InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    InstitutionBaylor College of Medicine
    DepartmentBreast Center
    DivisionBreast Cancer Center

    Collapse Research 
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    R01CA277838     (XIAO, HAN)Jul 3, 2023 - Jun 30, 2028
    Modulation of Epigenetic Target in the Bone to Treat Breast Cancer Metastasis
    Role: Co-Principal Investigator

    BCRF-20-178     (Xiang Zhang)Oct 1, 2020 - Sep 30, 2021
    Breast Cancer Research Foundation
    Diverse myeloid cell profiles impact breast cancer evolution and therapeutic responses
    Role: Principal Investigator

    U01CA253553     (WONG, STEPHEN TC ;ZHANG, XIANG)Sep 15, 2020 - Aug 31, 2025
    Spatiotemporal modeling of cancer-niche interactions in breast cancer bone metastasis
    Role: Co-Principal Investigator

    R01CA251950     (ZHANG, XIANG)Jul 1, 2020 - Jun 30, 2025
    Mechanistic and therapeutic investigation of secondary metastatic seeding from breast cancer bone lesion
    Role: Principal Investigator

    W81XWH-20-1-0375     (Xiang Zhang)Jun 1, 2020 - May 31, 2023
    Department of Defense
    The Epigenetic Adaptation of ER+ Breast Cancer Cells to the Bone Microenvironment
    Role: Principal Investigator

    R01CA227904     (SREEKUMAR, ARUN ;ZHANG, XIANG)Sep 1, 2019 - Aug 31, 2024
    Rewired Metabolism Regulates Vessel Normalization and Immunosuppression
    Role: Principal Investigator

    W81XWH-18-1-0574     (Xiang Zhang)Sep 15, 2018 - Sep 14, 2021
    Department of Defense
    From Cold to Hot: Leveraging RNA Splicing Therapeutics to Unleash Antitumor Immunity for Breast Cancer Patients
    Role: Partnering Principal Investigator

    R01CA221946     (ROWLEY, DAVID R)Sep 5, 2018 - Aug 31, 2023
    Osteogenic Niche Biology in Progression and Endocrine Resistance of Bone Metastases
    Role: Co-Principal Investigator

    W81XWH-16-1-0073     (Xiang Zhang)Mar 15, 2015 - Sep 14, 2021
    Department of Defense
    Targeting Breast Cancer Micrometastases: To Eliminate the Seeds of Evil
    Role: Principal Investigator

    2R01CA183878-06A1     (ZHANG, XIANG)Sep 1, 2014 - Mar 31, 2025
    Osteoclast-Independent Mechanisms of Early-Stage Bone Colonization of Breast Cancer
    Role: Principal Investigator

    R00CA151293     (ZHANG, XIANG H.-F.)Sep 1, 2010 - Aug 31, 2014
    Role: Principal Investigator

    K99CA151293     (ZHANG, XIANG H.-F.)Sep 1, 2010 - Aug 31, 2011
    Mechanisms of Src activation and its role in latent bone metastasis of breast and
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Bowling EA, Wang JH, Gong F, Wu W, Neill NJ, Kim IS, Tyagi S, Orellana M, Kurley SJ, Chung HC, Hsu TY, Dubrulle J, Saltzman AB, Li H, Meena JK, Canlas GM, Chamakuri S, Singh S, Simon LM, Olson CM, Dobrolecki LE, Lewis MT, Zhang B, Golding I, Rosen JM, Young DW, Malovannaya A, Stossi F, Miles G, Ellis MJ, Yu L, Buonamici S, Lin CY, Karlin KL, Zhang XH, Westbrook TF, Dominguez-Vida?a R. Spliceosome-targeted therapies trigger an antiviral immune response in triple-negative breast cancer. Cell. 2021 01 21; 184(2):384-403.e21. PMID: 33450205; PMCID: PMC8635244.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    2. Fukumura K, Malgulwar PB, Fischer GM, Hu X, Mao X, Song X, Hernandez SD, Zhang XH, Zhang J, Parra ER, Yu D, Debeb BG, Davies MA, Huse JT. Multi-omic molecular profiling reveals potentially targetable abnormalities shared across multiple histologies of brain metastasis. Acta Neuropathol. 2021 02; 141(2):303-321. PMID: 33394124; PMCID: PMC7852029.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    3. Singh S, Zhang XHF, Rosen JM. TIME Is a Great Healer-Targeting Myeloid Cells in the Tumor Immune Microenvironment to Improve Triple-Negative Breast Cancer Outcomes. Cells. 2020 12 23; 10(1). PMID: 33374595; PMCID: PMC7822423.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    4. Gu G, Tian L, Herzog SK, Rechoum Y, Gelsomino L, Gao M, Du L, Kim JA, Dustin D, Lo HC, Beyer AR, Edwards DG, Gonzalez T, Tsimelzon A, Huang HJ, Fernandez NM, Grimm SL, Hilsenbeck SG, Liu D, Xu J, Alaniz A, Li S, Mills GB, Janku F, Kittler R, Zhang XH, Coarfa C, Foulds CE, Symmans WF, Fuqua SAW, And? S. Hormonal modulation of ESR1 mutant metastasis. Oncogene. 2021 02; 40(5):997-1011. PMID: 33323970; PMCID: PMC8020875.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    5. Wu L, Zhang XH. Tumor-Associated Neutrophils and Macrophages-Heterogenous but Not Chaotic. Front Immunol. 2020; 11:553967. PMID: 33343560; PMCID: PMC7738476.
