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DANIEL MEDINA

TitleProfessor Emeritus
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
DivisionMolecular & Cellular Biology
AddressOne Baylor Plaza
Houston TX 77030
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    1. Smith GH, Medina D. Does the Mouse Mammary Gland Arise from Unipotent or Multipotent Mammary Stem/Progenitor Cells? J Mammary Gland Biol Neoplasia. 2018 Apr 11. PMID: 29644495.
      View in: PubMed
    2. Dolfi SC, Medina DJ, Kareddula A, Paratala B, Rose A, Dhami J, Chen S, Ganesan S, Mackay G, Vazquez A, Hirshfield KM. Riluzole exerts distinct antitumor effects from a metabotropic glutamate receptor 1-specific inhibitor on breast cancer cells. Oncotarget. 2017 Jul 04; 8(27):44639-44653. PMID: 28591718.
      View in: PubMed
    3. Hansford H, Hong Y, Kittrell F, Medina D, Behbod F. Whole Mammary Gland Transplantation in Mice Protocol. Bio Protoc. 2017 Jun 05; 7(11). PMID: 29119128.
      View in: PubMed
    4. Carron EC, Homra S, Rosenberg J, Coffelt SB, Kittrell F, Zhang Y, Creighton CJ, Fuqua SA, Medina D, Machado HL. Macrophages promote the progression of premalignant mammary lesions to invasive cancer. Oncotarget. 2017 Aug 01; 8(31):50731-50746. PMID: 28881599.
      View in: PubMed
    5. Su X, Napoli M, Abbas HA, Venkatanarayan A, Bui NH, Coarfa C, Gi YJ, Kittrell F, Gunaratne PH, Medina D, Rosen JM, Behbod F, Flores ER. TAp63 suppresses mammary tumorigenesis through regulation of the Hippo pathway. Oncogene. 2016 Nov 21. PMID: 27869165.
      View in: PubMed
    6. Bansal N, Bartucci M, Yusuff S, Davis S, Flaherty K, Huselid E, Patrizii M, Jones D, Cao L, Sydorenko N, Moon YC, Zhong H, Medina D, Kerrigan J, Stein MN, Kim IY, Davis TW, DiPaola RS, Bertino J, Sabaawy HE. BMI-1 Targeting Interferes with Patient-Derived Tumor-Initiating Cell Survival and Tumor Growth in Prostate Cancer. Clin Cancer Res. 2016 Dec 15; 22(24):6176-6191. PMID: 27307599.
      View in: PubMed
    7. Kittrell F, Valdez K, Elsarraj H, Hong Y, Medina D, Behbod F. Mouse Mammary Intraductal (MIND) Method for Transplantation of Patient Derived Primary DCIS Cells and Cell Lines. Bio Protoc. 2016 Mar 05; 6(5). PMID: 27446983.
      View in: PubMed
    8. Di-Cicco A, Petit V, Chiche A, Bresson L, Romagnoli M, Orian-Rousseau V, Vivanco Md, Medina D, Faraldo MM, Glukhova MA, Deugnier MA. Paracrine Met signaling triggers epithelial-mesenchymal transition in mammary luminal progenitors, affecting their fate. Elife. 2015; 4. PMID: 26165517.
      View in: PubMed
    9. Zheng ZY, Tian L, Bu W, Fan C, Gao X, Wang H, Liao YH, Li Y, Lewis MT, Edwards D, Zwaka TP, Hilsenbeck SG, Medina D, Perou CM, Creighton CJ, Zhang XH, Chang EC. Wild-Type N-Ras, Overexpressed in Basal-like Breast Cancer, Promotes Tumor Formation by Inducing IL-8 Secretion via JAK2 Activation. Cell Rep. 2015 Jul 21; 12(3):511-24. PMID: 26166574.
      View in: PubMed
    10. Suo J, Medina D, Herrera S, Zheng ZY, Jin L, Chamness GC, Contreras A, Gutierrez C, Hilsenbeck S, Umar A, Foekens JA, Hanash S, Schiff R, Zhang XH, Chang EC. Int6 reduction activates stromal fibroblasts to enhance transforming activity in breast epithelial cells. Cell Biosci. 2015; 5:10. PMID: 25774287; PMCID: PMC4359526.
    11. Dolfi SC, Jäger AV, Medina DJ, Haffty BG, Yang JM, Hirshfield KM. Fulvestrant treatment alters MDM2 protein turnover and sensitivity of human breast carcinoma cells to chemotherapeutic drugs. Cancer Lett. 2014 Aug 1; 350(1-2):52-60. PMID: 24747123.
      View in: PubMed
    12. Medina DJ, Abass-Shereef J, Walton K, Goodell L, Aviv H, Strair RK, Budak-Alpdogan T. Cobblestone-area forming cells derived from patients with mantle cell lymphoma are enriched for CD133+ tumor-initiating cells. PLoS One. 2014; 9(4):e91042. PMID: 24722054; PMCID: PMC3982953.
    13. Mukherjee M, Ge G, Zhang N, Edwards DG, Sumazin P, Sharan SK, Rao PH, Medina D, Pati D. MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ER?)-positive mammary adenocarcinomas. Oncogene. 2014 Nov 27; 33(48):5511-22. PMID: 24276237; PMCID: PMC4032816.
    14. Rehman SK, Li SH, Wyszomierski SL, Wang Q, Li P, Sahin O, Xiao Y, Zhang S, Xiong Y, Yang J, Wang H, Guo H, Zhang JD, Medina D, Muller WJ, Yu D. 14-3-3? orchestrates mammary tumor onset and progression via miR-221-mediated cell proliferation. Cancer Res. 2014 Jan 1; 74(1):363-73. PMID: 24197133; PMCID: PMC3947305.
    15. Chiche A, Moumen M, Petit V, Jonkers J, Medina D, Deugnier MA, Faraldo MM, Glukhova MA. Somatic loss of p53 leads to stem/progenitor cell amplification in both mammary epithelial compartments, basal and luminal. Stem Cells. 2013 Sep; 31(9):1857-67. PMID: 23712598.
      View in: PubMed
    16. Mehta MS, Dolfi SC, Bronfenbrener R, Bilal E, Chen C, Moore D, Lin Y, Rahim H, Aisner S, Kersellius RD, Teh J, Chen S, Toppmeyer DL, Medina DJ, Ganesan S, Vazquez A, Hirshfield KM. Metabotropic glutamate receptor 1 expression and its polymorphic variants associate with breast cancer phenotypes. PLoS One. 2013; 8(7):e69851. PMID: 23922822; PMCID: PMC3724883.
    17. Medina D. Pregnancy protection of breast cancer: new insights reveal unanswered questions. Breast Cancer Res. 2013; 15(3):103. PMID: 23659596; PMCID: PMC3706753.
    18. Machado HL, Kittrell FS, Edwards D, White AN, Atkinson RL, Rosen JM, Medina D, Lewis MT. Separation by cell size enriches for mammary stem cell repopulation activity. Stem Cells Transl Med. 2013 Mar; 2(3):199-203. PMID: 23408103; PMCID: PMC3659766.
    19. Raafat A, Strizzi L, Lashin K, Ginsburg E, McCurdy D, Salomon D, Smith GH, Medina D, Callahan R. Effects of age and parity on mammary gland lesions and progenitor cells in the FVB/N-RC mice. PLoS One. 2012; 7(8):e43624. PMID: 22952723; PMCID: PMC3431359.
    20. Mazumdar A, Medina D, Kittrell FS, Zhang Y, Hill JL, Edwards DE, Bissonnette RP, Brown PH. The combination of tamoxifen and the rexinoid LG100268 prevents ER-positive and ER-negative mammary tumors in p53-null mammary gland mice. Cancer Prev Res (Phila). 2012 Oct; 5(10):1195-202. PMID: 22926341; PMCID: PMC3837417.
    21. Lee S, Stewart S, Nagtegaal I, Luo J, Wu Y, Colditz G, Medina D, Allred DC. Differentially expressed genes regulating the progression of ductal carcinoma in situ to invasive breast cancer. Cancer Res. 2012 Sep 1; 72(17):4574-86. PMID: 22751464; PMCID: PMC3899801.
    22. Medina D, Edwards DG, Kittrell F, Lee S, Allred DC. Intra-mammary ductal transplantation: a tool to study premalignant progression. J Mammary Gland Biol Neoplasia. 2012 Jun; 17(2):131-3. PMID: 22688217.
      View in: PubMed
    23. Budak-Alpdogan T, Jeganathan G, Lee KC, Mrowiec ZR, Medina DJ, Todd D, Moore D, Bertino JR, Strair R. Irradiated allogeneic cells enhance umbilical cord blood stem cell engraftment in immunodeficient mice. Bone Marrow Transplant. 2012 Dec; 47(12):1569-76. PMID: 22609880.
      View in: PubMed
    24. Lewis MT, Landua JD, Adams HC, Medina D. A mystery wrapped in an enigma: Matrigel enhancement of mammary cell growth and morphogenesis. J Mammary Gland Biol Neoplasia. 2012 Jun; 17(2):99-101. PMID: 22581302.
      View in: PubMed
    25. Valdez KE, Fan F, Smith W, Allred DC, Medina D, Behbod F. Human primary ductal carcinoma in situ (DCIS) subtype-specific pathology is preserved in a mouse intraductal (MIND) xenograft model. J Pathol. 2011 Dec; 225(4):565-73. PMID: 22025213; PMCID: PMC3496769.
    26. Zhu M, Yi M, Kim CH, Deng C, Li Y, Medina D, Stephens RM, Green JE. Integrated miRNA and mRNA expression profiling of mouse mammary tumor models identifies miRNA signatures associated with mammary tumor lineage. Genome Biol. 2011; 12(8):R77. PMID: 21846369; PMCID: PMC3245617.
    27. Herschkowitz JI, Zhao W, Zhang M, Usary J, Murrow G, Edwards D, Knezevic J, Greene SB, Darr D, Troester MA, Hilsenbeck SG, Medina D, Perou CM, Rosen JM. Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):2778-83. PMID: 21633010; PMCID: PMC3286979.
    28. Nguyen DH, Oketch-Rabah HA, Illa-Bochaca I, Geyer FC, Reis-Filho JS, Mao JH, Ravani SA, Zavadil J, Borowsky AD, Jerry DJ, Dunphy KA, Seo JH, Haslam S, Medina D, Barcellos-Hoff MH. Radiation acts on the microenvironment to affect breast carcinogenesis by distinct mechanisms that decrease cancer latency and affect tumor type. Cancer Cell. 2011 May 17; 19(5):640-51. PMID: 21575864; PMCID: PMC3110779.
    29. Kittrell FS, Carletti MZ, Kerbawy S, Heestand J, Xian W, Zhang M, Lamarca HL, Sonnenberg A, Rosen JM, Medina D, Behbod F. Prospective isolation and characterization of committed and multipotent progenitors from immortalized mouse mammary epithelial cells with morphogenic potential. Breast Cancer Res. 2011; 13(2):R41. PMID: 21466693; PMCID: PMC3219204.
