"Quinidine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.
| Descriptor ID |
D011802
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| MeSH Number(s) |
D03.132.206.636 D03.605.687.637 D03.633.100.810.699
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Quinidine".
Below are MeSH descriptors whose meaning is more specific than "Quinidine".
This graph shows the total number of publications written about "Quinidine" by people in this website by year, and whether "Quinidine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2018 | 1 | 1 | 2 |
| 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "Quinidine" by people in Profiles.
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Functional and pharmacological investigation of novel and de novo KCND3 variants identified in patients with neurodevelopmental disorders. J Hum Genet. 2026 Apr; 71(4):187-193.
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Lack of response to quinidine in KCNT1-related neonatal epilepsy. Epilepsia. 2018 10; 59(10):1889-1898.
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Severe Babesia microti infection presenting as multiorgan failure in an immunocompetent host. BMJ Case Rep. 2018 May 30; 2018.
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PRISM II: an open-label study to assess effectiveness of dextromethorphan/quinidine for pseudobulbar affect in patients with dementia, stroke or traumatic brain injury. BMC Neurol. 2016 Jun 09; 16:89.
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An open-label study to assess safety, tolerability, and effectiveness of dextromethorphan/quinidine for pseudobulbar affect in dementia: PRISM II results. CNS Spectr. 2016 12; 21(6):450-459.
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Evaluation of in vivo P-glycoprotein phenotyping probes: a need for validation. Clin Pharmacokinet. 2010 Apr; 49(4):223-37.
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A common SCN5A variant alters the responsiveness of human sodium channels to class I antiarrhythmic agents. J Cardiovasc Electrophysiol. 2007 Apr; 18(4):434-40.
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Effect of quinidine and tetrodotoxin on the activation of non-adrenergic nerves in guinea-pig trachealis muscle. Comp Biochem Physiol C Comp Pharmacol Toxicol. 1987; 86(1):11-5.
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Evaluation of postextrasystolic T wave alterations in identification of patients with coronary artery disease or left ventricular dysfunction. Am Heart J. 1981 Oct; 102(4):658-63.
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Use of cardioactive drugs in acute myocardial infarction. Heart Lung. 1976 Jan-Feb; 5(1):44-61.