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MARY K. ESTES

TitleDistinguished Service Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular Virology & Microbiology
DivisionMolecular Virology & Microbiology
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Medicine
    DivisionMedicine-Gastroenterology & Hepatol


    Collapse ORNG Applications 
    Collapse Verify Publications

    Collapse Biography 
    Collapse awards and honors
    1966 - 1967Beta Beta Beta
    1967Biology Award, Elmira College
    1974American Cancer Society Postdoctoral Fellowship (declined)
    1974 - 1976National Institutes of Health Postdoctoral Fellowship
    1987 - 1988ASM Foundation for Microbiology, Lecturer in Virology
    1992Wallace P. Rowe Award for Excellence in Virologic Research
    1992 - 1994ASM Foundation for Microbiology, Lecturer in Virology
    1994 - 2003Editor, Journal of Virology
    19951995 Michael E. DeBakey Award for Outstanding Research
    19961996 Elected Fellow, American Academy of Microbiology
    1996 - 1997President, American Society for Virology
    20002000 Elected Fellow, American Association for the Advancement of Science
    2000Researcher/Investigator of the Year, Crohn’s & Colitis Foundation Gold Key Award
    2005Elected Member, Institute of Medicine, National Academy of Science
    2005Member, Academy of Medicine, Engineering and Science of Texas
    2006Cullen Foundation Endowed Chair of Human and Molecular Virology
    2007Elected Member, National Academy of Sciences
    2007Associate Editor, PLoS Pathogens
    2009Distinguished Faculty Award, Baylor College of Medicine
    2009mBio Board of Editors
    2010Distinguished Service Professor, Baylor College of Medicine
    2010AGA Distinguished Achievement Award
    2011 - 2013Co-Editor in Chief, Current Opinion in Virology
    2011Elected Fellow, American Gastroenterological Association

    Collapse Overview 
    Collapse overview
    Molecular Biology of Gastrointestinal Viruses

    The gastrointestinal (GI) tract represents the largest and most heterogeneous organ in the body. However, information on the molecular biology of most cell types in the GI tract remains limited. We are using viruses that infect distinct types of cells (enterocytes, crypt cells, M cells) in the GI tract as probes to learn about the biology, host response and gene expression of these cells. We are using multidisciplinary approaches to probe the structure and molecular biology of GI viruses to understand the basic mechanisms that control virus replication, morphogenesis, virus-host interactions, and pathogenesis.

    Our work uses two viruses, rotaviruses, the major cause of diarrhea in children and animals worldwide, and human caliciviruses, the major cause of epidemic gastroenteritis. Studies on the molecular biology of the rotaviruses seek to dissect the biologic, biochemical and structural role(s) inducing disease. Current studies are focusing on the rotavirus spike protein and the viral enterotoxin and how these proteins induce signaling pathways in cells that are important in immunity and pathogenesis. We are studying proteins expressed from inducible cDNAs in mammalian cells and virus-like particles (VLPs) produced using the baculovirus expression system. We aim to determine how specific domains of the viral proteins interact with intestinal cell receptors, affect cell signaling mechan-isms, and induce diarrhea. We also are evaluating how to effectively orally deliver virus-like particlesubunit vaccines to induce a mucosal immune response and protection from virus infection.

    Studies on the human caliciviruses are using molecular approaches to characterize Norwalk virus and related viruses. Sequence analysis and expression of genes from a cloned DNA library of Norwalk virus nucleic acid have classified this virus, determined its genome organization and relatedness to other Norwalk-like viruses and other gastroenteritis viruses such as astroviruses and enteroviruses, and produced new diagnostic assays. Use of these new assays is changing our understanding of the natural history and epidemiology of infections with these viruses. Notably, these viruses are being increasingly recognized as important causes of disease in children and in immunocompromised individuals. Expression of the capsid protein using mammalian and plant VLPs allowed the first crystallographic structure of a calicivirus to be solved and they are being tested directly as mucosal vaccines or as delivery systems for vaccines containing epitopes from other pathogens. Finally, the molecular basis of the restricted replication of Norwalk viruses to the gastrointestinal tract of humans is being probed by expression of Norwalk virus genes with different vectors and testing the interactions of virus with different cell lines and tissues derived from the gastrointestinal tract.