    30. Bussard KM, Boulanger CA, Kittrell FS, Behbod F, Medina D, Smith GH. Immortalized, pre-malignant epithelial cell populations contain long-lived, label-retaining cells that asymmetrically divide and retain their template DNA. Breast Cancer Res. 2010; 12(5):R86. PMID: 20964820.
      View in: PubMed
    31. Medina D. Of mice and women: A short history of mouse mammary cancer research with an emphasis on the paradigms inspired by the transplantation method. Cold Spring Harb Perspect Biol. 2010 Oct; 2(10):a004523. PMID: 20630995; PMCID: PMC2944362.
    32. Wang T, Gavin HM, Arlt VM, Lawrence BP, Fenton SE, Medina D, Vorderstrasse BA. Aryl hydrocarbon receptor activation during pregnancy, and in adult nulliparous mice, delays the subsequent development of DMBA-induced mammary tumors. Int J Cancer. 2011 Apr 1; 128(7):1509-23. PMID: 20521247; PMCID: PMC2974771.
    33. Dearth RK, Delgado DA, Hiney JK, Pathiraja T, Oesterreich S, Medina D, Dees WL, Lee AV. Parity-induced decrease in systemic growth hormone alters mammary gland signaling: a potential role in pregnancy protection from breast cancer. Cancer Prev Res (Phila). 2010 Mar; 3(3):312-21. PMID: 20145191; PMCID: PMC2833223.
    34. Yan H, Blackburn AC, McLary SC, Tao L, Roberts AL, Xavier EA, Dickinson ES, Seo JH, Arenas RB, Otis CN, Cao QJ, Lawlor RG, Osborne BA, Kittrell FS, Medina D, Jerry DJ. Pathways contributing to development of spontaneous mammary tumors in BALB/c-Trp53+/- mice. Am J Pathol. 2010 Mar; 176(3):1421-32. PMID: 20110418; PMCID: PMC2832161.
    35. Herynk MH, Lewis MT, Hopp TA, Medina D, Corona-Rodriguez A, Cui Y, Beyer AR, Fuqua SA. Accelerated mammary maturation and differentiation, and delayed MMTVneu-induced tumorigenesis of K303R mutant ERalpha transgenic mice. Oncogene. 2009 Sep 10; 28(36):3177-87. PMID: 19561644; PMCID: PMC4484624.
    36. Kaipparettu BA, Dobrzycka KM, Britton O, Lee AV, Herron AJ, Li Y, Lewis MT, Medina D, Oesterreich S. Scaffold Attachment Factor B1 (SAFB1) heterozygosity does not influence Wnt-1 or DMBA-induced tumorigenesis. Mol Cancer. 2009; 8:15. PMID: 19267898; PMCID: PMC2669049.
    37. Abba MC, Hu Y, Levy CC, Gaddis S, Kittrell FS, Hill J, Bissonnette RP, Brown PH, Medina D, Aldaz CM. Identification of modulated genes by three classes of chemopreventive agents at preneoplastic stages in a p53-null mouse mammary tumor model. Cancer Prev Res (Phila). 2009 Feb; 2(2):175-84. PMID: 19174580; PMCID: PMC3023963.
    38. Medina D, Kittrell F, Hill J, Zhang Y, Hilsenbeck SG, Bissonette R, Brown PH. Prevention of tumorigenesis in p53-null mammary epithelium by rexinoid bexarotene, tyrosine kinase inhibitor gefitinib, and celecoxib. Cancer Prev Res (Phila). 2009 Feb; 2(2):168-74. PMID: 19174577; PMCID: PMC2995265.
    39. Behbod F, Kittrell FS, LaMarca H, Edwards D, Kerbawy S, Heestand JC, Young E, Mukhopadhyay P, Yeh HW, Allred DC, Hu M, Polyak K, Rosen JM, Medina D. An intraductal human-in-mouse transplantation model mimics the subtypes of ductal carcinoma in situ. Breast Cancer Res. 2009; 11(5):R66. PMID: 19735549; PMCID: PMC2790841.
    40. Abba MC, Hu Y, Levy CC, Gaddis S, Kittrell FS, Zhang Y, Hill J, Bissonnette RP, Medina D, Brown PH, Aldaz CM. Transcriptomic signature of bexarotene (rexinoid LGD1069) on mammary gland from three transgenic mouse mammary cancer models. BMC Med Genomics. 2008; 1:40. PMID: 18786257; PMCID: PMC2563021.
    41. Zhang N, Ge G, Meyer R, Sethi S, Basu D, Pradhan S, Zhao YJ, Li XN, Cai WW, El-Naggar AK, Baladandayuthapani V, Kittrell FS, Rao PH, Medina D, Pati D. Overexpression of Separase induces aneuploidy and mammary tumorigenesis. Proc Natl Acad Sci U S A. 2008 Sep 2; 105(35):13033-8. PMID: 18728194; PMCID: PMC2529090.
    42. Allred DC, Medina D. The relevance of mouse models to understanding the development and progression of human breast cancer. J Mammary Gland Biol Neoplasia. 2008 Sep; 13(3):279-88. PMID: 18704660.
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    43. Medina D. Premalignant and malignant mammary lesions induced by MMTV and chemical carcinogens. J Mammary Gland Biol Neoplasia. 2008 Sep; 13(3):271-7. PMID: 18663563.
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    44. Zhang M, Behbod F, Atkinson RL, Landis MD, Kittrell F, Edwards D, Medina D, Tsimelzon A, Hilsenbeck S, Green JE, Michalowska AM, Rosen JM. Identification of tumor-initiating cells in a p53-null mouse model of breast cancer. Cancer Res. 2008 Jun 15; 68(12):4674-82. PMID: 18559513; PMCID: PMC2459340.
    45. Taddei I, Deugnier MA, Faraldo MM, Petit V, Bouvard D, Medina D, Fässler R, Thiery JP, Glukhova MA. Beta1 integrin deletion from the basal compartment of the mammary epithelium affects stem cells. Nat Cell Biol. 2008 Jun; 10(6):716-22. PMID: 18469806; PMCID: PMC2659707.
    46. Smith GH, Medina D. Re-evaluation of mammary stem cell biology based on in vivo transplantation. Breast Cancer Res. 2008; 10(1):203. PMID: 18304381; PMCID: PMC2374966.
    47. Parsa S, Ramasamy SK, De Langhe S, Gupte VV, Haigh JJ, Medina D, Bellusci S. Terminal end bud maintenance in mammary gland is dependent upon FGFR2b signaling. Dev Biol. 2008 May 1; 317(1):121-31. PMID: 18381212.
      View in: PubMed
    48. Allred DC, Wu Y, Mao S, Nagtegaal ID, Lee S, Perou CM, Mohsin SK, O'Connell P, Tsimelzon A, Medina D. Ductal carcinoma in situ and the emergence of diversity during breast cancer evolution. Clin Cancer Res. 2008 Jan 15; 14(2):370-8. PMID: 18223211.
      View in: PubMed
    49. Loehberg CR, Thompson T, Kastan MB, Maclean KH, Edwards DG, Kittrell FS, Medina D, Conneely OM, O'Malley BW. Ataxia telangiectasia-mutated and p53 are potential mediators of chloroquine-induced resistance to mammary carcinogenesis. Cancer Res. 2007 Dec 15; 67(24):12026-33. PMID: 18089834.
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    50. Li Z, Schem C, Shi YH, Medina D, Zhang M. Increased COX2 expression enhances tumor-induced osteoclastic lesions in breast cancer bone metastasis. Clin Exp Metastasis. 2008; 25(4):389-400. PMID: 17965942.
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    51. Gatza CE, Dumble M, Kittrell F, Edwards DG, Dearth RK, Lee AV, Xu J, Medina D, Donehower LA. Altered mammary gland development in the p53+/m mouse, a model of accelerated aging. Dev Biol. 2008 Jan 1; 313(1):130-41. PMID: 17996864; PMCID: PMC2234269.
    52. Deeb KK, Michalowska AM, Yoon CY, Krummey SM, Hoenerhoff MJ, Kavanaugh C, Li MC, Demayo FJ, Linnoila I, Deng CX, Lee EY, Medina D, Shih JH, Green JE. Identification of an integrated SV40 T/t-antigen cancer signature in aggressive human breast, prostate, and lung carcinomas with poor prognosis. Cancer Res. 2007 Sep 1; 67(17):8065-80. PMID: 17804718.
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    53. Lee S, Medina D, Tsimelzon A, Mohsin SK, Mao S, Wu Y, Allred DC. Alterations of gene expression in the development of early hyperplastic precursors of breast cancer. Am J Pathol. 2007 Jul; 171(1):252-62. PMID: 17591970; PMCID: PMC1941596.
    54. Koch JG, Gu X, Han Y, El-Naggar AK, Olson MV, Medina D, Jerry DJ, Blackburn AC, Peltz G, Amos CI, Lozano G. Mammary tumor modifiers in BALB/cJ mice heterozygous for p53. Mamm Genome. 2007 May; 18(5):300-9. PMID: 17557176.
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    55. Abba MC, Fabris VT, Hu Y, Kittrell FS, Cai WW, Donehower LA, Sahin A, Medina D, Aldaz CM. Identification of novel amplification gene targets in mouse and human breast cancer at a syntenic cluster mapping to mouse ch8A1 and human ch13q34. Cancer Res. 2007 May 1; 67(9):4104-12. PMID: 17483321; PMCID: PMC4166497.
    56. Goepfert TM, Moreno-Smith M, Edwards DG, Pathak S, Medina D, Brinkley WR. Loss of chromosomal integrity drives rat mammary tumorigenesis. Int J Cancer. 2007 Mar 1; 120(5):985-94. PMID: 17131329.
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    57. Rajkumar L, Kittrell FS, Guzman RC, Brown PH, Nandi S, Medina D. Hormone-induced protection of mammary tumorigenesis in genetically engineered mouse models. Breast Cancer Res. 2007; 9(1):R12. PMID: 17257424; PMCID: PMC1851398.
    58. Medina D. Chemical carcinogenesis of rat and mouse mammary glands. Breast Dis. 2007; 28:63-8. PMID: 18057544.
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    59. Medina D, Kittrell FS, Tsimelzon A, Fuqua SA. Inhibition of mammary tumorigenesis by estrogen and progesterone in genetically engineered mice. Ernst Schering Found Symp Proc. 2007; (1):109-26. PMID: 18540570.
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    60. Thiery JP, Sastre-Garau X, Vincent-Salomon B, Sigal-Zafrani X, Pierga JY, Decraene C, Meyniel JP, Gravier E, Asselain B, De Rycke Y, Hupe P, Barillot E, Ajaz S, Faraldo M, Deugnier MA, Glukhova M, Medina D. Challenges in the stratification of breast tumors for tailored therapies. Bull Cancer. 2006 Aug; 93(8):E81-9. PMID: 16935776.
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    61. Schmitt M, Walker MP, Richards RG, Bocchinfuso WP, Fukuda T, Medina D, Kittrell FS, Korach KS, DiAugustine RP. Expression of heregulin by mouse mammary tumor cells: role in activation of ErbB receptors. Mol Carcinog. 2006 Jul; 45(7):490-505. PMID: 16482517.
