InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    InstitutionBaylor College of Medicine
    DepartmentBreast Center
    DivisionBreast Cancer Center

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    K99CA151293     (ZHANG, XIANG H.-F.)Sep 1, 2010 - Aug 31, 2011
    Mechanisms of Src activation and its role in latent bone metastasis of breast and
    Role: Principal Investigator

    R00CA151293     (ZHANG, XIANG H.-F.)Sep 1, 2010 - Aug 31, 2014
    Role: Principal Investigator

    R01CA183878     (ZHANG, XIANG H.-F.)Sep 1, 2014 - Aug 31, 2019
    Osteoclast-independent mechanisms of early-stage bone colonization of breast canc
    Role: Principal Investigator

    R01CA221946     (ROWLEY, DAVID R)Sep 5, 2018 - Aug 31, 2023
    Osteogenic Niche Biology in Progression and Endocrine Resistance of Bone Metastases
    Role: Co-Principal Investigator

    R01CA227904     (ZHANG, XIANG H.-F.)Sep 1, 2019 - Aug 31, 2024
    Rewired Metabolism Regulates Vessel Normalization and Immunosuppression
    Role: Principal Investigator

    R01CA251950     (ZHANG, XIANG)Jul 1, 2020 - Jun 30, 2025
    Mechanistic and therapeutic investigation of secondary metastatic seeding from breast cancer bone lesion
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Welte T, Kim IS, Tian L, Gao X, Wang H, Li J, Holdman XB, Herschkowitz JI, Pond A, Xie G, Kurley S, Nguyen T, Liao L, Dobrolecki LE, Pang L, Mo Q, Edwards DP, Huang S, Xin L, Xu J, Li Y, Lewis MT, Wang T, Westbrook TF, Rosen JM, Zhang XH. Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation. Nat Cell Biol. 2016 06; 18(6):632-44. PMID: 27183469.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    2. Debeb BG, Lacerda L, Anfossi S, Diagaradjane P, Chu K, Bambhroliya A, Huo L, Wei C, Larson RA, Wolfe AR, Xu W, Smith DL, Li L, Ivan C, Allen PK, Wu W, Calin GA, Krishnamurthy S, Zhang XH, Buchholz TA, Ueno NT, Reuben JM, Woodward WA. miR-141-Mediated Regulation of Brain Metastasis From Breast Cancer. J Natl Cancer Inst. 2016 08; 108(8). PMID: 27075851.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    3. Welte T, Zhang XH. Interleukin-17 Could Promote Breast Cancer Progression at Several Stages of the Disease. Mediators Inflamm. 2015; 2015:804347. PMID: 26783383.
      Citations: 12     Fields:    Translation:Humans
    4. Welte T, Yu C, Zhang XH. Retrieval of Disseminated Tumor Cells Colonizing the Bone in Murine Breast Cancer Metastasis Models. J Mammary Gland Biol Neoplasia. 2015 Dec; 20(3-4):103-8. PMID: 26490041.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    5. Holdman XB, Welte T, Rajapakshe K, Pond A, Coarfa C, Mo Q, Huang S, Hilsenbeck SG, Edwards DP, Zhang X, Rosen JM. Upregulation of EGFR signaling is correlated with tumor stroma remodeling and tumor recurrence in FGFR1-driven breast cancer. Breast Cancer Res. 2015 Nov 18; 17:141. PMID: 26581390.
      Citations: 21     Fields:    Translation:AnimalsCells
    6. Hsu TY, Simon LM, Neill NJ, Marcotte R, Sayad A, Bland CS, Echeverria GV, Sun T, Kurley SJ, Tyagi S, Karlin KL, Dominguez-Vidaña R, Hartman JD, Renwick A, Scorsone K, Bernardi RJ, Skinner SO, Jain A, Orellana M, Lagisetti C, Golding I, Jung SY, Neilson JR, Zhang XH, Cooper TA, Webb TR, Neel BG, Shaw CA, Westbrook TF. The spliceosome is a therapeutic vulnerability in MYC-driven cancer. Nature. 2015 Sep 17; 525(7569):384-8. PMID: 26331541.
