"Saquinavir" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An HIV protease inhibitor which acts as an analog of an HIV protease cleavage site. It is a highly specific inhibitor of HIV-1 and HIV-2 proteases, and also inhibits CYTOCHROME P-450 CYP3A.
| Descriptor ID |
D019258
|
| MeSH Number(s) |
D03.633.100.531.770 D03.633.100.810.900
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Saquinavir".
Below are MeSH descriptors whose meaning is more specific than "Saquinavir".
This graph shows the total number of publications written about "Saquinavir" by people in this website by year, and whether "Saquinavir" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
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Below are the most recent publications written about "Saquinavir" by people in Profiles.
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CPY3A4-mediated a-hydroxyaldehyde formation in saquinavir metabolism. Drug Metab Dispos. 2014 Feb; 42(2):213-20.
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Can inhibition of proteasomes or NF-kappaB help control idiopathic nephrotic syndrome? Nephrol Dial Transplant. 2012 May; 27(5):1698-701.
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Effects of 5 HIV protease inhibitors on vasomotor function and superoxide anion production in porcine coronary arteries. J Acquir Immune Defic Syndr. 2005 Sep 01; 40(1):12-9.
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Pharmacokinetics of saquinavir in children during long term treatment. Pediatr Infect Dis J. 2002 Jul; 21(7):712-3.
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Pharmacokinetics and pharmacodynamics of saquinavir in pediatric patients with human immunodeficiency virus infection. Clin Pharmacol Ther. 2002 Mar; 71(3):122-30.
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Combination therapy with saquinavir soft gelatin capsules in children with human immunodeficiency virus infection. Pediatr Infect Dis J. 2001 Jul; 20(7):666-71.
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The efficacy and tolerability of combination antiretroviral therapy in pregnancy: infant and maternal outcome. Int J STD AIDS. 2000 Apr; 11(4):220-3.
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Advanced testicular germ cell tumor in a hemophilic patient with human immunodeficiency virus infection. Jpn J Clin Oncol. 1998 Sep; 28(9):567-70.