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DOUGLAS G BURRIN

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
DivisionPediatrics-Nutrition
Address1100 BATES STREET
PEDIATRICS - NUTRITION
HOUSTON TX 77030
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    Nutritional Regulation of Neonatal Gut and Liver Health and Disease

    My laboratory has several basic and translational projects designed to establish how nutritional support, enteral versus parenteral, effects gut and liver function and susceptibility to disease in early development. We have used the neonatal piglet to established unique models of parenteral nutrition-associated liver disease (PNALD), necrotizing enterocolitis (NEC) and short-bowel syndrome (SBS) to address clinically-relevant problems in pediatric gastroenterology.

    Current projects in the laboratory seek to identify the cellular and molecular mechanism that lead to PNALD and metabolic dysfunction associated with prematurity and neonatal parenteral nutrition (PN) support. Our recent studies show that chronic PN induces hepatic steatosis, cholestasis and insulin resistance in term and premature neonatal piglets. We are currently exploring how specific nutrients in commercial lipid emulsions alter the susceptibility to PNALD. We are exploring how nutrients affect interorgan and local cellular signaling pathways involved in hepatic lipid metabolism and bile acid homeostasis. We are also testing whether the adverse metabolic phenotype induced by PN is programmed and persists beyond the neonatal period and predisposes to adolescent fatty liver disease and type 2 diabetes.

    Studies also are aimed at establishing the cellular and physiological functions of glucagon-like peptide 2 (GLP-2), an FDA-approved gut hormone currently in clinical trial for treatment of adult short-bowel syndrome. Past studies in TPN-fed piglets were first to show the trophic and vasoactive actions of GLP-2 in the neonatal gut. We identified the cellular co-localization of the GLP-2 receptor in enteric neurons with neurotransmitters. Current studies are aimed at establishing unique enterally-mediated signaling mechanisms that trigger enteroendocrine cell GLP-2 secretion and GLP-2 receptor function. We are also testing the efficacy of GLP-2 administration for prevention of NEC and treatment of SBS in premature piglet models.

    We take an integrative experimental approach dictated by the research question to address relevant functions at the whole animal, tissue, cellular or molecular level. We use sophisticated metabolic, cell biological and molecular approaches, such as stable isotope metabolomics, laser-capture microdissection, gene microarray, and confocal microscopic imaging to identify the cellular localization of specific signals involved in the metabolism, proliferation and survival of relevant cell types, including mucosal epithelial cells and hepatocytes.


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Guthrie G, Tackett B, Stoll B, Martin C, Olutoye O, Burrin DG. Phytosterols Synergize With Endotoxin to Augment Inflammation in Kupffer Cells but Alone Have Limited Direct Effect on Hepatocytes. JPEN J Parenter Enteral Nutr. 2017 Aug 01; 148607117722752. PMID: 28792854.
      View in: PubMed
    2. Marini JC, Agarwal U, Robinson JL, Yuan Y, Cajo Didelija I, Stoll B, Burrin DG. THE INTESTINAL-RENAL AXIS FOR ARGININE SYNTHESIS IS PRESENT AND FUNCTIONAL IN THE NEONATAL PIG. Am J Physiol Endocrinol Metab. 2017 Jun 13; ajpendo.00055.2017. PMID: 28611027.
      View in: PubMed
    3. Burrin DG. Preserving Mother Nature's Best Food for Preterm Infants. J Nutr. 2017 Apr 12. PMID: 28404837.
      View in: PubMed
    4. Jordan K, Pontoppidan P, Uhlving H, Kielsen K, Burrin DG, Weichendorff S, Christensen IJ, Jørgensen MH, Heilmann C, Sengeløv H, Müller K. Gastrointestinal Toxicity, Systemic Inflammation and Liver Biochemistry in Allogeneic Haematological Stem Cell Transplantation. Biol Blood Marrow Transplant. 2017 Mar 23. PMID: 28344059.
      View in: PubMed
    5. Aunsholt L, Qvist N, Sangild PT, Vegge A, Stoll B, Burrin DG, Jeppesen PB, Eriksen T, Husby S, Thymann T. Minimal Enteral Nutrition to Improve Adaptation After Intestinal Resection in Piglets and Infants. JPEN J Parenter Enteral Nutr. 2017 Feb 01; 148607117690527. PMID: 28786308.
      View in: PubMed
    6. Guthrie G, Premkumar M, Burrin DG. Emerging Clinical Benefits of New-Generation Fat Emulsions in Preterm Neonates. Nutr Clin Pract. 2017 Jan 01; 884533616687500. PMID: 28129045.
      View in: PubMed
    7. Ettayebi K, Crawford SE, Murakami K, Broughman JR, Karandikar U, Tenge VR, Neill FH, Blutt SE, Zeng XL, Qu L, Kou B, Opekun AR, Burrin D, Graham DY, Ramani S, Atmar RL, Estes MK. Replication of human noroviruses in stem cell-derived human enteroids. Science. 2016 Sep 23; 353(6306):1387-1393. PMID: 27562956.
