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David D Moore

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
DivisionMolecular & Cellular Biology
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Medicine
    DivisionMedicine-Endocrinology

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Human Genetics
    DivisionMolecular & Human Genetics


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    R01DK043382     (MOORE, DAVID D)Aug 1, 1991 - Jul 31, 2002
    NIH/NIDDK
    BIOCHEMISTRY AND GENETICS OF THYROID HORMONE RECEPTORS
    Role: Principal Investigator

    T32DK007696     (MOORE, DAVID D)Sep 5, 1993 - Aug 31, 2013
    NIH/NIDDK
    Training Program in Molecular Endocrinology
    Role: Principal Investigator

    R01DK046546     (MOORE, DAVID D)Feb 1, 1995 - Aug 31, 2015
    NIH/NIDDK
    Functions of the Nuclear Receptor CAR
    Role: Principal Investigator

    R01DK053366     (MOORE, DAVID D)Apr 1, 1998 - Mar 31, 2007
    NIH/NIDDK
    Function of The Bile Acid Receptor FXR
    Role: Principal Investigator

    R13DK054265     (MOORE, DAVID D)Jul 22, 1998 - Jul 21, 1999
    NIH/NIDDK
    29TH GORDON CONFERENCE ON HORMONE ACTION
    Role: Principal Investigator

    P01DK057743     (MOORE, DAVID D)Jun 1, 2000 - May 31, 2005
    NIH/NIDDK
    ORPHAN RECEPTORS IN ORGANOGENESIS
    Role: Principal Investigator

    R01DK068804     (MOORE, DAVID D)Apr 1, 2005 - Mar 31, 2010
    NIH/NIDDK
    Functions of the Nuclear Receptor SHP
    Role: Principal Investigator

    R01DK083572     (MOORE, DAVID D)Jul 20, 2009 - Jun 30, 2011
    NIH/NIDDK
    Function of the Nuclear Receptor LRH-1
    Role: Principal Investigator

    R13DK117645     (MOORE, DAVID D)Jun 10, 2018 - Jun 9, 2019
    NIH/NIDDK
    FASEB SRC on Fundamental Biology and Pathophysiology of the Liver
    Role: Principal Investigator

    R01CA230848     (FU, LONING NONE)Sep 18, 2018 - Aug 31, 2023
    NIH/NCI
    (PQ6)Nuclear receptor mechanisms in circadian disruption induced hepatocarcinogenesis
    Role: Co-Principal Investigator

    R01CA238988     (FU, LONING NONE)Sep 1, 2019 - Aug 31, 2024
    NIH/NCI
    Sympathetic circadian dysfunction in obesity-related hepatocarcinogenesis
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wooton-Kee CR, Robertson M, Zhou Y, Dong B, Sun Z, Kim KH, Liu H, Xu Y, Putluri N, Saha P, Coarfa C, Moore DD, Nuotio-Antar AM. Metabolic dysregulation in the Atp7b-/- Wilson's disease mouse model. Proc Natl Acad Sci U S A. 2020 Jan 10. PMID: 31924743.
      View in: PubMed
    2. Dong B, Zhou Y, Wang W, Scott J, Kim KH, Sun Z, Guo Q, Lu Y, Gonzales NM, Wu H, Hartig S, York RB, Yang F, Moore DD. Vitamin D receptor activation in liver macrophages ameliorates hepatic inflammation, steatosis, and insulin resistance in mice. Hepatology. 2019 Sep 11. PMID: 31506976.
      View in: PubMed
    3. Mays SG, Flynn AR, Cornelison JL, Okafor CD, Wang H, Wang G, Huang X, Donaldson HN, Millings EJ, Polavarapu R, Moore DD, Calvert JW, Jui NT, Ortlund EA. Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design. J Med Chem. 2019 Dec 26; 62(24):11022-11034. PMID: 31419141.
      View in: PubMed
    4. Zhou Y, Dong B, Kim KH, Choi S, Sun Z, Wu N, Wu Y, Scott J, Moore DD. Vitamin D Receptor Activation in Liver Macrophages Protects Against Hepatic Endoplasmic Reticulum Stress in Mice. Hepatology. 2019 Aug 05. PMID: 31381163.
      View in: PubMed
    5. Choi S, Dong B, Lin CJ, Heo MJ, Kim KH, Sun Z, Wagner M, Putluri N, Suh JM, Wang MC, Moore DD. Methyl-Sensing Nuclear Receptor Liver Receptor Homolog-1 Regulates Mitochondrial Function in Mouse Hepatocytes. Hepatology. 2019 Jul 29. PMID: 31355949.
      View in: PubMed
    6. Wang W, Shen T, Dong B, Creighton CJ, Meng Y, Zhou W, Shi Q, Zhou H, Zhang Y, Moore DD, Yang F. MAPK4 overexpression promotes tumor progression via noncanonical activation of AKT/mTOR signaling. J Clin Invest. 2019 Mar 01; 129(3):1015-1029. PMID: 30688659.
      View in: PubMed
    7. Kim KH, Choi JM, Li F, Dong B, Wooton-Kee CR, Arizpe A, Anakk S, Jung SY, Hartig SM, Moore DD. Constitutive Androstane Receptor Differentially Regulates Bile Acid Homeostasis in Mouse Models of Intrahepatic Cholestasis. Hepatol Commun. 2019 Jan; 3(1):147-159. PMID: 30620001.
      View in: PubMed
    8. Bayrer JR, Wang H, Nattiv R, Suzawa M, Escusa HS, Fletterick RJ, Klein OD, Moore DD, Ingraham HA. LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival. Nat Commun. 2018 10 10; 9(1):4055. PMID: 30305617.
