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Institute for Clinical and Translational Research

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Rachel E. Rau

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
DivisionPediatrics-Oncology
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    K08CA201611     (RAU, RACHEL E)Apr 1, 2017 - Mar 31, 2020
    NIH/NCI
    DEFINING THE ROLE OF DOT1L IN DNMT3A-MUTANT LEUKEMIA
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Park CS, Lewis AH, Chen TJ, Bridges CS, Shen Y, Suppipat K, Puppi M, Tomolonis JA, Pang PD, Mistretta TA, Ma L, Green MR, Rau R, Lacorazza HD. KLF4 Represses DYRK2 Inhibition of Self-renewal and Survival Through c-Myc and p53 in Leukemia Stem/Progenitor Cells. Blood. 2019 Sep 12. PMID: 31515251.
      View in: PubMed
    2. Gruner SE, Sayeed H, Suarez-Ferguson L, Perez C, Rouce R, Fisher KE, Rau RE. Ponatinib use in two pediatric patients with relapsed Ph?+?ALL with ABL1 kinase domain mutations. Pediatr Hematol Oncol. 2019 Sep 11; 1-6. PMID: 31510844.
      View in: PubMed
    3. Hashmi SK, Punia JN, Marcogliese AN, Gaikwad AS, Fisher KE, Roy A, Rao P, Lopez-Terrada DH, Ringrose J, Loh ML, Niemeyer CM, Rau RE. Sustained remission with azacitidine monotherapy and an aberrant precursor B-lymphoblast population in juvenile myelomonocytic leukemia. Pediatr Blood Cancer. 2019 Oct; 66(10):e27905. PMID: 31250550.
      View in: PubMed
    4. Rau RE, Goodell MA. Measure Twice, Cut Once: Therapeutic Editing of HSPCs Requires Precise Planning. Cell Stem Cell. 2019 Apr 04; 24(4):511-512. PMID: 30951659.
      View in: PubMed
    5. Miller MB, Brackett J, Schafer ES, Rau RE. Prevention of mercaptopurine-induced hypoglycemia using allopurinol to reduce methylated thiopurine metabolites. Pediatr Blood Cancer. 2019 04; 66(4):e27577. PMID: 30548777.
      View in: PubMed
    6. Rau RE, Loh ML. Using genomics to define pediatric blood cancers and inform practice. Hematology Am Soc Hematol Educ Program. 2018 11 30; 2018(1):286-300. PMID: 30504323.
      View in: PubMed
    7. Annesley CE, Rabik C, Duffield AS, Rau RE, Magoon D, Li L, Huff V, Small D, Loeb DA, Brown P. Knock-in of the Wt1 R394W mutation causes MDS and cooperates with Flt3/ITD to drive aggressive myeloid neoplasms in mice. Oncotarget. 2018; 82(9):35313-35326.
    8. Annesley CE, Rabik C, Duffield AS, Rau RE, Magoon D, Li L, Huff V, Small D, Loeb DM, Brown P. Knock-in of the Wt1 R394W mutation causes MDS and cooperates with Flt3/ITD to drive aggressive myeloid neoplasms in mice. Oncotarget. 2018 Oct 19; 9(82):35313-35326. PMID: 30450160.
      View in: PubMed
    9. Schraw JM, Yiu TT, Lupo PJ, Tsavachidis S, Rau R, Bondy ML, Rabin KR, Shen L, Scheurer ME. Maternal folate genes and aberrant DNA hypermethylation in pediatric acute lymphoblastic leukemia. PLoS One. 2018; 13(5):e0197408. PMID: 29763473.
      View in: PubMed
    10. Schafer ES, Rau RE, Berg S, Liu X, Minard CG, D'Adamo D, Scott R, Reyderman L, Martinez G, Devarajan S, Reid JM, Fox E, Weigel BJ, Blaney SM. A phase 1 study of eribulin mesylate (E7389), a novel microtubule-targeting chemotherapeutic agent, in children with refractory or recurrent solid tumors: A Children's Oncology Group Phase 1 Consortium study (ADVL1314). Pediatr Blood Cancer. 2018 08; 65(8):e27066. PMID: 29719113.
      View in: PubMed
    11. Rau RE, Dreyer Z, Choi MR, Liang W, Skowronski R, Allamneni KP, Devidas M, Raetz EA, Adamson PC, Blaney SM, Loh ML, Hunger SP. Outcome of pediatric patients with acute lymphoblastic leukemia/lymphoblastic lymphoma with hypersensitivity to pegaspargase treated with PEGylated Erwinia asparaginase, pegcrisantaspase: A report from the Children's Oncology Group. Pediatr Blood Cancer. 2018 03; 65(3). PMID: 29090524.
