Phosphoenolpyruvate Carboxykinase (GTP)
"Phosphoenolpyruvate Carboxykinase (GTP)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme of the lyase class that catalyzes the conversion of GTP and oxaloacetate to GDP, phosphoenolpyruvate, and carbon dioxide. This reaction is part of gluconeogenesis in the liver. The enzyme occurs in both the mitochondria and cytosol of mammalian liver. (From Dorland, 27th ed) EC 4.1.1.32.
| Descriptor ID |
D010729
|
| MeSH Number(s) |
D08.811.520.224.125.550
|
| Concept/Terms |
Phosphoenolpyruvate Carboxykinase (GTP)- Phosphoenolpyruvate Carboxykinase (GTP)
- GTP-Dependent Phosphoenolpyruvate Carboxykinase
- Carboxykinase, GTP-Dependent Phosphoenolpyruvate
- GTP Dependent Phosphoenolpyruvate Carboxykinase
- Phosphoenolpyruvate Carboxykinase, GTP-Dependent
|
Below are MeSH descriptors whose meaning is more general than "Phosphoenolpyruvate Carboxykinase (GTP)".
Below are MeSH descriptors whose meaning is more specific than "Phosphoenolpyruvate Carboxykinase (GTP)".
This graph shows the total number of publications written about "Phosphoenolpyruvate Carboxykinase (GTP)" by people in this website by year, and whether "Phosphoenolpyruvate Carboxykinase (GTP)" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1996 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 2 | 0 | 2 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Phosphoenolpyruvate Carboxykinase (GTP)" by people in Profiles.
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The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis. Nature. 2020 04; 580(7804):530-535.
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Impact of adrenomedullin blockage on lipid metabolism in female mice exposed to high-fat diet. Endocrine. 2019 08; 65(2):278-285.
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Cooperation of C/EBP family proteins and chromatin remodeling proteins is essential for termination of liver regeneration. Hepatology. 2015 Jan; 61(1):315-25.
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A putative Alzheimer's disease risk allele in PCK1 influences brain atrophy in multiple sclerosis. PLoS One. 2010 Nov 30; 5(11):e14169.
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Phosphoenolpyruvate carboxykinase (Pck1) helps regulate the triglyceride/fatty acid cycle and development of insulin resistance in mice. J Lipid Res. 2010 Jun; 51(6):1452-63.
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Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesis. Cell. 2009 Mar 20; 136(6):1073-84.
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Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver. Cell Metab. 2007 Sep; 6(3):208-16.
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Growth hormone corrects proliferation and transcription of phosphoenolpyruvate carboxykinase in livers of old mice via elimination of CCAAT/enhancer-binding protein alpha-Brm complex. J Biol Chem. 2007 Jan 12; 282(2):1468-78.
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Dual role of the coactivator TORC2 in modulating hepatic glucose output and insulin signaling. Cell Metab. 2005 Nov; 2(5):331-8.
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Animal models for studying the genetic basis of metabolic regulation. J Nutr. 1996 Nov; 126(11):2697-708.