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JOSEPH HYSER

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular Virology & Microbiology
AddressOne Baylor Plaza
Houston, TX 77030
Email
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    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    R01AI158683     (CRAWFORD, SUE ELLEN;ESTES, MARY KOLB;HYSER, JOSEPH M.)Sep 21, 2021 - Aug 31, 2026
    NIH
    Dissecting Rotavirus Viroporin and Enterotoxin Calcium Signaling Pathways
    Role: Principal Investigator
    R21AI137710     (HYSER, JOSEPH M.)Nov 16, 2018 - Oct 31, 2021
    NIH
    Enteric Calicivirus Viroporin-Mediated Calcium Signaling
    Role: Principal Investigator
    R01DK115507     (HYSER, JOSEPH M.)Jul 13, 2018 - Jun 30, 2024
    NIH
    Enteric Virus Exploitation of Store-operated and Purinergic Calcium Signaling
    Role: Principal Investigator
    R03DK110270     (HYSER, JOSEPH M.)Apr 15, 2017 - Mar 31, 2019
    NIH
    Regulation of Enteric Virus Secretory Diarrhea
    Role: Principal Investigator
    K01DK093657     (HYSER, JOSEPH M.)Sep 15, 2012 - Apr 30, 2018
    NIH
    Enteric Virus Calcium Channel Inhibitors
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Gebert JT, Scribano FJ, Engevik KA, Hyser JM. Live Calcium Imaging of Virus-Infected Human Intestinal Organoid Monolayers Using Genetically Encoded Calcium Indicators. J Vis Exp. 2024 Jan 19; (203). PMID: 38314824.
      Citations:    Fields:    Translation:Humans
    2. Scribano FJ, Engevik KA, Gebert JT, Hyser JM. Live-Cell Fluorescence Imaging for Virus-Host Interactions. Methods Mol Biol. 2024; 2751:33-46. PMID: 38265708.
      Citations:    Fields:    Translation:Cells
    3. Perry JL, Scribano FJ, Gebert JT, Engevik KA, Ellis JM, Hyser JM. Host IP3R channels are dispensable for rotavirus Ca2+ signaling but critical for intercellular Ca2+ waves that prime uninfected cells for rapid virus spread. mBio. 2024 Jan 16; 15(1):e0214523. PMID: 38112482; PMCID: PMC10790754.
      Citations:    Fields:    Translation:HumansCells
    4. Engevik KA, Scribano FJ, Gebert JT, Perry JL, Crawford SE, Hyser JM, Engevik KA, Scribano FJ, Gebert JT, Perry JL, Crawford SE, Hyser JM. Distribution of P2Y and P2X purinergic receptor expression within the intestine. Am J Physiol Gastrointest Liver Physiol. 2024 02 01; 326(2):G107-G119. PMID: 37987757.
      Citations:    Fields:    Translation:HumansCells
    5. Perry JL, Scribano FJ, Gebert JT, Engevik KA, Ellis JM, Hyser JM. The Inositol Trisphosphate Receptor (IP 3 R) is Dispensable for Rotavirus-induced Ca 2+ Signaling and Replication but Critical for Paracrine Ca 2+ Signals that Prime Uninfected Cells for Rapid Virus Spread. bioRxiv. 2023 Aug 14. PMID: 37609335; PMCID: PMC10441394.
      Citations:    
    6. Hill AA, Kim M, Zegarra-Ruiz DF, Chang LC, Norwood K, Assi? A, Wu WH, Renfroe MC, Song HW, Major AM, Samuel BS, Hyser JM, Longman RS, Diehl GE. Acute high-fat diet impairs macrophage-supported intestinal damage resolution. JCI Insight. 2023 02 08; 8(3). PMID: 36538527; PMCID: PMC9977439.