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    62. Wang RA, Zhang H, Balasenthil S, Medina D, Kumar R. PAK1 hyperactivation is sufficient for mammary gland tumor formation. Oncogene. 2006 May 11; 25(20):2931-6. PMID: 16331248.
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    63. Deugnier MA, Faraldo MM, Teulière J, Thiery JP, Medina D, Glukhova MA. Isolation of mouse mammary epithelial progenitor cells with basal characteristics from the Comma-Dbeta cell line. Dev Biol. 2006 May 15; 293(2):414-25. PMID: 16545360.
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    64. Lee S, Mohsin SK, Mao S, Hilsenbeck SG, Medina D, Allred DC. Hormones, receptors, and growth in hyperplastic enlarged lobular units: early potential precursors of breast cancer. Breast Cancer Res. 2006; 8(1):R6. PMID: 16417654; PMCID: PMC1413990.
    65. Medina D. Mammary developmental fate and breast cancer risk. Endocr Relat Cancer. 2005 Sep; 12(3):483-95. PMID: 16172188.
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    66. Kuang SQ, Liao L, Wang S, Medina D, O'Malley BW, Xu J. Mice lacking the amplified in breast cancer 1/steroid receptor coactivator-3 are resistant to chemical carcinogen-induced mammary tumorigenesis. Cancer Res. 2005 Sep 1; 65(17):7993-8002. PMID: 16140972.
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    67. Medina D, Kittrell FS, Hill J, Shepard A, Thordarson G, Brown P. Tamoxifen inhibition of estrogen receptor-alpha-negative mouse mammary tumorigenesis. Cancer Res. 2005 Apr 15; 65(8):3493-6. PMID: 15833886.
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    68. Blackman B, Russell T, Nordeen SK, Medina D, Neville MC. Claudin 7 expression and localization in the normal murine mammary gland and murine mammary tumors. Breast Cancer Res. 2005; 7(2):R248-55. PMID: 15743505; PMCID: PMC1064138.
    69. Medina D, Kittrell F. Stroma is not a major target in DMBA-mediated tumorigenesis of mouse mammary preneoplasia. J Cell Sci. 2005 Jan 1; 118(Pt 1):123-7. PMID: 15585572.
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    70. Barcellos-Hoff MH, Medina D. New highlights on stroma-epithelial interactions in breast cancer. Breast Cancer Res. 2005; 7(1):33-6. PMID: 15642180; PMCID: PMC1064117.
    71. Hu Y, Sun H, Drake J, Kittrell F, Abba MC, Deng L, Gaddis S, Sahin A, Baggerly K, Medina D, Aldaz CM. From mice to humans: identification of commonly deregulated genes in mammary cancer via comparative SAGE studies. Cancer Res. 2004 Nov 1; 64(21):7748-55. PMID: 15520179; PMCID: PMC4170686.
    72. Allred DC, Brown P, Medina D. The origins of estrogen receptor alpha-positive and estrogen receptor alpha-negative human breast cancer. Breast Cancer Res. 2004; 6(6):240-5. PMID: 15535853; PMCID: PMC1064085.
    73. Pati D, Haddad BR, Haegele A, Thompson H, Kittrell FS, Shepard A, Montagna C, Zhang N, Ge G, Otta SK, McCarthy M, Ullrich RL, Medina D. Hormone-induced chromosomal instability in p53-null mammary epithelium. Cancer Res. 2004 Aug 15; 64(16):5608-16. PMID: 15313898.
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    74. Yi Y, Shepard A, Kittrell F, Mulac-Jericevic B, Medina D, Said TK. p19ARF determines the balance between normal cell proliferation rate and apoptosis during mammary gland development. Mol Biol Cell. 2004 May; 15(5):2302-11. PMID: 15105443; PMCID: PMC404024.
    75. Medina D. Stromal fibroblasts influence human mammary epithelial cell morphogenesis. Proc Natl Acad Sci U S A. 2004 Apr 6; 101(14):4723-4. PMID: 15051868; PMCID: PMC387314.
    76. Mollenhauer J, Helmke B, Medina D, Bergmann G, Gassler N, Müller H, Lyer S, Diedrichs L, Renner M, Wittig R, Blaich S, Hamann U, Madsen J, Holmskov U, Bikker F, Ligtenberg A, Carlén A, Olsson J, Otto HF, O'Malley B, Poustka A. Carcinogen inducibility in vivo and down-regulation of DMBT1 during breast carcinogenesis. Genes Chromosomes Cancer. 2004 Mar; 39(3):185-94. PMID: 14732920.
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    77. Medina D. Breast cancer: the protective effect of pregnancy. Clin Cancer Res. 2004 Jan 1; 10(1 Pt 2):380S-4S. PMID: 14734495.
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    78. Said TK, Medina D. Cell cycle genes in a mouse mammary hyperplasia model. J Mammary Gland Biol Neoplasia. 2004 Jan; 9(1):81-93. PMID: 15082920.
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    79. Medina D, Kittrell FS. p53 function is required for hormone-mediated protection of mouse mammary tumorigenesis. Cancer Res. 2003 Oct 1; 63(19):6140-3. PMID: 14559792.
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    80. Medina D, Kittrell FS, Shepard A, Contreras A, Rosen JM, Lydon J. Hormone dependence in premalignant mammary progression. Cancer Res. 2003 Mar 1; 63(5):1067-72. PMID: 12615724.
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    81. Shi HY, Zhang W, Liang R, Kittrell F, Templeton NS, Medina D, Zhang M. Modeling human breast cancer metastasis in mice: maspin as a paradigm. Histol Histopathol. 2003 Jan; 18(1):201-6. PMID: 12507299.
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    82. Green JE, Cardiff R, Hennighausen L, Wakefield L, Wagner U, Lee E, Rosen J, Medina D, Nitkin A, Liu E. Validation of transgenic mammary cancer models: goals of the NCI Mouse Models of Human Cancer Consortium and the mammary cancer CD-ROM. Transgenic Res. 2002 Dec; 11(6):635-6. PMID: 12509138.
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    83. Kong G, Chua SS, Yijun Y, Kittrell F, Moraes RC, Medina D, Said TK. Functional analysis of cyclin D2 and p27(Kip1) in cyclin D2 transgenic mouse mammary gland during development. Oncogene. 2002 Oct 17; 21(47):7214-25. PMID: 12370811.
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    84. Medina D. Biological and molecular characteristics of the premalignant mouse mammary gland. Biochim Biophys Acta. 2002 Oct 2; 1603(1):1-9. PMID: 12242106.
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    85. Aldaz CM, Hu Y, Daniel R, Gaddis S, Kittrell F, Medina D. Serial analysis of gene expression in normal p53 null mammary epithelium. Oncogene. 2002 Sep 12; 21(41):6366-76. PMID: 12214277.
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    86. Goepfert TM, Adigun YE, Zhong L, Gay J, Medina D, Brinkley WR. Centrosome amplification and overexpression of aurora A are early events in rat mammary carcinogenesis. Cancer Res. 2002 Jul 15; 62(14):4115-22. PMID: 12124350.
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    87. Sivaraman L, Gay J, Hilsenbeck SG, Shine HD, Conneely OM, Medina D, O'Malley BW. Effect of selective ablation of proliferating mammary epithelial cells on MNU induced rat mammary tumorigenesis. Breast Cancer Res Treat. 2002 May; 73(1):75-83. PMID: 12083633.
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    88. Medina D, Kittrell FS, Shepard A, Stephens LC, Jiang C, Lu J, Allred DC, McCarthy M, Ullrich RL. Biological and genetic properties of the p53 null preneoplastic mammary epithelium. FASEB J. 2002 Jun; 16(8):881-3. PMID: 11967232.
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    89. Cardiff RD, Bern HA, Faulkin LJ, Daniel CW, Smith GH, Young LJ, Medina D, Gardner MB, Wellings SR, Shyamala G, Guzman RC, Rajkumar L, Yang J, Thordarson G, Nandi S, MacLeod CL, Oshima RG, Man AK, Sawai ET, Gregg JP, Cheung AT, Lau DH. Contributions of mouse biology to breast cancer research. Comp Med. 2002 Feb; 52(1):12-31. PMID: 11900409.
      View in: PubMed
    90. Sivaraman L, Medina D. Hormone-induced protection against breast cancer. J Mammary Gland Biol Neoplasia. 2002 Jan; 7(1):77-92. PMID: 12160088.
      View in: PubMed
    91. Medina D, Ullrich R, Meyn R, Wiseman R, Donehower L. Environmental carcinogens and p53 tumor-suppressor gene interactions in a transgenic mouse model for mammary carcinogenesis. Environ Mol Mutagen. 2002; 39(2-3):178-83. PMID: 11921187.
      View in: PubMed
    92. Medina D, Sivaraman L, Hilsenbeck SG, Conneely O, Ginger M, Rosen J, Omalle BW. Mechanisms of hormonal prevention of breast cancer. Ann N Y Acad Sci. 2001 Dec; 952:23-35. PMID: 11795441.
      View in: PubMed
    93. Hollmann CA, Kittrell FS, Medina D, Butel JS. Wnt-1 and int-2 mammary oncogene effects on the beta-catenin pathway in immortalized mouse mammary epithelial cells are not sufficient for tumorigenesis. Oncogene. 2001 Nov 15; 20(52):7645-57. PMID: 11753642.
      View in: PubMed
    94. Sivaraman L, Conneely OM, Medina D, O'Malley BW. p53 is a potential mediator of pregnancy and hormone-induced resistance to mammary carcinogenesis. Proc Natl Acad Sci U S A. 2001 Oct 23; 98(22):12379-84. PMID: 11606748; PMCID: PMC60062.
    95. Sivaraman L, Hilsenbeck SG, Zhong L, Gay J, Conneely OM, Medina D, O'Malley BW. Early exposure of the rat mammary gland to estrogen and progesterone blocks co-localization of estrogen receptor expression and proliferation. J Endocrinol. 2001 Oct; 171(1):75-83. PMID: 11572792.
      View in: PubMed
    96. Shi HY, Zhang W, Liang R, Abraham S, Kittrell FS, Medina D, Zhang M. Blocking tumor growth, invasion, and metastasis by maspin in a syngeneic breast cancer model. Cancer Res. 2001 Sep 15; 61(18):6945-51. PMID: 11559574.
      View in: PubMed
    97. Medina D, Peterson LE, Moraes R, Gay J. Short-term exposure to estrogen and progesterone induces partial protection against N-nitroso-N-methylurea-induced mammary tumorigenesis in Wistar--Furth rats. Cancer Lett. 2001 Aug 10; 169(1):1-6. PMID: 11410318.
      View in: PubMed
    98. Said TK, Moraes RC, Singh U, Kittrell FS, Medina D. Cyclin-dependent kinase (cdk) inhibitors/cdk4/cdk2 complexes in early stages of mouse mammary preneoplasia. Cell Growth Differ. 2001 Jun; 12(6):285-95. PMID: 11432803.
