"Nelfinavir" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A potent HIV protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children.
| Descriptor ID |
D019888
|
| MeSH Number(s) |
D03.633.100.531.520
|
| Concept/Terms |
Nelfinavir Mesylate- Nelfinavir Mesylate
- Mesylate, Nelfinavir
- Nelfinavir Monomethane Sulfonate
- Monomethane Sulfonate, Nelfinavir
- Sulfonate, Nelfinavir Monomethane
|
Below are MeSH descriptors whose meaning is more general than "Nelfinavir".
Below are MeSH descriptors whose meaning is more specific than "Nelfinavir".
This graph shows the total number of publications written about "Nelfinavir" by people in this website by year, and whether "Nelfinavir" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 2000 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
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Below are the most recent publications written about "Nelfinavir" by people in Profiles.
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Phase 1 trial of nelfinavir added to standard cisplatin chemotherapy with concurrent pelvic radiation for locally advanced cervical cancer. Cancer. 2021 07 01; 127(13):2279-2293.
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Phase I trial of concurrent stereotactic body radiotherapy and nelfinavir for locally advanced borderline or unresectable pancreatic adenocarcinoma. Radiother Oncol. 2019 03; 132:55-62.
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Inhibiting Drivers of Non-mutational Drug Tolerance Is a Salvage Strategy for Targeted Melanoma Therapy. Cancer Cell. 2016 Mar 14; 29(3):270-284.
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Everything Old Is New Again: Using Nelfinavir to Radiosensitize Rectal Cancer. Clin Cancer Res. 2016 Apr 15; 22(8):1834-6.
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A phase I study of nelfinavir concurrent with temozolomide and radiotherapy in patients with glioblastoma multiforme. J Neurooncol. 2014 Jan; 116(2):365-372.
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Phase I study of nelfinavir in liposarcoma. Cancer Chemother Pharmacol. 2012 Dec; 70(6):791-9.
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Nelfinavir inhibits regulated intramembrane proteolysis of sterol regulatory element binding protein-1 and activating transcription factor 6 in castration-resistant prostate cancer. FEBS J. 2012 Jul; 279(13):2399-411.
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A phase I trial of the HIV protease inhibitor nelfinavir with concurrent chemoradiotherapy for unresectable stage IIIA/IIIB non-small cell lung cancer: a report of toxicities and clinical response. J Thorac Oncol. 2012 Apr; 7(4):709-15.
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Modulation of CCAAT/enhancer binding protein homologous protein (CHOP)-dependent DR5 expression by nelfinavir sensitizes glioblastoma multiforme cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). J Biol Chem. 2011 Aug 19; 286(33):29408-29416.
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Nelfinavir induces liposarcoma apoptosis through inhibition of regulated intramembrane proteolysis of SREBP-1 and ATF6. Clin Cancer Res. 2011 Apr 01; 17(7):1796-806.