      View in: PubMed
    12. Rau RE. CMML/JMML PDXs: as easy as 1, 2, NSG-SGM3. Blood. 2017 07 27; 130(4):385-386. PMID: 28751353.
      View in: PubMed
    13. Heikamp E, Rau R. 50 Years Ago in The Journal of Pediatrics: Sequential Therapy of Acute Leukemia in Childhood. J Pediatr. 2017 04; 183:140. PMID: 28343531.
      View in: PubMed
    14. Gramatges MM, Deshpande A, Lupo PJ, Rau RE, Redell ML, Horton TM, Scheurer ME, Rabin KR. Ethnic disparities relative to disease features and outcomes in children with acute myeloid leukemia. Pediatr Blood Cancer. 2017 Sep; 64(9). PMID: 28266784.
      View in: PubMed
    15. Yang L, Rodriguez B, Mayle A, Park HJ, Lin X, Luo M, Jeong M, Curry CV, Kim SB, Ruau D, Zhang X, Zhou T, Zhou M, Rebel VI, Challen GA, Göttgens B, Lee JS, Rau R, Li W, Goodell MA. DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias. Cancer Cell. 2016 08 08; 30(2):363-365. PMID: 27505680.
      View in: PubMed
    16. Rau RE, Carroll AJ, Heerema NA, Arland L, Carroll WL, Winick NJ, Raetz EA, Loh ML, Yang W, Relling MV, Dai Y, Devidas M, Hunger SP. Klinefelter syndrome and 47,XYY syndrome in children with B cell acute lymphoblastic leukaemia. Br J Haematol. 2017 12; 179(5):843-846. PMID: 27434379.
      View in: PubMed
    17. Rau RE, Rodriguez BA, Luo M, Jeong M, Rosen A, Rogers JH, Campbell CT, Daigle SR, Deng L, Song Y, Sweet S, Chevassut T, Andreeff M, Kornblau SM, Li W, Goodell MA. DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia. Blood. 2016 08 18; 128(7):971-81. PMID: 27335278.
      View in: PubMed
    18. Yang L, Rodriguez B, Mayle A, Park HJ, Lin X, Luo M, Jeong M, Curry CV, Kim SB, Ruau D, Zhang X, Zhou T, Zhou M, Rebel VI, Challen GA, Gottgens B, Lee JS, Rau R, Li W, Goodell MA. DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias. Cancer Cell. 2016 06 13; 29(6):922-934. PMID: 27300438.
      View in: PubMed
    19. Rau RE. Beyond KIT in CBF-AML: chromatin and cohesin. Blood. 2016 05 19; 127(20):2370-1. PMID: 27207321.
      View in: PubMed
    20. Eckstein OS, Wang L, Punia JN, Kornblau SM, Andreeff M, Wheeler DA, Goodell MA, Rau RE. Mixed-phenotype acute leukemia (MPAL) exhibits frequent mutations in DNMT3A and activated signaling genes. Exp Hematol. 2016 08; 44(8):740-4. PMID: 27208809.
      View in: PubMed
    21. Schafer ES, Rau RE, Liu X, Minard, CG, D’Adamo D, Scott R, Reyderman L, Martinez G, Fox E, Weigel BJ, Blaney SB. A phase 1 study of eribulin mesylate (E7389), a novel microtubule targeting chemotherapeutic agent in children with refractory or recurrent solid tumors (excluding CNS), including lymphomas: a Children’s Oncology Group Phase 1 Consortium study (ADVL1314). American Society of Clinical Oncology Annual Meeting. Poster presentation. Abstract #2567. 2016.
    22. Rau R, Brackett J. Prevention of mercaptopurine-induced hypoglycemia using allopurinol to reduce methylated thiopurine metabolites. American Society of Pediatric Hematology-Oncology Annual Meeting Abstracts. 2016.
    23. Annesley CE, Duffield AS, Rau RE, McCarty G, Magoon D, Li L, Huff V, Small D, Loeb D, Brown P. A Wilms Tumor 1 (WT1) Mutation Causes Myelodysplastic Syndrome in a Knock-in Mouse Model, and a Mixed Myelodysplastic/Myeloproliferative Neoplam in Double Knock-in Mice with WT1 and FLT3/ITD Mutations. Blood. 2015; 23(126).