      View in: PubMed
    8. Guthrie G, Kulkarni M, Vlaardingerbroek H, Stoll B, Ng K, Martin C, Belmont J, Hadsell D, Heird W, Newgard CB, Olutoye O, van Goudoever J, Lauridsen C, He X, Schuchman EH, Burrin D. Multi-omic profiles of hepatic metabolism in TPN-fed preterm pigs administered new generation lipid emulsions. J Lipid Res. 2016 Sep; 57(9):1696-711. PMID: 27474222.
      View in: PubMed
    9. Yun C, Yin T, Shatzer K, Burrin DG, Cui L, Tu Y, Hu M. Determination of 7?-OH cholesterol by LC-MS/MS: Application in assessing the activity of CYP7A1 in cholestatic minipigs. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jul 1; 1025:76-82. PMID: 27218859.
      View in: PubMed
    10. Yang C, Yang X, Lackeyram D, Rideout TC, Wang Z, Stoll B, Yin Y, Burrin DG, Fan MZ. Expression of apical Na(+)-L-glutamine co-transport activity, B(0)-system neutral amino acid co-transporter (B(0)AT1) and angiotensin-converting enzyme 2 along the jejunal crypt-villus axis in young pigs fed a liquid formula. Amino Acids. 2016 Jun; 48(6):1491-508. PMID: 26984322.
      View in: PubMed
    11. Shen RL, Thymann T, Østergaard MV, Støy AC, Krych ?, Nielsen DS, Lauridsen C, Hartmann B, Holst JJ, Burrin DG, Sangild PT. Early gradual feeding with bovine colostrum improves gut function and NEC resistance relative to infant formula in preterm pigs. Am J Physiol Gastrointest Liver Physiol. 2015 Sep 1; 309(5):G310-23. PMID: 26138468.
      View in: PubMed
    12. Zamora IJ, Stoll B, Ethun CG, Sheikh F, Yu L, Burrin DG, Brandt ML, Olutoye OO. Low Abdominal NIRS Values and Elevated Plasma Intestinal Fatty Acid-Binding Protein in a Premature Piglet Model of Necrotizing Enterocolitis. PLoS One. 2015; 10(6):e0125437. PMID: 26061399.
      View in: PubMed
    13. Ng K, Stoll B, Chacko S, Saenz de Pipaon M, Lauridsen C, Gray M, Squires EJ, Marini J, Zamora IJ, Olutoye OO, Burrin DG. Vitamin E in New-Generation Lipid Emulsions Protects Against Parenteral Nutrition-Associated Liver Disease in Parenteral Nutrition-Fed Preterm Pigs. JPEN J Parenter Enteral Nutr. 2015 Jan 16. PMID: 25596209.
      View in: PubMed
    14. Jain AK, Wen JX, Arora S, Blomenkamp KS, Rodrigues J, Blaufuss TA, Liou V, Burrin DG, Long JP, Teckman JH. Validating hyperbilirubinemia and gut mucosal atrophy with a novel ultramobile ambulatory total parenteral nutrition piglet model. Nutr Res. 2015 Feb; 35(2):169-74. PMID: 25649660.
      View in: PubMed
    15. Sangild PT, Ney DM, Sigalet DL, Vegge A, Burrin D. Animal models of gastrointestinal and liver diseases. Animal models of infant short bowel syndrome: translational relevance and challenges. Am J Physiol Gastrointest Liver Physiol. 2014 Dec 15; 307(12):G1147-68. PMID: 25342047; PMCID: PMC4269678.
    16. Patel AK, Lazar DA, Burrin DG, Smith EO, Magliaro TJ, Stark AR, Brandt ML, Zamora IJ, Sheikh F, Akinkuotu AC, Olutoye OO. Abdominal near-infrared spectroscopy measurements are lower in preterm infants at risk for necrotizing enterocolitis. Pediatr Crit Care Med. 2014 Oct; 15(8):735-41. PMID: 25068253.
      View in: PubMed
    17. Ghoneim N, Bauchart-Thevret C, Oosterloo B, Stoll B, Kulkarni M, de Pipaon MS, Zamora IJ, Olutoye OO, Berg B, Wittke A, Burrin DG. Delayed initiation but not gradual advancement of enteral formula feeding reduces the incidence of necrotizing enterocolitis (NEC) in preterm pigs. PLoS One. 2014; 9(9):e106888. PMID: 25238061; PMCID: PMC4169518.
    18. Thymann T, Stoll B, Mecklenburg L, Burrin DG, Vegge A, Qvist N, Eriksen T, Jeppesen PB, Sangild PT. Acute effects of the glucagon-like peptide 2 analogue, teduglutide, on intestinal adaptation in short bowel syndrome. J Pediatr Gastroenterol Nutr. 2014 Jun; 58(6):694-702. PMID: 24399211.
      View in: PubMed
    19. Oosterloo BC, Premkumar M, Stoll B, Olutoye O, Thymann T, Sangild PT, Burrin DG. Dual purpose use of preterm piglets as a model of pediatric GI disease. Vet Immunol Immunopathol. 2014 Jun 15; 159(3-4):156-65. PMID: 24656979.
