"Cytochrome P-450 CYP2B1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A major cytochrome P-450 enzyme which is inducible by PHENOBARBITAL in both the LIVER and SMALL INTESTINE. It is active in the metabolism of compounds like pentoxyresorufin, TESTOSTERONE, and ANDROSTENEDIONE. This enzyme, encoded by CYP2B1 gene, also mediates the activation of CYCLOPHOSPHAMIDE and IFOSFAMIDE to MUTAGENS.
| Descriptor ID |
D019362
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| MeSH Number(s) |
D08.244.453.005.550 D08.244.453.491.313 D08.811.682.690.708.170.010.550 D08.811.682.690.708.170.450.313 D12.776.422.220.453.010.550 D12.776.422.220.453.491.313
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| Concept/Terms |
Cytochrome P-450 CYP2B1- Cytochrome P-450 CYP2B1
- Cytochrome P 450 CYP2B1
- 7-Benzyloxyresorufin O-Dealkylase
- 7 Benzyloxyresorufin O Dealkylase
- PROD
- CYP 2B1
- BROD
- 7-Pentylresorufin O-Depentylase
- 7 Pentylresorufin O Depentylase
- Benzyloxyresorufin O-Dealkylase
- Benzyloxyresorufin O Dealkylase
- CYP2B1
- Pentoxyresorufin O-Dealkylase
- O-Dealkylase, Pentoxyresorufin
- Pentoxyresorufin O Dealkylase
- Cytochrome P450 2B1
|
Below are MeSH descriptors whose meaning is more general than "Cytochrome P-450 CYP2B1".
Below are MeSH descriptors whose meaning is more specific than "Cytochrome P-450 CYP2B1".
This graph shows the total number of publications written about "Cytochrome P-450 CYP2B1" by people in this website by year, and whether "Cytochrome P-450 CYP2B1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cytochrome P-450 CYP2B1" by people in Profiles.
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Analysis of multiple nuclear receptor binding sites for CAR/RXR in the phenobarbital responsive unit of CYP2B2. Arch Biochem Biophys. 2006 Jul 15; 451(2):119-27.
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Phenobarbitone-mediated translocation of the cytosolic proteins interacting with the 5'-proximal region of rat liver CYP2B1/B2 gene into the nucleus. Biochem Biophys Res Commun. 2002 Mar 29; 292(2):312-7.
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Receptor-mediated gene delivery approach demonstrates the role of 5'-proximal DNA region in conferring phenobarbitone responsiveness to CYP2B2 gene in rat liver in vivo. Biochem Biophys Res Commun. 2000 Feb 24; 268(3):734-9.