      View in: PubMed
    9. Pankowicz FP, Barzi M, Kim KH, Legras X, Martins CS, Wooton-Kee CR, Lagor WR, Marini JC, Elsea SH, Bissig-Choisat B, Moore DD, Bissig KD. Rapid Disruption of Genes Specifically in Livers of Mice Using Multiplex CRISPR/Cas9 Editing. Gastroenterology. 2018 12; 155(6):1967-1970.e6. PMID: 30170115.
      View in: PubMed
    10. Eblimit Z, Thevananther S, Karpen SJ, Taegtmeyer H, Moore DD, Adorini L, Penny DJ, Desai MS. TGR5 activation induces cytoprotective changes in the heart and improves myocardial adaptability to physiologic, inotropic, and pressure-induced stress in mice. Cardiovasc Ther. 2018 Oct; 36(5):e12462. PMID: 30070769.
      View in: PubMed
    11. Yim SY, Shim JJ, Shin JH, Jeong YS, Kang SH, Kim SB, Eun YG, Lee DJ, Conner EA, Factor VM, Moore DD, Johnson RL, Thorgeirsson SS, Lee JS. Integrated Genomic Comparison of Mouse Models Reveals Their Clinical Resemblance to Human Liver Cancer. Mol Cancer Res. 2018 11; 16(11):1713-1723. PMID: 30082483.
      View in: PubMed
    12. Koh EH, Chernis N, Saha PK, Xiao L, Bader DA, Zhu B, Rajapakshe K, Hamilton MP, Liu X, Perera D, Chen X, York B, Trauner M, Coarfa C, Bajaj M, Moore DD, Deng T, McGuire SE, Hartig SM. miR-30a Remodels Subcutaneous Adipose Tissue Inflammation to Improve Insulin Sensitivity in Obesity. Diabetes. 2018 12; 67(12):2541-2553. PMID: 30002134.
      View in: PubMed
    13. Kim KH, Choi JM, Li F, Arizpe A, Wooton-Kee CR, Anakk S, Jung SY, Finegold MJ, Moore DD. Xenobiotic Nuclear Receptor Signaling Determines Molecular Pathogenesis of Progressive Familial Intrahepatic Cholestasis. Endocrinology. 2018 06 01; 159(6):2435-2446. PMID: 29718219.
      View in: PubMed
    14. Duerrschmid C, He Y, Wang C, Li C, Bournat JC, Romere C, Saha PK, Lee ME, Phillips KJ, Jain M, Jia P, Zhao Z, Farias M, Wu Q, Milewicz DM, Sutton VR, Moore DD, Butte NF, Krashes MJ, Xu Y, Chopra AR. Asprosin is a centrally acting orexigenic hormone. Nat Med. 2017 Dec; 23(12):1444-1453. PMID: 29106398.
      View in: PubMed
    15. Kim KH, Choi S, Zhou Y, Kim EY, Lee JM, Saha PK, Anakk S, Moore DD. Hepatic FXR/SHP axis modulates systemic glucose and fatty acid homeostasis in aged mice. Hepatology. 2017 08; 66(2):498-509. PMID: 28378930.
      View in: PubMed
    16. Wang W, Meng Y, Dong B, Dong J, Ittmann MM, Creighton CJ, Lu Y, Zhang H, Shen T, Wang J, Rowley DR, Li Y, Chen F, Moore DD, Yang F. A Versatile Tumor Gene Deletion System Reveals a Crucial Role for FGFR1 in Breast Cancer Metastasis. Neoplasia. 2017 May; 19(5):421-428. PMID: 28433771.
      View in: PubMed
    17. Kumar R, Mota LC, Litoff EJ, Rooney JP, Boswell WT, Courter E, Henderson CM, Hernandez JP, Corton JC, Moore DD, Baldwin WS. Compensatory changes in CYP expression in three different toxicology mouse models: CAR-null, Cyp3a-null, and Cyp2b9/10/13-null mice. PLoS One. 2017; 12(3):e0174355. PMID: 28350814.
      View in: PubMed
    18. Preidis GA, Kim KH, Moore DD. Nutrient-sensing nuclear receptors PPARa and FXR control liver energy balance. J Clin Invest. 2017 Apr 03; 127(4):1193-1201. PMID: 28287408.
      View in: PubMed
    19. Kim KH, Moore DD. Regulation of Liver Energy Balance by the Nuclear Receptors Farnesoid X Receptor and Peroxisome Proliferator Activated Receptor a. Dig Dis. 2017; 35(3):203-209. PMID: 28249296.
      View in: PubMed
    20. Desai MS, Mathur B, Eblimit Z, Vasquez H, Taegtmeyer H, Karpen SJ, Penny DJ, Moore DD, Anakk S. Bile acid excess induces cardiomyopathy and metabolic dysfunctions in the heart. Hepatology. 2017 01; 65(1):189-201. PMID: 27774647.
      View in: PubMed
    21. Kettner NM, Voicu H, Finegold MJ, Coarfa C, Sreekumar A, Putluri N, Katchy CA, Lee C, Moore DD, Fu L. Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis. Cancer Cell. 2016 Dec 12; 30(6):909-924. PMID: 27889186.
      View in: PubMed
    22. Wu N, Kim KH, Zhou Y, Lee JM, Kettner NM, Mamrosh JL, Choi S, Fu L, Moore DD. Small Heterodimer Partner (NR0B2) Coordinates Nutrient Signaling and the Circadian Clock in Mice. Mol Endocrinol. 2016 Sep; 30(9):988-95. PMID: 27427832.
      View in: PubMed
    23. Kim KH, Lee JM, Zhou Y, Harpavat S, Moore DD. Glucocorticoids Have Opposing Effects on Liver Fibrosis in Hepatic Stellate and Immune Cells. Mol Endocrinol. 2016 Aug; 30(8):905-16. PMID: 27355192.
      View in: PubMed
    24. Sisley SR, Arble DM, Chambers AP, Gutierrez-Aguilar R, He Y, Xu Y, Gardner D, Moore DD, Seeley RJ, Sandoval DA. Hypothalamic Vitamin D Improves Glucose Homeostasis and Reduces Weight. Diabetes. 2016 09; 65(9):2732-41. PMID: 27217488.