      Citations: 14     Fields:    Translation:HumansCells
    6. Sawant Dessai A, Dominguez MP, Chen UI, Hasper J, Prechtl C, Yu C, Katsuta E, Dai T, Zhu B, Jung SY, Putluri N, Takabe K, Zhang XH, O'Malley BW, Dasgupta S. Transcriptional Repression of SIRT3 Potentiates Mitochondrial Aconitase Activation to Drive Aggressive Prostate Cancer to the Bone. Cancer Res. 2021 01 01; 81(1):50-63. PMID: 33115805; PMCID: PMC7878313.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    7. Wang H, Zhang W, Bado I, Zhang XH. Bone Tropism in Cancer Metastases. Cold Spring Harb Perspect Med. 2020 10 01; 10(10). PMID: 31615871; PMCID: PMC7528862.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    8. Xu L, Liu X, Peng F, Zhang W, Zheng L, Ding Y, Gu T, Lv K, Wang J, Ortinau L, Hu T, Shi X, Shi G, Shang G, Sun S, Iwawaki T, Ji Y, Li W, Rosen JM, Zhang XH, Park D, Adoro S, Catic A, Tong W, Qi L, Nakada D, Chen X. Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche interactions. Nat Cell Biol. 2020 10; 22(10):1162-1169. PMID: 32958856; PMCID: PMC7888538.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    9. Li P, Lu M, Shi J, Gong Z, Hua L, Li Q, Lim B, Zhang XH, Chen X, Li S, Shultz LD, Ren G. Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis. Nat Immunol. 2020 11; 21(11):1444-1455. PMID: 32958928; PMCID: PMC7584447.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    10. Muscarella AM, Dai W, Mitchell PG, Zhang W, Wang H, Jia L, Stossi F, Mancini MA, Chiu W, Zhang XH. Unique cellular protrusions mediate breast cancer cell migration by tethering to osteogenic cells. NPJ Breast Cancer. 2020; 6:42. PMID: 32964116; PMCID: PMC7477119.
      Citations: 6     
    11. Wang H, Zhang XH. Molecules in the blood of older people promote cancer spread. Nature. 2020 09; 585(7824):187-188. PMID: 32814911.
      Citations: 3     Fields:    Translation:Humans
    12. Xu L, Zhang W, Zhang XH, Chen X. Endoplasmic Reticulum Stress in Bone Metastases. Front Oncol. 2020; 10:1100. PMID: 32850317; PMCID: PMC7396666.
      Citations: 1     
    13. Arnold JM, Gu F, Ambati CR, Rasaily U, Ramirez-Pena E, Joseph R, Manikkam M, Martin RS, Charles C, Pan Y, Chatterjee SS, Den Hollander P, Zhang W, Nagi C, Sikora AG, Rowley D, Putluri N, Zhang XH, Karanam B, Mani SA, Sreekumar A. Correction: UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression. Oncogene. 2020 Apr; 39(15):3226-3228. PMID: 32214199; PMCID: PMC10473373.