      View in: PubMed
    99. Brantley DM, Chen CL, Muraoka RS, Bushdid PB, Bradberry JL, Kittrell F, Medina D, Matrisian LM, Kerr LD, Yull FE. Nuclear factor-kappaB (NF-kappaB) regulates proliferation and branching in mouse mammary epithelium. Mol Biol Cell. 2001 May; 12(5):1445-55. PMID: 11359934; PMCID: PMC34596.
    100. Sinha R, Unni E, Ganther HE, Medina D. Methylseleninic acid, a potent growth inhibitor of synchronized mouse mammary epithelial tumor cells in vitro. Biochem Pharmacol. 2001 Feb 1; 61(3):311-7. PMID: 11172735.
      View in: PubMed
    101. Medina D, Thompson H, Ganther H, Ip C. Se-methylselenocysteine: a new compound for chemoprevention of breast cancer. Nutr Cancer. 2001; 40(1):12-7. PMID: 11799917.
      View in: PubMed
    102. Zahnow CA, Cardiff RD, Laucirica R, Medina D, Rosen JM. A role for CCAAT/enhancer binding protein beta-liver-enriched inhibitory protein in mammary epithelial cell proliferation. Cancer Res. 2001 Jan 1; 61(1):261-9. PMID: 11196172.
      View in: PubMed
    103. Said TK, Moraes RC, Sinha R, Medina D. Mechanisms of suberoylanilide hydroxamic acid inhibition of mammary cell growth. Breast Cancer Res. 2001; 3(2):122-33. PMID: 11250759; PMCID: PMC13923.
    104. Kuperwasser C, Hurlbut GD, Kittrell FS, Dickinson ES, Laucirica R, Medina D, Naber SP, Jerry DJ. Development of spontaneous mammary tumors in BALB/c p53 heterozygous mice. A model for Li-Fraumeni syndrome. Am J Pathol. 2000 Dec; 157(6):2151-9. PMID: 11106587; PMCID: PMC1885755.
    105. Mixon M, Kittrell F, Medina D. Expression of Brca1 and splice variant Brca1delta11 RNA levels in mouse mammary gland during normal development and tumorigenesis. Oncogene. 2000 Nov 2; 19(46):5237-43. PMID: 11077440.
      View in: PubMed
    106. Goepfert TM, McCarthy M, Kittrell FS, Stephens C, Ullrich RL, Brinkley BR, Medina D. Progesterone facilitates chromosome instability (aneuploidy) in p53 null normal mammary epithelial cells. FASEB J. 2000 Nov; 14(14):2221-9. PMID: 11053243.
      View in: PubMed
    107. Medina D. The preneoplastic phenotype in murine mammary tumorigenesis. J Mammary Gland Biol Neoplasia. 2000 Oct; 5(4):393-407. PMID: 14973384.
      View in: PubMed
    108. Sivaraman L, Nawaz Z, Medina D, Conneely OM, O'Malley BW. The dual function steroid receptor coactivator/ubiquitin protein-ligase integrator E6-AP is overexpressed in mouse mammary tumorigenesis. Breast Cancer Res Treat. 2000 Aug; 62(3):185-95. PMID: 11072783.
      View in: PubMed
    109. Jerry DJ, Kittrell FS, Kuperwasser C, Laucirica R, Dickinson ES, Bonilla PJ, Butel JS, Medina D. A mammary-specific model demonstrates the role of the p53 tumor suppressor gene in tumor development. Oncogene. 2000 Feb 21; 19(8):1052-8. PMID: 10713689.
      View in: PubMed
    110. Hollmann CA, Medina D, Butel JS. Transfection of mouse mammary epithelial cells. In Vitro Cell Dev Biol Anim. 2000 Feb; 36(2):74-6. PMID: 10718361.
      View in: PubMed
    111. Sinha R, Kiley SC, Lu JX, Thompson HJ, Moraes R, Jaken S, Medina D. Effects of methylselenocysteine on PKC activity, cdk2 phosphorylation and gadd gene expression in synchronized mouse mammary epithelial tumor cells. Cancer Lett. 1999 Nov 15; 146(2):135-45. PMID: 10656618.
      View in: PubMed
    112. Murphy KL, Kittrell FS, Gay JP, Jäger R, Medina D, Rosen JM. Bcl-2 expression delays mammary tumor development in dimethylbenz(a)anthracene-treated transgenic mice. Oncogene. 1999 Nov 11; 18(47):6597-604. PMID: 10597264.
      View in: PubMed
    113. Bonnette SG, Kittrell FS, Stephens LC, Meyn RE, Medina D. Interactions of apoptosis, proliferation and host age in the regression of the mouse mammary preneoplasia, TM3, carrying an unusual mutation in p53. Carcinogenesis. 1999 Sep; 20(9):1715-20. PMID: 10469615.
      View in: PubMed
    114. Lydon JP, Ge G, Kittrell FS, Medina D, O'Malley BW. Murine mammary gland carcinogenesis is critically dependent on progesterone receptor function. Cancer Res. 1999 Sep 1; 59(17):4276-84. PMID: 10485472.
      View in: PubMed
    115. Stickeler E, Kittrell F, Medina D, Berget SM. Stage-specific changes in SR splicing factors and alternative splicing in mammary tumorigenesis. Oncogene. 1999 Jun 17; 18(24):3574-82. PMID: 10380879.
      View in: PubMed
    116. Dong Y, Asch HL, Medina D, Ip C, Ip M, Guzman R, Asch BB. Concurrent deregulation of gelsolin and cyclin D1 in the majority of human and rodent breast cancers. Int J Cancer. 1999 Jun 11; 81(6):930-8. PMID: 10362141.
      View in: PubMed
    117. Medina D, Smith GH. Chemical carcinogen-induced tumorigenesis in parous, involuted mouse mammary glands. J Natl Cancer Inst. 1999 Jun 2; 91(11):967-9. PMID: 10359550.
      View in: PubMed
    118. Pinkas J, Naber SP, Butel JS, Medina D, Jerry DJ. Expression of MDM2 during mammary tumorigenesis. Int J Cancer. 1999 Apr 12; 81(2):292-8. PMID: 10188733.
      View in: PubMed
    119. Jones JM, Cui XS, Medina D, Donehower LA. Heterozygosity of p21WAF1/CIP1 enhances tumor cell proliferation and cyclin D1-associated kinase activity in a murine mammary cancer model. Cell Growth Differ. 1999 Apr; 10(4):213-22. PMID: 10319991.
      View in: PubMed
    120. Schwahn DJ, Medina D. p96, a MAPK-related protein, is consistently downregulated during mouse mammary carcinogenesis. Oncogene. 1998 Sep 3; 17(9):1173-8. PMID: 9764828.
      View in: PubMed
    121. Sivaraman L, Stephens LC, Markaverich BM, Clark JA, Krnacik S, Conneely OM, O'Malley BW, Medina D. Hormone-induced refractoriness to mammary carcinogenesis in Wistar-Furth rats. Carcinogenesis. 1998 Sep; 19(9):1573-81. PMID: 9771927.
      View in: PubMed
    122. Wang XJ, Greenhalgh DA, Jiang A, He D, Zhong L, Medina D, Brinkley BR, Roop DR. Expression of a p53 mutant in the epidermis of transgenic mice accelerates chemical carcinogenesis. Oncogene. 1998 Jul 9; 17(1):35-45. PMID: 9671312.
      View in: PubMed
    123. Medina D, Stephens LC, Bonilla PJ, Hollmann CA, Schwahn D, Kuperwasser C, Jerry DJ, Butel JS, Meyn RE. Radiation-induced tumorigenesis in preneoplastic mouse mammary glands in vivo: significance of p53 status and apoptosis. Mol Carcinog. 1998 Jul; 22(3):199-207. PMID: 9688146.
      View in: PubMed
    124. Said TK, Medina D. Interaction of retinoblastoma protein and D cyclins during cell-growth inhibition by hexamethylenebisacetamide in TM2H mouse epithelial cells. Mol Carcinog. 1998 Jun; 22(2):128-43. PMID: 9655257.
      View in: PubMed
    125. Jeng MH, Kao C, Sivaraman L, Krnacik S, Chung LW, Medina D, Conneely OM, O'Malley BW. Reconstitution of estrogen-dependent transcriptional activation of an adenoviral target gene in select regions of the rat mammary gland. Endocrinology. 1998 Jun; 139(6):2916-25. PMID: 9607802.
      View in: PubMed
    126. Neville MC, Medina D, Monks J, Hovey RC. The mammary fat pad. J Mammary Gland Biol Neoplasia. 1998 Apr; 3(2):109-16. PMID: 10819521.
      View in: PubMed
    127. Li B, Murphy KL, Laucirica R, Kittrell F, Medina D, Rosen JM. A transgenic mouse model for mammary carcinogenesis. Oncogene. 1998 Feb 26; 16(8):997-1007. PMID: 9519874.
      View in: PubMed
    128. Jiang C, Juo L, Said TK, Thompson H, Medina D. Immortalized mouse mammary cells in vivo do not exhibit increased telomerase activity. Carcinogenesis. 1997 Nov; 18(11):2085-91. PMID: 9395206.
      View in: PubMed
    129. Said TK, Conneely OM, Medina D, O'Malley BW, Lydon JP. Progesterone, in addition to estrogen, induces cyclin D1 expression in the murine mammary epithelial cell, in vivo. Endocrinology. 1997 Sep; 138(9):3933-9. PMID: 9275084.
      View in: PubMed
    130. Jones JM, Attardi L, Godley LA, Laucirica R, Medina D, Jacks T, Varmus HE, Donehower LA. Absence of p53 in a mouse mammary tumor model promotes tumor cell proliferation without affecting apoptosis. Cell Growth Differ. 1997 Aug; 8(8):829-38. PMID: 9269892.
      View in: PubMed
    131. Sinha R, Medina D. Inhibition of cdk2 kinase activity by methylselenocysteine in synchronized mouse mammary epithelial tumor cells. Carcinogenesis. 1997 Aug; 18(8):1541-7. PMID: 9276628.
      View in: PubMed
    132. Said TK, Bonnette S, Medina D. Immortal, non-tumourigenic mouse mammary outgrowths express high levels of cyclin B1 and activation of cyclin B1/cdc2 kinase. Cell Prolif. 1996 Nov; 29(11):623-39. PMID: 9105418.
      View in: PubMed
    133. Sinha R, Said TK, Medina D. Organic and inorganic selenium compounds inhibit mouse mammary cell growth in vitro by different cellular pathways. Cancer Lett. 1996 Oct 22; 107(2):277-84. PMID: 8947525.
      View in: PubMed
    134. Raught B, Gingras AC, James A, Medina D, Sonenberg N, Rosen JM. Expression of a translationally regulated, dominant-negative CCAAT/enhancer-binding protein beta isoform and up-regulation of the eukaryotic translation initiation factor 2alpha are correlated with neoplastic transformation of mammary epithelial cells. Cancer Res. 1996 Oct 1; 56(19):4382-6. PMID: 8813130.
      View in: PubMed
    135. Slagle BL, Lee TH, Medina D, Finegold MJ, Butel JS. Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virus X gene. Mol Carcinog. 1996 Apr; 15(4):261-9. PMID: 8634084.