    24. Cohen G, Annesley CE, Rau RE, Kelley S, Magoon D, Brown P. Targeting BCL6-Mediated Resistance to BCR-ABL Targeted Tyrosine Kinase Inhibitors (TKIs) in Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ ALL) through the Addition of Histone Deacetylase (HDAC) Inhibitors. Blood. 2015; 23(126):1277.
    25. Sayeed H, Fisher K, Gramatges M, Somvanshi S, Rau RE, Merritt BY, Roy A, Marcogliese A, Punia JN, Horton TM, Bertuch AA, Redell ML, Rabin KR, López-Terrada D. A customized targeted next-generation sequencing mutation panel for clinical use in pediatric hematologic malignancies: a pilot study. Blood. 2015; 23(126).
    26. Deshpande A, Gramatges MM, Sasa GS, Lupo PJ, Rau RE, Redell MS, Horton TM, Scheurer ME, Rabin KR. Poorer relapse-free survival in hispanic children diagnosed with acute myeloid leukemia compared with non-hispanics: a Texas single institution experience. Blood. 2015; 23(126).
    27. Yang L, Rau R, Goodell MA. DNMT3A in haematological malignancies. Nat Rev Cancer. 2015 Mar; 15(3):152-65. PMID: 25693834.
      View in: PubMed
    28. Sison EA, Magoon D, Li L, Annesley CE, Rau RE, Small D, Brown P. Plerixafor as a chemosensitizing agent in pediatric acute lymphoblastic leukemia: efficacy and potential mechanisms of resistance to CXCR4 inhibition. Oncotarget. 2014 Oct 15; 5(19):8947-58. PMID: 25333254.
      View in: PubMed
    29. Matheny CJ, Wei MC, Bassik MC, Donnelly AJ, Kampmann M, Iwasaki M, Piloto O, Solow-Cordero DE, Bouley DM, Rau R, Brown P, McManus MT, Weissman JS, Cleary ML. Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens. Chem Biol. 2013 Nov 21; 20(11):1352-63. PMID: 24183972.
      View in: PubMed
    30. Rau R, Magoon D, Greenblatt S, Li L, Annesley C, Duffield AS, Huso D, McIntyre E, Clohessy JG, Reschke M, Pandolfi PP, Small D, Brown P. NPMc+ cooperates with Flt3/ITD mutations to cause acute leukemia recapitulating human disease. Exp Hematol. 2014 Feb; 42(2):101-13.e5. PMID: 24184354.
      View in: PubMed
    31. Sison EA, Rau RE, McIntyre E, Li L, Small D, Brown P. MLL-rearranged acute lymphoblastic leukaemia stem cell interactions with bone marrow stroma promote survival and therapeutic resistance that can be overcome with CXCR4 antagonism. Br J Haematol. 2013 Mar; 160(6):785-97. PMID: 23294096.
      View in: PubMed
    32. Karafin M, Romagnoli M, Fink DL, Howard T, Rau R, Milstone AM, Carroll KC. Fatal infection caused by Cupriavidus gilardii in a child with aplastic anemia. J Clin Microbiol. 2010 Mar; 48(3):1005-7. PMID: 20071544.
      View in: PubMed
    33. Rau R, Brown P. Nucleophosmin (NPM1) mutations in adult and childhood acute myeloid leukaemia: towards definition of a new leukaemia entity. Hematol Oncol. 2009 Dec; 27(4):171-81. PMID: 19569254.
      View in: PubMed
    34. Rau R, Fitzhugh CD, Baird K, Cortez KJ, Li L, Fischer SH, Cowen EW, Balow JE, Walsh TJ, Cohen JI, Wayne AS. Triad of severe abdominal pain, inappropriate antidiuretic hormone secretion, and disseminated varicella-zoster virus infection preceding cutaneous manifestations after hematopoietic stem cell transplantation: utility of PCR for early recognition and therapy. Pediatr Infect Dis J. 2008 Mar; 27(3):265-8. PMID: 18277922.
      View in: PubMed
    35. Brown P, McIntyre E, Rau R, Meshinchi S, Lacayo N, Dahl G, Alonzo TA, Chang M, Arceci RJ, Small D. The incidence and clinical significance of nucleophosmin mutations in childhood AML. Blood. 2007 Aug 01; 110(3):979-85. PMID: 17440048.
      View in: PubMed
    36. Cordero L, Rau R, Taylor D, Ayers LW. Enteric gram-negative bacilli bloodstream infections: 17 years' experience in a neonatal intensive care unit. Am J Infect Control. 2004 Jun; 32(4):189-95. PMID: 15175611.
      View in: PubMed
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