"Munc18 Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of proteins involved in intracellular membrane trafficking. They interact with SYNTAXINS and play important roles in vesicular docking and fusion during EXOCYTOSIS. Their name derives from the fact that they are related to Unc-18 protein, C elegans.
| Descriptor ID |
D051938
|
| MeSH Number(s) |
D12.776.543.990.587
|
| Concept/Terms |
Munc18 Proteins- Munc18 Proteins
- Syntaxin Binding Protein Munc18
- Sec1-Munc18 Protein Family
- Sec1 Munc18 Protein Family
- Munc-18 Proteins
- Munc 18 Proteins
- Munc18 Syntaxin Binding Proteins
|
Below are MeSH descriptors whose meaning is more general than "Munc18 Proteins".
Below are MeSH descriptors whose meaning is more specific than "Munc18 Proteins".
This graph shows the total number of publications written about "Munc18 Proteins" by people in this website by year, and whether "Munc18 Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2012 | 2 | 0 | 2 |
| 2015 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Munc18 Proteins" by people in Profiles.
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GABAergic/Glycinergic and Glutamatergic Neurons Mediate Distinct Neurodevelopmental Phenotypes of STXBP1 Encephalopathy. J Neurosci. 2024 Apr 03; 44(14).
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Stxbp1/Munc18-1 haploinsufficiency impairs inhibition and mediates key neurological features of STXBP1 encephalopathy. Elife. 2020 02 19; 9.
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Different Munc18 proteins mediate baseline and stimulated airway mucin secretion. JCI Insight. 2019 03 21; 4(6).
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Munc18-2, but not Munc18-1 or Munc18-3, regulates platelet exocytosis, hemostasis, and thrombosis. J Biol Chem. 2019 03 29; 294(13):4784-4792.
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Munc18-2, but not Munc18-1 or Munc18-3, controls compound and single-vesicle-regulated exocytosis in mast cells. J Biol Chem. 2018 05 11; 293(19):7148-7159.
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Disruption of protein complexes containing protein phosphatase?2B and Munc18c reduces the secretion of von Willebrand factor from endothelial cells. J Thromb Haemost. 2017 05; 15(5):1032-1039.
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Loss of Munc18-1 long splice variant in GABAergic terminals is associated with cognitive decline and increased risk of dementia in a community sample. Mol Neurodegener. 2015 Dec 02; 10:65.
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Late-onset severe chronic active EBV in a patient for five years with mutations in STXBP2 (MUNC18-2) and PRF1 (perforin 1). J Clin Immunol. 2015 Jul; 35(5):445-8.
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Munc18b is an essential gene in mice whose expression is limiting for secretion by airway epithelial and mast cells. Biochem J. 2012 Sep 15; 446(3):383-94.
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Novel 9q34.11 gene deletions encompassing combinations of four Mendelian disease genes: STXBP1, SPTAN1, ENG, and TOR1A. Genet Med. 2012 Oct; 14(10):868-76.