TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
AddressOne Baylor Plaza
Houston, TX 77030
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    R56AR063686     (HU, ZHAOYONG)Sep 10, 2020 - Aug 31, 2021
    Mechanisms of Protein-Energy-Wasting in chronic kidney disease
    Role: Principal Investigator

    R01AR063686     (HU, ZHAOYONG)Jul 1, 2013 - Apr 30, 2019
    Mechanisms of Protein-Energy-Wasting in Chronic Kidney Disease
    Role: Principal Investigator

    R01DK037175     (HU, ZHAOYONG)Sep 1, 1985 - Mar 31, 2022
    Protein Nutrition in Experimental Uremia
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Huang Q, Sun Y, Sun J, Peng L, Shang H, Wei D, Li C, Hu Z, Peng H. Proteomic Characterization of Peritoneal Extracellular Vesicles in a Mouse Model of Peritoneal Fibrosis. J Proteome Res. 2023 03 03; 22(3):908-918. PMID: 36648763.
      Citations:    Fields:    Translation:AnimalsCells
    2. Li Y, Lin H, Shu S, Sun Y, Lai W, Chen W, Hu Z, Peng H. Integrative transcriptome analysis reveals TEKT2 and PIAS2 involvement in diabetic nephropathy. FASEB J. 2022 11; 36(11):e22592. PMID: 36251411.
    3. Thomas SS, Wu J, Davogustto G, Holliday MW, Eckel-Mahan K, Hu Z, Mitch WE, Taegtmeyer H, Verzola D, Garibotto G. SIRPa Mediates IGF1 Receptor in Cardiomyopathy Induced by Chronic Kidney Disease. Circ Res. 2022 07 22; 131(3):207-221. PMID: 35722884; PMCID: PMC10010047.
      Citations:    Fields:    Translation:AnimalsCells
    4. Lin H, Ma X, Sun Y, Peng H, Wang Y, Thomas SS, Hu Z. Decoding the transcriptome of denervated muscle at single-nucleus resolution. J Cachexia Sarcopenia Muscle. 2022 08; 13(4):2102-2117. PMID: 35726356; PMCID: PMC9398230.
      Citations:    Fields:    
    5. An C, Wen J, Hu Z, Mitch WE, Wang Y. Phosphoinositide 3-kinase ? deficiency attenuates kidney injury and fibrosis in angiotensin II-induced hypertension. Nephrol Dial Transplant. 2020 09 01; 35(9):1491-1500. PMID: 32500132; PMCID: PMC7778344.
      Citations: 7     Fields:    Translation:AnimalsCells
    6. Wu Y, An C, Jin X, Hu Z, Wang Y. Disruption of CXCR6 Ameliorates Kidney Inflammation and Fibrosis in Deoxycorticosterone Acetate/Salt Hypertension. Sci Rep. 2020 01 10; 10(1):133. PMID: 31924817; PMCID: PMC6954216.
      Citations: 5     Fields:    Translation:AnimalsCells
    7. Zhou J, An C, Jin X, Hu Z, Safirstein RL, Wang Y. TAK1 deficiency attenuates cisplatin-induced acute kidney injury. Am J Physiol Renal Physiol. 2020 01 01; 318(1):F209-F215. PMID: 31813254; PMCID: PMC6985823.
      Citations: 10     Fields:    Translation:AnimalsCells
    8. Wu J, Dong J, Hruska K, Hu Z, Mitch WE, Thomas SS, Verzola D, Garibotto G. Signal regulatory protein alpha initiates cachexia through muscle to adipose tissue crosstalk. J Cachexia Sarcopenia Muscle. 2019 12; 10(6):1210-1227. PMID: 31507080; PMCID: PMC6903446.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    9. Si M, Wang Q, Li Y, Lin H, Luo D, Zhao W, Dou X, Liu J, Zhang H, Huang Y, Lou T, Hu Z, Peng H. Inhibition of hyperglycolysis in mesothelial cells prevents peritoneal fibrosis. Sci Transl Med. 2019 06 05; 11(495). PMID: 31167927.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    10. Sun L, Si M, Liu X, Choi JM, Wang Y, Thomas SS, Peng H, Hu Z. Long-noncoding RNA Atrolnc-1 promotes muscle wasting in mice with chronic kidney disease. J Cachexia Sarcopenia Muscle. 2018 10; 9(5):962-974. PMID: 30043444; PMCID: PMC6204593.