      View in: PubMed
    20. Vlaardingerbroek H, Ng K, Stoll B, Benight N, Chacko S, Kluijtmans LA, Kulik W, Squires EJ, Olutoye O, Schady D, Finegold ML, van Goudoever JB, Burrin DG. New generation lipid emulsions prevent PNALD in chronic parenterally fed preterm pigs. J Lipid Res. 2014 Mar; 55(3):466-77. PMID: 24478031; PMCID: PMC3934731.
    21. Burrin DG, Ng K, Stoll B, Sáenz De Pipaón M. Impact of new-generation lipid emulsions on cellular mechanisms of parenteral nutrition-associated liver disease. Adv Nutr. 2014 Jan; 5(1):82-91. PMID: 24425726; PMCID: PMC3884104.
    22. Jensen ML, Thymann T, Cilieborg MS, Lykke M, Mølbak L, Jensen BB, Schmidt M, Kelly D, Mulder I, Burrin DG, Sangild PT. Antibiotics modulate intestinal immunity and prevent necrotizing enterocolitis in preterm neonatal piglets. Am J Physiol Gastrointest Liver Physiol. 2014 Jan 1; 306(1):G59-71. PMID: 24157972; PMCID: PMC4073901.
    23. Ipharraguerre IR, Tedó G, Menoyo D, de Diego Cabero N, Holst JJ, Nofrarías M, Mereu A, Burrin DG. Bile acids induce glucagon-like peptide 2 secretion with limited effects on intestinal adaptation in early weaned pigs. J Nutr. 2013 Dec; 143(12):1899-905. PMID: 24047704.
      View in: PubMed
    24. Sangild PT, Thymann T, Schmidt M, Stoll B, Burrin DG, Buddington RK. Invited review: the preterm pig as a model in pediatric gastroenterology. J Anim Sci. 2013 Oct; 91(10):4713-29. PMID: 23942716; PMCID: PMC3984402.
    25. Shi X, Zhou F, Li X, Chang B, Li D, Wang Y, Tong Q, Xu Y, Fukuda M, Zhao JJ, Li D, Burrin DG, Chan L, Guan X. Central GLP-2 enhances hepatic insulin sensitivity via activating PI3K signaling in POMC neurons. Cell Metab. 2013 Jul 2; 18(1):86-98. PMID: 23823479; PMCID: PMC3752162.
    26. Vegge A, Thymann T, Lund P, Stoll B, Bering SB, Hartmann B, Jelsing J, Qvist N, Burrin DG, Jeppesen PB, Holst JJ, Sangild PT. Glucagon-like peptide-2 induces rapid digestive adaptation following intestinal resection in preterm neonates. Am J Physiol Gastrointest Liver Physiol. 2013 Aug 15; 305(4):G277-85. PMID: 23764891; PMCID: PMC4073902.
    27. Benight NM, Stoll B, Olutoye OO, Holst JJ, Burrin DG. GLP-2 delays but does not prevent the onset of necrotizing enterocolitis in preterm pigs. J Pediatr Gastroenterol Nutr. 2013 Jun; 56(6):623-30. PMID: 23343934; PMCID: PMC3976429.
    28. Burrin D, Stoll B, Moore D. Digestive physiology of the pig symposium: intestinal bile acid sensing is linked to key endocrine and metabolic signaling pathways. J Anim Sci. 2013 May; 91(5):1991-2000. PMID: 23729782; PMCID: PMC3984497.
    29. Bauchart-Thevret C, Stoll B, Benight NM, Olutoye O, Lazar D, Burrin DG. Supplementing monosodium glutamate to partial enteral nutrition slows gastric emptying in preterm pigs(1-3). J Nutr. 2013 May; 143(5):563-70. PMID: 23446960; PMCID: PMC3970318.
    30. Puiman P, Stoll B, Mølbak L, de Bruijn A, Schierbeek H, Boye M, Boehm G, Renes I, van Goudoever J, Burrin D. Modulation of the gut microbiota with antibiotic treatment suppresses whole body urea production in neonatal pigs. Am J Physiol Gastrointest Liver Physiol. 2013 Feb 1; 304(3):G300-10. PMID: 23139222; PMCID: PMC3566514.
    31. Marini JC, Stoll B, Didelija IC, Burrin DG. De novo synthesis is the main source of ornithine for citrulline production in neonatal pigs. Am J Physiol Endocrinol Metab. 2012 Dec 1; 303(11):E1348-53. PMID: 23074237; PMCID: PMC3774079.
    32. Taylor-Edwards CC, Burrin DG, Kristensen NB, Holst JJ, McLeod KR, Harmon DL. Glucagon-like peptide-2 (GLP-2) increases net amino acid utilization by the portal-drained viscera of ruminating calves. Animal. 2012 Dec; 6(12):1985-97. PMID: 23031436; PMCID: PMC3973745.
    33. Benight NM, Stoll B, Marini JC, Burrin DG. Preventative oral methylthioadenosine is anti-inflammatory and reduces DSS-induced colitis in mice. Am J Physiol Gastrointest Liver Physiol. 2012 Jul; 303(1):G71-82. PMID: 22556140; PMCID: PMC3404577.
