"Chromosome Fragility" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Susceptibility of chromosomes to breakage leading to translocation; CHROMOSOME INVERSION; SEQUENCE DELETION; or other CHROMOSOME BREAKAGE related aberrations.
| Descriptor ID |
D002873
|
| MeSH Number(s) |
C23.550.210.110.180 C23.550.362.180.180 G05.365.590.175.165.180 G05.370.180.180
|
| Concept/Terms |
Chromosome Fragility- Chromosome Fragility
- Fragility, Chromosome
- Chromosomal Fragility
- Fragility, Chromosomal
|
Below are MeSH descriptors whose meaning is more general than "Chromosome Fragility".
Below are MeSH descriptors whose meaning is more specific than "Chromosome Fragility".
This graph shows the total number of publications written about "Chromosome Fragility" by people in this website by year, and whether "Chromosome Fragility" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 2001 | 1 | 0 | 1 |
| 2003 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Chromosome Fragility" by people in Profiles.
-
Two mechanisms of chromosome fragility at replication-termination sites in bacteria. Sci Adv. 2021 06; 7(25).
-
Phenotypic Spectrum of Epidermolysis Bullosa: The Paradigm of Syndromic versus Non-Syndromic Skin Fragility Disorders. J Invest Dermatol. 2019 03; 139(3):522-527.
-
Deletion of Brca2 exon 27 causes hypersensitivity to DNA crosslinks, chromosomal instability, and reduced life span in mice. Genes Chromosomes Cancer. 2003 Apr; 36(4):317-31.
-
Regional localization of 10 mariner transposon-like ESTs by means of FISH--evidence for a correlation with fragile sites. Mamm Genome. 2001 Apr; 12(4):326-8.
-
Detection of chromosome 11q13 breakpoints by interphase fluorescence in situ hybridization. A useful ancillary method for the diagnosis of mantle cell lymphoma. Am J Clin Pathol. 2000 Aug; 114(2):248-57.
-
The murine Fhit gene is highly similar to its human orthologue and maps to a common fragile site region. Cancer Res. 1998 Aug 01; 58(15):3409-14.
-
Chromosomal fragile sites and DNA amplification in drug-resistant cells. Biochem Pharmacol. 1998 Jul 01; 56(1):7-13.
-
Analysis of the FHIT gene and FRA3B region in sporadic breast cancer, preneoplastic lesions, and familial breast cancer probands. Cancer Res. 1997 Sep 01; 57(17):3664-8.
-
FHIT and FRA3B 3p14.2 allele loss are common in lung cancer and preneoplastic bronchial lesions and are associated with cancer-related FHIT cDNA splicing aberrations. Cancer Res. 1997 Jun 01; 57(11):2256-67.
-
A 350-kb cosmid contig in 3p14.2 that crosses the t(3;8) hereditary renal cell carcinoma translocation breakpoint and 17 aphidicolin-induced FRA3B breakpoints. Genomics. 1996 Jul 01; 35(1):87-93.