"Immunological Synapses" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The interfaces between T-CELLS and ANTIGEN-PRESENTING CELLS. Supramolecular organization of proteins takes place at these synapses involving various types of immune cells. Immunological synapses can have several functions including LYMPHOCYTE ACTIVATION; enhancing, balancing, or terminating signaling; or directing cytokine secretion.
| Descriptor ID |
D054992
|
| MeSH Number(s) |
A11.284.149.165.420.548 A15.382.370
|
| Concept/Terms |
Immunological Synapses- Immunological Synapses
- Immunological Synapse
- Synapse, Immunological
- Synapses, Immunological
|
Below are MeSH descriptors whose meaning is more general than "Immunological Synapses".
Below are MeSH descriptors whose meaning is more specific than "Immunological Synapses".
This graph shows the total number of publications written about "Immunological Synapses" by people in this website by year, and whether "Immunological Synapses" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 1 | 2 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 1 | 1 | 2 |
| 2018 | 1 | 1 | 2 |
| 2019 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Immunological Synapses" by people in Profiles.
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In vitro machine learning-based CAR T immunological synapse quality measurements correlate with patient clinical outcomes. PLoS Comput Biol. 2022 03; 18(3):e1009883.
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Human signal transducer and activator of transcription 5b (STAT5b) mutation causes dysregulated human natural killer cell maturation and impaired lytic function. J Allergy Clin Immunol. 2020 01; 145(1):345-357.e9.
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PD-1 blocks lytic granule polarization with concomitant impairment of integrin outside-in signaling in the natural killer cell immunological synapse. J Allergy Clin Immunol. 2018 10; 142(4):1311-1321.e8.
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Nanoscale Dynamism of Actin Enables Secretory Function in Cytolytic Cells. Curr Biol. 2018 02 19; 28(4):489-502.e9.
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Mutations in PI3K110d cause impaired natural killer cell function partially rescued by rapamycin treatment. J Allergy Clin Immunol. 2018 08; 142(2):605-617.e7.
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Reversible Transgene Expression Reduces Fratricide and Permits 4-1BB Costimulation of CAR T Cells Directed to T-cell Malignancies. Cancer Immunol Res. 2018 01; 6(1):47-58.
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Recycling endosomes in human cytotoxic T lymphocytes constitute an auxiliary intracellular trafficking pathway for newly synthesized perforin. Immunol Res. 2017 10; 65(5):1031-1045.
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Quantitative Imaging Approaches to Study the CAR Immunological Synapse. Mol Ther. 2017 08 02; 25(8):1757-1768.
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Measurement of Lytic Granule Convergence After Formation of an NK Cell Immunological Synapse. Methods Mol Biol. 2017; 1584:497-515.
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Human NK cell development requires CD56-mediated motility and formation of the developmental synapse. Nat Commun. 2016 07 20; 7:12171.