    34. Stoll B, Puiman PJ, Cui L, Chang X, Benight NM, Bauchart-Thevret C, Hartmann B, Holst JJ, Burrin DG. Continuous parenteral and enteral nutrition induces metabolic dysfunction in neonatal pigs. JPEN J Parenter Enteral Nutr. 2012 Sep; 36(5):538-50. PMID: 22549765; PMCID: PMC4000127.
    35. Jain AK, Stoll B, Burrin DG, Holst JJ, Moore DD. Enteral bile acid treatment improves parenteral nutrition-related liver disease and intestinal mucosal atrophy in neonatal pigs. Am J Physiol Gastrointest Liver Physiol. 2012 Jan 15; 302(2):G218-24. PMID: 22094603; PMCID: PMC3341112.
    36. Gay AN, Lazar DA, Stoll B, Naik-Mathuria B, Mushin OP, Rodriguez MA, Burrin DG, Olutoye OO. Near-infrared spectroscopy measurement of abdominal tissue oxygenation is a useful indicator of intestinal blood flow and necrotizing enterocolitis in premature piglets. J Pediatr Surg. 2011 Jun; 46(6):1034-40. PMID: 21683194; PMCID: PMC3121185.
    37. Benight NM, Stoll B, Chacko S, da Silva VR, Marini JC, Gregory JF, Stabler SP, Burrin DG. B-vitamin deficiency is protective against DSS-induced colitis in mice. Am J Physiol Gastrointest Liver Physiol. 2011 Aug; 301(2):G249-59. PMID: 21596995; PMCID: PMC3154603.
    38. Puiman PJ, Jensen M, Stoll B, Renes IB, de Bruijn AC, Dorst K, Schierbeek H, Schmidt M, Boehm G, Burrin DG, Sangild PT, van Goudoever JB. Intestinal threonine utilization for protein and mucin synthesis is decreased in formula-fed preterm pigs. J Nutr. 2011 Jul; 141(7):1306-11. PMID: 21593357.
      View in: PubMed
    39. Cilieborg MS, Schmidt M, Skovgaard K, Boye M, Weber NR, Heegaard PM, Burrin DG, Sangild PT. Fetal lipopolysaccharide exposure modulates diet-dependent gut maturation and sensitivity to necrotising enterocolitis in pre-term pigs. Br J Nutr. 2011 Sep; 106(6):852-61. PMID: 21676273.
      View in: PubMed
    40. Taylor-Edwards CC, Burrin DG, Holst JJ, McLeod KR, Harmon DL. Glucagon-like peptide-2 (GLP-2) increases small intestinal blood flow and mucosal growth in ruminating calves. J Dairy Sci. 2011 Feb; 94(2):888-98. PMID: 21257057.
      View in: PubMed
    41. Puiman PJ, Stoll B, van Goudoever JB, Burrin DG. Enteral arginine does not increase superior mesenteric arterial blood flow but induces mucosal growth in neonatal pigs. J Nutr. 2011 Jan; 141(1):63-70. PMID: 21106927; PMCID: PMC3001236.
    42. Yang C, Albin DM, Wang Z, Stoll B, Lackeyram D, Swanson KC, Yin Y, Tappenden KA, Mine Y, Yada RY, Burrin DG, Fan MZ. Apical Na+-D-glucose cotransporter 1 (SGLT1) activity and protein abundance are expressed along the jejunal crypt-villus axis in the neonatal pig. Am J Physiol Gastrointest Liver Physiol. 2011 Jan; 300(1):G60-70. PMID: 21030609; PMCID: PMC3025512.
    43. Stoll B, Horst DA, Cui L, Chang X, Ellis KJ, Hadsell DL, Suryawan A, Kurundkar A, Maheshwari A, Davis TA, Burrin DG. Chronic parenteral nutrition induces hepatic inflammation, steatosis, and insulin resistance in neonatal pigs. J Nutr. 2010 Dec; 140(12):2193-200. PMID: 20980637; PMCID: PMC2981005.
    44. Bauchart-Thevret C, Cui L, Wu G, Burrin DG. Arginine-induced stimulation of protein synthesis and survival in IPEC-J2 cells is mediated by mTOR but not nitric oxide. Am J Physiol Endocrinol Metab. 2010 Dec; 299(6):E899-909. PMID: 20841502.
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    45. Taylor-Edwards CC, Burrin DG, Matthews JC, McLeod KR, Holst JJ, Harmon DL. Expression of mRNA for proglucagon and glucagon-like peptide-2 (GLP-2) receptor in the ruminant gastrointestinal tract and the influence of energy intake. Domest Anim Endocrinol. 2010 Oct; 39(3):181-93. PMID: 20688461.
      View in: PubMed
    46. Davis TA, Suryawan A, Orellana RA, Fiorotto ML, Burrin DG. Amino acids and insulin are regulators of muscle protein synthesis in neonatal pigs. Animal. 2010; 4(11):1790-1796. PMID: 21779306.