      Citations: 122     Fields:    Translation:HumansAnimalsCells
    7. Zheng ZY, Tian L, Bu W, Fan C, Gao X, Wang H, Liao YH, Li Y, Lewis MT, Edwards D, Zwaka TP, Hilsenbeck SG, Medina D, Perou CM, Creighton CJ, Zhang XH, Chang EC. Wild-Type N-Ras, Overexpressed in Basal-like Breast Cancer, Promotes Tumor Formation by Inducing IL-8 Secretion via JAK2 Activation. Cell Rep. 2015 Jul 21; 12(3):511-24. PMID: 26166574.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    8. Suo J, Medina D, Herrera S, Zheng ZY, Jin L, Chamness GC, Contreras A, Gutierrez C, Hilsenbeck S, Umar A, Foekens JA, Hanash S, Schiff R, Zhang XH, Chang EC. Int6 reduction activates stromal fibroblasts to enhance transforming activity in breast epithelial cells. Cell Biosci. 2015; 5:10. PMID: 25774287.
    9. Xu J, Acharya S, Sahin O, Zhang Q, Saito Y, Yao J, Wang H, Li P, Zhang L, Lowery FJ, Kuo WL, Xiao Y, Ensor J, Sahin AA, Zhang XH, Hung MC, Zhang JD, Yu D. 14-3-3? turns TGF-ß's function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2. Cancer Cell. 2015 Feb 09; 27(2):177-92. PMID: 25670079.
      Citations: 50     Fields:    Translation:HumansCells
    10. Wang H, Yu C, Gao X, Welte T, Muscarella AM, Tian L, Zhao H, Zhao Z, Du S, Tao J, Lee B, Westbrook TF, Wong ST, Jin X, Rosen JM, Osborne CK, Zhang XH. The osteogenic niche promotes early-stage bone colonization of disseminated breast cancer cells. Cancer Cell. 2015 Feb 09; 27(2):193-210. PMID: 25600338.
      Citations: 105     Fields:    Translation:HumansCells
    11. Giuliano M, Herrera S, Christiny P, Shaw C, Creighton CJ, Mitchell T, Bhat R, Zhang X, Mao S, Dobrolecki LE, Al-rawi A, Chen F, Veneziani BM, Zhang XH, Hilsenbeck SG, Contreras A, Gutierrez C, Jeselsohn RM, Rimawi MF, Osborne CK, Lewis MT, Schiff R, Trivedi MV. Circulating and disseminated tumor cells from breast cancer patient-derived xenograft-bearing mice as a novel model to study metastasis. Breast Cancer Res. 2015 Jan 09; 17:3. PMID: 25572662.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    12. Karlin KL, Mondal G, Hartman JK, Tyagi S, Kurley SJ, Bland CS, Hsu TY, Renwick A, Fang JE, Migliaccio I, Callaway C, Nair A, Dominguez-Vidana R, Nguyen DX, Osborne CK, Schiff R, Yu-Lee LY, Jung SY, Edwards DP, Hilsenbeck SG, Rosen JM, Zhang XH, Shaw CA, Couch FJ, Westbrook TF. The oncogenic STP axis promotes triple-negative breast cancer via degradation of the REST tumor suppressor. Cell Rep. 2014 Nov 20; 9(4):1318-32. PMID: 25453754.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    13. Valiente M, Obenauf AC, Jin X, Chen Q, Zhang XH, Lee DJ, Chaft JE, Kris MG, Huse JT, Brogi E, Massagué J. Serpins promote cancer cell survival and vascular co-option in brain metastasis. Cell. 2014 Feb 27; 156(5):1002-16. PMID: 24581498.
      Citations: 202     Fields:    Translation:HumansAnimalsCells
    14. Zhang XH, Giuliano M, Trivedi MV, Schiff R, Osborne CK. Metastasis dormancy in estrogen receptor-positive breast cancer. Clin Cancer Res. 2013 Dec 01; 19(23):6389-97. PMID: 24298069.