      View in: PubMed
    25. Romere C, Duerrschmid C, Bournat J, Constable P, Jain M, Xia F, Saha PK, Del Solar M, Zhu B, York B, Sarkar P, Rendon DA, Gaber MW, LeMaire SA, Coselli JS, Milewicz DM, Sutton VR, Butte NF, Moore DD, Chopra AR. Asprosin, a Fasting-Induced Glucogenic Protein Hormone. Cell. 2016 Apr 21; 165(3):566-79. PMID: 27087445.
      View in: PubMed
    26. Gomez-Ospina N, Potter CJ, Xiao R, Manickam K, Kim MS, Kim KH, Shneider BL, Picarsic JL, Jacobson TA, Zhang J, He W, Liu P, Knisely AS, Finegold MJ, Muzny DM, Boerwinkle E, Lupski JR, Plon SE, Gibbs RA, Eng CM, Yang Y, Washington GC, Porteus MH, Berquist WE, Kambham N, Singh RJ, Xia F, Enns GM, Moore DD. Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis. Nat Commun. 2016 Feb 18; 7:10713. PMID: 26888176.
      View in: PubMed
    27. Ahn HY, Kim HH, Kim YA, Kim M, Ohn JH, Chung SS, Lee YK, Park DJ, Park KS, Moore DD, Park YJ. Thyroid Hormone Regulates the mRNA Expression of Small Heterodimer Partner through Liver Receptor Homolog-1. Endocrinol Metab (Seoul). 2015 Dec; 30(4):584-92. PMID: 26485468.
      View in: PubMed
    28. Wagner M, Choi S, Panzitt K, Mamrosh JL, Lee JM, Zaufel A, Xiao R, Wooton-Kee R, Ståhlman M, Newgard CB, Borén J, Moore DD. Liver receptor homolog-1 is a critical determinant of methyl-pool metabolism. Hepatology. 2016 Jan; 63(1):95-106. PMID: 26267291.
      View in: PubMed
    29. Wooton-Kee CR, Jain AK, Wagner M, Grusak MA, Finegold MJ, Lutsenko S, Moore DD. Elevated copper impairs hepatic nuclear receptor function in Wilson's disease. J Clin Invest. 2015 Sep; 125(9):3449-60. PMID: 26241054.
      View in: PubMed
    30. Mamrosh JL, Lee JM, Wagner M, Stambrook PJ, Whitby RJ, Sifers RN, Wu SP, Tsai MJ, DeMayo FJ, Moore DD. Correction: Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution. Elife. 2015 Jul 24; 4:e10084. PMID: 26205891.
      View in: PubMed
    31. Yuk JM, Kim TS, Kim SY, Lee HM, Han J, Dufour CR, Kim JK, Jin HS, Yang CS, Park KS, Lee CH, Kim JM, Kweon GR, Choi HS, Vanacker JM, Moore DD, Giguère V, Jo EK. Orphan Nuclear Receptor ERRa Controls Macrophage Metabolic Signaling and A20 Expression to Negatively Regulate TLR-Induced Inflammation. Immunity. 2015 Jul 21; 43(1):80-91. PMID: 26200012.
      View in: PubMed
    32. Hartig SM, Bader DA, Abadie KV, Motamed M, Hamilton MP, Long W, York B, Mueller M, Wagner M, Trauner M, Chan L, Bajaj M, Moore DD, Mancini MA, McGuire SE. Ubc9 Impairs Activation of the Brown Fat Energy Metabolism Program in Human White Adipocytes. Mol Endocrinol. 2015 Sep; 29(9):1320-33. PMID: 26192107.
      View in: PubMed
    33. Kettner NM, Mayo SA, Hua J, Lee C, Moore DD, Fu L. Circadian Dysfunction Induces Leptin Resistance in Mice. Cell Metab. 2015 Sep 01; 22(3):448-59. PMID: 26166747.
      View in: PubMed
    34. Mamrosh JL, Moore DD. Using Google Reverse Image Search to Decipher Biological Images. Curr Protoc Mol Biol. 2015 Jul 01; 111:19.13.1-19.13.4. PMID: 26131848.
      View in: PubMed
    35. Fu X, Dong B, Tian Y, Lefebvre P, Meng Z, Wang X, Pattou F, Han W, Wang X, Lou F, Jove R, Staels B, Moore DD, Huang W. MicroRNA-26a regulates insulin sensitivity and metabolism of glucose and lipids. J Clin Invest. 2015 Jun; 125(6):2497-509. PMID: 25961460.
      View in: PubMed
    36. Tseng HT, Park YJ, Lee YK, Moore DD. The orphan nuclear receptor small heterodimer partner is required for thiazolidinedione effects in leptin-deficient mice. J Biomed Sci. 2015 May 08; 22:30. PMID: 25951943.
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    37. Dong B, Lee JS, Park YY, Yang F, Xu G, Huang W, Finegold MJ, Moore DD. Activating CAR and ß-catenin induces uncontrolled liver growth and tumorigenesis. Nat Commun. 2015 Feb 09; 6:5944. PMID: 25661872.
      View in: PubMed
    38. Folick A, Oakley HD, Yu Y, Armstrong EH, Kumari M, Sanor L, Moore DD, Ortlund EA, Zechner R, Wang MC. Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans. Science. 2015 Jan 02; 347(6217):83-6. PMID: 25554789.
      View in: PubMed
    39. Lee JM, Wagner M, Xiao R, Kim KH, Feng D, Lazar MA, Moore DD. Nutrient-sensing nuclear receptors coordinate autophagy. Nature. 2014 Dec 04; 516(7529):112-5. PMID: 25383539.
