Core Binding Factor Alpha 2 Subunit
"Core Binding Factor Alpha 2 Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain. Runx1 is frequently mutated in human LEUKEMIAS.
| Descriptor ID |
D050676
|
| MeSH Number(s) |
D12.776.930.155.200.200
|
| Concept/Terms |
Core Binding Factor Alpha 2 Subunit- Core Binding Factor Alpha 2 Subunit
- Runx1 Protein
- Pebp2a2 Protein
- Runt-Related Transcription Factor 1
- Runt Related Transcription Factor 1
- Acute Myeloid Leukemia 1 Protein
- Core-Binding Factor Alpha 2 Protein
- Core Binding Factor Alpha 2 Protein
|
Below are MeSH descriptors whose meaning is more general than "Core Binding Factor Alpha 2 Subunit".
Below are MeSH descriptors whose meaning is more specific than "Core Binding Factor Alpha 2 Subunit".
This graph shows the total number of publications written about "Core Binding Factor Alpha 2 Subunit" by people in this website by year, and whether "Core Binding Factor Alpha 2 Subunit" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 1 | 1 | 2 |
| 2008 | 0 | 1 | 1 |
| 2010 | 1 | 1 | 2 |
| 2011 | 0 | 1 | 1 |
| 2014 | 2 | 1 | 3 |
| 2015 | 0 | 3 | 3 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 2 | 3 |
| 2019 | 3 | 0 | 3 |
| 2021 | 2 | 1 | 3 |
| 2022 | 0 | 1 | 1 |
| 2023 | 1 | 0 | 1 |
| 2024 | 2 | 0 | 2 |
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Core Binding Factor Alpha 2 Subunit" by people in Profiles.
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Co-Occurrence of ETV6::RUNX1 and P2RY8::CRLF2 Fusion in a Patient with Relapsed Acute B Lymphoblastic Leukemia. Ann Clin Lab Sci. 2025 Jan; 55(1):133-141.
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Enhanced osteogenic potential of iPSC-derived mesenchymal progenitor cells following genome editing of GWAS variants in the RUNX1 gene. Bone Res. 2024 Dec 06; 12(1):70.
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Expression pattern of Runt-related transcription factor (RUNX) family members and the role of RUNX1 during kidney development. Biochem Biophys Res Commun. 2024 08 30; 722:150155.
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The E3 ligase DTX2 inhibits RUNX1 function by binding its C terminus and prevents the growth of RUNX1-dependent leukemia cells. FEBS J. 2023 11; 290(21):5141-5157.
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Acute myeloid leukemia in a child with familial platelet disorder and a cryptic runx1 intragenic deletion. Pediatr Hematol Oncol. 2022 09; 39(6):580-585.
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Converging genetic and epigenetic drivers of paediatric acute lymphoblastic leukaemia identified by an information-theoretic analysis. Nat Biomed Eng. 2021 04; 5(4):360-376.
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Favorable Trisomies and ETV6-RUNX1 Predict Cure in Low-Risk B-Cell Acute Lymphoblastic Leukemia: Results From Children's Oncology Group Trial AALL0331. J Clin Oncol. 2021 05 10; 39(14):1540-1552.
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The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis. Nat Commun. 2021 02 05; 12(1):821.
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ClinGen Myeloid Malignancy Variant Curation Expert Panel recommendations for germline RUNX1 variants. Blood Adv. 2019 10 22; 3(20):2962-2979.
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Thermodynamic investigation of DNA-binding affinity of wild-type and mutant transcription factor RUNX1. PLoS One. 2019; 14(5):e0216203.