      View in: PubMed
    47. Bauchart-Thevret C, Stoll B, Burrin DG. Intestinal metabolism of sulfur amino acids. Nutr Res Rev. 2009 Dec; 22(2):175-87. PMID: 19835653.
      View in: PubMed
    48. Thymann T, Møller HK, Stoll B, Støy AC, Buddington RK, Bering SB, Jensen BB, Olutoye OO, Siggers RH, Mølbak L, Sangild PT, Burrin DG. Carbohydrate maldigestion induces necrotizing enterocolitis in preterm pigs. Am J Physiol Gastrointest Liver Physiol. 2009 Dec; 297(6):G1115-25. PMID: 19808655; PMCID: PMC2850085.
    49. Verbruggen S, Sy J, Gordon WE, Hsu J, Wu M, Chacko S, Zurakowski D, Burrin D, Castillo L. Ontogeny of methionine utilization and splanchnic uptake in critically ill children. Am J Physiol Endocrinol Metab. 2009 Nov; 297(5):E1046-55. PMID: 19724018.
      View in: PubMed
    50. Burrin DG, Stoll B. Metabolic fate and function of dietary glutamate in the gut. Am J Clin Nutr. 2009 Sep; 90(3):850S-856S. PMID: 19587091.
      View in: PubMed
    51. Bauchart-Thevret C, Stoll B, Chacko S, Burrin DG. Sulfur amino acid deficiency upregulates intestinal methionine cycle activity and suppresses epithelial growth in neonatal pigs. Am J Physiol Endocrinol Metab. 2009 Jun; 296(6):E1239-50. PMID: 19293331; PMCID: PMC2692405.
    52. Bertolo RF, Burrin DG. Comparative aspects of tissue glutamine and proline metabolism. J Nutr. 2008 Oct; 138(10):2032S-2039S. PMID: 18806120.
      View in: PubMed
    53. Bjornvad CR, Thymann T, Deutz NE, Burrin DG, Jensen SK, Jensen BB, Mølbak L, Boye M, Larsson LI, Schmidt M, Michaelsen KF, Sangild PT. Enteral feeding induces diet-dependent mucosal dysfunction, bacterial proliferation, and necrotizing enterocolitis in preterm pigs on parenteral nutrition. Am J Physiol Gastrointest Liver Physiol. 2008 Nov; 295(5):G1092-103. PMID: 18818317.
      View in: PubMed
    54. Thivierge MC, Bush JA, Suryawan A, Nguyen HV, Orellana RA, Burrin DG, Jahoor F, Davis TA. Positive net movements of amino acids in the hindlimb after overnight food deprivation contribute to sustaining the elevated anabolism of neonatal pigs. J Appl Physiol (1985). 2008 Dec; 105(6):1959-66. PMID: 18801965; PMCID: PMC2612466.
    55. Burrin DG, Janeczko MJ, Stoll B. Emerging aspects of dietary glutamate metabolism in the developing gut. Asia Pac J Clin Nutr. 2008; 17 Suppl 1:368-71. PMID: 18296381.
      View in: PubMed
    56. Janeczko MJ, Stoll B, Chang X, Guan X, Burrin DG. Extensive gut metabolism limits the intestinal absorption of excessive supplemental dietary glutamate loads in infant pigs. J Nutr. 2007 Nov; 137(11):2384-90. PMID: 17951474.
      View in: PubMed
    57. Haÿs SP, Ordonez JM, Burrin DG, Sunehag AL. Dietary glutamate is almost entirely removed in its first pass through the splanchnic bed in premature infants. Pediatr Res. 2007 Sep; 62(3):353-6. PMID: 17622957.
      View in: PubMed
    58. Riedijk MA, Stoll B, Chacko S, Schierbeek H, Sunehag AL, van Goudoever JB, Burrin DG. Methionine transmethylation and transsulfuration in the piglet gastrointestinal tract. Proc Natl Acad Sci U S A. 2007 Feb 27; 104(9):3408-13. PMID: 17360659; PMCID: PMC1805557.
    59. Burrin DG, Stoll B. Emerging aspects of gut sulfur amino acid metabolism. Curr Opin Clin Nutr Metab Care. 2007 Jan; 10(1):63-8. PMID: 17143057.
      View in: PubMed
    60. Lambert BD, Filip R, Stoll B, Junghans P, Derno M, Hennig U, Souffrant WB, Pierzynowski S, Burrin DG. First-pass metabolism limits the intestinal absorption of enteral alpha-ketoglutarate in young pigs. J Nutr. 2006 Nov; 136(11):2779-84. PMID: 17056800.
      View in: PubMed
    61. Wang H, Khaoustov VI, Krishnan B, Cai W, Stoll B, Burrin DG, Yoffe B. Total parenteral nutrition induces liver steatosis and apoptosis in neonatal piglets. J Nutr. 2006 Oct; 136(10):2547-52. PMID: 16988124.
      View in: PubMed
    62. Burrin DG, Stoll B, Guan X, Cui L, Chang X, Hadsell D. GLP-2 rapidly activates divergent intracellular signaling pathways involved in intestinal cell survival and proliferation in neonatal piglets. Am J Physiol Endocrinol Metab. 2007 Jan; 292(1):E281-91. PMID: 16954336.