      Citations:    Fields:    Translation:AnimalsCells
    7. Goodrum F, Lakdawala S, Alwine J, Casadevall A, Lowen AC, Imperiale MJ, Atwood W, Avgousti D, Baines J, Banfield B, Banks L, Bhaduri-McIntosh S, Bhattacharya D, Blanco-Melo D, Bloom D, Boon A, Boulant S, Brandt C, Broadbent A, Brooke C, Cameron C, Campos S, Caposio P, Chan G, Cliffe A, Coffin J, Collins K, Damania B, Daugherty M, Debbink K, DeCaprio J, Dermody T, Dikeakos J, DiMaio D, Dinglasan R, Duprex WP, Dutch R, Elde N, Emerman M, Enquist L, Fane B, Fernandez-Sesma A, Flenniken M, Frappier L, Frieman M, Frueh K, Gack M, Gaglia M, Gallagher T, Galloway D, Garc?a-Sastre A, Geballe A, Glaunsinger B, Goff S, Greninger A, Hancock M, Harris E, Heaton N, Heise M, Heldwein E, Hogue B, Horner S, Hutchinson E, Hyser J, Jackson W, Kalejta R, Kamil J, Karst S, Kirchhoff F, Knipe D, Kowalik T, Lagunoff M, Laimins L, Langlois R, Lauring A, Lee B, Leib D, Liu SL, Longnecker R, Lopez C, Luftig M, Lund J, Manicassamy B, McFadden G, McIntosh M, Mehle A, Miller WA, Mohr I, Moody C, Moorman N, Moscona A, Mounce B, Munger J, M?nger K, Murphy E, Naghavi M, Nelson J, Neufeldt C, Nikolich J, O'Connor C, Ono A, Orenstein W, Ornelles D, Ou JH, Parker J, Parrish C, Pekosz A, Pellett P, Pfeiffer J, Plemper R, Polyak S, Purdy J, Pyeon D, Quinones-Mateu M, Renne R, Rice C, Schoggins J, Roller R, Russell C, Sandri-Goldin R, Sapp M, Schang L, Schmid S, Schultz-Cherry S, Semler B, Shenk T, Silvestri G, Simon V, Smith G, Smith J, Spindler K, Stanifer M, Subbarao K, Sundquist W, Suthar M, Sutton T, Tai A, Tarakanova V, tenOever B, Tibbetts S, Tompkins S, Toth Z, van Doorslaer K, Vignuzzi M, Wallace N, Walsh D, Weekes M, Weinberg J, Weitzman M, Weller S, Whelan S, White E, Williams B, Wobus C, Wong S, Yurochko A. Virology under the Microscope-a Call for Rational Discourse. J Virol. 2023 02 28; 97(2):e0008923. PMID: 36700640; PMCID: PMC9972907.
      Citations: 4     Fields:    Translation:HumansCellsPHPublic Health
    8. Goodrum F, Lakdawala S, Alwine J, Casadevall A, Lowen AC, Imperiale MJ, Atwood W, Avgousti D, Baines J, Banfield B, Banks L, Bhaduri-McIntosh S, Bhattacharya D, Blanco-Melo D, Bloom D, Boon A, Boulant S, Brandt C, Broadbent A, Brooke C, Cameron C, Campos S, Caposio P, Chan G, Cliffe A, Coffin J, Collins K, Damania B, Daugherty M, Debbink K, DeCaprio J, Dermody T, Dikeakos J, DiMaio D, Dinglasan R, Duprex WP, Dutch R, Elde N, Emerman M, Enquist L, Fane B, Fernandez-Sesma A, Flenniken M, Frappier L, Frieman M, Frueh K, Gack M, Gaglia M, Gallagher T, Galloway D, Garc?a-Sastre A, Geballe A, Glaunsinger B, Goff S, Greninger A, Hancock M, Harris E, Heaton N, Heise M, Heldwein E, Hogue B, Horner S, Hutchinson E, Hyser J, Jackson W, Kalejta R, Kamil J, Karst S, Kirchhoff F, Knipe D, Kowalik T, Lagunoff M, Laimins L, Langlois R, Lauring A, Lee B, Leib D, Liu SL, Longnecker R, Lopez C, Luftig M, Lund J, Manicassamy B, McFadden G, McIntosh M, Mehle A, Miller WA, Mohr I, Moody C, Moorman N, Moscona A, Mounce B, Munger J, M?nger K, Murphy E, Naghavi M, Nelson J, Neufeldt C, Nikolich J, O'Connor C, Ono A, Orenstein W, Ornelles D, Ou JH, Parker J, Parrish C, Pekosz A, Pellett P, Pfeiffer J, Plemper R, Polyak S, Purdy J, Pyeon D, Quinones-Mateu M, Renne R, Rice C, Schoggins J, Roller R, Russell C, Sandri-Goldin R, Sapp M, Schang L, Schmid S, Schultz-Cherry S, Semler B, Shenk T, Silvestri G, Simon V, Smith G, Smith J, Spindler K, Stanifer M, Subbarao K, Sundquist W, Suthar M, Sutton T, Tai A, Tarakanova V, tenOever B, Tibbetts S, Tompkins S, Toth Z, van Doorslaer K, Vignuzzi M, Wallace N, Walsh D, Weekes M, Weinberg J, Weitzman M, Weller S, Whelan S, White E, Williams B, Wobus C, Wong S, Yurochko A. Virology under the Microscope-a Call for Rational Discourse. mBio. 2023 02 28; 14(1):e0018823. PMID: 36700642; PMCID: PMC9973315.
      Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
    9. Goodrum F, Lakdawala S, Alwine J, Casadevall A, Lowen AC, Imperiale MJ, Atwood W, Avgousti D, Baines J, Banfield B, Banks L, Bhaduri-McIntosh S, Bhattacharya D, Blanco-Melo D, Bloom D, Boon A, Boulant S, Brandt C, Broadbent A, Brooke C, Cameron C, Campos S, Caposio P, Chan G, Cliffe A, Coffin J, Collins K, Damania B, Daugherty M, Debbink K, DeCaprio J, Dermody T, Dikeakos J, DiMaio D, Dinglasan R, Duprex WP, Dutch R, Elde N, Emerman M, Enquist L, Fane B, Fernandez-Sesma A, Flenniken M, Frappier L, Frieman M, Frueh K, Gack M, Gaglia M, Gallagher T, Galloway D, Garc?a-Sastre A, Geballe A, Glaunsinger B, Goff S, Greninger A, Hancock M, Harris E, Heaton N, Heise M, Heldwein E, Hogue B, Horner S, Hutchinson E, Hyser J, Jackson W, Kalejta R, Kamil J, Karst S, Kirchhoff F, Knipe D, Kowalik T, Lagunoff M, Laimins L, Langlois R, Lauring A, Lee B, Leib D, Liu SL, Longnecker R, Lopez C, Luftig M, Lund J, Manicassamy B, McFadden G, McIntosh M, Mehle A, Miller WA, Mohr I, Moody C, Moorman N, Moscona A, Mounce B, Munger J, M?nger K, Murphy E, Naghavi M, Nelson J, Neufeldt C, Nikolich J, O'Connor C, Ono A, Orenstein W, Ornelles D, Ou JH, Parker J, Parrish C, Pekosz A, Pellett P, Pfeiffer J, Plemper R, Polyak S, Purdy J, Pyeon D, Quinones-Mateu M, Renne R, Rice C, Schoggins J, Roller R, Russell C, Sandri-Goldin R, Sapp M, Schang L, Schmid S, Schultz-Cherry S, Semler B, Shenk T, Silvestri G, Simon V, Smith G, Smith J, Spindler K, Stanifer M, Subbarao K, Sundquist W, Suthar M, Sutton T, Tai A, Tarakanova V, tenOever B, Tibbetts S, Tompkins S, Toth Z, van Doorslaer K, Vignuzzi M, Wallace N, Walsh D, Weekes M, Weinberg J, Weitzman M, Weller S, Whelan S, White E, Williams B, Wobus C, Wong S, Yurochko A. Virology under the Microscope-a Call for Rational Discourse. mSphere. 2023 04 20; 8(2):e0003423. PMID: 36700653; PMCID: PMC10117089.
      Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
    10. Wang Y, Zhu D, Ortiz-Velez LC, Perry JL, Pennington MW, Hyser JM, Britton RA, Beeton C. A bioengineered probiotic for the oral delivery of a peptide Kv1.3 channel blocker to treat rheumatoid arthritis. Proc Natl Acad Sci U S A. 2023 01 10; 120(2):e2211977120. PMID: 36595694; PMCID: PMC9926172.
      Citations: 4     Fields:    Translation:HumansAnimals
    11. Gebert JT, Scribano F, Engevik KA, Perry JL, Hyser JM. Gastrointestinal organoids in the study of viral infections. Am J Physiol Gastrointest Liver Physiol. 2023 01 01; 324(1):G51-G59. PMID: 36414538; PMCID: PMC9799139.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    12. Shin JN, Rao L, Sha Y, Abdel Fattah E, Hyser J, Eissa NT. p38 MAPK Activity Is Required to Prevent Hyperactivation of NLRP3 Inflammasome. J Immunol. 2021 07 15; 207(2):661-670. PMID: 34193605.
      Citations:    Fields:    Translation:HumansAnimalsCells
    13. Engevik MA, Danhof HA, Ruan W, Engevik AC, Chang-Graham AL, Engevik KA, Shi Z, Zhao Y, Brand CK, Krystofiak ES, Venable S, Liu X, Hirschi KD, Hyser JM, Spinler JK, Britton RA, Versalovic J. Fusobacterium nucleatum Secretes Outer Membrane Vesicles and Promotes Intestinal Inflammation. mBio. 2021 03 02; 12(2). PMID: 33653893; PMCID: PMC8092269.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    14. Ihekweazu FD, Engevik MA, Ruan W, Shi Z, Fultz R, Engevik KA, Chang-Graham AL, Freeborn J, Park ES, Venable S, Horvath TD, Haidacher SJ, Haag AM, Goodwin A, Schady DA, Hyser JM, Spinler JK, Liu Y, Versalovic J. Bacteroides ovatus Promotes IL-22 Production and Reduces Trinitrobenzene Sulfonic Acid-Driven Colonic Inflammation. Am J Pathol. 2021 04; 191(4):704-719. PMID: 33516788; PMCID: PMC8027925.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    15. Engevik MA, Herrmann B, Ruan W, Engevik AC, Engevik KA, Ihekweazu F, Shi Z, Luck B, Chang-Graham AL, Esparza M, Venable S, Horvath TD, Haidacher SJ, Hoch KM, Haag AM, Schady DA, Hyser JM, Spinler JK, Versalovic J. Bifidobacterium dentium-derived y-glutamylcysteine suppresses ER-mediated goblet cell stress and reduces TNBS-driven colonic inflammation. Gut Microbes. 2021 Jan-Dec; 13(1):1-21. PMID: 33985416; PMCID: PMC8128206.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    16. Chang-Graham AL, Perry JL, Engevik MA, Engevik KA, Scribano FJ, Gebert JT, Danhof HA, Nelson JC, Kellen JS, Strtak AC, Sastri NP, Estes MK, Britton RA, Versalovic J, Hyser JM. Rotavirus induces intercellular calcium waves through ADP signaling. Science. 2020 11 20; 370(6519). PMID: 33214249; PMCID: PMC7957961.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    17. Engevik MA, Engevik AC, Engevik KA, Auchtung JM, Chang-Graham AL, Ruan W, Luna RA, Hyser JM, Spinler JK, Versalovic J. Mucin-Degrading Microbes Release Monosaccharides That Chemoattract Clostridioides difficile and Facilitate Colonization of the Human Intestinal Mucus Layer. ACS Infect Dis. 2021 05 14; 7(5):1126-1142. PMID: 33176423; PMCID: PMC8110611.
      Citations: 6     Fields:    Translation:HumansCells
    18. Engevik MA, Danhof HA, Shrestha R, Chang-Graham AL, Hyser JM, Haag AM, Mohammad MA, Britton RA, Versalovic J, Sorg JA, Spinler JK. Reuterin disrupts Clostridioides difficile metabolism and pathogenicity through reactive oxygen species generation. Gut Microbes. 2020 11 09; 12(1):1788898. PMID: 32804011; PMCID: PMC7524292.
