"Ornithine Decarboxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pyridoxal-phosphate protein, believed to be the rate-limiting compound in the biosynthesis of polyamines. It catalyzes the decarboxylation of ornithine to form putrescine, which is then linked to a propylamine moiety of decarboxylated S-adenosylmethionine to form spermidine.
| Descriptor ID |
D009955
|
| MeSH Number(s) |
D08.811.520.224.125.425
|
| Concept/Terms |
Ornithine Decarboxylase- Ornithine Decarboxylase
- Decarboxylase, Ornithine
- Ornithine Carboxy-lyase
- Carboxy-lyase, Ornithine
- Ornithine Carboxy lyase
|
Below are MeSH descriptors whose meaning is more general than "Ornithine Decarboxylase".
Below are MeSH descriptors whose meaning is more specific than "Ornithine Decarboxylase".
This graph shows the total number of publications written about "Ornithine Decarboxylase" by people in this website by year, and whether "Ornithine Decarboxylase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 2 | 2 |
| 1995 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 1 | 0 | 1 |
| 2000 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2004 | 2 | 0 | 2 |
| 2010 | 0 | 2 | 2 |
| 2013 | 0 | 1 | 1 |
| 2022 | 1 | 1 | 2 |
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Below are the most recent publications written about "Ornithine Decarboxylase" by people in Profiles.
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Improvement of dermatological symptoms in patients with Bachmann-Bupp syndrome using difluoromethylornithine treatment. Pediatr Dermatol. 2023 May-Jun; 40(3):528-531.
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Systemic L-ornithine supplementation specifically increases ovarian putrescine levels during ovulation in mice?. Biol Reprod. 2022 04 26; 106(4):792-801.
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Ornithine is a key mediator in hyperphosphatemia-mediated human umbilical vein endothelial cell apoptosis: Insights gained from metabolomics. Life Sci. 2016 Feb 01; 146:73-80.
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Liver function in rats acclimatized to a simulated altitude of 5500 m. High Alt Med Biol. 2013 Dec; 14(4):375-82.
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Semi-high throughput method of measuring proteasome inhibition in vitro and in cultured cells. Cell Biol Toxicol. 2011 Apr; 27(2):123-31.
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ZNF9 activation of IRES-mediated translation of the human ODC mRNA is decreased in myotonic dystrophy type 2. PLoS One. 2010 Feb 18; 5(2):e9301.
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Prostanoids, ornithine decarboxylase, and polyamines in primary chemoprevention of familial adenomatous polyposis. Gastroenterology. 2004 Feb; 126(2):425-31.
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Resveratrol inhibits N-nitrosodiethylamine-induced ornithine decarboxylase and cyclooxygenase in mice. J Nutr Sci Vitaminol (Tokyo). 2004 Feb; 50(1):61-5.
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Apoptotic response to 5-fluorouracil treatment is mediated by reduced polyamines, non-autocrine Fas ligand and induced tumor necrosis factor receptor 2. Cancer Biol Ther. 2003 Sep-Oct; 2(5):572-8.
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Celecoxib and difluoromethylornithine in combination have strong therapeutic activity against UV-induced skin tumors in mice. Carcinogenesis. 2003 May; 24(5):945-52.