 RACHEL E. RAU
| Title | Assistant Professor |
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| Institution | Baylor College of Medicine |
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| Department | Department of Pediatrics |
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| Division | Pediatrics-Oncology |
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| Address | Department of Pediatrics - Hem/Onc
6701 Fannin St., D1510
Houston TX 77030
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| vCard | Download vCard |
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 ORNG Applications Research K08CA201611 (RAU, RACHEL E)Apr 1, 2017 - Mar 31, 2020 NIH/NCI
DEFINING THE ROLE OF DOT1L IN DNMT3A-MUTANT LEUKEMIA
Role: Principal Investigator |
Bibliographic
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Rau RE, Goodell MA. Measure Twice, Cut Once: Therapeutic Editing of HSPCs Requires Precise Planning. Cell Stem Cell. 2019 Apr 04; 24(4):511-512. PMID: 30951659.
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Miller MB, Brackett J, Schafer ES, Rau RE. Prevention of mercaptopurine-induced hypoglycemia using allopurinol to reduce methylated thiopurine metabolites. Pediatr Blood Cancer. 2019 Apr; 66(4):e27577. PMID: 30548777.
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Rau RE, Loh ML. Using genomics to define pediatric blood cancers and inform practice. Hematology Am Soc Hematol Educ Program. 2018 11 30; 2018(1):286-300. PMID: 30504323.
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Annesley CE, Rabik C, Duffield AS, Rau RE, Magoon D, Li L, Huff V, Small D, Loeb DA, Brown P. Knock-in of the Wt1 R394W mutation causes MDS and cooperates with Flt3/ITD to drive aggressive myeloid neoplasms in mice. Oncotarget. 2018; 82(9):35313-35326.
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Annesley CE, Rabik C, Duffield AS, Rau RE, Magoon D, Li L, Huff V, Small D, Loeb DM, Brown P. Knock-in of the Wt1 R394W mutation causes MDS and cooperates with Flt3/ITD to drive aggressive myeloid neoplasms in mice. Oncotarget. 2018 Oct 19; 9(82):35313-35326. PMID: 30450160.
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Schraw JM, Yiu TT, Lupo PJ, Tsavachidis S, Rau R, Bondy ML, Rabin KR, Shen L, Scheurer ME. Maternal folate genes and aberrant DNA hypermethylation in pediatric acute lymphoblastic leukemia. PLoS One. 2018; 13(5):e0197408. PMID: 29763473.
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Schafer ES, Rau RE, Berg S, Liu X, Minard CG, D'Adamo D, Scott R, Reyderman L, Martinez G, Devarajan S, Reid JM, Fox E, Weigel BJ, Blaney SM. A phase 1 study of eribulin mesylate (E7389), a novel microtubule-targeting chemotherapeutic agent, in children with refractory or recurrent solid tumors: A Children's Oncology Group Phase 1 Consortium study (ADVL1314). Pediatr Blood Cancer. 2018 Aug; 65(8):e27066. PMID: 29719113.
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Rau RE, Dreyer Z, Choi MR, Liang W, Skowronski R, Allamneni KP, Devidas M, Raetz EA, Adamson PC, Blaney SM, Loh ML, Hunger SP. Outcome of pediatric patients with acute lymphoblastic leukemia/lymphoblastic lymphoma with hypersensitivity to pegaspargase treated with PEGylated Erwinia asparaginase, pegcrisantaspase: A report from the Children's Oncology Group. Pediatr Blood Cancer. 2018 03; 65(3). PMID: 29090524.
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Rau RE. CMML/JMML PDXs: as easy as 1, 2, NSG-SGM3. Blood. 2017 07 27; 130(4):385-386. PMID: 28751353.
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Heikamp E, Rau R. 50 Years Ago in The Journal of Pediatrics: Sequential Therapy of Acute Leukemia in Childhood. J Pediatr. 2017 04; 183:140. PMID: 28343531.