      Citations: 2     Fields:    
    14. Zheng ZY, Anurag M, Lei JT, Cao J, Singh P, Peng J, Kennedy H, Nguyen NC, Chen Y, Lavere P, Li J, Du XH, Cakar B, Song W, Kim BJ, Shi J, Seker S, Chan DW, Zhao GQ, Chen X, Banks KC, Lanman RB, Shafaee MN, Zhang XH, Vasaikar S, Zhang B, Hilsenbeck SG, Li W, Foulds CE, Ellis MJ, Chang EC. Neurofibromin Is an Estrogen Receptor-a Transcriptional Co-repressor in Breast Cancer. Cancer Cell. 2020 03 16; 37(3):387-402.e7. PMID: 32142667; PMCID: PMC7286719.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    15. Wang H, Zhang XH. Bone-in-culture Array to Model Bone Metastasis in ex vivo Condition. Bio Protoc. 2020 Jan 20; 10(2):e3495. PMID: 33654726; PMCID: PMC7842296.
    16. Bado I, Zhang XH. Senesce to Survive: YAP-Mediated Dormancy Escapes EGFR/MEK Inhibition. Cancer Cell. 2020 01 13; 37(1):1-2. PMID: 31951560.
      Citations: 4     Fields:    
    17. Wang H, Zhang W, Bado I, Zhang XH. Erratum: Bone Tropism in Cancer Metastases. Cold Spring Harb Perspect Med. 2019 Nov 01; 9(11). PMID: 31676496; PMCID: PMC6824402.
      Citations:    Fields:    
    18. Kim IS, Gao Y, Welte T, Wang H, Liu J, Janghorban M, Sheng K, Niu Y, Goldstein A, Zhao N, Bado I, Lo HC, Toneff MJ, Nguyen T, Bu W, Jiang W, Arnold J, Gu F, He J, Jebakumar D, Walker K, Li Y, Mo Q, Westbrook TF, Zong C, Rao A, Sreekumar A, Rosen JM, Zhang XH. Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms. Nat Cell Biol. 2019 09; 21(9):1113-1126. PMID: 31451770; PMCID: PMC6726554.
      Citations: 88     Fields:    Translation:AnimalsCells
    19. Arnold JM, Gu F, Ambati CR, Rasaily U, Ramirez-Pena E, Joseph R, Manikkam M, San Martin R, Charles C, Pan Y, Chatterjee SS, Den Hollander P, Zhang W, Nagi C, Sikora AG, Rowley D, Putluri N, Zhang XH, Karanam B, Mani SA, Sreekumar A. UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression. Oncogene. 2020 04; 39(15):3089-3101. PMID: 31308490; PMCID: PMC6960374.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    20. Gao Y, Bado I, Wang H, Zhang W, Rosen JM, Zhang XH. Metastasis Organotropism: Redefining the Congenial Soil. Dev Cell. 2019 05 06; 49(3):375-391. PMID: 31063756; PMCID: PMC6506189.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    21. Zhang W, Bado I, Wang H, Lo HC, Zhang XH. Bone Metastasis: Find Your Niche and Fit in. Trends Cancer. 2019 02; 5(2):95-110. PMID: 30755309; PMCID: PMC6383208.
      Citations: 29     Fields:    Translation:Humans
    22. Wang H, Tian L, Liu J, Goldstein A, Bado I, Zhang W, Arenkiel BR, Li Z, Yang M, Du S, Zhao H, Rowley DR, Wong STC, Gugala Z, Zhang XH. The Osteogenic Niche Is a Calcium Reservoir of Bone Micrometastases and Confers Unexpected Therapeutic Vulnerability. Cancer Cell. 2018 11 12; 34(5):823-839.e7. PMID: 30423299; PMCID: PMC6239211.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    23. Huang F, Shi Q, Li Y, Xu L, Xu C, Chen F, Wang H, Liao H, Chang Z, Liu F, Zhang XH, Feng XH, Han JJ, Luo S, Chen YG. HER2/EGFR-AKT Signaling Switches TGF? from Inhibiting Cell Proliferation to Promoting Cell Migration in Breast Cancer. Cancer Res. 2018 11 01; 78(21):6073-6085. PMID: 30171053.
      Citations: 25     Fields:    Translation:HumansCells
    24. Janghorban M, Xin L, Rosen JM, Zhang XH. Notch Signaling as a Regulator of the Tumor Immune Response: To Target or Not To Target? Front Immunol. 2018; 9:1649. PMID: 30061899; PMCID: PMC6055003.