      Citations: 7     Fields:    Translation:HumansCells
    19. Rajan A, Robertson MJ, Carter HE, Poole NM, Clark JR, Green SI, Criss ZK, Zhao B, Karandikar U, Xing Y, Jain N, Wilson RL, Bai F, Hyser JM, Petrosino J, Shroyer NF, Blutt SE, Coarfa C, Song X, Prasad BV, Amieva MR, Grande-Allen J, Estes MK, Okhuysen PC, Maresso AW, Margalef-Catal? M. Enteroaggregative E. coli Adherence to Human Heparan Sulfate Proteoglycans Drives Segment and Host Specific Responses to Infection. PLoS Pathog. 2020 09; 16(9):e1008851. PMID: 32986782; PMCID: PMC7553275.
      Citations: 12     Fields:    Translation:HumansCells
    20. Engevik MA, Luck B, Visuthranukul C, Ihekweazu FD, Engevik AC, Shi Z, Danhof HA, Chang-Graham AL, Hall A, Endres BT, Haidacher SJ, Horvath TD, Haag AM, Devaraj S, Garey KW, Britton RA, Hyser JM, Shroyer NF, Versalovic J. Human-Derived Bifidobacterium dentium Modulates the Mammalian Serotonergic System and Gut-Brain Axis. Cell Mol Gastroenterol Hepatol. 2021; 11(1):221-248. PMID: 32795610; PMCID: PMC7683275.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    21. Ruan W, Engevik MA, Chang-Graham AL, Danhof HA, Goodwin A, Engevik KA, Shi Z, Hall A, Rienzi SCD, Venable S, Britton RA, Hyser J, Versalovic J. Enhancing responsiveness of human jejunal enteroids to host and microbial stimuli. J Physiol. 2020 08; 598(15):3085-3105. PMID: 32428244; PMCID: PMC7674265.
      Citations: 7     Fields:    Translation:HumansCells
    22. Engevik MA, Banks LD, Engevik KA, Chang-Graham AL, Perry JL, Hutchinson DS, Ajami NJ, Petrosino JF, Hyser JM. Rotavirus infection induces glycan availability to promote ileum-specific changes in the microbiome aiding rotavirus virulence. Gut Microbes. 2020 09 02; 11(5):1324-1347. PMID: 32404017; PMCID: PMC7524290.
      Citations: 18     Fields:    Translation:AnimalsCells
    23. Engevik MA, Danhof HA, Chang-Graham AL, Spinler JK, Engevik KA, Herrmann B, Endres BT, Garey KW, Hyser JM, Britton RA, Versalovic J. Human intestinal enteroids as a model of Clostridioides difficile-induced enteritis. Am J Physiol Gastrointest Liver Physiol. 2020 05 01; 318(5):G870-G888. PMID: 32223302; PMCID: PMC7272722.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    24. Minor MM, Hollinger FB, McNees AL, Jung SY, Jain A, Hyser JM, Bissig KD, Slagle BL. Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex. Cells. 2020 03 30; 9(4). PMID: 32235678; PMCID: PMC7226812.
      Citations: 9     Fields:    Translation:HumansCells
    25. Tomaro-Duchesneau C, LeValley SL, Roeth D, Sun L, Horrigan FT, Kalkum M, Hyser JM, Britton RA. Discovery of a bacterial peptide as a modulator of GLP-1 and metabolic disease. Sci Rep. 2020 03 18; 10(1):4922. PMID: 32188864; PMCID: PMC7080827.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    26. Philip AA, Perry JL, Eaton HE, Shmulevitz M, Hyser JM, Patton JT. Generation of Recombinant Rotavirus Expressing NSP3-UnaG Fusion Protein by a Simplified Reverse Genetics System. J Virol. 2019 12 15; 93(24). PMID: 31597761; PMCID: PMC6880180.