      View in: PubMed
    136. Meyn RE, Stephens LC, Mason KA, Medina D. Radiation-induced apoptosis in normal and pre-neoplastic mammary glands in vivo: significance of gland differentiation and p53 status. Int J Cancer. 1996 Feb 8; 65(4):466-72. PMID: 8621229.
      View in: PubMed
    137. Medina D. The mammary gland: a unique organ for the study of development and tumorigenesis. J Mammary Gland Biol Neoplasia. 1996 Jan; 1(1):5-19. PMID: 10887477.
      View in: PubMed
    138. Medina D. Preneoplasia in mammary tumorigenesis. Cancer Treat Res. 1996; 83:37-69. PMID: 8826641.
      View in: PubMed
    139. Donehower LA, Godley LA, Aldaz CM, Pyle R, Shi YP, Pinkel D, Gray J, Bradley A, Medina D, Varmus HE. The role of p53 loss in genomic instability and tumor progression in a murine mammary cancer model. Prog Clin Biol Res. 1996; 395:1-11. PMID: 8895979.
      View in: PubMed
    140. Said TK, Luo L, Medina D. Mouse mammary hyperplasias and neoplasias exhibit different patterns of cyclins D1 and D2 binding to cdk4. Carcinogenesis. 1995 Oct; 16(10):2507-13. PMID: 7586159.
      View in: PubMed
    141. Li B, Kittrell FS, Medina D, Rosen JM. Delay of dimethylbenz[a]anthracene-induced mammary tumorigenesis in transgenic mice by apoptosis induced by an unusual mutant p53 protein. Mol Carcinog. 1995 Oct; 14(2):75-83. PMID: 7576102.
      View in: PubMed
    142. Mukhopadhyay R, Medina D, Butel JS. Expression of the mouse mammary tumor virus long terminal repeat open reading frame promotes tumorigenic potential of hyperplastic mouse mammary epithelial cells. Virology. 1995 Aug 1; 211(1):74-93. PMID: 7645239.
      View in: PubMed
    143. Greenberg NM, DeMayo F, Finegold MJ, Medina D, Tilley WD, Aspinall JO, Cunha GR, Donjacour AA, Matusik RJ, Rosen JM. Prostate cancer in a transgenic mouse. Proc Natl Acad Sci U S A. 1995 Apr 11; 92(8):3439-43. PMID: 7724580; PMCID: PMC42182.
    144. Said TK, Medina D. Cell cyclins and cyclin-dependent kinase activities in mouse mammary tumor development. Carcinogenesis. 1995 Apr; 16(4):823-30. PMID: 7728962.
      View in: PubMed
    145. Said TK, Medina D. Tyrosine phosphorylation in mouse mammary hyperplasias. Carcinogenesis. 1995 Apr; 16(4):923-30. PMID: 7728975.
      View in: PubMed
    146. Donehower LA, Godley LA, Aldaz CM, Pyle R, Shi YP, Pinkel D, Gray J, Bradley A, Medina D, Varmus HE. Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability. Genes Dev. 1995 Apr 1; 9(7):882-95. PMID: 7705663.
      View in: PubMed
    147. Li B, Greenberg N, Stephens LC, Meyn R, Medina D, Rosen JM. Preferential overexpression of a 172Arg-->Leu mutant p53 in the mammary gland of transgenic mice results in altered lobuloalveolar development. Cell Growth Differ. 1994 Jul; 5(7):711-21. PMID: 7947386.
      View in: PubMed
    148. Jerry DJ, Butel JS, Donehower LA, Paulson EJ, Cochran C, Wiseman RW, Medina D. Infrequent p53 mutations in 7,12-dimethylbenz[a]anthracene-induced mammary tumors in BALB/c and p53 hemizygous mice. Mol Carcinog. 1994 Mar; 9(3):175-83. PMID: 8142019.
      View in: PubMed
    149. Jerry DJ, Medina D, Butel JS. p53 mutations in COMMA-D cells. In Vitro Cell Dev Biol Anim. 1994 Feb; 30A(2):87-9. PMID: 8012661.
      View in: PubMed
    150. Sapino A, Macri L, Gugliotta P, Pacchioni D, Liu YJ, Medina D, Bussolati G. Immunophenotypic properties and estrogen dependency of budding cell structures in the developing mouse mammary gland. Differentiation. 1993 Dec; 55(1):13-8. PMID: 7507867.
      View in: PubMed
    151. Ozbun MA, Medina D, Butel JS. p53 mutations in mouse mammary epithelial cells: instability in culture and discordant selection of mutations in vitro versus in vivo. Cell Growth Differ. 1993 Oct; 4(10):811-9. PMID: 8274450.
      View in: PubMed
    152. Sinha R, Bansal MP, Ganther H, Medina D. Significance of selenium-labeled proteins for selenium's chemopreventive functions. Carcinogenesis. 1993 Sep; 14(9):1895-900. PMID: 8403216.
      View in: PubMed
    153. Jerry DJ, Ozbun MA, Kittrell FS, Lane DP, Medina D, Butel JS. Mutations in p53 are frequent in the preneoplastic stage of mouse mammary tumor development. Cancer Res. 1993 Jul 15; 53(14):3374-81. PMID: 8324748.
      View in: PubMed
    154. Ozbun MA, Jerry DJ, Kittrell FS, Medina D, Butel JS. p53 mutations selected in vivo when mouse mammary epithelial cells form hyperplastic outgrowths are not necessary for establishment of mammary cell lines in vitro. Cancer Res. 1993 Apr 1; 53(7):1646-52. PMID: 8453637.
      View in: PubMed
    155. Markaverich B, Schauweker T, Gregory R, Varma R, Varma M, Kittrell F, Medina D. Combination therapy with a nuclear type-ii site agonist and 5-Fluorouracil - inhibition of mammary-tumor growth. Int J Oncol. 1993 Mar; 2(3):385-92. PMID: 21573566.
      View in: PubMed
    156. Bansal MP, Medina D. Expression of fatty acid-binding proteins in the developing mouse mammary gland. Biochem Biophys Res Commun. 1993 Feb 26; 191(1):61-9. PMID: 8447836.
      View in: PubMed
    157. Medina D, Kittrell FS, Liu YJ, Schwartz M. Morphological and functional properties of TM preneoplastic mammary outgrowths. Cancer Res. 1993 Feb 1; 53(3):663-7. PMID: 7678778.
      View in: PubMed
    158. Medina D, Kittrell FS, Oborn CJ, Schwartz M. Growth factor dependency and gene expression in preneoplastic mouse mammary epithelial cells. Cancer Res. 1993 Feb 1; 53(3):668-74. PMID: 8425201.
      View in: PubMed
    159. Zhang L, Medina D. Gene expression screening for specific genes associated with mouse mammary tumor development. Mol Carcinog. 1993; 8(2):123-6. PMID: 8397796.
      View in: PubMed
    160. Medina D, Kittrell FS. Immortalization phenotype dissociated from the preneoplastic phenotype in mouse mammary epithelial outgrowths in vivo. Carcinogenesis. 1993 Jan; 14(1):25-8. PMID: 8425268.
      View in: PubMed
    161. Schwartz MS, Smith GH, Medina D. The effect of parity, tumor latency and transplantation on the activation of int loci in MMTV-induced, transplanted C3H mammary pre-neoplasias and their tumors. Int J Cancer. 1992 Jul 9; 51(5):805-11. PMID: 1351886.
      View in: PubMed
    162. Markaverich BM, Schauweker TH, Gregory RR, Varma M, Kittrell FS, Medina D, Varma RS. Nuclear type II sites and malignant cell proliferation: inhibition by 2,6-bis-benzylidenecyclohexanones. Cancer Res. 1992 May 1; 52(9):2482-8. PMID: 1568218.
      View in: PubMed
    163. Kittrell FS, Oborn CJ, Medina D. Development of mammary preneoplasias in vivo from mouse mammary epithelial cell lines in vitro. Cancer Res. 1992 Apr 1; 52(7):1924-32. PMID: 1372532.
      View in: PubMed
    164. Bansal MP, Ip C, Medina D. Levels and 75Se-labeling of specific proteins as a consequence of dietary selenium concentration in mice and rats. Proc Soc Exp Biol Med. 1991 Feb; 196(2):147-54. PMID: 1990404.
      View in: PubMed
    165. Bansal MP, Mukhopadhyay T, Scott J, Cook RG, Mukhopadhyay R, Medina D. DNA sequencing of a mouse liver protein that binds selenium: implications for selenium's mechanism of action in cancer prevention. Carcinogenesis. 1990 Nov; 11(11):2071-3. PMID: 2225343.
      View in: PubMed
    166. Kumar R, Medina D, Sukumar S. Activation of H-ras oncogenes in preneoplastic mouse mammary tissues. Oncogene. 1990 Aug; 5(8):1271-7. PMID: 2118247.
      View in: PubMed
    167. Durban EM, Knepper JE, Medina D, Butel JS. Influence of mammary cell differentiation on the expression of proteins encoded by endogenous BALB/c mouse mammary tumor virus genes. Virus Res. 1990 Jul; 16(3):307-23. PMID: 2168113.
      View in: PubMed
    168. Markaverich BM, Gregory RR, Alejandro M, Kittrell FS, Medina D, Clark JH, Varma M, Varma RS. Methyl p-hydroxyphenyllactate and nuclear type II binding sites in malignant cells: metabolic fate and mammary tumor growth. Cancer Res. 1990 Mar 1; 50(5):1470-8. PMID: 2302712.
      View in: PubMed
    169. Mekhail-Ishak K, Medina D, Batist G. Biochemical characteristics of mouse mammary tissues, preneoplastic lesions and tumors. Carcinogenesis. 1989 Dec; 10(12):2363-6. PMID: 2574078.
      View in: PubMed
    170. Bansal MP, Cook RG, Danielson KG, Medina D. A 14-kilodalton selenium-binding protein in mouse liver is fatty acid-binding protein. J Biol Chem. 1989 Aug 15; 264(23):13780-4. PMID: 2760043.
      View in: PubMed
    171. Danielson KG, Knepper JE, Kittrell FS, Butel JS, Medina D, Durban EM. Clonal populations of the mouse mammary cell line, COMMA-D, which retain capability of morphogenesis in vivo. In Vitro Cell Dev Biol. 1989 Jun; 25(6):535-43. PMID: 2544547.
      View in: PubMed
    172. Lane HW, Medina D, Wolfe LG. Proposed mechanisms for selenium-inhibition of mammary tumorigenesis (review). In Vivo. 1989 May-Jun; 3(3):151-60. PMID: 2519849.
      View in: PubMed
    173. Morrison DG, Bansal MP, Kittrell F, Medina D. Distribution of selenium-binding proteins in different tissues of the mouse and rat. In Vivo. 1989 May-Jun; 3(3):167-72. PMID: 2519850.
      View in: PubMed
    174. Bansal MP, Oborn CJ, Danielson KG, Medina D. Evidence for two selenium-binding proteins distinct from glutathione peroxidase in mouse liver. Carcinogenesis. 1989 Mar; 10(3):541-6. PMID: 2924398.
