"Ornithine Decarboxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pyridoxal-phosphate protein, believed to be the rate-limiting compound in the biosynthesis of polyamines. It catalyzes the decarboxylation of ornithine to form putrescine, which is then linked to a propylamine moiety of decarboxylated S-adenosylmethionine to form spermidine.
| Descriptor ID |
D009955
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| MeSH Number(s) |
D08.811.520.224.125.425
|
| Concept/Terms |
Ornithine Decarboxylase- Ornithine Decarboxylase
- Decarboxylase, Ornithine
- Ornithine Carboxy-lyase
- Carboxy-lyase, Ornithine
- Ornithine Carboxy lyase
|
Below are MeSH descriptors whose meaning is more general than "Ornithine Decarboxylase".
Below are MeSH descriptors whose meaning is more specific than "Ornithine Decarboxylase".
This graph shows the total number of publications written about "Ornithine Decarboxylase" by people in this website by year, and whether "Ornithine Decarboxylase" was a major or minor topic of these publications.
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Below are the most recent publications written about "Ornithine Decarboxylase" by people in Profiles.
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Improvement of dermatological symptoms in patients with Bachmann-Bupp syndrome using difluoromethylornithine treatment. Pediatr Dermatol. 2023 May-Jun; 40(3):528-531.
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Systemic L-ornithine supplementation specifically increases ovarian putrescine levels during ovulation in mice?. Biol Reprod. 2022 04 26; 106(4):792-801.
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Liver function in rats acclimatized to a simulated altitude of 5500 m. High Alt Med Biol. 2013 Dec; 14(4):375-82.
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MMP-3 response to compressive forces in vitro and in vivo. J Dent Res. 2008 Jul; 87(7):692-6.
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Celecoxib and difluoromethylornithine in combination have strong therapeutic activity against UV-induced skin tumors in mice. Carcinogenesis. 2003 May; 24(5):945-52.
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Phase I dose de-escalation trial of alpha-difluoromethylornithine in patients with grade 3 cervical intraepithelial neoplasia. Clin Cancer Res. 1998 Feb; 4(2):303-10.
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Cycloheximide sensitivity of orotic acid biosynthesis induced by ammonia and glycine administration. Eur J Biochem. 1998 Feb 01; 251(3):597-604.
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Multisite phosphorylation of ornithine decarboxylase in transformed macrophages results in increased intracellular enzyme stability and catalytic efficiency. J Biol Chem. 1996 Oct 04; 271(40):24945-53.
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Involvement of the polyamine pathway in breast cancer progression. Cancer Lett. 1995 May 25; 92(1):49-57.
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Phosphorylation of ornithine decarboxylase at both serine and threonine residues in the ODC-overproducing, Abelson virus-transformed RAW264 cell line. Cancer Res. 1994 Aug 01; 54(15):3967-70.