      Citations: 64     Fields:    Translation:Humans
    15. Bu W, Zhang X, Dai H, Huang S, Li Y. Mammary cells with active Wnt signaling resist ErbB2-induced tumorigenesis. PLoS One. 2013; 8(11):e78720. PMID: 24265712.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    16. Zhang XH, Jin X, Malladi S, Zou Y, Wen YH, Brogi E, Smid M, Foekens JA, Massagué J. Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma. Cell. 2013 Aug 29; 154(5):1060-1073. PMID: 23993096.
      Citations: 155     Fields:    Translation:HumansAnimalsCells
    17. Martinez J, Zhang XH. BMP/Coco antagonism as a deterministic factor of metastasis dormancy in lung. Breast Cancer Res. 2013 Jan 15; 15(1):302. PMID: 23320613.
      Citations: 3     Fields:    Translation:HumansCells
    18. Calon A, Espinet E, Palomo-Ponce S, Tauriello DV, Iglesias M, Céspedes MV, Sevillano M, Nadal C, Jung P, Zhang XH, Byrom D, Riera A, Rossell D, Mangues R, Massagué J, Sancho E, Batlle E. Dependency of colorectal cancer on a TGF-ß-driven program in stromal cells for metastasis initiation. Cancer Cell. 2012 Nov 13; 22(5):571-84. PMID: 23153532.
      Citations: 272     Fields:    Translation:HumansAnimalsCells
    19. Xi Q, Wang Z, Zaromytidou AI, Zhang XH, Chow-Tsang LF, Liu JX, Kim H, Barlas A, Manova-Todorova K, Kaartinen V, Studer L, Mark W, Patel DJ, Massagué J. A poised chromatin platform for TGF-ß access to master regulators. Cell. 2011 Dec 23; 147(7):1511-24. PMID: 22196728.
      Citations: 117     Fields:    Translation:HumansAnimalsCells
    20. Chen Q, Zhang XH, Massagué J. Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs. Cancer Cell. 2011 Oct 18; 20(4):538-49. PMID: 22014578.
      Citations: 175     Fields:    Translation:HumansAnimalsCells
    21. Oskarsson T, Acharyya S, Zhang XH, Vanharanta S, Tavazoie SF, Morris PG, Downey RJ, Manova-Todorova K, Brogi E, Massagué J. Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs. Nat Med. 2011 Jun 26; 17(7):867-74. PMID: 21706029.
      Citations: 319     Fields:    Translation:AnimalsCells
    22. Png KJ, Yoshida M, Zhang XH, Shu W, Lee H, Rimner A, Chan TA, Comen E, Andrade VP, Kim SW, King TA, Hudis CA, Norton L, Hicks J, Massagué J, Tavazoie SF. MicroRNA-335 inhibits tumor reinitiation and is silenced through genetic and epigenetic mechanisms in human breast cancer. Genes Dev. 2011 Feb 01; 25(3):226-31. PMID: 21289068.
      Citations: 95     Fields:    Translation:HumansCells
    23. Kim MY, Oskarsson T, Acharyya S, Nguyen DX, Zhang XH, Norton L, Massagué J. Tumor self-seeding by circulating cancer cells. Cell. 2009 Dec 24; 139(7):1315-26. PMID: 20064377.
      Citations: 416     Fields:    Translation:HumansAnimalsCells
    24. Zhang XH, Wang Q, Gerald W, Hudis CA, Norton L, Smid M, Foekens JA, Massagué J. Latent bone metastasis in breast cancer tied to Src-dependent survival signals. Cancer Cell. 2009 Jul 07; 16(1):67-78. PMID: 19573813.
      Citations: 274     Fields:    Translation:HumansCells
    25. Nguyen DX, Chiang AC, Zhang XH, Kim JY, Kris MG, Ladanyi M, Gerald WL, Massagué J. WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis. Cell. 2009 Jul 10; 138(1):51-62. PMID: 19576624.
      Citations: 231     Fields:    Translation:HumansAnimalsCells
    26. Bos PD, Zhang XH, Nadal C, Shu W, Gomis RR, Nguyen DX, Minn AJ, van de Vijver MJ, Gerald WL, Foekens JA, Massagué J. Genes that mediate breast cancer metastasis to the brain. Nature. 2009 Jun 18; 459(7249):1005-9. PMID: 19421193.