      View in: PubMed
    175. Knepper JE, Kittrell FS, Medina D, Butel JS. Spontaneous progression of hyperplastic outgrowths of the D1 lineage to mammary tumors: expression of mouse mammary tumor virus and cellular proto-oncogenes. Mol Carcinog. 1989; 1(4):229-38. PMID: 2551332.
      View in: PubMed
    176. Morrison DG, Medina D. Time course of selenite metabolism in confluent cultures of mouse mammary epithelial cells. Chem Biol Interact. 1989; 71(2-3):177-86. PMID: 2598295.
      View in: PubMed
    177. Morrison DG, Oborn CJ, Medina D. Selenite distribution in log and confluent growth phase murine mammary epithelial cells. Cancer Lett. 1988 Dec 15; 43(3):227-36. PMID: 3203341.
      View in: PubMed
    178. Morrison DG, Medina D. Distinguishing features of cytotoxic and pharmacological effects of selenite in murine mammary epithelial cells in vitro. Toxicol Lett. 1988 Dec; 44(3):307-14. PMID: 3217946.
      View in: PubMed
    179. Morrison DG, Dishart MK, Medina D. Serine and methionine enhancement of selenite inhibition of DNA synthesis in a mouse mammary epithelial cell line. Carcinogenesis. 1988 Oct; 9(10):1811-5. PMID: 3139318.
      View in: PubMed
    180. Morrison DG, Dishart MK, Medina D. Intracellular 58-kd selenoprotein levels correlate with inhibition of DNA synthesis in mammary epithelial cells. Carcinogenesis. 1988 Oct; 9(10):1801-10. PMID: 3168159.
      View in: PubMed
    181. Campbell SM, Taha MM, Medina D, Rosen JM. A clonal derivative of mammary epithelial cell line COMMA-D retains stem cell characteristics of unique morphological and functional heterogeneity. Exp Cell Res. 1988 Jul; 177(1):109-21. PMID: 2455648.
      View in: PubMed
    182. Medina D. The preneoplastic state in mouse mammary tumorigenesis. Carcinogenesis. 1988 Jul; 9(7):1113-9. PMID: 3289782.
      View in: PubMed
    183. Smith GH, Medina D. A morphologically distinct candidate for an epithelial stem cell in mouse mammary gland. J Cell Sci. 1988 May; 90 ( Pt 1):173-83. PMID: 3198708.
      View in: PubMed
    184. Morrison DG, Berdan RC, Pauly DF, Turner DS, Oborn CJ, Medina D. Selenium distribution in mammary epithelial cells reveals its possible mechanism of inhibition of cell growth. Anticancer Res. 1988 Jan-Feb; 8(1):51-63. PMID: 2451895.
      View in: PubMed
    185. Medina D, Morrison DG. Current ideas on selenium as a chemopreventive agent. Pathol Immunopathol Res. 1988; 7(3):187-99. PMID: 3057483.
      View in: PubMed
    186. Morrison DG, Pauly DF, Berdan RC, Dishart MK, Turner DS, Oborn CJ, Medina D. Mitochondrial inclusions and mitochondrial respiratory function in selenite-treated mammary epithelial cell lines. Anticancer Res. 1988 Jan-Feb; 8(1):65-71. PMID: 3358640.
      View in: PubMed
    187. Schwartz MS, Medina D. Characterization of the DIM series of BALB/c preneoplasms for mouse mammary tumor virus-mediated oncogenesis. Cancer Res. 1987 Nov 1; 47(21):5707-14. PMID: 2822232.
      View in: PubMed
    188. Knepper JE, Medina D, Butel JS. Activation of endogenous MMTV proviruses in murine mammary cancer induced by chemical carcinogen. Int J Cancer. 1987 Sep 15; 40(3):414-22. PMID: 3040604.
      View in: PubMed
    189. Medina D, Li ML, Oborn CJ, Bissell MJ. Casein gene expression in mouse mammary epithelial cell lines: dependence upon extracellular matrix and cell type. Exp Cell Res. 1987 Sep; 172(1):192-203. PMID: 3653254.
      View in: PubMed
    190. Medina D, Schwartz M, Taha M, Oborn CJ, Smith GH. Expression of differentiation-specific proteins in preneoplastic mammary tissues in BALB/c mice. Cancer Res. 1987 Sep 1; 47(17):4686-93. PMID: 3621162.
      View in: PubMed
    191. Medina D, Kittrell FS. Enhancement of tumorigenicity with morphological progression in a BALB/c preneoplastic outgrowth line. J Natl Cancer Inst. 1987 Sep; 79(3):569-76. PMID: 3041094.
      View in: PubMed
    192. Slagle BL, Medina D, Butel JS. Mammary cancer stages in BALB/cV mice: mouse mammary tumor virus expression and virus-host interactions. J Natl Cancer Inst. 1987 Aug; 79(2):323-35. PMID: 3037152.
      View in: PubMed
    193. Smith GH, Young LJ, Benjamini F, Medina D, Cardiff RD. Proteins antigenically related to peptides encoded by the mouse mammary tumour virus long terminal repeat sequence are associated with intracytoplasmic A particles. J Gen Virol. 1987 Feb; 68 ( Pt 2):473-86. PMID: 3029286.
      View in: PubMed
    194. Gama-Sosa MA, Breznik T, Butel JS, Medina D, Cohen JC. Mammary preneoplasia and tumorigenesis in the BALB/c mouse: structure and modification of mouse mammary tumor virus DNA sequences. Virus Res. 1987 Feb; 7(1):1-15. PMID: 3031894.
      View in: PubMed
    195. Danielson KG, Medina D. Distribution of selenoproteins in mouse mammary epithelial cells in vitro and in vivo. Cancer Res. 1986 Sep; 46(9):4582-9. PMID: 2942239.
      View in: PubMed
    196. Knepper JE, Medina D, Butel JS. Differential expression of endogenous mouse mammary tumor virus genes during development of the BALB/c mammary gland. J Virol. 1986 Aug; 59(2):518-21. PMID: 3016314; PMCID: PMC253107.
    197. Medina D, Oborn CJ, Kittrell FS, Ullrich RL. Properties of mouse mammary epithelial cell lines characterized by in vivo transplantation and in vitro immunocytochemical methods. J Natl Cancer Inst. 1986 Jun; 76(6):1143-56. PMID: 2423737.
      View in: PubMed
    198. Medina D. Mechanisms of selenium inhibition of tumorigenesis. Adv Exp Med Biol. 1986; 206:465-72. PMID: 3591534.
      View in: PubMed
    199. Lane HW, Medina D. Mode of action of selenium inhibition of 7,12-dimethylbenz[a]anthracene-induced mouse mammary tumorigenesis. J Natl Cancer Inst. 1985 Oct; 75(4):675-9. PMID: 3930823.
      View in: PubMed
    200. Medina D, Morrison D, Oborn CJ. Selenium retention and inhibition of cell growth in mouse mammary epithelial cell lines in vitro. Biol Trace Elem Res. 1985 Aug; 8(1):19-35. PMID: 24259225.
      View in: PubMed
    201. Durban EM, Medina D, Butel JS. Comparative analysis of casein synthesis during mammary cell differentiation in collagen and mammary gland development in vivo. Dev Biol. 1985 Jun; 109(2):288-98. PMID: 3996752.
      View in: PubMed
    202. Slagle BL, Wheeler DA, Hager GL, Medina D, Butel JS. Molecular basis of altered mouse mammary tumor virus expression in the D-2 hyperplastic alveolar nodule line of BALB/c mice. Virology. 1985 May; 143(1):1-15. PMID: 2414907.
      View in: PubMed
    203. Lane HW, Butel JS, Howard C, Shepherd F, Halligan R, Medina D. The role of high levels of dietary fat in 7,12-dimethylbenzanthracene-induced mouse mammary tumorigenesis: lack of an effect on lipid peroxidation. Carcinogenesis. 1985 Mar; 6(3):403-7. PMID: 3919956.
      View in: PubMed
    204. Medina D, Oborn CJ. Selenium inhibition of DNA synthesis in mouse mammary epithelial cell line YN-4. Cancer Res. 1984 Oct; 44(10):4361-5. PMID: 6467198.
      View in: PubMed
    205. Medina D, Shepherd FS. Selenium inhibition of the neoplastic transformation in preneoplastic mammary cell populations. Cancer Lett. 1984 Sep; 24(2):227-34. PMID: 6090012.
      View in: PubMed
    206. Smith GH, Vonderhaar BK, Graham DE, Medina D. Expression of pregnancy-specific genes in preneoplastic mouse mammary tissues from virgin mice. Cancer Res. 1984 Aug; 44(8):3426-37. PMID: 6430550.
      View in: PubMed
    207. Breznik T, Traina-Dorge V, Gama-Sosa M, Gehrke CW, Ehrlich M, Medina D, Butel JS, Cohen JC. Mouse mammary tumor virus DNA methylation: tissue-specific variation. Virology. 1984 Jul 15; 136(1):69-77. PMID: 6330997.
      View in: PubMed
    208. Danielson KG, Oborn CJ, Durban EM, Butel JS, Medina D. Epithelial mouse mammary cell line exhibiting normal morphogenesis in vivo and functional differentiation in vitro. Proc Natl Acad Sci U S A. 1984 Jun; 81(12):3756-60. PMID: 6587390; PMCID: PMC345298.
    209. Slagle BL, Lanford RE, Medina D, Butel JS. Expression of mammary tumor virus proteins in preneoplastic outgrowth lines and mammary tumors of BALB/cV mice. Cancer Res. 1984 May; 44(5):2155-62. PMID: 6324998.
      View in: PubMed
    210. Graham DE, Medina D, Smith GH. Increased concentration of an indigenous proviral mouse mammary tumor virus long terminal repeat-containing transcript is associated with neoplastic transformation of mammary epithelium in C3H/Sm mice. J Virol. 1984 Mar; 49(3):819-27. PMID: 6321767; PMCID: PMC255543.
    211. Butel JS, Wong C, Medina D. Transformation of mouse mammary epithelial cells by papovavirus SV40. Exp Mol Pathol. 1984 Feb; 40(1):79-108. PMID: 6319177.
      View in: PubMed
    212. Lane HW, Tracey CK, Medina D. Growth, reproduction rates and mammary gland selenium concentration and glutathione-peroxidase activity of BALB/c female mice fed two dietary levels of selenium. J Nutr. 1984 Feb; 114(2):323-31. PMID: 6693995.
      View in: PubMed
    213. Medina D, Lane HW, Shepherd F. Effect of dietary selenium levels on 7,12-dimethylbenzanthracene-induced mouse mammary tumorigenesis. Carcinogenesis. 1983 Sep; 4(9):1159-63. PMID: 6411377.
      View in: PubMed
    214. Riser ME, Huff BC, Medina D. Pepsin can be used to subculture viable mammary epithelial cells. In Vitro. 1983 Sep; 19(9):730-4. PMID: 6413391.
