T-Lymphoma Invasion and Metastasis-inducing Protein 1
"T-Lymphoma Invasion and Metastasis-inducing Protein 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A Rho guanine nucleotide exchange factor that consists of two pleckstrin homology domains flanking central Ras-binding, Dbl-homology (DH) and PDZ domains. It stimulates GTP-GDP exchange of rho-like GTPases such as RAC1 PROTEIN; CDC42 PROTEIN; and RHOA PROTEIN, and functions to link extracellular signals to remodeling of the CYTOSKELETON for CELL ADHESION and CELL MOVEMENT.
| Descriptor ID |
D000075684
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| MeSH Number(s) |
D12.644.360.325.300.850 D12.776.476.325.300.850
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "T-Lymphoma Invasion and Metastasis-inducing Protein 1".
Below are MeSH descriptors whose meaning is more specific than "T-Lymphoma Invasion and Metastasis-inducing Protein 1".
This graph shows the total number of publications written about "T-Lymphoma Invasion and Metastasis-inducing Protein 1" by people in this website by year, and whether "T-Lymphoma Invasion and Metastasis-inducing Protein 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 2 | 2 |
| 2013 | 0 | 2 | 2 |
| 2014 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2022 | 1 | 2 | 3 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "T-Lymphoma Invasion and Metastasis-inducing Protein 1" by people in Profiles.
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Tiam1-mediated maladaptive plasticity underlying morphine tolerance and hyperalgesia. Brain. 2024 Jul 05; 147(7):2507-2521.
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TIAM1-mediated synaptic plasticity underlies comorbid depression-like and ketamine antidepressant-like actions in chronic pain. J Clin Invest. 2022 12 15; 132(24).
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RASAL2 mediated the enhancement of YAP1/TIAM1 signaling promotes malignant phenotypes of pancreatic ductal adenocarcinoma. Int J Biol Sci. 2022; 18(10):4245-4259.
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Loss-of-function variants in TIAM1 are associated with developmental delay, intellectual disability, and seizures. Am J Hum Genet. 2022 04 07; 109(4):571-586.
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The Rac-GEF Tiam1 Promotes Dendrite and Synapse Stabilization of Dentate Granule Cells and Restricts Hippocampal-Dependent Memory Functions. J Neurosci. 2021 02 10; 41(6):1191-1206.
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Dynamic control of excitatory synapse development by a Rac1 GEF/GAP regulatory complex. Dev Cell. 2014 Jun 23; 29(6):701-15.
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The Rac-GAP Bcr is a novel regulator of the Par complex that controls cell polarity. Mol Biol Cell. 2013 Dec; 24(24):3857-68.
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The adhesion-GPCR BAI1 regulates synaptogenesis by controlling the recruitment of the Par3/Tiam1 polarity complex to synaptic sites. J Neurosci. 2013 Apr 17; 33(16):6964-78.
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16-kDa prolactin inhibits endothelial cell migration by down-regulating the Ras-Tiam1-Rac1-Pak1 signaling pathway. Cancer Res. 2007 Nov 15; 67(22):11045-53.
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The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development. Proc Natl Acad Sci U S A. 2007 Apr 24; 104(17):7265-70.