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Gramatges MM, Deshpande A, Lupo PJ, Rau RE, Redell ML, Horton TM, Scheurer ME, Rabin KR. Ethnic disparities relative to disease features and outcomes in children with acute myeloid leukemia. Pediatr Blood Cancer. 2017 Sep; 64(9). PMID: 28266784.
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Yang L, Rodriguez B, Mayle A, Park HJ, Lin X, Luo M, Jeong M, Curry CV, Kim SB, Ruau D, Zhang X, Zhou T, Zhou M, Rebel VI, Challen GA, Göttgens B, Lee JS, Rau R, Li W, Goodell MA. DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias. Cancer Cell. 2016 08 08; 30(2):363-365. PMID: 27505680.
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Rau RE, Carroll AJ, Heerema NA, Arland L, Carroll WL, Winick NJ, Raetz EA, Loh ML, Yang W, Relling MV, Dai Y, Devidas M, Hunger SP. Klinefelter syndrome and 47,XYY syndrome in children with B cell acute lymphoblastic leukaemia. Br J Haematol. 2017 12; 179(5):843-846. PMID: 27434379.
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Rau RE, Rodriguez BA, Luo M, Jeong M, Rosen A, Rogers JH, Campbell CT, Daigle SR, Deng L, Song Y, Sweet S, Chevassut T, Andreeff M, Kornblau SM, Li W, Goodell MA. DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia. Blood. 2016 08 18; 128(7):971-81. PMID: 27335278.
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Yang L, Rodriguez B, Mayle A, Park HJ, Lin X, Luo M, Jeong M, Curry CV, Kim SB, Ruau D, Zhang X, Zhou T, Zhou M, Rebel VI, Challen GA, Gottgens B, Lee JS, Rau R, Li W, Goodell MA. DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias. Cancer Cell. 2016 06 13; 29(6):922-934. PMID: 27300438.
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Rau RE. Beyond KIT in CBF-AML: chromatin and cohesin. Blood. 2016 05 19; 127(20):2370-1. PMID: 27207321.
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Eckstein OS, Wang L, Punia JN, Kornblau SM, Andreeff M, Wheeler DA, Goodell MA, Rau RE. Mixed-phenotype acute leukemia (MPAL) exhibits frequent mutations in DNMT3A and activated signaling genes. Exp Hematol. 2016 08; 44(8):740-4. PMID: 27208809.
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Schafer ES, Rau RE, Liu X, Minard, CG, D’Adamo D, Scott R, Reyderman L, Martinez G, Fox E, Weigel BJ, Blaney SB. A phase 1 study of eribulin mesylate (E7389), a novel microtubule targeting chemotherapeutic agent in children with refractory or recurrent solid tumors (excluding CNS), including lymphomas: a Children’s Oncology Group Phase 1 Consortium study (ADVL1314). American Society of Clinical Oncology Annual Meeting. Poster presentation. Abstract #2567. 2016.
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Rau R, Brackett J. Prevention of mercaptopurine-induced hypoglycemia using allopurinol to reduce methylated thiopurine metabolites. American Society of Pediatric Hematology-Oncology Annual Meeting Abstracts. 2016.
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Annesley CE, Duffield AS, Rau RE, McCarty G, Magoon D, Li L, Huff V, Small D, Loeb D, Brown P. A Wilms Tumor 1 (WT1) Mutation Causes Myelodysplastic Syndrome in a Knock-in Mouse Model, and a Mixed Myelodysplastic/Myeloproliferative Neoplam in Double Knock-in Mice with WT1 and FLT3/ITD Mutations. Blood. 2015; 23(126).
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Cohen G, Annesley CE, Rau RE, Kelley S, Magoon D, Brown P. Targeting BCL6-Mediated Resistance to BCR-ABL Targeted Tyrosine Kinase Inhibitors (TKIs) in Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ ALL) through the Addition of Histone Deacetylase (HDAC) Inhibitors. Blood. 2015; 23(126):1277.
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Sayeed H, Fisher K, Gramatges M, Somvanshi S, Rau RE, Merritt BY, Roy A, Marcogliese A, Punia JN, Horton TM, Bertuch AA, Redell ML, Rabin KR, López-Terrada D. A customized targeted next-generation sequencing mutation panel for clinical use in pediatric hematologic malignancies: a pilot study. Blood. 2015; 23(126).