      View in: PubMed
    215. Medina D, Lane HW. Stage specificity of selenium-mediated inhibition of mouse mammary tumorigenesis. Biol Trace Elem Res. 1983 Aug; 5(4-5):297-306. PMID: 24263568.
      View in: PubMed
    216. Markaverich BM, Medina D, Clark JH. Effects of combination estrogen:cyclophosphamide treatment on the growth of the MXT transplantable mammary tumor in the mouse. Cancer Res. 1983 Jul; 43(7):3208-11. PMID: 6850631.
      View in: PubMed
    217. Steiner MR, Richards CS, Butel JS, Medina D. Correlation of amino acid fucoside labeling patterns with tumorigenicity of mouse mammary epithelial cells. Cancer Res. 1983 Jun; 43(6):2628-31. PMID: 6406050.
      View in: PubMed
    218. Medina D, Miller F, Oborn CJ, Asch BB. Mitochondrial inclusions in selenium-treated mouse mammary epithelial cell lines. Cancer Res. 1983 May; 43(5):2100-5. PMID: 6187443.
      View in: PubMed
    219. Medina D, Lane HW, Tracey CM. Selenium and mouse mammary tumorigenesis: an investigation of possible mechanisms. Cancer Res. 1983 May; 43(5 Suppl):2460s-2464s. PMID: 6403237.
      View in: PubMed
    220. Wheeler DA, Butel JS, Medina D, Cardiff RD, Hager GL. Transcription of mouse mammary tumor virus: identification of a candidate mRNA for the long terminal repeat gene product. J Virol. 1983 Apr; 46(1):42-9. PMID: 6298469; PMCID: PMC255091.
    221. Lane HW, Medina D. Selenium concentration and glutathione peroxidase activity in normal and neoplastic development of the mouse mammary gland. Cancer Res. 1983 Apr; 43(4):1558-61. PMID: 6831402.
      View in: PubMed
    222. Medina D. Initiation and promotion in mouse mammary tumorigenesis. Prog Clin Biol Res. 1983; 132B:187-203. PMID: 6634755.
      View in: PubMed
    223. Wolff GL, Kodell RL, Cameron AM, Medina D. Accelerated appearance of chemically induced mammary carcinomas in obese yellow (Avy/A) (BALB/c X VY) F1 hybrid mice. J Toxicol Environ Health. 1982 Jul; 10(1):131-42. PMID: 6290678.
      View in: PubMed
    224. Richards CS, Medina D, Butel JS, Steiner MR. Correlation of surface fucopeptide patterns with tumorigenicity of mouse mammary epithelial cells. Cancer Res. 1981 Dec; 41(12 Pt 1):4967-72. PMID: 7306996.
      View in: PubMed
    225. Drohan W, Teramoto YA, Medina D, Schlom J. Isolation and characterization of a new mouse mammary tumor virus from BALB/c mice. Virology. 1981 Oct 15; 114(1):175-86. PMID: 6269283.
      View in: PubMed
    226. Miller FR, Medina D, Heppner GH. Preferential growth of mammary tumors in intact mammary fatpads. Cancer Res. 1981 Oct; 41(10):3863-7. PMID: 7284994.
      View in: PubMed
    227. Smith NK, Stabler SB, Cameron IL, Medina D. X-ray microanalysis of electrolyte content of normal, preneoplastic, and neoplastic mouse mammary tissue. Cancer Res. 1981 Oct; 41(10):3877-80. PMID: 7284996.
      View in: PubMed
    228. Medina D. Hormones and mouse mammary tumorigenesis. Cancer Res. 1981 Sep; 41(9 Pt 2):3819-20. PMID: 7260954.
      View in: PubMed
    229. Medina D, Oborn CJ. Differential effects of selenium on the growth of mouse mammary cells in vitro. Cancer Lett. 1981 Sep; 13(4):333-44. PMID: 7306960.
      View in: PubMed
    230. Butel JS, Dusing-Swartz S, Socher SH, Medina D. Partial expression of endogenous mouse mammary tumor virus in mammary tumors induced in BALB/c mice by chemical, hormonal, and physical agents. J Virol. 1981 May; 38(2):571-80. PMID: 6264129; PMCID: PMC171188.
    231. Watson CS, Medina D, Clark JH. Estrogenic effects of nafoxidine on ovarian-dependent and independent mammary tumor lines in the mouse. Endocrinology. 1981 Feb; 108(2):668-72. PMID: 7449742.
      View in: PubMed
    232. Smith GH, Teramoto YA, Medina D. Hormones, chemicals and proviral gene expression as contributing factors during mammary carcinogenesis in C3H/StWi mice. Int J Cancer. 1981 Jan 15; 27(1):81-6. PMID: 6265386.
      View in: PubMed
    233. Medina D, Lane H, Shepherd F. Effects of selenium on mouse mammary tumorigenesis and glutathione peroxidase activity. Anticancer Res. 1981; 1(6):377-82. PMID: 6807190.
      View in: PubMed
    234. Medina D, Shepherd F. Selenium-mediated inhibition of 7,12-dimethylbenz[a]anthracene-induced mouse mammary tumorigenesis. Carcinogenesis. 1981; 2(5):451-5. PMID: 6791857.
      View in: PubMed
    235. Teramoto YA, Medina D, McGrath C, Schlom J. Noncoordinate expression of murine mammary tumor virus gene products. Virology. 1980 Dec; 107(2):345-53. PMID: 6256936.
      View in: PubMed
    236. Medina D, Oborn CJ. Growth of preneoplastic mammary epithelial cells in serum-free medium. Cancer Res. 1980 Nov; 40(11):3982-7. PMID: 6162540.
      View in: PubMed
    237. Watson CS, Medina D, Clark JH. Characterization of progesterone receptors, estrogen receptors, and estrogen (type II)-binding sites in the hormone-independent variant of the MXT-3590 mouse mammary tumor. Endocrinology. 1980 Nov; 107(5):1432-7. PMID: 7428677.
      View in: PubMed
    238. Dudley JP, Medina D, Butel JS. Characterization of a 7,12-dimethylbenz(alpha)anthracene-induced BALB/c mouse mammary tumor epithelial cell line. In Vitro. 1980 Nov; 16(11):941-8. PMID: 6778814.
      View in: PubMed
    239. Smith GH, Arthur LA, Medina D. Evidence of separate pathways for viral and chemical carcinogenesis in C3H/StWi mouse mammary glands. Int J Cancer. 1980 Sep 15; 26(3):373-9. PMID: 6270008.
      View in: PubMed
    240. Beall PT, Asch BB, Chang DC, Medina D, Hazlewood CF. Distinction of normal, preneoplastic, and neoplastic mouse mammary primary cell cultures by water nuclear magnetic resonance relaxation times. J Natl Cancer Inst. 1980 Feb; 64(2):335-8. PMID: 6928225.
      View in: PubMed
    241. Medina D, Butel JS, Socher SH, Miller FL. Mammary tumorigenesis in 7,12-dimethybenzanthracene-treated C57BL x DBA/2f F1 mice. Cancer Res. 1980 Feb; 40(2):368-73. PMID: 6243251.
      View in: PubMed
    242. Medina D, Oborn CJ, Asch BB. Distinction between preneopastic and neoplastic mammary cell populations in vitro by cytochalasin B-induced multinucleation. Cancer Res. 1980 Feb; 40(2):329-33. PMID: 7356516.
      View in: PubMed
    243. Medina D, Shepherd F. Selenium-mediated inhibition of mouse mammary tumorigenesis. Cancer Lett. 1980 Jan; 8(3):241-5. PMID: 6261942.
      View in: PubMed
    244. Pauley RJ, Medina D, Socher SH. Hormonal regulation of murine mammary tumor virus RNA expression during mammary tumorigenesis in BALB/c mice. J Virol. 1979 Nov; 32(2):557-66. PMID: 228079; PMCID: PMC353588.
    245. Dusing-Swartz S, Medina D, Butel JS, Socher SH. Mouse mammary tumor virus genome expression in chemical carcinogen-induced mammary tumors in low- and high-tumor-incidence mouse strains. Proc Natl Acad Sci U S A. 1979 Oct; 76(10):5360-4. PMID: 228289; PMCID: PMC413142.
    246. Watson CS, Medina D, Clark JH. Characterization and estrogen stimulation of cytoplasmic progesterone receptor in the ovarian-dependent MXT-3590 mammary tumor line. Cancer Res. 1979 Oct; 39(10):4098-104. PMID: 476646.
      View in: PubMed
    247. Wolff GL, Medina D, Umholtz RL. Manifestation of hyperplastic alveolar nodules and mammary tumors in "viable yellow" and non-yellow mice. J Natl Cancer Inst. 1979 Sep; 63(3):781-5. PMID: 288935.
      View in: PubMed
    248. Ruppert B, Blazar B, Medina D, Heppner G. In situ lymphoid cells of mouse mammary tumors. IV. Comparison of functional activity of lymphoid cells separated from mammary tumors to that of spleen and lymph node cells of tumor-sensitized mice. J Immunol. 1979 Jun; 122(6):2180-3. PMID: 448122.
      View in: PubMed
    249. Wei WZ, Miller FR, Blazar BA, Medina D, Heppner G. Opposing effects of cryostat sections of preneoplastic and neoplastic mouse mammary lesions on in vitro migration of peritoneal exudate cells. J Immunol. 1979 May; 122(5):2059-67. PMID: 448117.
      View in: PubMed
    250. Asch BB, Medina D, Brinkley BR. Microtubules and actin-containing filaments of normal, preneoplastic, and neoplastic mouse mammary epithelial cells. Cancer Res. 1979 Mar; 39(3):893-907. PMID: 371792.
      View in: PubMed
    251. Medina D. Serial transplantation of chemical carcinogen-induced mouse mammary ductal dysplasias. J Natl Cancer Inst. 1979 Feb; 62(2):397-405. PMID: 105203.
      View in: PubMed
    252. Pauley RJ, Medina D, Socher SH. Murine mammary tumor virus expression during mammary tumorigenesis in BALB/c mice. J Virol. 1979 Feb; 29(2):483-93. PMID: 219243; PMCID: PMC353180.
    253. Asch BB, Medina D. Concanavalin A-induced agglutinability of normal, preneoplastic, and neoplastic mouse mammary cells. J Natl Cancer Inst. 1978 Dec; 61(6):1423-30. PMID: 281551.
      View in: PubMed
    254. Smith GH, Pauley RJ, Socher SH, Medina D. Chemical carcinogenesis in C3H/StWi mice, a worthwhile experimental model for breast cancer. Cancer Res. 1978 Dec; 38(12):4504-9. PMID: 214224.
      View in: PubMed
    255. Ruppert B, Wei W, Medina D, Heppner GH. Effect of chemical carcinogen treatment on the immunogenicity of mouse mammary tumors arising from hyperplastic alveolar nodule outgrowth lines. J Natl Cancer Inst. 1978 Oct; 61(4):1165-9. PMID: 100605.
      View in: PubMed
    256. Steiner MR, Altenburg B, Richards CS, Dudley JP, Medina D, Butel JS. Differential response of cultured mouse mammary cells of varying tumorigenicity to cytochalasin B. Cancer Res. 1978 Sep; 38(9):2719-21. PMID: 679176.
