"Frailty" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A state of increased vulnerability to stressors, following declines in function and reserves across multiple physiologic systems, characterized by MUSCLE WEAKNESS; FATIGUE; slowed motor performance; low physical activity; and unintentional weight loss.
| Descriptor ID |
D000073496
|
| MeSH Number(s) |
C23.550.359
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Frailty".
Below are MeSH descriptors whose meaning is more specific than "Frailty".
This graph shows the total number of publications written about "Frailty" by people in this website by year, and whether "Frailty" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 3 | 0 | 3 |
| 2018 | 5 | 3 | 8 |
| 2019 | 8 | 2 | 10 |
| 2020 | 11 | 0 | 11 |
| 2021 | 16 | 1 | 17 |
| 2022 | 8 | 0 | 8 |
| 2023 | 14 | 0 | 14 |
| 2024 | 13 | 0 | 13 |
| 2025 | 12 | 1 | 13 |
| 2026 | 5 | 2 | 7 |
To return to the timeline,
click here.
Below are the most recent publications written about "Frailty" by people in Profiles.
-
Current perspectives and emerging directions in research and practice: highlights from the 15th Annual International Workshop on Aging and HIV. J Gerontol A Biol Sci Med Sci. 2026 May 07; 81(6).
-
Clinically Meaningful, Patient-Centered Endpoints for Real-World Evidence Generation in Breast Cancer: Perspectives from the Multidisciplinary TRIUMPH Initiative. Adv Ther. 2026 May; 43(5):1855-1868.
-
Geroprotective effects of diet and exercise plus metformin in frail older veterans with obesity: The DEMFOS randomized trial protocol. Contemp Clin Trials. 2026 Jun; 165:108321.
-
Assessing health in aging male and female mice: does cardiac function dictate frailty or physical resilience? J Gerontol A Biol Sci Med Sci. 2026 Apr 07; 81(5).
-
Relative impact of multidomain lifestyle interventions on deficit accumulation frailty over 24 months in the U.S. POINTER trial. J Gerontol A Biol Sci Med Sci. 2026 Apr 07; 81(5).
-
Randomized phase 2b dose-escalation trial of stem cell therapy with laromestrocel for aging frailty. Cell Stem Cell. 2026 Mar 05; 33(3):393-404.e4.
-
How does Frailty Impact Peri-Operative and Speech Recognition Outcomes for Cochlear Implants in Veterans? Otolaryngol Head Neck Surg. 2026 Mar; 174(3):825-832.
-
Clinical and Prognostic Utility of the Essential Frailty Toolset in Older Patients With Heart Failure. J Am Geriatr Soc. 2025 Nov; 73(11):3455-3463.
-
Analysis of safety of carotid endarterectomy in nonagenarians and the implications of frailty - A National surgical quality improvement program analysis. Clin Neurol Neurosurg. 2025 11; 258:109138.
-
Frailty associates with respiratory exacerbations and mortality in the COPDGene cohort. Aging (Albany NY). 2025 07 03; 17(7):1590-1623.