"Bufanolides" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cyclopentanophenanthrenes with a 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. They are found in BUFONIDAE and often possess cardiotonic properties.
| Descriptor ID |
D002018
|
| MeSH Number(s) |
D04.210.500.155.580.064
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Bufanolides".
Below are MeSH descriptors whose meaning is more specific than "Bufanolides".
This graph shows the total number of publications written about "Bufanolides" by people in this website by year, and whether "Bufanolides" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2014 | 1 | 1 | 2 |
| 2015 | 2 | 0 | 2 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Bufanolides" by people in Profiles.
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Bufalin suppresses endometriosis progression by inducing pyroptosis and apoptosis. J Endocrinol. 2018 06; 237(3):255-269.
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Involvement of the Bufadienolides in the Detection and Therapy of the Acute Respiratory Distress Syndrome. Lung. 2017 06; 195(3):323-332.
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Steroid Receptor Coactivator-3 (SRC-3/AIB1) as a Novel Therapeutic Target in Triple Negative Breast Cancer and Its Inhibition with a Phospho-Bufalin Prodrug. PLoS One. 2015; 10(10):e0140011.
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Bufalin is a steroid receptor coactivator inhibitor-response. Cancer Res. 2015 Mar 15; 75(6):1157.
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Cardiotonic steroids induce anti-angiogenic and anti-proliferative profiles in first trimester extravillous cytotrophoblast cells. Placenta. 2014 Nov; 35(11):932-6.
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Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1. Cancer Res. 2014 Mar 01; 74(5):1506-1517.
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Bufalin enhances the anti-proliferative effect of sorafenib on human hepatocellular carcinoma cells through downregulation of ERK. Mol Biol Rep. 2012 Feb; 39(2):1683-9.
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Na+/K+-ATPase a3 mediates sensitivity of hepatocellular carcinoma cells to bufalin. Oncol Rep. 2011 Mar; 25(3):825-30.
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Ouabain- and marinobufagenin-induced proliferation of human umbilical vein smooth muscle cells and a rat vascular smooth muscle cell line, A7r5. Circulation. 2003 Dec 16; 108(24):3048-53.