"Tight Junctions" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cell-cell junctions that seal adjacent epithelial cells together, preventing the passage of most dissolved molecules from one side of the epithelial sheet to the other. (Alberts et al., Molecular Biology of the Cell, 2nd ed, p22)
| Descriptor ID |
D019108
|
| MeSH Number(s) |
A11.284.149.165.420.820
|
| Concept/Terms |
Tight Junctions- Tight Junctions
- Junction, Tight
- Junctions, Tight
- Tight Junction
- Zonula Occludens
- Occluden, Zonula
- Occludens, Zonula
- Zonula Occluden
- Occluding Junctions
- Junction, Occluding
- Junctions, Occluding
- Occluding Junction
|
Below are MeSH descriptors whose meaning is more general than "Tight Junctions".
Below are MeSH descriptors whose meaning is more specific than "Tight Junctions".
This graph shows the total number of publications written about "Tight Junctions" by people in this website by year, and whether "Tight Junctions" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1997 | 1 | 0 | 1 |
| 1999 | 0 | 1 | 1 |
| 2003 | 0 | 3 | 3 |
| 2004 | 1 | 1 | 2 |
| 2005 | 1 | 2 | 3 |
| 2007 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 1 | 2 |
| 2014 | 2 | 0 | 2 |
| 2015 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 0 | 3 | 3 |
| 2020 | 0 | 1 | 1 |
| 2022 | 0 | 2 | 2 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Tight Junctions" by people in Profiles.
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Vascular heterogeneity of tight junction Claudins guides organotropic metastasis. Nat Cancer. 2024 Sep; 5(9):1371-1389.
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Cingulin family: Structure, function and clinical significance. Life Sci. 2024 Mar 15; 341:122504.
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Bi-allelic variants in the ESAM tight-junction gene cause a neurodevelopmental disorder associated with fetal intracranial hemorrhage. Am J Hum Genet. 2023 04 06; 110(4):681-690.
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The alpha7 integrin subunit in astrocytes promotes endothelial blood-brain barrier integrity. Development. 2023 03 15; 150(6).
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Investigation of murine host sex as a biological variable in epithelial barrier function and muscle contractility in human intestinal organoids. FASEB J. 2022 11; 36(11):e22613.
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Matrix metalloproteinase 7 contributes to intestinal barrier dysfunction by degrading tight junction protein Claudin-7. Front Immunol. 2022; 13:1020902.
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PLEKHA7 signaling is necessary for the growth of mutant KRAS driven colorectal cancer. Exp Cell Res. 2021 12 15; 409(2):112930.
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SARS-CoV-2 Envelope (E) protein interacts with PDZ-domain-2 of host tight junction protein ZO1. PLoS One. 2021; 16(6):e0251955.
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In?Vivo Transplantation of Human Intestinal Organoids Enhances Select Tight Junction Gene Expression. J Surg Res. 2021 03; 259:500-508.
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High Mobility Group Box 1 Mediates TMAO-Induced Endothelial Dysfunction. Int J Mol Sci. 2019 Jul 22; 20(14).