"Glutamate Decarboxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pyridoxal-phosphate protein that catalyzes the alpha-decarboxylation of L-glutamic acid to form gamma-aminobutyric acid and carbon dioxide. The enzyme is found in bacteria and in invertebrate and vertebrate nervous systems. It is the rate-limiting enzyme in determining GAMMA-AMINOBUTYRIC ACID levels in normal nervous tissues. The brain enzyme also acts on L-cysteate, L-cysteine sulfinate, and L-aspartate. EC 4.1.1.15.
| Descriptor ID |
D005968
|
| MeSH Number(s) |
D08.811.520.224.125.250
|
| Concept/Terms |
Glutamate Decarboxylase- Glutamate Decarboxylase
- Decarboxylase, Glutamate
- Glutamic Acid Decarboxylase
- Acid Decarboxylase, Glutamic
- Decarboxylase, Glutamic Acid
- Glutamate Carboxy-Lyase
- Carboxy-Lyase, Glutamate
- Glutamate Carboxy Lyase
|
Below are MeSH descriptors whose meaning is more general than "Glutamate Decarboxylase".
Below are MeSH descriptors whose meaning is more specific than "Glutamate Decarboxylase".
This graph shows the total number of publications written about "Glutamate Decarboxylase" by people in this website by year, and whether "Glutamate Decarboxylase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 1997 | 1 | 1 | 2 |
| 1998 | 1 | 0 | 1 |
| 2001 | 1 | 1 | 2 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2006 | 1 | 1 | 2 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 1 | 1 | 2 |
| 2012 | 1 | 1 | 2 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 1 | 2 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 2 | 3 |
| 2017 | 1 | 1 | 2 |
| 2019 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Glutamate Decarboxylase" by people in Profiles.
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IT-DEX and B cell depletion in a child with anti-GAD 65 autoimmune encephalitis presenting as NORSE: A case report. J Neuroimmunol. 2024 Oct 15; 395:578430.
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Gastrointestinal Infections Modulate the Risk for Insulin Autoantibodies as the First-Appearing Autoantibody in the TEDDY Study. Diabetes Care. 2023 11 01; 46(11):1908-1915.
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Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel. Diabetes. 2020 10; 69(10):2037-2047.
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Anti-glutamic acid decarboxylase (GAD) positive cerebellar Ataxia with transitioning to progressive encephalomyelitis with rigidity and myoclonus (PERM), responsive to immunotherapy: A case report and review of literature. J Neuroimmunol. 2019 07 15; 332:135-137.
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GABAergic Interneuron Differentiation in the Basal Forebrain Is Mediated through Direct Regulation of Glutamic Acid Decarboxylase Isoforms by Dlx Homeobox Transcription Factors. J Neurosci. 2017 09 06; 37(36):8816-8829.
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Can Non-HLA Single Nucleotide Polymorphisms Help Stratify Risk in TrialNet Relatives at Risk for Type 1 Diabetes? J Clin Endocrinol Metab. 2017 08 01; 102(8):2873-2880.
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Identification of Unique Antigenic Determinants in the Amino Terminus of IA-2 (ICA512) in Childhood and Adult Autoimmune Diabetes: New Biomarker Development. Diabetes Care. 2017 Apr; 40(4):561-568.
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GAD1 gene polymorphisms are associated with hyperactivity in Attention-Deficit/Hyperactivity Disorder. Am J Med Genet B Neuropsychiatr Genet. 2016 12; 171(8):1099-1104.
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Dissecting heterogeneity in paediatric Type 1 diabetes: association of TCF7L2 rs7903146 TT and low-risk human leukocyte antigen (HLA) genotypes. Diabet Med. 2017 02; 34(2):286-290.
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New inducible genetic method reveals critical roles of GABA in the control of feeding and metabolism. Proc Natl Acad Sci U S A. 2016 Mar 29; 113(13):3645-50.