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Deshpande A, Gramatges MM, Sasa GS, Lupo PJ, Rau RE, Redell MS, Horton TM, Scheurer ME, Rabin KR. Poorer relapse-free survival in hispanic children diagnosed with acute myeloid leukemia compared with non-hispanics: a Texas single institution experience. Blood. 2015; 23(126).
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Yang L, Rau R, Goodell MA. DNMT3A in haematological malignancies. Nat Rev Cancer. 2015 Mar; 15(3):152-65. PMID: 25693834.
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Sison EA, Magoon D, Li L, Annesley CE, Rau RE, Small D, Brown P. Plerixafor as a chemosensitizing agent in pediatric acute lymphoblastic leukemia: efficacy and potential mechanisms of resistance to CXCR4 inhibition. Oncotarget. 2014 Oct 15; 5(19):8947-58. PMID: 25333254.
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Matheny CJ, Wei MC, Bassik MC, Donnelly AJ, Kampmann M, Iwasaki M, Piloto O, Solow-Cordero DE, Bouley DM, Rau R, Brown P, McManus MT, Weissman JS, Cleary ML. Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens. Chem Biol. 2013 Nov 21; 20(11):1352-63. PMID: 24183972.
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Rau R, Magoon D, Greenblatt S, Li L, Annesley C, Duffield AS, Huso D, McIntyre E, Clohessy JG, Reschke M, Pandolfi PP, Small D, Brown P. NPMc+ cooperates with Flt3/ITD mutations to cause acute leukemia recapitulating human disease. Exp Hematol. 2014 Feb; 42(2):101-13.e5. PMID: 24184354.
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Sison EA, Rau RE, McIntyre E, Li L, Small D, Brown P. MLL-rearranged acute lymphoblastic leukaemia stem cell interactions with bone marrow stroma promote survival and therapeutic resistance that can be overcome with CXCR4 antagonism. Br J Haematol. 2013 Mar; 160(6):785-97. PMID: 23294096.
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Karafin M, Romagnoli M, Fink DL, Howard T, Rau R, Milstone AM, Carroll KC. Fatal infection caused by Cupriavidus gilardii in a child with aplastic anemia. J Clin Microbiol. 2010 Mar; 48(3):1005-7. PMID: 20071544.
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Rau R, Brown P. Nucleophosmin (NPM1) mutations in adult and childhood acute myeloid leukaemia: towards definition of a new leukaemia entity. Hematol Oncol. 2009 Dec; 27(4):171-81. PMID: 19569254.
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Rau R, Fitzhugh CD, Baird K, Cortez KJ, Li L, Fischer SH, Cowen EW, Balow JE, Walsh TJ, Cohen JI, Wayne AS. Triad of severe abdominal pain, inappropriate antidiuretic hormone secretion, and disseminated varicella-zoster virus infection preceding cutaneous manifestations after hematopoietic stem cell transplantation: utility of PCR for early recognition and therapy. Pediatr Infect Dis J. 2008 Mar; 27(3):265-8. PMID: 18277922.
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Brown P, McIntyre E, Rau R, Meshinchi S, Lacayo N, Dahl G, Alonzo TA, Chang M, Arceci RJ, Small D. The incidence and clinical significance of nucleophosmin mutations in childhood AML. Blood. 2007 Aug 01; 110(3):979-85. PMID: 17440048.
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Cordero L, Rau R, Taylor D, Ayers LW. Enteric gram-negative bacilli bloodstream infections: 17 years' experience in a neonatal intensive care unit. Am J Infect Control. 2004 Jun; 32(4):189-95. PMID: 15175611.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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| Year | Publications |
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| 2004 | 1 | | 2007 | 1 | | 2008 | 1 | | 2009 | 1 | | 2010 | 1 | | 2013 | 3 | | 2014 | 1 | | 2015 | 5 | | 2016 | 8 | | 2017 | 4 | | 2018 | 6 | | 2019 | 1 |
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