      View in: PubMed
    257. Vaage J, Medina D. Mammary tumor virus oncogenesis and tumor immunogenicity in three sublines of the C3H mouse. Cancer Res. 1978 Aug; 38(8):2443-7. PMID: 208767.
      View in: PubMed
    258. Tseng WC, Medina D, Randerath K. Specific inhibition of transfer RNA methylation and modification in tissues of mice treated with 5-fluorouracil. Cancer Res. 1978 May; 38(5):1250-7. PMID: 639058.
      View in: PubMed
    259. Medina D, Shepherd F, Gropp T. Enhancement of the tumorigenicity of preneoplastic mammary nodule lines by enzymatic dissociation. J Natl Cancer Inst. 1978 May; 60(5):1121-6. PMID: 205661.
      View in: PubMed
    260. Beall PT, Medina D, Chang DC, Seitz PK, Hazlewood CF. Systemic effect of benign and malignant mammary tumors on the spin-lattice relaxation time of water protons in mouse serum. J Natl Cancer Inst. 1977 Nov; 59(5):1431-3. PMID: 909106.
      View in: PubMed
    261. Medina D, Shepherd F. Enhancement and inhibition of mammary tumor formation and growth by cytostatic drugs. Cancer Res. 1977 Oct; 37(10):3571-7. PMID: 908008.
      View in: PubMed
    262. Watson C, Medina D, Clark JH. Estrogen receptor characterization in a transplantable mouse mammary tumor. Cancer Res. 1977 Sep; 37(9):3344-8. PMID: 195726.
      View in: PubMed
    263. Medina D, O'Bryan SB, Warner MR, Sinha YN, VanderLaan WP, McCormack S, Hahn P. Mammary tumorigenesis in chemical carcinogen-treated mice. VII. Prolactin and progesterone levels in BALB/c mice. J Natl Cancer Inst. 1977 Jul; 59(1):213-9. PMID: 406413.
      View in: PubMed
    264. Butel JS, Dudley JP, Medina D. Comparison of the growth properties in vitro and transplantability of continuous mouse mammary tumor cell lines and clonal derivatives. Cancer Res. 1977 Jun; 37(6):1892-900. PMID: 192465.
      View in: PubMed
    265. Medina D. Tumor formation in preneoplastic mammary nodule lines in mice treated with nafoxidine, testosterone, and 2-bromo-alpha-ergocryptine. J Natl Cancer Inst. 1977 Apr; 58(4):1107-10. PMID: 576622.
      View in: PubMed
    266. Brem SS, Gullino PM, Medina D. Angiogenesis: a marker for neoplastic transformation of mammary papillary hyperplasia. Science. 1977 Mar 4; 195(4281):880-2. PMID: 402692.
      View in: PubMed
    267. Medina D. Enhancement of mammary tumor formation in mice by a cytostatic drug, melphalan. Cancer Res. 1977 Jan; 37(1):317-9. PMID: 830417.
      View in: PubMed
    268. Medina D. Mammary tumorigenesis in chemical carcinogen-treated mice. VI. Tumor-producing capabilities of mammary dysplasias in BALB/cCrgl mice. J Natl Cancer Inst. 1976 Nov; 57(5):1185-9. PMID: 187796.
      View in: PubMed
    269. Medina D, Warner MR. Mammary tumorigenesis in chemical carcinogen-treated mice. IV. Induction of mammary ductal hyperplasias. J Natl Cancer Inst. 1976 Aug; 57(2):331-7. PMID: 826649.
      View in: PubMed
    270. Medina D. Preneoplastic lesions in murine mammary cancer. Cancer Res. 1976 Jul; 36(7 PT 2):2589-95. PMID: 179706.
      View in: PubMed
    271. Medina D. Mammary gland as a morphological end point in carcinogenesis studies. J Toxicol Environ Health. 1976 Mar; 1(4):551-60. PMID: 177787.
      View in: PubMed
    272. Heppner GH, Kopp JS, Medina D. Microcytotoxicity assay of immune responses to non-mammary tumor virus-induced, preneoplastic, and neoplastic mammary lesions in BALB/c mice. Cancer Res. 1976 Feb; 36(2 pt 2):753-8. PMID: 1253160.
      View in: PubMed
    273. Medina D, Iramain CA, Clark JH. Hormone dependence and estradiol receptors in the D series of mammary nodule outgrowth lines and tumors. Cancer Res. 1975 Sep; 35(9):2355-69. PMID: 167955.
      View in: PubMed
    274. Daniel CW, Aidells BD, Medina D, Faulkin LJ. Unlimited division potential of precancerous mouse mammary cells after spontaneous or carcinogen-induced transformation. Fed Proc. 1975 Jan; 34(1):64-7. PMID: 162797.
      View in: PubMed
    275. Medina D, Stockman G, Griswold D. Significance of chemical carcinogen-induced immunosuppression in mammary tumorigenesis in BALB-c mice. Cancer Res. 1974 Oct; 34(10):2663-8. PMID: 4607071.
      View in: PubMed
    276. Medina D. Mammary tumorigenesis in chemical carcinogen-treated mice. I. Incidence in BALB-c and C57BL mice. J Natl Cancer Inst. 1974 Jul; 53(1):213-21. PMID: 4835107.
      View in: PubMed
    277. Medina D. Mammary tumorigenesis in chemical carcinogen-treated mice. II. Dependence on hormone stimulation for tumorigenesis. J Natl Cancer Inst. 1974 Jul; 53(1):223-6. PMID: 4835108.
      View in: PubMed
    278. Vaage J, Medina D. Virus oncogenesis and tumor immunogenicity in the mouse mammary tumor system. Cancer Res. 1974 Jun; 34(6):1319-24. PMID: 4363654.
      View in: PubMed
    279. Hazlewood CF, Cleveland G, Medina D. Relationship between hydration and proton nuclear magnetic resonance relaxation times in tissues of tumor-bearing and non-tumor-bearing mice: implications for cancer detection. J Natl Cancer Inst. 1974 Jun; 52(6):1849-53. PMID: 4365678.
      View in: PubMed
    280. Medina D, Vaage J, Sedlacek R. Mammary noduligenesis and tumorigenesis in pathogen-free C3Hf mice. J Natl Cancer Inst. 1973 Sep; 51(3):961-5. PMID: 4743563.
      View in: PubMed
    281. Abraham S, Bartley J, DeOme KB, Faulkin LJ, Medina D. Enzyme activities in induced and serially transplanted murine mammary adenocarcinomas. J Natl Cancer Inst. 1973 Jul; 51(1):251-6. PMID: 4720875.
      View in: PubMed
    282. Medina D. Serial transplantation of carcinogen-treated mammary nodule outgrowths. 3. Dissociation of carcinogen-induced cell variants by dose and chemical structure of carcinogen. J Natl Cancer Inst. 1973 Jun; 50(6):1555-9. PMID: 4717566.
      View in: PubMed
    283. Hazelwood CF, Chang DC, Medina D, Cleveland G, Nichols BL. Distinction between the preneoplastic and neoplastic state of murine mammary glands. Proc Natl Acad Sci U S A. 1972 Jun; 69(6):1478-80. PMID: 4504364; PMCID: PMC426730.
    284. Medina D. Serial transplantation of methylcholanthrene-treated mammary nodule outgrowth line D1. J Natl Cancer Inst. 1972 May; 48(5):1363-70. PMID: 5030953.
      View in: PubMed
    285. Medina D. Serial transplantation of urethan-treated mammary nodule outgrowth line D1. J Natl Cancer Inst. 1972 May; 48(5):1371-5. PMID: 4337908.
      View in: PubMed
    286. Medina D, DeOme KB, Pitelka DR, Colley VB. Appearance of virus particles in BALB-c mammary nodule outgrowth lines transplanted into BALB-c f. C3H and (C3Hf x BALB-c)F1 mice. J Natl Cancer Inst. 1971 Jun; 46(6):1153-60. PMID: 4325928.
      View in: PubMed
    287. Medina D. Effect of hormone stimulation, dose, and time of administration of carcinogen on carcinogen-induced mammary tumors from preneoplastic nodule outgrowths. J Natl Cancer Inst. 1971 Apr; 46(4):909-16. PMID: 5573775.
      View in: PubMed
    288. Adamson R, Banerjee MR, Medina D. Susceptibility of mammary-tumor-virus-free BALB-c mouse mammary nodule outgrowth cells in DNA synthesis to 3-methylcholanthrene tumorigenesis. J Natl Cancer Inst. 1971 Apr; 46(4):899-907. PMID: 5573774.
      View in: PubMed
    289. Daniel CW, Young LJ, Medina D, DeOme KB. The influence of mammogenic hormones on serially transplanted mouse mammary gland. Exp Gerontol. 1971 Feb 1; 6(1):95-101. PMID: 5572743.
      View in: PubMed
    290. Young LJ, Medina D, DeOme KB, Daniel CW. The influence of host and tissue age on life span and growth rate of serially transplanted mouse mammary gland. Exp Gerontol. 1971 Feb 1; 6(1):49-56. PMID: 5572739.
      View in: PubMed
    291. Medina D, DeOme KB. Effects of various oncogenic agents on tumor-producing capabilities of series D BALB-c mammary nodule outgrowth lines. J Natl Cancer Inst. 1970 Aug; 45(2):353-63. PMID: 4324612.
      View in: PubMed
    292. Medina D, DeOme KB. Carcinogen-induced mammary tumors from preneoplastic nodule outgrowths in BALB-c mice. Cancer Res. 1970 Apr; 30(4):1055-9. PMID: 5504348.
      View in: PubMed
    293. Medina D, DeOme KB, Young L. Tumor-producing capabilities of hyperplastic alveolar nodules in virgin and hormone-stimulated BALB/c f. C3H and C3Hf mice. J Natl Cancer Inst. 1970 Jan; 44(1):167-74. PMID: 11515028.
      View in: PubMed
    294. Medina D, Faulkin LJ, DeOme KB. Combined effects of 3-methylcholanthrene, mammary tumor virus, nodule-inducing virus, and prolonged hormonal stimulation on the tumor-producing capabilities of the nodule outgrowth line D1. J Natl Cancer Inst. 1970 Jan; 44(1):159-65. PMID: 11515027.
      View in: PubMed
    295. DeOme KB, Medina D. A new approach to mammary tumorigenesis in rodents. Cancer. 1969 Dec; 24(6):1255-8. PMID: 4311120.
      View in: PubMed
    296. Medina D, DeOme KB. Response of hyperplastic alveolar nodule outgrowth-line D1 to mammary tumor virus, nodule-inducing virus, and prolonged hormonal stimulation acting singly and in combination. J Natl Cancer Inst. 1969 Feb; 42(2):303-10. PMID: 4303882.
      View in: PubMed
    297. Medina D, DeOme KB. Influence of mammary tumor virus on the tumor-producing capabilities of nodule outgrowth free of mammary tumor virus. J Natl Cancer Inst. 1968 Jun; 40(6):1303-8. PMID: 4298252.
      View in: PubMed
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