      View in: PubMed
    40. Gustafsson JA, Katzenellenbogen B, Jameson JL, Roth J, Melmed S, McDonnell D, Wartofsky L, Crowley WF, Griz LH, Becker C, Moore DD, Drucker D, Singh N, O'Malley B. Endocrine Society 2014 Laureate Awards. Horm Cancer. 2014 Oct; 5(5):339-55. PMID: 25091407.
      View in: PubMed
    41. Mamrosh JL, Lee JM, Wagner M, Stambrook PJ, Whitby RJ, Sifers RN, Wu SP, Tsai MJ, Demayo FJ, Moore DD. Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution. Elife. 2014 Apr 15; 3:e01694. PMID: 24737860.
      View in: PubMed
    42. Kim SC, Kim CK, Axe D, Cook A, Lee M, Li T, Smallwood N, Chiang JY, Hardwick JP, Moore DD, Lee YK. All-trans-retinoic acid ameliorates hepatic steatosis in mice by a novel transcriptional cascade. Hepatology. 2014 May; 59(5):1750-60. PMID: 24038081.
      View in: PubMed
    43. Desai MS, Eblimit Z, Thevananther S, Kosters A, Moore DD, Penny DJ, Karpen SJ. Cardiomyopathy reverses with recovery of liver injury, cholestasis and cholanemia in mouse model of biliary fibrosis. Liver Int. 2015 Apr; 35(4):1464-77. PMID: 24330504.
      View in: PubMed
    44. Chow EC, Magomedova L, Quach HP, Patel R, Durk MR, Fan J, Maeng HJ, Irondi K, Anakk S, Moore DD, Cummins CL, Pang KS. Vitamin D receptor activation down-regulates the small heterodimer partner and increases CYP7A1 to lower cholesterol. Gastroenterology. 2014 Apr; 146(4):1048-59. PMID: 24365583.
      View in: PubMed
    45. Anakk S, Bhosale M, Schmidt VA, Johnson RL, Finegold MJ, Moore DD. Bile acids activate YAP to promote liver carcinogenesis. Cell Rep. 2013 Nov 27; 5(4):1060-9. PMID: 24268772.
      View in: PubMed
    46. Shah P, Guo T, Moore DD, Ghose R. Role of constitutive androstane receptor in Toll-like receptor-mediated regulation of gene expression of hepatic drug-metabolizing enzymes and transporters. Drug Metab Dispos. 2014 Jan; 42(1):172-81. PMID: 24194512.
      View in: PubMed
    47. Moore DD. Physiology: A metabolic minuet. Nature. 2013 Oct 24; 502(7472):454-5. PMID: 24153294.
      View in: PubMed
    48. Kerr TA, Matsumoto Y, Matsumoto H, Xie Y, Hirschberger LL, Stipanuk MH, Anakk S, Moore DD, Watanabe M, Kennedy S, Davidson NO. Cysteine sulfinic acid decarboxylase regulation: A role for farnesoid X receptor and small heterodimer partner in murine hepatic taurine metabolism. Hepatol Res. 2014 Oct; 44(10):E218-28. PMID: 24033844.
      View in: PubMed
    49. Jung D, York JP, Wang L, Yang C, Zhang A, Francis HL, Webb P, McKeehan WL, Alpini G, Lesage GD, Moore DD, Xia X. FXR-induced secretion of FGF15/19 inhibits CYP27 expression in cholangiocytes through p38 kinase pathway. Pflugers Arch. 2014 May; 466(5):1011-9. PMID: 24068255.
      View in: PubMed
    50. Lee J, Moulik M, Fang Z, Saha P, Zou F, Xu Y, Nelson DL, Ma K, Moore DD, Yechoor VK. Bmal1 and ß-cell clock are required for adaptation to circadian disruption, and their loss of function leads to oxidative stress-induced ß-cell failure in mice. Mol Cell Biol. 2013 Jun; 33(11):2327-38. PMID: 23547261.
      View in: PubMed
    51. Xia X, Jung D, Webb P, Zhang A, Zhang B, Li L, Ayers SD, Gabbi C, Ueno Y, Gustafsson JÅ, Alpini G, Moore DD, Lesage GD. Liver X receptor ß and peroxisome proliferator-activated receptor d regulate cholesterol transport in murine cholangiocytes. Hepatology. 2012 Dec; 56(6):2288-96. PMID: 22729460.
      View in: PubMed
    52. Chen WD, Fu X, Dong B, Wang YD, Shiah S, Moore DD, Huang W. Neonatal activation of the nuclear receptor CAR results in epigenetic memory and permanent change of drug metabolism in mouse liver. Hepatology. 2012 Oct; 56(4):1499-509. PMID: 22488010.
      View in: PubMed
    53. Moore DD. Nuclear receptors reverse McGarry's vicious cycle to insulin resistance. Cell Metab. 2012 May 02; 15(5):615-22. PMID: 22560214.
      View in: PubMed
    54. Park YJ, Lee EK, Lee YK, Park DJ, Jang HC, Moore DD. Opposing regulation of cytochrome P450 expression by CAR and PXR in hypothyroid mice. Toxicol Appl Pharmacol. 2012 Sep 01; 263(2):131-7. PMID: 22503787.
      View in: PubMed
    55. Xiao R, Sun D, Ayers S, Xi Y, Li W, Baxter JD, Moore DD. Research resource: The estrogen receptor a cistrome defined by DamIP. Mol Endocrinol. 2012 Feb; 26(2):349-57. PMID: 22207717.
      View in: PubMed
    56. Reese VC, Moore DD, McLachlan A. Limited effects of bile acids and small heterodimer partner on hepatitis B virus biosynthesis in vivo. J Virol. 2012 Mar; 86(5):2760-8. PMID: 22171277.
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    57. Jain AK, Stoll B, Burrin DG, Holst JJ, Moore DD. Enteral bile acid treatment improves parenteral nutrition-related liver disease and intestinal mucosal atrophy in neonatal pigs. Am J Physiol Gastrointest Liver Physiol. 2012 Jan 15; 302(2):G218-24. PMID: 22094603.