      Citations: 12     Fields:    Translation:AnimalsCells
    27. Strtak AC, Perry JL, Sharp MN, Chang-Graham AL, Farkas T, Hyser JM. Recovirus NS1-2 Has Viroporin Activity That Induces Aberrant Cellular Calcium Signaling To Facilitate Virus Replication. mSphere. 2019 09 18; 4(5). PMID: 31533997; PMCID: PMC6751491.
      Citations: 7     Fields:    Translation:AnimalsCells
    28. Chang-Graham AL, Perry JL, Strtak AC, Ramachandran NK, Criglar JM, Philip AA, Patton JT, Estes MK, Hyser JM. Rotavirus Calcium Dysregulation Manifests as Dynamic Calcium Signaling in the Cytoplasm and Endoplasmic Reticulum. Sci Rep. 2019 07 25; 9(1):10822. PMID: 31346185; PMCID: PMC6658527.
      Citations: 22     Fields:    Translation:HumansCells
    29. Engevik MA, Luk B, Chang-Graham AL, Hall A, Herrmann B, Ruan W, Endres BT, Shi Z, Garey KW, Hyser JM, Versalovic J. Bifidobacterium dentium Fortifies the Intestinal Mucus Layer via Autophagy and Calcium Signaling Pathways. mBio. 2019 06 18; 10(3). PMID: 31213556; PMCID: PMC6581858.
      Citations: 43     Fields:    Translation:AnimalsCells
    30. Chang-Graham AL, Danhof HA, Engevik MA, Tomaro-Duchesneau C, Karandikar UC, Estes MK, Versalovic J, Britton RA, Hyser JM. Human Intestinal Enteroids With Inducible Neurogenin-3 Expression as a Novel Model of Gut Hormone Secretion. Cell Mol Gastroenterol Hepatol. 2019; 8(2):209-229. PMID: 31029854; PMCID: PMC6664234.
      Citations: 33     Fields:    Translation:HumansCells
    31. Pham T, Perry JL, Dosey TL, Delcour AH, Hyser JM. The Rotavirus NSP4 Viroporin Domain is a Calcium-conducting Ion Channel. Sci Rep. 2017 03 03; 7:43487. PMID: 28256607; PMCID: PMC5335360.
      Citations: 23     Fields:    Translation:Cells
    32. Hyser JM, Estes MK. Pathophysiological Consequences of Calcium-Conducting Viroporins. Annu Rev Virol. 2015 Nov; 2(1):473-96. PMID: 26958925; PMCID: PMC6538290.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    33. Perry JL, Ramachandran NK, Utama B, Hyser JM. Use of genetically-encoded calcium indicators for live cell calcium imaging and localization in virus-infected cells. Methods. 2015 Nov 15; 90:28-38. PMID: 26344758; PMCID: PMC4655165.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    34. Sastri NP, Viskovska M, Hyser JM, Tanner MR, Horton LB, Sankaran B, Prasad BV, Estes MK. Structural plasticity of the coiled-coil domain of rotavirus NSP4. J Virol. 2014 Dec; 88(23):13602-12. PMID: 25231315; PMCID: PMC4248954.
      Citations: 11     Fields:    Translation:Cells
    35. Foulke-Abel J, In J, Kovbasnjuk O, Zachos NC, Ettayebi K, Blutt SE, Hyser JM, Zeng XL, Crawford SE, Broughman JR, Estes MK, Donowitz M. Human enteroids as an ex-vivo model of host-pathogen interactions in the gastrointestinal tract. Exp Biol Med (Maywood). 2014 Sep; 239(9):1124-34. PMID: 24719375; PMCID: PMC4380516.
      Citations: 102     Fields:    Translation:HumansCells
    36. Kovbasnjuk O, Zachos NC, In J, Foulke-Abel J, Ettayebi K, Hyser JM, Broughman JR, Zeng XL, Middendorp S, de Jonge HR, Estes MK, Donowitz M. Human enteroids: preclinical models of non-inflammatory diarrhea. Stem Cell Res Ther. 2013; 4 Suppl 1:S3. PMID: 24564938; PMCID: PMC4029787.
