"Cardiac Glycosides" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose.
| Descriptor ID |
D002301
|
| MeSH Number(s) |
D04.210.500.155.580 D09.408.180
|
| Concept/Terms |
Cardiac Glycosides- Cardiac Glycosides
- Glycosides, Cardiac
- Cardiotonic Steroids
- Steroids, Cardiotonic
|
Below are MeSH descriptors whose meaning is more general than "Cardiac Glycosides".
Below are MeSH descriptors whose meaning is more specific than "Cardiac Glycosides".
This graph shows the total number of publications written about "Cardiac Glycosides" by people in this website by year, and whether "Cardiac Glycosides" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Cardiac Glycosides" by people in Profiles.
-
Cytotoxic and non-cytotoxic cardiac glycosides isolated from the combined flowers, leaves, and twigs of Streblus asper. Bioorg Med Chem. 2020 02 15; 28(4):115301.
-
Cardiac Glycoside Constituents of Streblus asper with Potential Antineoplastic Activity. J Nat Prod. 2017 03 24; 80(3):648-658.
-
Cardiac glycosides display selective efficacy for STK11 mutant lung cancer. Sci Rep. 2016 07 19; 6:29721.
-
A p38 mitogen-activated protein kinase inhibitor attenuates cardiotonic steroids-induced apoptotic and stress signaling in a Sw-71 cytotrophoblast cell line. Placenta. 2015 Nov; 36(11):1276-82.
-
PBI-05204, a supercritical CO2 extract of Nerium oleander, inhibits growth of human pancreatic cancer via targeting the PI3K/mTOR pathway. Invest New Drugs. 2015 Apr; 33(2):271-9.
-
Cardiotonic steroids induce anti-angiogenic and anti-proliferative profiles in first trimester extravillous cytotrophoblast cells. Placenta. 2014 Nov; 35(11):932-6.
-
Intracellular calcium regulates nonsense-mediated mRNA decay. Nat Med. 2014 Aug; 20(8):961-6.
-
In vitro and in vivo neuroprotective activity of the cardiac glycoside oleandrin from Nerium oleander in brain slice-based stroke models. J Neurochem. 2011 Nov; 119(4):805-14.
-
Huachansu, containing cardiac glycosides, enhances radiosensitivity of human lung cancer cells. Anticancer Res. 2011 Jun; 31(6):2141-8.
-
Common cardiovascular medications in cancer therapeutics. Pharmacol Ther. 2011 May; 130(2):177-90.