      View in: PubMed
    58. Lee J, Kim MS, Li R, Liu VY, Fu L, Moore DD, Ma K, Yechoor VK. Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in ß-cells. Islets. 2011 Nov-Dec; 3(6):381-8. PMID: 22045262.
      View in: PubMed
    59. Park YJ, Kim SC, Kim J, Anakk S, Lee JM, Tseng HT, Yechoor V, Park J, Choi JS, Jang HC, Lee KU, Novak CM, Moore DD, Lee YK. Dissociation of diabetes and obesity in mice lacking orphan nuclear receptor small heterodimer partner. J Lipid Res. 2011 Dec; 52(12):2234-44. PMID: 21949050.
      View in: PubMed
    60. Sberna AL, Assem M, Xiao R, Ayers S, Gautier T, Guiu B, Deckert V, Chevriaux A, Grober J, Le Guern N, Pais de Barros JP, Moore DD, Lagrost L, Masson D. Constitutive androstane receptor activation decreases plasma apolipoprotein B-containing lipoproteins and atherosclerosis in low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol. 2011 Oct; 31(10):2232-9. PMID: 21778422.
      View in: PubMed
    61. Yuk JM, Shin DM, Lee HM, Kim JJ, Kim SW, Jin HS, Yang CS, Park KA, Chanda D, Kim DK, Huang SM, Lee SK, Lee CH, Kim JM, Song CH, Lee SY, Hur GM, Moore DD, Choi HS, Jo EK. The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by Toll-like receptors. Nat Immunol. 2011 Jul 03; 12(8):742-51. PMID: 21725320.
      View in: PubMed
    62. Wagner M, Moore DD. Endoplasmic reticulum stress and glucose homeostasis. Curr Opin Clin Nutr Metab Care. 2011 Jul; 14(4):367-73. PMID: 21543975.
      View in: PubMed
    63. Smetanina MA, Pakharukova MY, Kurinna SM, Dong B, Hernandez JP, Moore DD, Merkulova TI. Ortho-aminoazotoluene activates mouse constitutive androstane receptor (mCAR) and increases expression of mCAR target genes. Toxicol Appl Pharmacol. 2011 Aug 15; 255(1):76-85. PMID: 21672546.
      View in: PubMed
    64. Lee JM, Lee YK, Mamrosh JL, Busby SA, Griffin PR, Pathak MC, Ortlund EA, Moore DD. A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects. Nature. 2011 May 25; 474(7352):506-10. PMID: 21614002.
      View in: PubMed
    65. Dwivedi SK, Singh N, Kumari R, Mishra JS, Tripathi S, Banerjee P, Shah P, Kukshal V, Tyagi AM, Gaikwad AN, Chaturvedi RK, Mishra DP, Trivedi AK, Sanyal S, Chattopadhyay N, Ramachandran R, Siddiqi MI, Bandyopadhyay A, Arora A, Lundåsen T, Anakk SP, Moore DD, Sanyal S. Bile acid receptor agonist GW4064 regulates PPAR? coactivator-1a expression through estrogen receptor-related receptor a. Mol Endocrinol. 2011 Jun; 25(6):922-32. PMID: 21493670.
      View in: PubMed
    66. Xiao R, Moore DD. DamIP: using mutant DNA adenine methyltransferase to study DNA-protein interactions in vivo. Curr Protoc Mol Biol. 2011 Apr; Chapter 21:Unit21.21. PMID: 21472695.
      View in: PubMed
    67. Moore DD. Physiology. Crise de foie, redux? Science. 2011 Mar 11; 331(6022):1275-6. PMID: 21393533.
      View in: PubMed
    68. Chopra AR, Kommagani R, Saha P, Louet JF, Salazar C, Song J, Jeong J, Finegold M, Viollet B, DeMayo F, Chan L, Moore DD, O'Malley BW. Cellular energy depletion resets whole-body energy by promoting coactivator-mediated dietary fuel absorption. Cell Metab. 2011 Jan 05; 13(1):35-43. PMID: 21195347.
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    69. Anakk S, Watanabe M, Ochsner SA, McKenna NJ, Finegold MJ, Moore DD. Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis. J Clin Invest. 2011 Jan; 121(1):86-95. PMID: 21123943.
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    70. Gupte AA, Liu JZ, Ren Y, Minze LJ, Wiles JR, Collins AR, Lyon CJ, Pratico D, Finegold MJ, Wong ST, Webb P, Baxter JD, Moore DD, Hsueh WA. Rosiglitazone attenuates age- and diet-associated nonalcoholic steatohepatitis in male low-density lipoprotein receptor knockout mice. Hepatology. 2010 Dec; 52(6):2001-11. PMID: 20938947.
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    71. Lee S, Donehower LA, Herron AJ, Moore DD, Fu L. Disrupting circadian homeostasis of sympathetic signaling promotes tumor development in mice. PLoS One. 2010 Jun 07; 5(6):e10995. PMID: 20539819.
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    72. Xiao R, Roman-Sanchez R, Moore DD. DamIP: a novel method to identify DNA binding sites in vivo. Nucl Recept Signal. 2010 Apr 16; 8:e003. PMID: 20419059.
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    73. Dong B, Saha PK, Huang W, Chen W, Abu-Elheiga LA, Wakil SJ, Stevens RD, Ilkayeva O, Newgard CB, Chan L, Moore DD. Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease. Proc Natl Acad Sci U S A. 2009 Nov 03; 106(44):18831-6. PMID: 19850873.
      View in: PubMed
    74. Ma K, Xiao R, Tseng HT, Shan L, Fu L, Moore DD. Circadian dysregulation disrupts bile acid homeostasis. PLoS One. 2009 Aug 31; 4(8):e6843. PMID: 19718444.
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    75. Margolis RN, Moore DD, Willson TM, Guy RK. Chemical approaches to nuclear receptors in metabolism. Sci Signal. 2009 Aug 04; 2(82):mr5. PMID: 19654413.
