Core Binding Factor Alpha 3 Subunit
"Core Binding Factor Alpha 3 Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain.
| Descriptor ID |
D050677
|
| MeSH Number(s) |
D12.776.930.155.200.300
|
| Concept/Terms |
Core Binding Factor Alpha 3 Subunit- Core Binding Factor Alpha 3 Subunit
- AML2 Protein
- CBFA3 Protein
- Runx3 Protein
- PEBP2A3 Protein
- Runt Domain Transcription Factor AML-2
- Runt-Related Transcription Factor 3 Protein
- Runt Related Transcription Factor 3 Protein
- Acute Myeloid Leukemia 2 Protein
- Core-Binding Factor Alpha 3 Protein
- Core Binding Factor Alpha 3 Protein
|
Below are MeSH descriptors whose meaning is more general than "Core Binding Factor Alpha 3 Subunit".
Below are MeSH descriptors whose meaning is more specific than "Core Binding Factor Alpha 3 Subunit".
This graph shows the total number of publications written about "Core Binding Factor Alpha 3 Subunit" by people in this website by year, and whether "Core Binding Factor Alpha 3 Subunit" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Core Binding Factor Alpha 3 Subunit" by people in Profiles.
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RUNX3 Promotes the Tumorigenic Phenotype in KGN, a Human Granulosa Cell Tumor-Derived Cell Line. Int J Mol Sci. 2019 Jul 15; 20(14).
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Aberrant gene methylation in non-neoplastic mucosa as a predictive marker of ulcerative colitis-associated CRC. Oncotarget. 2016 Mar 01; 7(9):10322-31.
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It's a SMAD/SMAD World. Cell. 2015 Jun 04; 161(6):1245-6.
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RUNX3 promoter hypermethylation is frequent in leukaemia cell lines and associated with acute myeloid leukaemia inv(16) subtype. Br J Haematol. 2015 May; 169(3):344-51.
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Dysfunctional transforming growth factor-? signaling with constitutively active Notch signaling in Barrett's esophageal adenocarcinoma. Cancer. 2011 Aug 15; 117(16):3691-702.
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A multicenter, double-blinded validation study of methylation biomarkers for progression prediction in Barrett's esophagus. Cancer Res. 2009 May 15; 69(10):4112-5.
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Inhibition of the growth and metastasis of human colon cancer by restoration of RUNX3 expression in cancer cells. Int J Oncol. 2008 Nov; 33(5):979-84.
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RUNX3 protein is overexpressed in human epithelial ovarian cancer. Gynecol Oncol. 2009 Feb; 112(2):325-30.
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The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells. J Exp Med. 2007 Aug 06; 204(8):1945-57.
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RUNX3 inhibits the expression of vascular endothelial growth factor and reduces the angiogenesis, growth, and metastasis of human gastric cancer. Clin Cancer Res. 2006 Nov 01; 12(21):6386-94.