      Citations: 40     Fields:    
    25. Lo HC, Zhang XH. EMT in Metastasis: Finding the Right Balance. Dev Cell. 2018 06 18; 45(6):663-665. PMID: 29920271.
      Citations: 19     Fields:    Translation:Humans
    26. Nguyen TM, Kabotyanski EB, Dou Y, Reineke LC, Zhang P, Zhang XH, Malovannaya A, Jung SY, Mo Q, Roarty KP, Chen Y, Zhang B, Neilson JR, Lloyd RE, Perou CM, Ellis MJ, Rosen JM. FGFR1-Activated Translation of WNT Pathway Components with Structured 5' UTRs Is Vulnerable to Inhibition of EIF4A-Dependent Translation Initiation. Cancer Res. 2018 08 01; 78(15):4229-4240. PMID: 29844125; PMCID: PMC6072612.
      Citations: 9     Fields:    Translation:AnimalsCells
    27. Dasgupta S, Rajapakshe K, Zhu B, Nikolai BC, Yi P, Putluri N, Choi JM, Jung SY, Coarfa C, Westbrook TF, Zhang XH, Foulds CE, Tsai SY, Tsai MJ, O'Malley BW. Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer. Nature. 2018 04; 556(7700):249-254. PMID: 29615789; PMCID: PMC5895503.
      Citations: 72     Fields:    Translation:HumansAnimalsCells
    28. Ren D, Zhu X, Kong R, Zhao Z, Sheng J, Wang J, Xu X, Liu J, Cui K, Zhang XH, Zhao H, Wong STC. Targeting Brain-Adaptive Cancer Stem Cells Prohibits Brain Metastatic Colonization of Triple-Negative Breast Cancer. Cancer Res. 2018 04 15; 78(8):2052-2064. PMID: 29567857; PMCID: PMC5899649.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    29. Zhang W, Lo HC, Zhang XH. Mapping bone marrow niches of disseminated tumor cells. Sci China Life Sci. 2017 Oct; 60(10):1125-1132. PMID: 29027156.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    30. Tan YD, Zhang XHF, Mo Q. New statistical methods for estimation of recombination fractions in F2 population. BMC Bioinformatics. 2017 Oct 03; 18(Suppl 11):404. PMID: 28984187; PMCID: PMC5629630.
      Citations: 1     Fields:    Translation:Animals
    31. Tian L, Zhang XHF, Mani SA. Effective models for antimetastatic therapies. Oncotarget. 2017 Nov 07; 8(55):93295-93296. PMID: 29212140; PMCID: PMC5706786.
      Citations:    Fields:    
    32. Wang H, Tian L, Goldstein A, Liu J, Lo HC, Sheng K, Welte T, Wong STC, Gugala Z, Stossi F, Zong C, Li Z, Mancini MA, Zhang XH. Bone-in-culture array as a platform to model early-stage bone metastases and discover anti-metastasis therapies. Nat Commun. 2017 04 21; 8:15045. PMID: 28429794; PMCID: PMC5413944.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    33. Tian L, Goldstein A, Wang H, Ching Lo H, Sun Kim I, Welte T, Sheng K, Dobrolecki LE, Zhang X, Putluri N, Phung TL, Mani SA, Stossi F, Sreekumar A, Mancini MA, Decker WK, Zong C, Lewis MT, Zhang XH. Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming. Nature. 2017 04 13; 544(7649):250-254. PMID: 28371798; PMCID: PMC5788037.
      Citations: 237     Fields:    Translation:HumansAnimalsCells
    34. Welte T, Zhang XH, Rosen JM. Repurposing Antiestrogens for Tumor Immunotherapy. Cancer Discov. 2017 01; 7(1):17-19. PMID: 28062672; PMCID: PMC5224927.
      Citations: 6     Fields:    Translation:HumansCells
    35. Kim IS, Zhang XH. One microenvironment does not fit all: heterogeneity beyond cancer cells. Cancer Metastasis Rev. 2016 12; 35(4):601-629. PMID: 27858305; PMCID: PMC5215976.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    36. Yu C, Wang H, Muscarella A, Goldstein A, Zeng HC, Bae Y, Lee BH, Zhang XH. Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis. J Vis Exp. 2016 09 26; (115). PMID: 27768029; PMCID: PMC5092070.
      Citations: 13     Fields:    Translation:HumansAnimals
    37. Welte T, Rosen JM, Zhang XH. Fatal attraction: TICs and MDSCs. Cell Cycle. 2016 10; 15(19):2545-2546. PMID: 27574951; PMCID: PMC5053568.
