"Chromosome Fragility" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Susceptibility of chromosomes to breakage leading to translocation; CHROMOSOME INVERSION; SEQUENCE DELETION; or other CHROMOSOME BREAKAGE related aberrations.
| Descriptor ID |
D002873
|
| MeSH Number(s) |
C23.550.210.110.180 C23.550.362.180.180 G05.365.590.175.165.180 G05.370.180.180
|
| Concept/Terms |
Chromosome Fragility- Chromosome Fragility
- Fragility, Chromosome
- Chromosomal Fragility
- Fragility, Chromosomal
|
Below are MeSH descriptors whose meaning is more general than "Chromosome Fragility".
Below are MeSH descriptors whose meaning is more specific than "Chromosome Fragility".
This graph shows the total number of publications written about "Chromosome Fragility" by people in this website by year, and whether "Chromosome Fragility" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 2 | 0 | 2 |
| 1995 | 0 | 1 | 1 |
| 1996 | 3 | 1 | 4 |
| 1997 | 2 | 0 | 2 |
| 1998 | 3 | 0 | 3 |
| 2000 | 1 | 1 | 2 |
| 2001 | 1 | 0 | 1 |
| 2002 | 1 | 0 | 1 |
| 2003 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2021 | 1 | 1 | 2 |
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Below are the most recent publications written about "Chromosome Fragility" by people in Profiles.
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Translesion polymerase eta both facilitates DNA replication and promotes increased human genetic variation at common fragile sites. Proc Natl Acad Sci U S A. 2021 11 30; 118(48).
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Two mechanisms of chromosome fragility at replication-termination sites in bacteria. Sci Adv. 2021 06; 7(25).
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G-quadruplex structures formed at the HOX11 breakpoint region contribute to its fragility during t(10;14) translocation in T-cell leukemia. Mol Cell Biol. 2013 Nov; 33(21):4266-81.
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Deletion of Brca2 exon 27 causes hypersensitivity to DNA crosslinks, chromosomal instability, and reduced life span in mice. Genes Chromosomes Cancer. 2003 Apr; 36(4):317-31.
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Direct correlation between FRA3B expression and cigarette smoking. Genes Chromosomes Cancer. 2002 Jul; 34(3):333-40.
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Regional localization of 10 mariner transposon-like ESTs by means of FISH--evidence for a correlation with fragile sites. Mamm Genome. 2001 Apr; 12(4):326-8.
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Inactivation of 14-3-3sigma influences telomere behavior and ionizing radiation-induced chromosomal instability. Mol Cell Biol. 2000 Oct; 20(20):7764-72.
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Detection of chromosome 11q13 breakpoints by interphase fluorescence in situ hybridization. A useful ancillary method for the diagnosis of mantle cell lymphoma. Am J Clin Pathol. 2000 Aug; 114(2):248-57.
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WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer. Cancer Res. 2000 Apr 15; 60(8):2140-5.
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The murine Fhit gene is highly similar to its human orthologue and maps to a common fragile site region. Cancer Res. 1998 Aug 01; 58(15):3409-14.