      Citations: 647     Fields:    Translation:HumansAnimalsCells
    27. Zhang XH, Arias MA, Ke S, Chasin LA. Splicing of designer exons reveals unexpected complexity in pre-mRNA splicing. RNA. 2009 Mar; 15(3):367-76. PMID: 19155327.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    28. Yu Y, Maroney PA, Denker JA, Zhang XH, Dybkov O, Lührmann R, Jankowsky E, Chasin LA, Nilsen TW. Dynamic regulation of alternative splicing by silencers that modulate 5' splice site competition. Cell. 2008 Dec 26; 135(7):1224-36. PMID: 19109894.
      Citations: 67     Fields:    Translation:HumansCells
    29. Padua D, Zhang XH, Wang Q, Nadal C, Gerald WL, Gomis RR, Massagué J. TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell. 2008 Apr 04; 133(1):66-77. PMID: 18394990.
      Citations: 365     Fields:    Translation:HumansAnimalsCells
    30. Ke S, Zhang XH, Chasin LA. Positive selection acting on splicing motifs reflects compensatory evolution. Genome Res. 2008 Apr; 18(4):533-43. PMID: 18204002.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    31. Xi Q, He W, Zhang XH, Le HV, Massagué J. Genome-wide impact of the BRG1 SWI/SNF chromatin remodeler on the transforming growth factor beta transcriptional program. J Biol Chem. 2008 Jan 11; 283(2):1146-55. PMID: 18003620.
      Citations: 51     Fields:    Translation:HumansCells
    32. Zhang XH, Chasin LA. Comparison of multiple vertebrate genomes reveals the birth and evolution of human exons. Proc Natl Acad Sci U S A. 2006 Sep 05; 103(36):13427-32. PMID: 16938881.
      Citations: 74     Fields:    Translation:HumansAnimalsCells
    33. Zhang SL, Yeromin AV, Zhang XH, Yu Y, Safrina O, Penna A, Roos J, Stauderman KA, Cahalan MD. Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity. Proc Natl Acad Sci U S A. 2006 Jun 13; 103(24):9357-62. PMID: 16751269.
      Citations: 365     Fields:    Translation:HumansAnimalsCells
    34. Zhang XH, Leslie CS, Chasin LA. Computational searches for splicing signals. Methods. 2005 Dec; 37(4):292-305. PMID: 16314258.
      Citations: 20     Fields:    Translation:HumansCells
    35. Zhang XH, Kangsamaksin T, Chao MS, Banerjee JK, Chasin LA. Exon inclusion is dependent on predictable exonic splicing enhancers. Mol Cell Biol. 2005 Aug; 25(16):7323-32. PMID: 16055740.
      Citations: 59     Fields:    Translation:HumansCells
    36. Zhang XH, Leslie CS, Chasin LA. Dichotomous splicing signals in exon flanks. Genome Res. 2005 Jun; 15(6):768-79. PMID: 15930489.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    37. Zhang XH, Chasin LA. Computational definition of sequence motifs governing constitutive exon splicing. Genes Dev. 2004 Jun 01; 18(11):1241-50. PMID: 15145827.
      Citations: 207     Fields:    Translation:HumansAnimalsCells
    38. Zhang XH, Chasin LA. Latent splice sites and stop codons revisited. RNA. 2004 Jan; 10(1):5-6. PMID: 14681578.
      Citations: 2     Fields:    Translation:HumansCells
    39. Zhang XH, Heller KA, Hefter I, Leslie CS, Chasin LA. Sequence information for the splicing of human pre-mRNA identified by support vector machine classification. Genome Res. 2003 Dec; 13(12):2637-50. PMID: 14656968.
      Citations: 48     Fields:    Translation:HumansCells
    40. Zhang X, Lee J, Chasin LA. The effect of nonsense codons on splicing: a genomic analysis. RNA. 2003 Jun; 9(6):637-9. PMID: 12756320.
      Citations: 8     Fields:    Translation:HumansCells
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