      Citations: 1     Fields:    Translation:Cells
    38. Welte T, Kim IS, Tian L, Gao X, Wang H, Li J, Holdman XB, Herschkowitz JI, Pond A, Xie G, Kurley S, Nguyen T, Liao L, Dobrolecki LE, Pang L, Mo Q, Edwards DP, Huang S, Xin L, Xu J, Li Y, Lewis MT, Wang T, Westbrook TF, Rosen JM, Zhang XH. Erratum: Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation. Nat Cell Biol. 2016 06 28; 18(7):822. PMID: 27350446.
      Citations: 1     Fields:    
    39. Kwon OJ, Zhang L, Wang J, Su Q, Feng Q, Zhang XH, Mani SA, Paulter R, Creighton CJ, Ittmann MM, Xin L. Notch promotes tumor metastasis in a prostate-specific Pten-null mouse model. J Clin Invest. 2016 07 01; 126(7):2626-41. PMID: 27294523; PMCID: PMC4922719.
      Citations: 29     Fields:    Translation:AnimalsCells
    40. Welte T, Kim IS, Tian L, Gao X, Wang H, Li J, Holdman XB, Herschkowitz JI, Pond A, Xie G, Kurley S, Nguyen T, Liao L, Dobrolecki LE, Pang L, Mo Q, Edwards DP, Huang S, Xin L, Xu J, Li Y, Lewis MT, Wang T, Westbrook TF, Rosen JM, Zhang XH. Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation. Nat Cell Biol. 2016 06; 18(6):632-44. PMID: 27183469; PMCID: PMC4884142.
      Citations: 98     Fields:    Translation:HumansAnimalsCells
    41. Debeb BG, Lacerda L, Anfossi S, Diagaradjane P, Chu K, Bambhroliya A, Huo L, Wei C, Larson RA, Wolfe AR, Xu W, Smith DL, Li L, Ivan C, Allen PK, Wu W, Calin GA, Krishnamurthy S, Zhang XH, Buchholz TA, Ueno NT, Reuben JM, Woodward WA. miR-141-Mediated Regulation of Brain Metastasis From Breast Cancer. J Natl Cancer Inst. 2016 08; 108(8). PMID: 27075851; PMCID: PMC5017951.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    42. Welte T, Zhang XH. Interleukin-17 Could Promote Breast Cancer Progression at Several Stages of the Disease. Mediators Inflamm. 2015; 2015:804347. PMID: 26783383; PMCID: PMC4691460.
      Citations: 24     Fields:    Translation:Humans
    43. Welte T, Yu C, Zhang XH. Retrieval of Disseminated Tumor Cells Colonizing the Bone in Murine Breast Cancer Metastasis Models. J Mammary Gland Biol Neoplasia. 2015 Dec; 20(3-4):103-8. PMID: 26490041; PMCID: PMC4863992.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    44. Holdman XB, Welte T, Rajapakshe K, Pond A, Coarfa C, Mo Q, Huang S, Hilsenbeck SG, Edwards DP, Zhang X, Rosen JM. Upregulation of EGFR signaling is correlated with tumor stroma remodeling and tumor recurrence in FGFR1-driven breast cancer. Breast Cancer Res. 2015 Nov 18; 17:141. PMID: 26581390; PMCID: PMC4652386.
      Citations: 35     Fields:    Translation:AnimalsCells
    45. Hsu TY, Simon LM, Neill NJ, Marcotte R, Sayad A, Bland CS, Echeverria GV, Sun T, Kurley SJ, Tyagi S, Karlin KL, Hartman JD, Renwick A, Scorsone K, Bernardi RJ, Skinner SO, Jain A, Orellana M, Lagisetti C, Golding I, Jung SY, Neilson JR, Zhang XH, Cooper TA, Webb TR, Neel BG, Shaw CA, Westbrook TF, Dominguez-Vida?a R. The spliceosome is a therapeutic vulnerability in MYC-driven cancer. Nature. 2015 Sep 17; 525(7569):384-8. PMID: 26331541; PMCID: PMC4831063.
      Citations: 211     Fields:    Translation:HumansAnimalsCells
    46. Zheng ZY, Tian L, Bu W, Fan C, Gao X, Wang H, Liao YH, Li Y, Lewis MT, Edwards D, Zwaka TP, Hilsenbeck SG, Medina D, Perou CM, Creighton CJ, Zhang XH, Chang EC. Wild-Type N-Ras, Overexpressed in Basal-like Breast Cancer, Promotes Tumor Formation by Inducing IL-8 Secretion via JAK2 Activation. Cell Rep. 2015 Jul 21; 12(3):511-24. PMID: 26166574; PMCID: PMC4512851.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    47. Wang H, Yu C, Zhang XH. Devil's Wake: Early-stage bone colonization by breast cancer. Mol Cell Oncol. 2016 May; 3(3):e1026526. PMID: 27314064; PMCID: PMC4909432.
