"Tight Junctions" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cell-cell junctions that seal adjacent epithelial cells together, preventing the passage of most dissolved molecules from one side of the epithelial sheet to the other. (Alberts et al., Molecular Biology of the Cell, 2nd ed, p22)
| Descriptor ID |
D019108
|
| MeSH Number(s) |
A11.284.149.165.420.820
|
| Concept/Terms |
Tight Junctions- Tight Junctions
- Junction, Tight
- Junctions, Tight
- Tight Junction
- Zonula Occludens
- Occluden, Zonula
- Occludens, Zonula
- Zonula Occluden
- Occluding Junctions
- Junction, Occluding
- Junctions, Occluding
- Occluding Junction
|
Below are MeSH descriptors whose meaning is more general than "Tight Junctions".
Below are MeSH descriptors whose meaning is more specific than "Tight Junctions".
This graph shows the total number of publications written about "Tight Junctions" by people in this website by year, and whether "Tight Junctions" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1999 | 0 | 1 | 1 |
| 2003 | 0 | 3 | 3 |
| 2004 | 1 | 1 | 2 |
| 2005 | 1 | 2 | 3 |
| 2007 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 1 | 2 |
| 2014 | 2 | 0 | 2 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 0 | 3 | 3 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
| 2022 | 0 | 2 | 2 |
| 2023 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
| 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "Tight Junctions" by people in Profiles.
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Destructive and protective effects and therapeutic targets of IL-36 family cytokines in dry eye disease. Ocul Surf. 2025 Apr; 36:83-93.
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HDAC3 promotes Sertoli cell maturation and maintains the blood-testis barrier dynamics. FASEB J. 2024 03 15; 38(5):e23526.
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Bi-allelic variants in the ESAM tight-junction gene cause a neurodevelopmental disorder associated with fetal intracranial hemorrhage. Am J Hum Genet. 2023 04 06; 110(4):681-690.
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Investigation of murine host sex as a biological variable in epithelial barrier function and muscle contractility in human intestinal organoids. FASEB J. 2022 11; 36(11):e22613.
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Matrix metalloproteinase 7 contributes to intestinal barrier dysfunction by degrading tight junction protein Claudin-7. Front Immunol. 2022; 13:1020902.
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SOX9-COL9A3-dependent regulation of choroid plexus epithelial polarity governs blood-cerebrospinal fluid barrier integrity. Proc Natl Acad Sci U S A. 2021 02 09; 118(6).
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In?Vivo Transplantation of Human Intestinal Organoids Enhances Select Tight Junction Gene Expression. J Surg Res. 2021 03; 259:500-508.
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High Mobility Group Box 1 Mediates TMAO-Induced Endothelial Dysfunction. Int J Mol Sci. 2019 Jul 22; 20(14).
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Changes of tight junction and interleukin-8 expression using a human gastroid monolayer model of Helicobacter pylori infection. Helicobacter. 2019 Jun; 24(3):e12583.
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The Tri-phasic Role of Hydrogen Peroxide in Blood-Brain Barrier Endothelial cells. Sci Rep. 2019 01 15; 9(1):133.