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JOSEPH MICHAEL HYSER

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular Virology & Microbiology
DivisionMolecular Virology & Microbiology
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    Other Positions
    TitleAssistant Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular Physiology & Biophysics
    DivisionMolecular Physiology & Biophysics


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    K01DK093657     (HYSER, JOSEPH M.)Sep 15, 2012 - Apr 30, 2017
    NIH/NIDDK
    Enteric Virus Calcium Channel Inhibitors
    Role: Principal Investigator

    R03DK110270     (HYSER, JOSEPH M.)Apr 15, 2017 - Mar 31, 2019
    NIH/NIDDK
    Regulation of Enteric Virus Secretory Diarrhea
    Role: Principal Investigator

    R01DK115507     (HYSER, JOSEPH M.)Jul 13, 2018 - Jun 30, 2023
    NIH/NIDDK
    Enteric Virus Exploitation of Store-operated and Purinergic Calcium Signaling
    Role: Principal Investigator

    R21AI137710     (HYSER, JOSEPH M.)Nov 16, 2018 - Oct 31, 2020
    NIH/NIAID
    Enteric Calicivirus Viroporin-Mediated Calcium Signaling
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Chang-Graham AL, Danhof HA, Engevik MA, Tomaro-Duchesneau C, Karandikar UC, Estes MK, Versalovic J, Britton RA, Hyser JM. Human Intestinal Enteroids With Inducible Neurogenin-3 Expression as a Novel Model of Gut Hormone Secretion. Cell Mol Gastroenterol Hepatol. 2019 Apr 25. PMID: 31029854.
      View in: PubMed
    2. Pham T, Perry JL, Dosey TL, Delcour AH, Hyser JM. The Rotavirus NSP4 Viroporin Domain is a Calcium-conducting Ion Channel. Sci Rep. 2017 03 03; 7:43487. PMID: 28256607.
      View in: PubMed
    3. Hyser JM, Estes MK. Pathophysiological Consequences of Calcium-Conducting Viroporins. Annu Rev Virol. 2015 Nov; 2(1):473-96. PMID: 26958925.
      View in: PubMed
    4. Perry JL, Ramachandran NK, Utama B, Hyser JM. Use of genetically-encoded calcium indicators for live cell calcium imaging and localization in virus-infected cells. Methods. 2015 Nov 15; 90:28-38. PMID: 26344758.
      View in: PubMed
    5. Sastri NP, Viskovska M, Hyser JM, Tanner MR, Horton LB, Sankaran B, Prasad BV, Estes MK. Structural plasticity of the coiled-coil domain of rotavirus NSP4. J Virol. 2014 Dec; 88(23):13602-12. PMID: 25231315.
      View in: PubMed
    6. Foulke-Abel J, In J, Kovbasnjuk O, Zachos NC, Ettayebi K, Blutt SE, Hyser JM, Zeng XL, Crawford SE, Broughman JR, Estes MK, Donowitz M. Human enteroids as an ex-vivo model of host-pathogen interactions in the gastrointestinal tract. Exp Biol Med (Maywood). 2014 Sep; 239(9):1124-34. PMID: 24719375.
      View in: PubMed
    7. Kovbasnjuk O, Zachos NC, In J, Foulke-Abel J, Ettayebi K, Hyser JM, Broughman JR, Zeng XL, Middendorp S, de Jonge HR, Estes MK, Donowitz M. Human enteroids: preclinical models of non-inflammatory diarrhea. Stem Cell Res Ther. 2013; 4 Suppl 1:S3. PMID: 24564938.
      View in: PubMed
    8. Criglar JM, Hu L, Crawford SE, Hyser JM, Broughman JR, Prasad BV, Estes MK. A novel form of rotavirus NSP2 and phosphorylation-dependent NSP2-NSP5 interactions are associated with viroplasm assembly. J Virol. 2014 Jan; 88(2):786-98. PMID: 24198401.
      View in: PubMed
    9. Hyser JM, Utama B, Crawford SE, Broughman JR, Estes MK. Activation of the endoplasmic reticulum calcium sensor STIM1 and store-operated calcium entry by rotavirus requires NSP4 viroporin activity. J Virol. 2013 Dec; 87(24):13579-88. PMID: 24109210.
      View in: PubMed
    10. Crawford SE, Hyser JM, Utama B, Estes MK. Autophagy hijacked through viroporin-activated calcium/calmodulin-dependent kinase kinase-ß signaling is required for rotavirus replication. Proc Natl Acad Sci U S A. 2012 Dec 11; 109(50):E3405-13. PMID: 23184977.
      View in: PubMed
    11. Hu L, Crawford SE, Hyser JM, Estes MK, Prasad BV. Rotavirus non-structural proteins: structure and function. Curr Opin Virol. 2012 Aug; 2(4):380-8. PMID: 22789743.
      View in: PubMed
    12. Hyser JM, Utama B, Crawford SE, Estes MK. Genetic divergence of rotavirus nonstructural protein 4 results in distinct serogroup-specific viroporin activity and intracellular punctate structure morphologies. J Virol. 2012 May; 86(9):4921-34. PMID: 22357281.
      View in: PubMed
    13. Hodgson AJ, Hyser JM, Keasler VV, Cang Y, Slagle BL. Hepatitis B virus regulatory HBx protein binding to DDB1 is required but is not sufficient for maximal HBV replication. Virology. 2012 Apr 25; 426(1):73-82. PMID: 22342275.
      View in: PubMed
    14. Hyser JM, Collinson-Pautz MR, Utama B, Estes MK. Rotavirus disrupts calcium homeostasis by NSP4 viroporin activity. MBio. 2010 Nov 30; 1(5). PMID: 21151776.
      View in: PubMed
    15. Hyser JM, Estes MK. Rotavirus vaccines and pathogenesis: 2008. Curr Opin Gastroenterol. 2009 Jan; 25(1):36-43. PMID: 19114772.
      View in: PubMed
    16. Seo NS, Zeng CQ, Hyser JM, Utama B, Crawford SE, Kim KJ, Höök M, Estes MK. Integrins alpha1beta1 and alpha2beta1 are receptors for the rotavirus enterotoxin. Proc Natl Acad Sci U S A. 2008 Jul 01; 105(26):8811-8. PMID: 18587047.
      View in: PubMed
    17. Hyser JM, Zeng CQ, Beharry Z, Palzkill T, Estes MK. Epitope mapping and use of epitope-specific antisera to characterize the VP5* binding site in rotavirus SA11 NSP4. Virology. 2008 Mar 30; 373(1):211-28. PMID: 18164740.
      View in: PubMed
    18. Crawford SE, Patel DG, Cheng E, Berkova Z, Hyser JM, Ciarlet M, Finegold MJ, Conner ME, Estes MK. Rotavirus viremia and extraintestinal viral infection in the neonatal rat model. J Virol. 2006 May; 80(10):4820-32. PMID: 16641274.
      View in: PubMed
    19. Ciarlet M, Hyser JM, Estes MK. Sequence analysis of the VP4, VP6, VP7, and NSP4 gene products of the bovine rotavirus WC3. Virus Genes. 2002 Mar; 24(2):107-18. PMID: 12018701.
      View in: PubMed
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