    48. Suo J, Medina D, Herrera S, Zheng ZY, Jin L, Chamness GC, Contreras A, Gutierrez C, Hilsenbeck S, Umar A, Foekens JA, Hanash S, Schiff R, Zhang XH, Chang EC. Int6 reduction activates stromal fibroblasts to enhance transforming activity in breast epithelial cells. Cell Biosci. 2015; 5:10. PMID: 25774287; PMCID: PMC4359526.
      Citations: 5     
    49. Xu J, Acharya S, Sahin O, Zhang Q, Saito Y, Yao J, Wang H, Li P, Zhang L, Lowery FJ, Kuo WL, Xiao Y, Ensor J, Sahin AA, Zhang XH, Hung MC, Zhang JD, Yu D. 14-3-3? turns TGF-?'s function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2. Cancer Cell. 2015 Feb 09; 27(2):177-92. PMID: 25670079; PMCID: PMC4325275.
      Citations: 88     Fields:    Translation:HumansCells
    50. Wang H, Yu C, Gao X, Welte T, Muscarella AM, Tian L, Zhao H, Zhao Z, Du S, Tao J, Lee B, Westbrook TF, Wong ST, Jin X, Rosen JM, Osborne CK, Zhang XH. The osteogenic niche promotes early-stage bone colonization of disseminated breast cancer cells. Cancer Cell. 2015 Feb 09; 27(2):193-210. PMID: 25600338; PMCID: PMC4326554.
      Citations: 170     Fields:    Translation:HumansCells
    51. Giuliano M, Herrera S, Christiny P, Shaw C, Creighton CJ, Mitchell T, Bhat R, Zhang X, Mao S, Dobrolecki LE, Al-rawi A, Chen F, Veneziani BM, Zhang XH, Hilsenbeck SG, Contreras A, Gutierrez C, Jeselsohn RM, Rimawi MF, Osborne CK, Lewis MT, Schiff R, Trivedi MV. Circulating and disseminated tumor cells from breast cancer patient-derived xenograft-bearing mice as a novel model to study metastasis. Breast Cancer Res. 2015 Jan 09; 17:3. PMID: 25572662; PMCID: PMC4318479.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    52. Karlin KL, Mondal G, Hartman JK, Tyagi S, Kurley SJ, Bland CS, Hsu TY, Renwick A, Fang JE, Migliaccio I, Callaway C, Nair A, Dominguez-Vidana R, Nguyen DX, Osborne CK, Schiff R, Yu-Lee LY, Jung SY, Edwards DP, Hilsenbeck SG, Rosen JM, Zhang XH, Shaw CA, Couch FJ, Westbrook TF. The oncogenic STP axis promotes triple-negative breast cancer via degradation of the REST tumor suppressor. Cell Rep. 2014 Nov 20; 9(4):1318-32. PMID: 25453754; PMCID: PMC4427000.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    53. Calon A, Espinet E, Palomo-Ponce S, Tauriello DVF, Iglesias M, Sevillano M, Zhang XH, Byrom D, Riera A, Rossell D, Massague J, Sancho E, Batlle E, C?spedes MV, Nadal C, Jung P, Mangues R. Immunostaining Protocol: P-Stat3 (Xenograft and Mice). Bio Protoc. 2014 May 05; 4(9). PMID: 29104885; PMCID: PMC5669275.
    54. Valiente M, Obenauf AC, Jin X, Chen Q, Zhang XH, Lee DJ, Chaft JE, Kris MG, Huse JT, Brogi E, Massagu? J. Serpins promote cancer cell survival and vascular co-option in brain metastasis. Cell. 2014 Feb 27; 156(5):1002-16. PMID: 24581498; PMCID: PMC3988473.
      Citations: 330     Fields:    Translation:HumansAnimalsCells
    55. Zhang XH, Giuliano M, Trivedi MV, Schiff R, Osborne CK. Metastasis dormancy in estrogen receptor-positive breast cancer. Clin Cancer Res. 2013 Dec 01; 19(23):6389-97. PMID: 24298069; PMCID: PMC3878717.