      View in: PubMed
    63. Thymann T, Burrin DG, Tappenden KA, Bjornvad CR, Jensen SK, Sangild PT. Formula-feeding reduces lactose digestive capacity in neonatal pigs. Br J Nutr. 2006 Jun; 95(6):1075-81. PMID: 16768828.
      View in: PubMed
    64. Sangild PT, Siggers RH, Schmidt M, Elnif J, Bjornvad CR, Thymann T, Grondahl ML, Hansen AK, Jensen SK, Boye M, Moelbak L, Buddington RK, Weström BR, Holst JJ, Burrin DG. Diet- and colonization-dependent intestinal dysfunction predisposes to necrotizing enterocolitis in preterm pigs. Gastroenterology. 2006 May; 130(6):1776-92. PMID: 16697741.
      View in: PubMed
    65. Stoll B, Burrin DG. Measuring splanchnic amino acid metabolism in vivo using stable isotopic tracers. J Anim Sci. 2006 Apr; 84 Suppl:E60-72. PMID: 16582093.
      View in: PubMed
    66. Stoll B, Price PT, Reeds PJ, Chang X, Henry JF, van Goudoever JB, Holst JJ, Burrin DG. Feeding an elemental diet vs a milk-based formula does not decrease intestinal mucosal growth in infant pigs. JPEN J Parenter Enteral Nutr. 2006 Jan-Feb; 30(1):32-9. PMID: 16387897.
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    67. Guan X, Karpen HE, Stephens J, Bukowski JT, Niu S, Zhang G, Stoll B, Finegold MJ, Holst JJ, Hadsell D, Hadsell DL, Nichols BL, Burrin DG. GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood flow. Gastroenterology. 2006 Jan; 130(1):150-64. PMID: 16401478.
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    68. van Goudoever JB, van der Schoor SR, Stoll B, Burrin DG, Wattimena D, Schierbeek H, Schaart MW, Riedijk MA, van der Lugt J. Intestinal amino acid metabolism in neonates. Nestle Nutr Workshop Ser Pediatr Program. 2006; 58:95-102; discussion 102-8. PMID: 16902328.
      View in: PubMed
    69. Cottrell JJ, Stoll B, Buddington RK, Stephens JE, Cui L, Chang X, Burrin DG. Glucagon-like peptide-2 protects against TPN-induced intestinal hexose malabsorption in enterally refed piglets. Am J Physiol Gastrointest Liver Physiol. 2006 Feb; 290(2):G293-300. PMID: 16166344.
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    70. Stephens J, Stoll B, Cottrell J, Chang X, Helmrath M, Burrin DG. Glucagon-like peptide-2 acutely increases proximal small intestinal blood flow in TPN-fed neonatal piglets. Am J Physiol Regul Integr Comp Physiol. 2006 Feb; 290(2):R283-9. PMID: 16166200.
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    71. Zeisel SH, Freake HC, Bauman DE, Bier DM, Burrin DG, German JB, Klein S, Marquis GS, Milner JA, Pelto GH, Rasmussen KM. The nutritional phenotype in the age of metabolomics. J Nutr. 2005 Jul; 135(7):1613-6. PMID: 15987837; PMCID: PMC2430109.
    72. Shoveller AK, Stoll B, Ball RO, Burrin DG. Nutritional and functional importance of intestinal sulfur amino acid metabolism. J Nutr. 2005 Jul; 135(7):1609-12. PMID: 15987836.
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    73. Thivierge MC, Bush JA, Suryawan A, Nguyen HV, Orellana RA, Burrin DG, Jahoor F, Davis TA. Whole-body and hindlimb protein breakdown are differentially altered by feeding in neonatal piglets. J Nutr. 2005 Jun; 135(6):1430-7. PMID: 15930448.
      View in: PubMed
    74. Schaart MW, Schierbeek H, van der Schoor SR, Stoll B, Burrin DG, Reeds PJ, van Goudoever JB. Threonine utilization is high in the intestine of piglets. J Nutr. 2005 Apr; 135(4):765-70. PMID: 15795432.
      View in: PubMed
    75. Bos C, Stoll B, Fouillet H, Gaudichon C, Guan X, Grusak MA, Reeds PJ, Burrin DG, Tomé D. Postprandial intestinal and whole body nitrogen kinetics and distribution in piglets fed a single meal. Am J Physiol Endocrinol Metab. 2005 Feb; 288(2):E436-46. PMID: 15507535.
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    76. Burrin DG, Stoll B, Guan X, Cui L, Chang X, Holst JJ. Glucagon-like peptide 2 dose-dependently activates intestinal cell survival and proliferation in neonatal piglets. Endocrinology. 2005 Jan; 146(1):22-32. PMID: 15486229.
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    77. German JB, Bauman DE, Burrin DG, Failla ML, Freake HC, King JC, Klein S, Milner JA, Pelto GH, Rasmussen KM, Zeisel SH. Metabolomics in the opening decade of the 21st century: building the roads to individualized health. J Nutr. 2004 Oct; 134(10):2729-32. PMID: 15465774.