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    76. Dong B, Qatanani M, Moore DD. Constitutive androstane receptor mediates the induction of drug metabolism in mouse models of type 1 diabetes. Hepatology. 2009 Aug; 50(2):622-9. PMID: 19489075.
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    77. Del Bas JM, Ricketts ML, Vaqué M, Sala E, Quesada H, Ardevol A, Salvadó MJ, Blay M, Arola L, Moore DD, Pujadas G, Fernandez-Larrea J, Bladé C. Dietary procyanidins enhance transcriptional activity of bile acid-activated FXR in vitro and reduce triglyceridemia in vivo in a FXR-dependent manner. Mol Nutr Food Res. 2009 Jul; 53(7):805-14. PMID: 19496086.
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    78. Li T, Ma H, Park YJ, Lee YK, Strom S, Moore DD, Chiang JY. Forkhead box transcription factor O1 inhibits cholesterol 7alpha-hydroxylase in human hepatocytes and in high fat diet-fed mice. Biochim Biophys Acta. 2009 Oct; 1791(10):991-6. PMID: 19463968.
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    79. McKenna NJ, Cooney AJ, DeMayo FJ, Downes M, Glass CK, Lanz RB, Lazar MA, Mangelsdorf DJ, Moore DD, Qin J, Steffen DL, Tsai MJ, Tsai SY, Yu R, Margolis RN, Evans RM, O'Malley BW. Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas. Mol Endocrinol. 2009 Jun; 23(6):740-6. PMID: 19423650.
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    80. Li Y, Ross-Viola JS, Shay NF, Moore DD, Ricketts ML. Human CYP3A4 and murine Cyp3A11 are regulated by equol and genistein via the pregnane X receptor in a species-specific manner. J Nutr. 2009 May; 139(5):898-904. PMID: 19297428.
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    81. Zhang L, Huang X, Meng Z, Dong B, Shiah S, Moore DD, Huang W. Significance and mechanism of CYP7a1 gene regulation during the acute phase of liver regeneration. Mol Endocrinol. 2009 Feb; 23(2):137-45. PMID: 19056864.
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    82. Wang YD, Chen WD, Moore DD, Huang W. FXR: a metabolic regulator and cell protector. Cell Res. 2008 Nov; 18(11):1087-95. PMID: 18825165.
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    83. Blanco-Bose WE, Murphy MJ, Ehninger A, Offner S, Dubey C, Huang W, Moore DD, Trumpp A. C-Myc and its target FoxM1 are critical downstream effectors of constitutive androstane receptor (CAR) mediated direct liver hyperplasia. Hepatology. 2008 Oct; 48(4):1302-11. PMID: 18798339.
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    84. Del Bas JM, Ricketts ML, Baiges I, Quesada H, Ardevol A, Salvadó MJ, Pujadas G, Blay M, Arola L, Bladé C, Moore DD, Fernandez-Larrea J. Dietary procyanidins lower triglyceride levels signaling through the nuclear receptor small heterodimer partner. Mol Nutr Food Res. 2008 Oct; 52(10):1172-81. PMID: 18720348.
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    85. Kleiner HE, Xia X, Sonoda J, Zhang J, Pontius E, Abey J, Evans RM, Moore DD, DiGiovanni J. Effects of naturally occurring coumarins on hepatic drug-metabolizing enzymes in mice. Toxicol Appl Pharmacol. 2008 Oct 15; 232(2):337-50. PMID: 18692084.
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    86. Zhang Y, Xu P, Park K, Choi Y, Moore DD, Wang L. Orphan receptor small heterodimer partner suppresses tumorigenesis by modulating cyclin D1 expression and cellular proliferation. Hepatology. 2008 Jul; 48(1):289-98. PMID: 18537191.
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    87. Merrell MD, Jackson JP, Augustine LM, Fisher CD, Slitt AL, Maher JM, Huang W, Moore DD, Zhang Y, Klaassen CD, Cherrington NJ. The Nrf2 activator oltipraz also activates the constitutive androstane receptor. Drug Metab Dispos. 2008 Aug; 36(8):1716-21. PMID: 18474683.
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    88. Park YJ, Qatanani M, Chua SS, LaRey JL, Johnson SA, Watanabe M, Moore DD, Lee YK. Loss of orphan receptor small heterodimer partner sensitizes mice to liver injury from obstructive cholestasis. Hepatology. 2008 May; 47(5):1578-86. PMID: 18393320.
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    89. Lee YK, Moore DD. Liver receptor homolog-1, an emerging metabolic modulator. Front Biosci. 2008 May 01; 13:5950-8. PMID: 18508634.
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    90. Masson D, Qatanani M, Sberna AL, Xiao R, Pais de Barros JP, Grober J, Deckert V, Athias A, Gambert P, Lagrost L, Moore DD, Assem M. Activation of the constitutive androstane receptor decreases HDL in wild-type and human apoA-I transgenic mice. J Lipid Res. 2008 Aug; 49(8):1682-91. PMID: 18441373.
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    91. Roth A, Looser R, Kaufmann M, Blättler SM, Rencurel F, Huang W, Moore DD, Meyer UA. Regulatory cross-talk between drug metabolism and lipid homeostasis: constitutive androstane receptor and pregnane X receptor increase Insig-1 expression. Mol Pharmacol. 2008 Apr; 73(4):1282-9. PMID: 18187584.
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    92. Carter BA, Taylor OA, Prendergast DR, Zimmerman TL, Von Furstenberg R, Moore DD, Karpen SJ. Stigmasterol, a soy lipid-derived phytosterol, is an antagonist of the bile acid nuclear receptor FXR. Pediatr Res. 2007 Sep; 62(3):301-6. PMID: 17622954.
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    93. Huang J, Iqbal J, Saha PK, Liu J, Chan L, Hussain MM, Moore DD, Wang L. Molecular characterization of the role of orphan receptor small heterodimer partner in development of fatty liver. Hepatology. 2007 Jul; 46(1):147-57. PMID: 17526026.