      Citations: 110     Fields:    Translation:Humans
    56. Bu W, Zhang X, Dai H, Huang S, Li Y. Mammary cells with active Wnt signaling resist ErbB2-induced tumorigenesis. PLoS One. 2013; 8(11):e78720. PMID: 24265712; PMCID: PMC3827100.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    57. Zhang XH, Jin X, Malladi S, Zou Y, Wen YH, Brogi E, Smid M, Foekens JA, Massagu? J. Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma. Cell. 2013 Aug 29; 154(5):1060-1073. PMID: 23993096; PMCID: PMC3974915.
      Citations: 205     Fields:    Translation:HumansAnimalsCells
    58. Martinez J, Zhang XH. BMP/Coco antagonism as a deterministic factor of metastasis dormancy in lung. Breast Cancer Res. 2013 Jan 15; 15(1):302. PMID: 23320613; PMCID: PMC3672727.
      Citations: 4     Fields:    Translation:HumansCells
    59. Calon A, Espinet E, Palomo-Ponce S, Tauriello DV, Iglesias M, Sevillano M, Nadal C, Jung P, Zhang XH, Byrom D, Riera A, Rossell D, Sancho E, Batlle E, C?spedes MV, Mangues R, Massagu? J. Dependency of colorectal cancer on a TGF-?-driven program in stromal cells for metastasis initiation. Cancer Cell. 2012 Nov 13; 22(5):571-84. PMID: 23153532; PMCID: PMC3512565.
      Citations: 456     Fields:    Translation:HumansAnimalsCells
    60. Xi Q, Wang Z, Zaromytidou AI, Zhang XH, Chow-Tsang LF, Liu JX, Kim H, Barlas A, Manova-Todorova K, Kaartinen V, Studer L, Mark W, Patel DJ, Massagu? J. A poised chromatin platform for TGF-? access to master regulators. Cell. 2011 Dec 23; 147(7):1511-24. PMID: 22196728; PMCID: PMC3582033.
      Citations: 148     Fields:    Translation:HumansAnimalsCells
    61. Chen Q, Zhang XH, Massagu? J. Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs. Cancer Cell. 2011 Oct 18; 20(4):538-49. PMID: 22014578; PMCID: PMC3293160.
      Citations: 253     Fields:    Translation:HumansAnimalsCells
    62. Oskarsson T, Acharyya S, Zhang XH, Vanharanta S, Tavazoie SF, Morris PG, Downey RJ, Manova-Todorova K, Brogi E, Massagu? J. Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs. Nat Med. 2011 Jun 26; 17(7):867-74. PMID: 21706029; PMCID: PMC4020577.
      Citations: 425     Fields:    Translation:AnimalsCells
    63. Png KJ, Yoshida M, Zhang XH, Shu W, Lee H, Rimner A, Chan TA, Comen E, Andrade VP, Kim SW, King TA, Hudis CA, Norton L, Hicks J, Tavazoie SF, Massagu? J. MicroRNA-335 inhibits tumor reinitiation and is silenced through genetic and epigenetic mechanisms in human breast cancer. Genes Dev. 2011 Feb 01; 25(3):226-31. PMID: 21289068; PMCID: PMC3034897.
      Citations: 108     Fields:    Translation:HumansCells
    64. Kim MY, Oskarsson T, Acharyya S, Nguyen DX, Zhang XH, Norton L, Massagu? J. Tumor self-seeding by circulating cancer cells. Cell. 2009 Dec 24; 139(7):1315-26. PMID: 20064377; PMCID: PMC2810531.
      Citations: 538     Fields:    Translation:HumansAnimalsCells
    65. Zhang XH, Wang Q, Gerald W, Hudis CA, Norton L, Smid M, Foekens JA, Massagu? J. Latent bone metastasis in breast cancer tied to Src-dependent survival signals. Cancer Cell. 2009 Jul 07; 16(1):67-78. PMID: 19573813; PMCID: PMC2749247.
      Citations: 347     Fields:    Translation:HumansCells
    66. Nguyen DX, Chiang AC, Zhang XH, Kim JY, Kris MG, Ladanyi M, Gerald WL, Massagu? J. WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis. Cell. 2009 Jul 10; 138(1):51-62. PMID: 19576624; PMCID: PMC2742946.
      Citations: 305     Fields:    Translation:HumansAnimalsCells
    67. Bos PD, Zhang XH, Nadal C, Shu W, Gomis RR, Nguyen DX, Minn AJ, van de Vijver MJ, Gerald WL, Foekens JA, Massagu? J. Genes that mediate breast cancer metastasis to the brain. Nature. 2009 Jun 18; 459(7249):1005-9. PMID: 19421193; PMCID: PMC2698953.