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    88. Bos C, Stoll B, Fouillet H, Gaudichon C, Guan X, Grusak MA, Reeds PJ, Tomé D, Burrin DG. Intestinal lysine metabolism is driven by the enteral availability of dietary lysine in piglets fed a bolus meal. Am J Physiol Endocrinol Metab. 2003 Dec; 285(6):E1246-57. PMID: 12851176.
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    90. Burrin DG, Stoll B, Guan X. Glucagon-like peptide 2 function in domestic animals. Domest Anim Endocrinol. 2003 Mar; 24(2):103-22. PMID: 12586312.
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    92. Lambert BD, Stoll B, Niinikoski H, Pierzynowski S, Burrin DG. Net portal absorption of enterally fed alpha-ketoglutarate is limited in young pigs. J Nutr. 2002 Nov; 132(11):3383-6. PMID: 12421855.
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    93. Bush JA, Burrin DG, Suryawan A, O'Connor PM, Nguyen HV, Reeds PJ, Steele NC, Van Goudoever JB, Davis TA. Somatotropin-induced protein anabolism in hindquarters and portal-drained viscera of growing pigs. Am J Physiol Endocrinol Metab. 2003 Feb; 284(2):E302-12. PMID: 12388127.
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    94. Davis TA, Fiorotto ML, Burrin DG, Vann RC, Reeds PJ, Nguyen HV, Beckett PR, Bush JA. Acute IGF-I infusion stimulates protein synthesis in skeletal muscle and other tissues of neonatal pigs. Am J Physiol Endocrinol Metab. 2002 Oct; 283(4):E638-47. PMID: 12217880.
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    96. Owens L, Burrin DG, Berseth CL. Minimal enteral feeding induces maturation of intestinal motor function but not mucosal growth in neonatal dogs. J Nutr. 2002 Sep; 132(9):2717-22. PMID: 12221235.
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    101. van der Schoor SR, van Goudoever JB, Stoll B, Henry JF, Rosenberger JR, Burrin DG, Reeds PJ. The pattern of intestinal substrate oxidation is altered by protein restriction in pigs. Gastroenterology. 2001 Nov; 121(5):1167-75. PMID: 11677209.
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    102. Burrin DG, Stoll B, Fan MZ, Dudley MA, Donovan SM, Reeds PJ. Oral IGF-I alters the posttranslational processing but not the activity of lactase-phlorizin hydrolase in formula-fed neonatal pigs. J Nutr. 2001 Sep; 131(9):2235-41. PMID: 11533260.
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    106. van Goudoever JB, Stoll B, Hartmann B, Holst JJ, Reeds PJ, Burrin DG. Secretion of trophic gut peptides is not different in bolus- and continuously fed piglets. J Nutr. 2001 Mar; 131(3):729-32. PMID: 11238751.
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    108. Fan MZ, Stoll B, Jiang R, Burrin DG. Enterocyte digestive enzyme activity along the crypt-villus and longitudinal axes in the neonatal pig small intestine. J Anim Sci. 2001 Feb; 79(2):371-81. PMID: 11219446.
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    112. Jiang R, Chang X, Stoll B, Ellis KJ, Shypailo RJ, Weaver E, Campbell J, Burrin DG. Dietary plasma protein is used more efficiently than extruded soy protein for lean tissue growth in early-weaned pigs. J Nutr. 2000 Aug; 130(8):2016-9. PMID: 10917918.
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    116. Reeds PJ, Burrin DG, Stoll B, Jahoor F. Intestinal glutamate metabolism. J Nutr. 2000 Apr; 130(4S Suppl):978S-82S. PMID: 10736365.
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    117. Lewis AJ, Wester TJ, Burrin DG, Dauncey MJ. Exogenous growth hormone induces somatotrophic gene expression in neonatal liver and skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2000 Apr; 278(4):R838-44. PMID: 10749770.
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    122. Davis TA, Fiorotto ML, Nguyen HV, Burrin DG. Aminoacyl-tRNA and tissue free amino acid pools are equilibrated after a flooding dose of phenylalanine. Am J Physiol. 1999 Jul; 277(1 Pt 1):E103-9. PMID: 10409133.
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    124. Burrin DG, Wester TJ, Davis TA, Fiorotto ML, Chang X. Dexamethasone inhibits small intestinal growth via increased protein catabolism in neonatal pigs. Am J Physiol. 1999 Feb; 276(2 Pt 1):E269-77. PMID: 9950786.
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    125. Burrin DG, Fiorotto ML, Hadsell DL. Transgenic hypersecretion of des(1-3) human insulin-like growth factor I in mouse milk has limited effects on the gastrointestinal tract in suckling pups. J Nutr. 1999 Jan; 129(1):51-6. PMID: 9915875.
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    126. Stoll B, Burrin DG, Henry JF, Jahoor F, Reeds PJ. Dietary and systemic phenylalanine utilization for mucosal and hepatic constitutive protein synthesis in pigs. Am J Physiol. 1999 Jan; 276(1 Pt 1):G49-57. PMID: 9886978.