      Citations: 28     Fields:    Translation:HumansCells
    37. Criglar JM, Hu L, Crawford SE, Hyser JM, Broughman JR, Prasad BV, Estes MK. A novel form of rotavirus NSP2 and phosphorylation-dependent NSP2-NSP5 interactions are associated with viroplasm assembly. J Virol. 2014 Jan; 88(2):786-98. PMID: 24198401; PMCID: PMC3911676.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    38. Hyser JM, Utama B, Crawford SE, Broughman JR, Estes MK. Activation of the endoplasmic reticulum calcium sensor STIM1 and store-operated calcium entry by rotavirus requires NSP4 viroporin activity. J Virol. 2013 Dec; 87(24):13579-88. PMID: 24109210; PMCID: PMC3838237.
      Citations: 29     Fields:    Translation:HumansCells
    39. Crawford SE, Hyser JM, Utama B, Estes MK. Autophagy hijacked through viroporin-activated calcium/calmodulin-dependent kinase kinase-? signaling is required for rotavirus replication. Proc Natl Acad Sci U S A. 2012 Dec 11; 109(50):E3405-13. PMID: 23184977; PMCID: PMC3528557.
      Citations: 82     Fields:    Translation:AnimalsCells
    40. Hu L, Crawford SE, Hyser JM, Estes MK, Prasad BV. Rotavirus non-structural proteins: structure and function. Curr Opin Virol. 2012 Aug; 2(4):380-8. PMID: 22789743; PMCID: PMC3422752.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    41. Hyser JM, Utama B, Crawford SE, Estes MK. Genetic divergence of rotavirus nonstructural protein 4 results in distinct serogroup-specific viroporin activity and intracellular punctate structure morphologies. J Virol. 2012 May; 86(9):4921-34. PMID: 22357281; PMCID: PMC3347366.
      Citations: 12     Fields:    Translation:AnimalsCells
    42. Hodgson AJ, Hyser JM, Keasler VV, Cang Y, Slagle BL. Hepatitis B virus regulatory HBx protein binding to DDB1 is required but is not sufficient for maximal HBV replication. Virology. 2012 Apr 25; 426(1):73-82. PMID: 22342275; PMCID: PMC3294142.
      Citations: 36     Fields:    Translation:HumansCells
    43. Hyser JM, Collinson-Pautz MR, Utama B, Estes MK. Rotavirus disrupts calcium homeostasis by NSP4 viroporin activity. mBio. 2010 Nov 30; 1(5). PMID: 21151776; PMCID: PMC2999940.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    44. Hyser JM, Estes MK. Rotavirus vaccines and pathogenesis: 2008. Curr Opin Gastroenterol. 2009 Jan; 25(1):36-43. PMID: 19114772; PMCID: PMC2673536.
      Citations: 13     Fields:    Translation:HumansCellsPHPublic Health
    45. Seo NS, Zeng CQ, Hyser JM, Utama B, Crawford SE, Kim KJ, Estes MK, H??k M. Integrins alpha1beta1 and alpha2beta1 are receptors for the rotavirus enterotoxin. Proc Natl Acad Sci U S A. 2008 Jul 01; 105(26):8811-8. PMID: 18587047; PMCID: PMC3021436.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    46. Hyser JM, Zeng CQ, Beharry Z, Palzkill T, Estes MK. Epitope mapping and use of epitope-specific antisera to characterize the VP5* binding site in rotavirus SA11 NSP4. Virology. 2008 Mar 30; 373(1):211-28. PMID: 18164740; PMCID: PMC2377065.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    47. Crawford SE, Patel DG, Cheng E, Berkova Z, Hyser JM, Ciarlet M, Finegold MJ, Conner ME, Estes MK. Rotavirus viremia and extraintestinal viral infection in the neonatal rat model. J Virol. 2006 May; 80(10):4820-32. PMID: 16641274; PMCID: PMC1472071.
      Citations: 56     Fields:    Translation:AnimalsCells
    48. Ciarlet M, Hyser JM, Estes MK. Sequence analysis of the VP4, VP6, VP7, and NSP4 gene products of the bovine rotavirus WC3. Virus Genes. 2002 Mar; 24(2):107-18. PMID: 12018701.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
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