      Citations: 857     Fields:    Translation:HumansAnimalsCells
    68. Zhang XH, Arias MA, Ke S, Chasin LA. Splicing of designer exons reveals unexpected complexity in pre-mRNA splicing. RNA. 2009 Mar; 15(3):367-76. PMID: 19155327; PMCID: PMC2657016.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    69. Yu Y, Maroney PA, Denker JA, Zhang XH, Dybkov O, Jankowsky E, Chasin LA, Nilsen TW, L?hrmann R. Dynamic regulation of alternative splicing by silencers that modulate 5' splice site competition. Cell. 2008 Dec 26; 135(7):1224-36. PMID: 19109894; PMCID: PMC2645801.
      Citations: 73     Fields:    Translation:HumansCells
    70. Padua D, Zhang XH, Wang Q, Nadal C, Gerald WL, Gomis RR, Massagu? J. TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell. 2008 Apr 04; 133(1):66-77. PMID: 18394990; PMCID: PMC2390892.
      Citations: 461     Fields:    Translation:HumansAnimalsCells
    71. Ke S, Zhang XH, Chasin LA. Positive selection acting on splicing motifs reflects compensatory evolution. Genome Res. 2008 Apr; 18(4):533-43. PMID: 18204002; PMCID: PMC2279241.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    72. Xi Q, He W, Zhang XH, Le HV, Massagu? J. Genome-wide impact of the BRG1 SWI/SNF chromatin remodeler on the transforming growth factor beta transcriptional program. J Biol Chem. 2008 Jan 11; 283(2):1146-55. PMID: 18003620; PMCID: PMC2692279.
      Citations: 60     Fields:    Translation:HumansCells
    73. Zhang XH, Chasin LA. Comparison of multiple vertebrate genomes reveals the birth and evolution of human exons. Proc Natl Acad Sci U S A. 2006 Sep 05; 103(36):13427-32. PMID: 16938881; PMCID: PMC1569180.
      Citations: 79     Fields:    Translation:HumansAnimalsCells
    74. Zhang SL, Yeromin AV, Zhang XH, Yu Y, Safrina O, Penna A, Roos J, Stauderman KA, Cahalan MD. Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity. Proc Natl Acad Sci U S A. 2006 Jun 13; 103(24):9357-62. PMID: 16751269; PMCID: PMC1482614.
      Citations: 426     Fields:    Translation:HumansAnimalsCells
    75. Zhang XH, Leslie CS, Chasin LA. Computational searches for splicing signals. Methods. 2005 Dec; 37(4):292-305. PMID: 16314258.
      Citations: 22     Fields:    Translation:HumansCells
    76. Zhang XH, Kangsamaksin T, Chao MS, Banerjee JK, Chasin LA. Exon inclusion is dependent on predictable exonic splicing enhancers. Mol Cell Biol. 2005 Aug; 25(16):7323-32. PMID: 16055740; PMCID: PMC1190244.
      Citations: 63     Fields:    Translation:HumansCells
    77. Zhang XH, Leslie CS, Chasin LA. Dichotomous splicing signals in exon flanks. Genome Res. 2005 Jun; 15(6):768-79. PMID: 15930489; PMCID: PMC1142467.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    78. Zhang XH, Chasin LA. Computational definition of sequence motifs governing constitutive exon splicing. Genes Dev. 2004 Jun 01; 18(11):1241-50. PMID: 15145827; PMCID: PMC420350.
      Citations: 233     Fields:    Translation:HumansAnimalsCells
    79. Zhang XH, Chasin LA. Latent splice sites and stop codons revisited. RNA. 2004 Jan; 10(1):5-6. PMID: 14681578; PMCID: PMC1370511.
      Citations: 2     Fields:    Translation:HumansCells
    80. Zhang XH, Heller KA, Hefter I, Leslie CS, Chasin LA. Sequence information for the splicing of human pre-mRNA identified by support vector machine classification. Genome Res. 2003 Dec; 13(12):2637-50. PMID: 14656968; PMCID: PMC403805.
      Citations: 55     Fields:    Translation:HumansCells
    81. Zhang X, Lee J, Chasin LA. The effect of nonsense codons on splicing: a genomic analysis. RNA. 2003 Jun; 9(6):637-9. PMID: 12756320; PMCID: PMC1370429.
      Citations: 9     Fields:    Translation:HumansCells
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