"Quinidine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.
| Descriptor ID |
D011802
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| MeSH Number(s) |
D03.132.206.636 D03.605.687.637 D03.633.100.810.699
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Quinidine".
Below are MeSH descriptors whose meaning is more specific than "Quinidine".
This graph shows the total number of publications written about "Quinidine" by people in this website by year, and whether "Quinidine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Quinidine" by people in Profiles.
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PRISM II: an open-label study to assess effectiveness of dextromethorphan/quinidine for pseudobulbar affect in patients with dementia, stroke or traumatic brain injury. BMC Neurol. 2016 Jun 09; 16:89.
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An open-label study to assess safety, tolerability, and effectiveness of dextromethorphan/quinidine for pseudobulbar affect in dementia: PRISM II results. CNS Spectr. 2016 12; 21(6):450-459.
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Efficacy and safety of dextromethorphan/quinidine at two dosage levels for diabetic neuropathic pain: a double-blind, placebo-controlled, multicenter study. Pain Med. 2012 Feb; 13(2):243-54.
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Evaluation of in vivo P-glycoprotein phenotyping probes: a need for validation. Clin Pharmacokinet. 2010 Apr; 49(4):223-37.
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A case of Brugada syndrome presenting with incessant polymorphic ventricular tachycardia. Clin Cardiol. 2010 Mar; 33(3):E33-5.
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A common SCN5A variant alters the responsiveness of human sodium channels to class I antiarrhythmic agents. J Cardiovasc Electrophysiol. 2007 Apr; 18(4):434-40.
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Characterization of multidrug resistance P-glycoprotein transport function with an organotechnetium cation. Biochemistry. 1995 Sep 26; 34(38):12210-20.
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Effect of quinidine and tetrodotoxin on the activation of non-adrenergic nerves in guinea-pig trachealis muscle. Comp Biochem Physiol C Comp Pharmacol Toxicol. 1987; 86(1):11-5.
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Treatment of chronic ventricular dysrhythmias in the young. Pacing Clin Electrophysiol. 1981 Nov; 4(6):658-69.
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Intoxication with quinidine. Chest. 1978 Feb; 73(2):129-31.