Core Binding Factor Alpha 1 Subunit
"Core Binding Factor Alpha 1 Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain and is involved in genetic regulation of skeletal development and CELL DIFFERENTIATION.
| Descriptor ID |
D050659
|
| MeSH Number(s) |
D12.776.930.155.200.100
|
| Concept/Terms |
Core Binding Factor Alpha 1 Subunit- Core Binding Factor Alpha 1 Subunit
- AML3 Transcription Factor
- CBFA-1 Protein
- CBFA 1 Protein
- CBFA1 Protein
- CBFalpha Runt Domain Transcription Factor 1
- Osf2 Transcription Factor
- PEBP2alphaA Protein
- Runx2 Protein
- SEF1 Protein
- SL3-3 Enhancer Factor 1
- SL3 3 Enhancer Factor 1
- Acute Myeloid Leukemia 3 Protein
- CBFalpha1 Protein
|
Below are MeSH descriptors whose meaning is more general than "Core Binding Factor Alpha 1 Subunit".
Below are MeSH descriptors whose meaning is more specific than "Core Binding Factor Alpha 1 Subunit".
This graph shows the total number of publications written about "Core Binding Factor Alpha 1 Subunit" by people in this website by year, and whether "Core Binding Factor Alpha 1 Subunit" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2011 | 0 | 2 | 2 |
| 2013 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Core Binding Factor Alpha 1 Subunit" by people in Profiles.
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PRDM16 Enhances Osteoblastogenic RUNX2 via Canonical WNT10b/?-CATENIN Pathway in Testosterone-Treated Hypogonadal Men. Biomolecules. 2025 Jan 08; 15(1).
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Yap and Taz promote osteogenesis and prevent chondrogenesis in neural crest cells in vitro and in vivo. Sci Signal. 2022 10 25; 15(757):eabn9009.
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Hes4: A potential prognostic biomarker for newly diagnosed patients with high-grade osteosarcoma. Pediatr Blood Cancer. 2017 05; 64(5).
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Thymidine phosphorylase exerts complex effects on bone resorption and formation in myeloma. Sci Transl Med. 2016 08 24; 8(353):353ra113.
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Loss of Runx2 sensitises osteosarcoma to chemotherapy-induced apoptosis. Br J Cancer. 2015 Nov 03; 113(9):1289-97.
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Kaempferol induces chondrogenesis in ATDC5 cells through activation of ERK/BMP-2 signaling pathway. Food Chem Toxicol. 2013 Dec; 62:238-45.
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Genetic and molecular control of osterix in skeletal formation. J Cell Biochem. 2013 May; 114(5):975-84.
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Coordinated transcriptional regulation of bone homeostasis by Ebf1 and Zfp521 in both mesenchymal and hematopoietic lineages. J Exp Med. 2013 May 06; 210(5):969-85.
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Regulation of breast cancer metastasis by Runx2 and estrogen signaling: the role of SNAI2. Breast Cancer Res. 2011; 13(6):R127.
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Opposing effects of Runx2 and estradiol on breast cancer cell proliferation: in vitro identification of reciprocally regulated gene signature related to clinical letrozole responsiveness. Clin Cancer Res. 2012 Feb 01; 18(3):901-11.