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    94. Moore DD. Physiology. Sister act. Science. 2007 Jun 08; 316(5830):1436-8. PMID: 17556573.
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    95. Hernandez JP, Huang W, Chapman LM, Chua S, Moore DD, Baldwin WS. The environmental estrogen, nonylphenol, activates the constitutive androstane receptor. Toxicol Sci. 2007 Aug; 98(2):416-26. PMID: 17483497.
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    96. Ricketts ML, Boekschoten MV, Kreeft AJ, Hooiveld GJ, Moen CJ, Müller M, Frants RR, Kasanmoentalib S, Post SM, Princen HM, Porter JG, Katan MB, Hofker MH, Moore DD. The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors. Mol Endocrinol. 2007 Jul; 21(7):1603-16. PMID: 17456796.
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    97. Yang F, Huang X, Yi T, Yen Y, Moore DD, Huang W. Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor. Cancer Res. 2007 Feb 01; 67(3):863-7. PMID: 17283114.
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    98. Farhana L, Dawson MI, Leid M, Wang L, Moore DD, Liu G, Xia Z, Fontana JA. Adamantyl-substituted retinoid-related molecules bind small heterodimer partner and modulate the Sin3A repressor. Cancer Res. 2007 Jan 01; 67(1):318-25. PMID: 17210713.
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    99. Moore DD, Kato S, Xie W, Mangelsdorf DJ, Schmidt DR, Xiao R, Kliewer SA. International Union of Pharmacology. LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor. Pharmacol Rev. 2006 Dec; 58(4):742-59. PMID: 17132852.
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    100. Anakk S, Huang W, Staudinger JL, Tan K, Cole TJ, Moore DD, Strobel HW. Gender dictates the nuclear receptor-mediated regulation of CYP3A44. Drug Metab Dispos. 2007 Jan; 35(1):36-42. PMID: 17020958.
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    101. Baskin-Bey ES, Huang W, Ishimura N, Isomoto H, Bronk SF, Braley K, Craig RW, Moore DD, Gores GJ. Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins. Hepatology. 2006 Jul; 44(1):252-62. PMID: 16799968.
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    102. Wang L, Huang J, Saha P, Kulkarni RN, Hu M, Kim Y, Park K, Chan L, Rajan AS, Lee I, Moore DD. Orphan receptor small heterodimer partner is an important mediator of glucose homeostasis. Mol Endocrinol. 2006 Nov; 20(11):2671-81. PMID: 16803864.
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    103. Huang W, Ma K, Zhang J, Qatanani M, Cuvillier J, Liu J, Dong B, Huang X, Moore DD. Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration. Science. 2006 Apr 14; 312(5771):233-6. PMID: 16614213.
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    104. Ma K, Saha PK, Chan L, Moore DD. Farnesoid X receptor is essential for normal glucose homeostasis. J Clin Invest. 2006 Apr; 116(4):1102-9. PMID: 16557297.
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    105. Lee YK, Choi YH, Chua S, Park YJ, Moore DD. Phosphorylation of the hinge domain of the nuclear hormone receptor LRH-1 stimulates transactivation. J Biol Chem. 2006 Mar 24; 281(12):7850-5. PMID: 16439367.
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    106. Datta S, Wang L, Moore DD, Osborne TF. Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase promoter by nuclear receptors liver receptor homologue-1 and small heterodimer partner: a mechanism for differential regulation of cholesterol synthesis and uptake. J Biol Chem. 2006 Jan 13; 281(2):807-12. PMID: 16282330.
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    107. Columbano A, Ledda-Columbano GM, Pibiri M, Cossu C, Menegazzi M, Moore DD, Huang W, Tian J, Locker J. Gadd45beta is induced through a CAR-dependent, TNF-independent pathway in murine liver hyperplasia. Hepatology. 2005 Nov; 42(5):1118-26. PMID: 16231353.
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    108. Wang L, Liu J, Saha P, Huang J, Chan L, Spiegelman B, Moore DD. The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes. Cell Metab. 2005 Oct; 2(4):227-38. PMID: 16213225.
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    109. Ricketts ML, Moore DD, Banz WJ, Mezei O, Shay NF. Molecular mechanisms of action of the soy isoflavones includes activation of promiscuous nuclear receptors. A review. J Nutr Biochem. 2005 Jun; 16(6):321-30. PMID: 15936643.
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    110. Huang W, Zhang J, Washington M, Liu J, Parant JM, Lozano G, Moore DD. Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor. Mol Endocrinol. 2005 Jun; 19(6):1646-53. PMID: 15831521.
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    111. Ortlund EA, Lee Y, Solomon IH, Hager JM, Safi R, Choi Y, Guan Z, Tripathy A, Raetz CR, McDonnell DP, Moore DD, Redinbo MR. Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. Nat Struct Mol Biol. 2005 Apr; 12(4):357-63. PMID: 15723037.
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    112. Moore DD. 'No, really, how do they work?'. Genes Dev. 2005 Feb 15; 19(4):413-4. PMID: 15713837.
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    113. Stedman CA, Liddle C, Coulter SA, Sonoda J, Alvarez JG, Moore DD, Evans RM, Downes M. Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury. Proc Natl Acad Sci U S A. 2005 Feb 08; 102(6):2063-8. PMID: 15684063.
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    114. Moore DD. CAR: three new models for a problem child. Cell Metab. 2005 Jan; 1(1):6-8. PMID: 16054039.
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    115. Qatanani M, Zhang J, Moore DD. Role of the constitutive androstane receptor in xenobiotic-induced thyroid hormone metabolism. Endocrinology. 2005 Mar; 146(3):995-1002. PMID: 15564320.
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    116. Zhang J, Huang W, Qatanani M, Evans RM, Moore DD. The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity. J Biol Chem. 2004 Nov 19; 279(47):49517-22. PMID: 15358766.