      Citations: 30     Fields:    Translation:AnimalsCells
    11. Peng H, Wang Q, Lou T, Qin J, Jung S, Shetty V, Li F, Wang Y, Feng XH, Mitch WE, Graham BH, Hu Z. Myokine mediated muscle-kidney crosstalk suppresses metabolic reprogramming and fibrosis in damaged kidneys. Nat Commun. 2017 11 14; 8(1):1493. PMID: 29138395; PMCID: PMC5686208.
      Citations: 44     Fields:    Translation:Animals
    12. Cao J, Yu Y, Zhang Z, Chen X, Hu Z, Tong Q, Chang J, Feng XH, Lin X. SCP4 Promotes Gluconeogenesis Through FoxO1/3a Dephosphorylation. Diabetes. 2018 01; 67(1):46-57. PMID: 28851713; PMCID: PMC5741142.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    13. Zhou J, Jia L, Hu Z, Wang Y. Pharmacological Inhibition of PTEN Aggravates Acute Kidney Injury. Sci Rep. 2017 08 25; 7(1):9503. PMID: 28842716; PMCID: PMC5572703.
      Citations: 12     Fields:    Translation:AnimalsCells
    14. Liang H, Zhang Z, Yan J, Wang Y, Hu Z, Mitch WE, Wang Y. The IL-4 receptor a has a critical role in bone marrow-derived fibroblast activation and renal fibrosis. Kidney Int. 2017 12; 92(6):1433-1443. PMID: 28739140; PMCID: PMC5696054.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    15. Wang Y, Jia L, Hu Z, Entman ML, Mitch WE, Wang Y. AMP-activated protein kinase/myocardin-related transcription factor-A signaling regulates fibroblast activation and renal fibrosis. Kidney Int. 2018 01; 93(1):81-94. PMID: 28739141; PMCID: PMC5750062.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    16. Liu X, Yu R, Sun L, Garibotto G, Lin X, Wang Y, Thomas SS, Li R, Hu Z. The nuclear phosphatase SCP4 regulates FoxO?transcription factors during muscle wasting?in chronic kidney disease. Kidney Int. 2017 08; 92(2):336-348. PMID: 28506762; PMCID: PMC5511577.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    17. Yu R, Chen JA, Xu J, Cao J, Wang Y, Thomas SS, Hu Z. Suppression of muscle wasting by the plant-derived compound ursolic acid in a model of chronic kidney disease. J Cachexia Sarcopenia Muscle. 2017 Apr; 8(2):327-341. PMID: 27897418; PMCID: PMC5377392.
      Citations: 26     Fields:    Translation:AnimalsCells
    18. Zhou X, Li R, Liu X, Wang L, Hui P, Chan L, Saha PK, Hu Z. ROCK1 reduces mitochondrial content and irisin production in muscle suppressing adipocyte browning and impairing insulin sensitivity. Sci Rep. 2016 07 14; 6:29669. PMID: 27411515; PMCID: PMC4944137.
      Citations: 15     Fields:    Translation:AnimalsCells
    19. Liang H, Ma Z, Peng H, He L, Hu Z, Wang Y. CXCL16 Deficiency Attenuates Renal Injury and Fibrosis in Salt-Sensitive Hypertension. Sci Rep. 2016 06 29; 6:28715. PMID: 27353044; PMCID: PMC4926114.
      Citations: 18     Fields:    Translation:Animals
    20. Peng H, Li Y, Wang C, Zhang J, Chen Y, Chen W, Cao J, Wang Y, Hu Z, Lou T. ROCK1 Induces Endothelial-to-Mesenchymal Transition in Glomeruli to Aggravate Albuminuria in Diabetic Nephropathy. Sci Rep. 2016 Feb 04; 6:20304. PMID: 26842599; PMCID: PMC4740844.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    21. Peng H, Cao J, Yu R, Danesh F, Wang Y, Mitch WE, Xu J, Hu Z. CKD Stimulates Muscle Protein Loss Via Rho-associated Protein Kinase 1 Activation. J Am Soc Nephrol. 2016 Feb; 27(2):509-19. PMID: 26054539; PMCID: PMC4731120.
      Citations: 12     Fields:    Translation:Animals
    22. Zhou X, Wang C, Tian J, Wang Y, Li Y, Hu Z, Li R. Mitogen-activated protein kinase mediates mevalonate-stimulated human mesangial cell proliferation. Mol Med Rep. 2015 Aug; 12(2):2643-9. PMID: 25936991; PMCID: PMC4464046.
