Commun. 2024 Dec 30; 15(1):10806.
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A recurrent de novo splice site variant involving DNM1 exon 10a causes developmental and epileptic encephalopathy through a dominant-negative mechanism. Am J Hum Genet. 2022 12 01; 109(12):2253-2269.
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Mitochondrial Fusion: The Machineries In and Out. Trends Cell Biol. 2021 01; 31(1):62-74.
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Novel role of dynamin-related-protein 1 in dynamics of ER-lipid droplets in adipose tissue. FASEB J. 2020 06; 34(6):8265-8282.
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Mitochondrial fusion exploits a therapeutic vulnerability of pancreatic cancer. JCI Insight. 2019 07 23; 5.
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De novo missense variant in the GTPase effector domain (GED) of DNM1L leads to static encephalopathy and seizures. Cold Spring Harb Mol Case Stud. 2019 06; 5(3).
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Drp1S600 phosphorylation regulates mitochondrial fission and progression of nephropathy in diabetic mice. J Clin Invest. 2019 05 07; 129(7):2807-2823.
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Sonic hedgehog protects endometrial hyperplasial cells against oxidative stress via suppressing mitochondrial fission protein dynamin-like GTPase (Drp1). Free Radic Biol Med. 2018 12; 129:582-599.
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The expanding neurological phenotype of DNM1L-related disorders. Brain. 2018 04 01; 141(4):e28.
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Zdhhc13-dependent Drp1 S-palmitoylation impacts brain bioenergetics, anxiety, coordination and motor skills. Sci Rep. 2017 10 16; 7(1):12796.