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    127. Wester TJ, Fiorotto ML, Klindt J, Burrin DG. Feeding colostrum increases circulating insulin-like growth factor I in newborn pigs independent of endogenous growth hormone secretion. J Anim Sci. 1998 Dec; 76(12):3003-9. PMID: 9928604.
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    128. Wray-Cahen D, Nguyen HV, Burrin DG, Beckett PR, Fiorotto ML, Reeds PJ, Wester TJ, Davis TA. Response of skeletal muscle protein synthesis to insulin in suckling pigs decreases with development. Am J Physiol. 1998 Oct; 275(4 Pt 1):E602-9. PMID: 9755078.
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    129. Stoll B, Burrin DG, Henry J, Yu H, Jahoor F, Reeds PJ. Dietary amino acids are the preferential source of hepatic protein synthesis in piglets. J Nutr. 1998 Sep; 128(9):1517-24. PMID: 9732313.
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    130. Stoll B, Henry J, Reeds PJ, Yu H, Jahoor F, Burrin DG. Catabolism dominates the first-pass intestinal metabolism of dietary essential amino acids in milk protein-fed piglets. J Nutr. 1998 Mar; 128(3):606-14. PMID: 9482771.
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    131. Dudley MA, Burrin DG, Wykes LJ, Toffolo G, Cobelli C, Nichols BL, Rosenberger J, Jahoor F, Reeds PJ. Protein kinetics determined in vivo with a multiple-tracer, single-sample protocol: application to lactase synthesis. Am J Physiol. 1998 Mar; 274(3 Pt 1):G591-8. PMID: 9530162.
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    133. Dudley MA, Wykes LJ, Dudley AW, Burrin DG, Nichols BL, Rosenberger J, Jahoor F, Heird WC, Reeds PJ. Parenteral nutrition selectively decreases protein synthesis in the small intestine. Am J Physiol. 1998 Jan; 274(1 Pt 1):G131-7. PMID: 9458782.
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    136. Stoll B, Burrin DG, Henry J, Jahoor F, Reeds PJ. Phenylalanine utilization by the gut and liver measured with intravenous and intragastric tracers in pigs. Am J Physiol. 1997 Dec; 273(6 Pt 1):G1208-17. PMID: 9435545.
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    138. Schoknecht PA, Ebner S, Skottner A, Burrin DG, Davis TA, Ellis K, Pond WG. Exogenous insulin-like growth factor-I increases weight gain in intrauterine growth-retarded neonatal pigs. Pediatr Res. 1997 Aug; 42(2):201-7. PMID: 9262223.
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    143. Dudley MA, Wykes L, Dudley AW, Fiorotto M, Burrin DG, Rosenberger J, Jahoor F, Reeds PJ. Lactase phlorizin hydrolase synthesis is decreased in protein-malnourished pigs. J Nutr. 1997 May; 127(5):687-93. PMID: 9164987.
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    147. Davis TA, Burrin DG, Fiorotto ML, Nguyen HV. Protein synthesis in skeletal muscle and jejunum is more responsive to feeding in 7-than in 26-day-old pigs. Am J Physiol. 1996 May; 270(5 Pt 1):E802-9. PMID: 8967468.
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    148. Wykes LJ, Fiorotto M, Burrin DG, Del Rosario M, Frazer ME, Pond WG, Jahoor F. Chronic low protein intake reduces tissue protein synthesis in a pig model of protein malnutrition. J Nutr. 1996 May; 126(5):1481-8. PMID: 8618147.
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    150. Burrin DG, Wester TJ, Davis TA, Amick S, Heath JP. Orally administered IGF-I increases intestinal mucosal growth in formula-fed neonatal pigs. Am J Physiol. 1996 May; 270(5 Pt 2):R1085-91. PMID: 8928910.
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    152. Pond WG, Ellis KJ, Mersmann HJ, Heath JP, Krook LP, Burrin DG, Dudley MA, Sheng HP. Severe protein deficiency and repletion alter body and brain composition and organ weights in infant pigs. J Nutr. 1996 Jan; 126(1):290-302. PMID: 8558314.
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    153. Burrin DG, Davis TA, Ebner S, Schoknecht PA, Fiorotto ML, Reeds PJ, McAvoy S. Nutrient-independent and nutrient-dependent factors stimulate protein synthesis in colostrum-fed newborn pigs. Pediatr Res. 1995 May; 37(5):593-9. PMID: 7603776.
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    158. Burrin DG, Shulman RJ, Langston C, Storm MC. Supplemental alanylglutamine, organ growth, and nitrogen metabolism in neonatal pigs fed by total parenteral nutrition. JPEN J Parenter Enteral Nutr. 1994 Jul-Aug; 18(4):313-9. PMID: 7933437.
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    162. Burrin DG, Britton RA, Ferrell CL, Bauer ML. Level of nutrition and visceral organ protein synthetic capacity and nucleic acid content in sheep. J Anim Sci. 1992 Apr; 70(4):1137-45. PMID: 1374754.
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