      Citations: 2     Fields:    Translation:HumansCells
    23. Lin J, Shi Y, Peng H, Shen X, Thomas S, Wang Y, Truong LD, Dryer SE, Hu Z, Xu J. Loss of PTEN promotes podocyte cytoskeletal rearrangement, aggravating diabetic nephropathy. J Pathol. 2015 May; 236(1):30-40. PMID: 25641678; PMCID: PMC4398628.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    24. Hu Z, Klein JD, Mitch WE, Zhang L, Martinez I, Wang XH. MicroRNA-29 induces cellular senescence in aging muscle through multiple signaling pathways. Aging (Albany NY). 2014 Mar; 6(3):160-75. PMID: 24659628; PMCID: PMC4012934.
      Citations: 56     Fields:    Translation:AnimalsCells
    25. Yang J, Lin SC, Chen G, He L, Hu Z, Chan L, Trial J, Entman ML, Wang Y. Adiponectin promotes monocyte-to-fibroblast transition in renal fibrosis. J Am Soc Nephrol. 2013 Oct; 24(10):1644-59. PMID: 23833260; PMCID: PMC3785282.
      Citations: 55     Fields:    Translation:AnimalsCells
    26. Jin X, Chen J, Hu Z, Chan L, Wang Y. Genetic deficiency of adiponectin protects against acute kidney injury. Kidney Int. 2013 Apr; 83(4):604-14. PMID: 23302722; PMCID: PMC3612389.
      Citations: 42     Fields:    Translation:AnimalsCells
    27. Xu J, Li R, Workeneh B, Dong Y, Wang X, Hu Z. Transcription factor FoxO1, the dominant mediator of muscle wasting in chronic kidney disease, is inhibited by microRNA-486. Kidney Int. 2012 Aug; 82(4):401-11. PMID: 22475820; PMCID: PMC3393843.
      Citations: 100     Fields:    Translation:AnimalsCells
    28. Wang W, He B, Shi W, Liang X, Ma J, Shan Z, Hu Z, Danesh FR. Deletion of scavenger receptor A protects mice from progressive nephropathy independent of lipid control during diet-induced hyperlipidemia. Kidney Int. 2012 May; 81(10):1002-1014. PMID: 22377830; PMCID: PMC3343314.
      Citations: 9     Fields:    Translation:AnimalsCells
    29. Wang XH, Hu Z, Klein JD, Zhang L, Fang F, Mitch WE. Decreased miR-29 suppresses myogenesis in CKD. J Am Soc Nephrol. 2011 Nov; 22(11):2068-76. PMID: 21965375; PMCID: PMC3231783.
      Citations: 52     Fields:    Translation:AnimalsCells
    30. Zhang L, Rajan V, Lin E, Hu Z, Han HQ, Zhou X, Song Y, Min H, Wang X, Du J, Mitch WE. Pharmacological inhibition of myostatin suppresses systemic inflammation and muscle atrophy in mice with chronic kidney disease. FASEB J. 2011 May; 25(5):1653-63. PMID: 21282204; PMCID: PMC3079306.
      Citations: 132     Fields:    Translation:AnimalsCells
    31. Wang H, Liu D, Cao P, Lecker S, Hu Z. Atrogin-1 affects muscle protein synthesis and degradation when energy metabolism is impaired by the antidiabetes drug berberine. Diabetes. 2010 Aug; 59(8):1879-89. PMID: 20522589; PMCID: PMC2911075.
      Citations: 18     Fields:    Translation:AnimalsCells
    32. Hu Z, Wang H, Lee IH, Modi S, Wang X, Du J, Mitch WE. PTEN inhibition improves muscle regeneration in mice fed a high-fat diet. Diabetes. 2010 Jun; 59(6):1312-20. PMID: 20200318; PMCID: PMC2874691.
      Citations: 58     Fields:    Translation:AnimalsCells
    33. Ye Y, Hu Z, Lin Y, Zhang C, Perez-Polo JR. Downregulation of microRNA-29 by antisense inhibitors and a PPAR-gamma agonist protects against myocardial ischaemia-reperfusion injury. Cardiovasc Res. 2010 Aug 01; 87(3):535-44. PMID: 20164119.