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    117. Huang W, Zhang J, Wei P, Schrader WT, Moore DD. Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR. Mol Endocrinol. 2004 Oct; 18(10):2402-8. PMID: 15272053.
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    118. Qatanani M, Wei P, Moore DD. Alterations in the distribution and orexigenic effects of dexamethasone in CAR-null mice. Pharmacol Biochem Behav. 2004 Jun; 78(2):285-91. PMID: 15219769.
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    119. Watanabe M, Houten SM, Wang L, Moschetta A, Mangelsdorf DJ, Heyman RA, Moore DD, Auwerx J. Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J Clin Invest. 2004 May; 113(10):1408-18. PMID: 15146238.
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    120. Assem M, Schuetz EG, Leggas M, Sun D, Yasuda K, Reid G, Zelcer N, Adachi M, Strom S, Evans RM, Moore DD, Borst P, Schuetz JD. Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice. J Biol Chem. 2004 May 21; 279(21):22250-7. PMID: 15004017.
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    121. Saini SP, Sonoda J, Xu L, Toma D, Uppal H, Mu Y, Ren S, Moore DD, Evans RM, Xie W. A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification. Mol Pharmacol. 2004 Feb; 65(2):292-300. PMID: 14742670.
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    122. Huang W, Zhang J, Moore DD. A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR. J Clin Invest. 2004 Jan; 113(1):137-43. PMID: 14702117.
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    123. Cherrington NJ, Slitt AL, Maher JM, Zhang XX, Zhang J, Huang W, Wan YJ, Moore DD, Klaassen CD. Induction of multidrug resistance protein 3 (mrp3) in vivo is independent of constitutive androstane receptor. Drug Metab Dispos. 2003 Nov; 31(11):1315-9. PMID: 14570762.
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    124. Wang L, Han Y, Kim CS, Lee YK, Moore DD. Resistance of SHP-null mice to bile acid-induced liver damage. J Biol Chem. 2003 Nov 07; 278(45):44475-81. PMID: 12933814.
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    125. Tzameli I, Chua SS, Cheskis B, Moore DD. Complex effects of rexinoids on ligand dependent activation or inhibition of the xenobiotic receptor, CAR. Nucl Recept. 2003 Jun 06; 1(1):2. PMID: 12904257.
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    126. Huang W, Zhang J, Chua SS, Qatanani M, Han Y, Granata R, Moore DD. Induction of bilirubin clearance by the constitutive androstane receptor (CAR). Proc Natl Acad Sci U S A. 2003 Apr 01; 100(7):4156-61. PMID: 12644704.
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    127. Urizar NL, Moore DD. GUGULIPID: a natural cholesterol-lowering agent. Annu Rev Nutr. 2003; 23:303-13. PMID: 12626688.
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    128. Lee YK, Moore DD. The orphan receptor SHP and the three-hybrid interference assay. Methods Enzymol. 2003; 364:152-9. PMID: 14631844.
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    129. Zhang J, Huang W, Chua SS, Wei P, Moore DD. Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR. Science. 2002 Oct 11; 298(5592):422-4. PMID: 12376703.
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    130. Moore DD. Does loss of bile acid homeostasis make mice melancholy? J Clin Invest. 2002 Oct; 110(8):1067-9. PMID: 12393840.
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    131. Wang L, Lee YK, Bundman D, Han Y, Thevananther S, Kim CS, Chua SS, Wei P, Heyman RA, Karin M, Moore DD. Redundant pathways for negative feedback regulation of bile acid production. Dev Cell. 2002 Jun; 2(6):721-31. PMID: 12062085.
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    132. Urizar NL, Liverman AB, Dodds DT, Silva FV, Ordentlich P, Yan Y, Gonzalez FJ, Heyman RA, Mangelsdorf DJ, Moore DD. A natural product that lowers cholesterol as an antagonist ligand for FXR. Science. 2002 May 31; 296(5573):1703-6. PMID: 11988537.
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    133. Hwang ST, Urizar NL, Moore DD, Henning SJ. Bile acids regulate the ontogenic expression of ileal bile acid binding protein in the rat via the farnesoid X receptor. Gastroenterology. 2002 May; 122(5):1483-92. PMID: 11984532.
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    134. Chen Q, Dowhan DH, Liang D, Moore DD, Overbeek PA. CREB-binding protein/p300 co-activation of crystallin gene expression. J Biol Chem. 2002 Jul 05; 277(27):24081-9. PMID: 11943779.
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    135. Seo YW, Sanyal S, Kim HJ, Won DH, An JY, Amano T, Zavacki AM, Kwon HB, Shi YB, Kim WS, Kang H, Moore DD, Choi HS. FOR, a novel orphan nuclear receptor related to farnesoid X receptor. J Biol Chem. 2002 May 17; 277(20):17836-44. PMID: 11867625.
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    136. Sanyal S, Kim JY, Kim HJ, Takeda J, Lee YK, Moore DD, Choi HS. Differential regulation of the orphan nuclear receptor small heterodimer partner (SHP) gene promoter by orphan nuclear receptor ERR isoforms. J Biol Chem. 2002 Jan 18; 277(3):1739-48. PMID: 11705994.
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    137. Nishizawa H, Yamagata K, Shimomura I, Takahashi M, Kuriyama H, Kishida K, Hotta K, Nagaretani H, Maeda N, Matsuda M, Kihara S, Nakamura T, Nishigori H, Tomura H, Moore DD, Takeda J, Funahashi T, Matsuzawa Y. Small heterodimer partner, an orphan nuclear receptor, augments peroxisome proliferator-activated receptor gamma transactivation. J Biol Chem. 2002 Jan 11; 277(2):1586-92. PMID: 11696534.
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    138. Lee YK, Moore DD. Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner. J Biol Chem. 2002 Jan 25; 277(4):2463-7. PMID: 11668176.
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