"Novobiocin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189)
| Descriptor ID |
D009675
|
| MeSH Number(s) |
D03.383.663.283.446.139.500 D03.633.100.150.446.139.500 D09.408.554
|
| Concept/Terms |
Novobiocin- Novobiocin
- Streptonivicin
- Crystallinic Acid
Novobiocin Sodium- Novobiocin Sodium
- Sodium, Novobiocin
- Novobiocin, Monosodium Salt
- Monosodium Salt Novobiocin
|
Below are MeSH descriptors whose meaning is more general than "Novobiocin".
Below are MeSH descriptors whose meaning is more specific than "Novobiocin".
This graph shows the total number of publications written about "Novobiocin" by people in this website by year, and whether "Novobiocin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1997 | 1 | 0 | 1 |
| 1998 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Novobiocin" by people in Profiles.
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Novobiocin blocks nucleic acid binding to Pol? and inhibits stimulation of its ATPase activity. Nucleic Acids Res. 2023 Oct 13; 51(18):9920-9937.
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In vitro evaluation of photosensitivity risk related to genetic polymorphisms of human ABC transporter ABCG2 and inhibition by drugs. Drug Metab Pharmacokinet. 2007 Dec; 22(6):428-40.
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Breast cancer resistance protein-mediated efflux of androgen in putative benign and malignant prostate stem cells. Cancer Res. 2005 Aug 01; 65(15):6640-50.
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A prospective crossover randomized trial of novobiocin and rifampin prophylaxis for the prevention of intravascular catheter infections in cancer patients treated with interleukin-2. Cancer. 1998 Jan 15; 82(2):403-11.
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The high-resolution crystal structure of a 24-kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin. Proteins. 1997 May; 28(1):41-52.
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Antibiotics and prevention of microbial colonization of catheters. Antimicrob Agents Chemother. 1995 Nov; 39(11):2397-400.
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Effect of novobiocin and other DNA gyrase inhibitors on virus replication and DNA synthesis in herpes simplex virus type 1-infected BHK cells. J Gen Virol. 1981 Feb; 52(Pt 2):401-4.