      Citations: 97     Fields:    Translation:AnimalsCells
    34. Keyes KT, Xu J, Long B, Zhang C, Hu Z, Ye Y. Pharmacological inhibition of PTEN limits myocardial infarct size and improves left ventricular function postinfarction. Am J Physiol Heart Circ Physiol. 2010 Apr; 298(4):H1198-208. PMID: 20097771.
      Citations: 46     Fields:    Translation:AnimalsCells
    35. Hu Z, Wang H, Lee IH, Du J, Mitch WE. Endogenous glucocorticoids and impaired insulin signaling are both required to stimulate muscle wasting under pathophysiological conditions in mice. J Clin Invest. 2009 Oct; 119(10):3059-69. PMID: 19759515; PMCID: PMC2752071.
      Citations: 84     Fields:    Translation:AnimalsCells
    36. Zhang L, Du J, Hu Z, Han G, Delafontaine P, Garcia G, Mitch WE. IL-6 and serum amyloid A synergy mediates angiotensin II-induced muscle wasting. J Am Soc Nephrol. 2009 Mar; 20(3):604-12. PMID: 19158350; PMCID: PMC2653674.
      Citations: 123     Fields:    Translation:HumansAnimalsCells
    37. Deboer MD, Zhu X, Levasseur PR, Inui A, Hu Z, Han G, Mitch WE, Taylor JE, Halem HA, Dong JZ, Datta R, Culler MD, Marks DL. Ghrelin treatment of chronic kidney disease: improvements in lean body mass and cytokine profile. Endocrinology. 2008 Feb; 149(2):827-35. PMID: 18039782; PMCID: PMC2219314.
      Citations: 50     Fields:    Translation:Animals
    38. Zhou Q, Du J, Hu Z, Walsh K, Wang XH. Evidence for adipose-muscle cross talk: opposing regulation of muscle proteolysis by adiponectin and Fatty acids. Endocrinology. 2007 Dec; 148(12):5696-705. PMID: 17761767.
      Citations: 47     Fields:    Translation:AnimalsCells
    39. Hu Z, Lee IH, Wang X, Sheng H, Zhang L, Du J, Mitch WE. PTEN expression contributes to the regulation of muscle protein degradation in diabetes. Diabetes. 2007 Oct; 56(10):2449-56. PMID: 17623817.
      Citations: 33     Fields:    Translation:AnimalsCells
    40. Workeneh BT, Rondon-Berrios H, Zhang L, Hu Z, Ayehu G, Ferrando A, Kopple JD, Wang H, Storer T, Fournier M, Lee SW, Du J, Mitch WE. Development of a diagnostic method for detecting increased muscle protein degradation in patients with catabolic conditions. J Am Soc Nephrol. 2006 Nov; 17(11):3233-9. PMID: 17005936.
      Citations: 37     Fields:    Translation:Humans
    41. Wang X, Hu Z, Hu J, Du J, Mitch WE. Insulin resistance accelerates muscle protein degradation: Activation of the ubiquitin-proteasome pathway by defects in muscle cell signaling. Endocrinology. 2006 Sep; 147(9):4160-8. PMID: 16777975.
      Citations: 221     Fields:    Translation:AnimalsCells
    42. Bailey JL, Zheng B, Hu Z, Price SR, Mitch WE. Chronic kidney disease causes defects in signaling through the insulin receptor substrate/phosphatidylinositol 3-kinase/Akt pathway: implications for muscle atrophy. J Am Soc Nephrol. 2006 May; 17(5):1388-94. PMID: 16611720.
      Citations: 99     Fields:    Translation:AnimalsCells
    43. Du J, Hu Z, Mitch WE. Cellular signals activating muscle proteolysis in chronic kidney disease: a two-stage process. Int J Biochem Cell Biol. 2005 Oct; 37(10):2147-55. PMID: 15982920.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    44. Mitch WE, Hu Z, Lee SW, Du J. Strategies for suppressing muscle atrophy in chronic kidney disease: mechanisms activating distinct proteolytic systems. J Ren Nutr. 2005 Jan; 15(1):23-7. PMID: 15648002.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    45. Lee SW, Dai G, Hu Z, Wang X, Du J, Mitch WE. Regulation of muscle protein degradation: coordinated control of apoptotic and ubiquitin-proteasome systems by phosphatidylinositol 3 kinase. J Am Soc Nephrol. 2004 Jun; 15(6):1537-45. PMID: 15153564.
      Citations: 112     Fields:    Translation:AnimalsCells
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