    Collapse Research 
    Collapse research activities and funding
    R01AM030144     (ESTES, MARY KOLB)Aug 1, 1981 - Jul 31, 1989
    NIH/NIADDK
    MOLECULAR BIOLOGY OF THE ROTAVIRUSES
    Role: Principal Investigator

    R01DK030144     (ESTES, MARY KOLB)Aug 1, 1981 - Jun 30, 2006
    NIH/NIDDK
    MOLECULAR BIOLOGY OF THE ROTAVIRUSES
    Role: Principal Investigator

    R56DK030144     (ESTES, MARY KOLB)Aug 1, 1981 - Jun 30, 2009
    NIH/NIDDK
    Molecular Biology of the Rotaviruses
    Role: Principal Investigator

    R22AI020649     (ESTES, MARY KOLB)Sep 30, 1984 - Jul 31, 1991
    NIH/NIAID
    ANTIGENIC VARIATION OF HUMAN ROTAVIRUSES
    Role: Principal Investigator

    R01AI020649     (ESTES, MARY KOLB)Sep 30, 1984 - Nov 30, 1992
    NIH/NIAID
    ANTIGENIC VARIATION OF HUMAN ROTAVIRUSES
    Role: Principal Investigator

    R01AI024998     (CONNER, MARGARET E.)Jul 1, 1987 - Nov 30, 2014
    NIH/NIAID
    Intestinal Mucosal Immunity
    Role: Co-Principal Investigator

    U01AI030448     (ESTES, MARY KOLB)Jul 1, 1990 - Jun 30, 1995
    NIH/NIAID
    DEVELOPMENT OF DIAGNOSTIC TESTS FOR NORWALK VIRUSES
    Role: Principal Investigator

    R13AI030488     (ESTES, MARY KOLB)Dec 1, 1990 - Nov 30, 1991
    NIH/NIAID
    INTERNATIONAL SYMPOSIUM ON DOUBLE-STRANDED RNA VIRUSES
    Role: Principal Investigator

    U01AI038036     (ESTES, MARY KOLB)Jul 1, 1995 - Jun 30, 1999
    NIH/NIAID
    STRUCTURE DIRECTED ANTIVIRAL STRATEGIES FOR CALICIVIRUSE
    Role: Principal Investigator

    R21AI042646     (ESTES, MARY KOLB)Sep 30, 1997 - Sep 29, 2000
    NIH/NIAID
    MUCOSAL VACCINE FOR HIV
    Role: Principal Investigator

    P30DK056338     (EL-SERAG, HASHEM B)Dec 1, 1999 - Feb 28, 2023
    NIH/NIDDK
    Texas Medical Center Digestive Diseases Center
    Role: Co-Principal Investigator

    R01AI046581     (ESTES, MARY KOLB)Jan 15, 2000 - Dec 31, 2004
    NIH/NIAID
    MOLECULAR AND ANTIGENIC ANALYSIS OF HUMAN CALICIVIRUS
    Role: Principal Investigator

    P01AI057788     (ESTES, MARY KOLB)Dec 1, 2003 - May 31, 2020
    NIH/NIAID
    Molecular Dissection of Norovirus Replication and Pathogenesis to Develop Therapeutics
    Role: Principal Investigator

    R03TW007764     (ESTES, MARY KOLB)Jul 1, 2007 - Apr 30, 2011
    NIH/FIC
    CALICIVIRAL INFECTIONS AND DISEASE IN SOUTHERN INDIA
    Role: Principal Investigator

    R56AI080656     (ESTES, MARY KOLB)Dec 1, 2008 - Jul 31, 2015
    NIH/NIAID
    Regulation of Rotavirus Replication
    Role: Principal Investigator

    R01AI080656     (ESTES, MARY KOLB)Aug 11, 2009 - Jan 31, 2020
    NIH/NIAID
    Regulation of Rotavirus Replication
    Role: Principal Investigator

    T32GM088129     (VAN DEN VEYVER, IGNATIA B)Jul 1, 2010 - Jun 30, 2020
    NIH/NIGMS
    Training Program in Translational Biology and Molecular Medicine
    Role: Co-Principal Investigator

    R01AI105101     (ESTES, MARY KOLB)Jul 1, 2013 - Jun 30, 2017
    NIH/NIAID
    Intestinal and Milk Glycan Expression in Restriction of Neonatal Infection
    Role: Principal Investigator

    U01DK103168     (ESTES, MARY KOLB)Sep 5, 2014 - Aug 31, 2019
    NIH/NIDDK
    Intestinal Stem Cell Response to Infection
    Role: Principal Investigator

    U19AI116497     (ESTES, MARY KOLB)Mar 15, 2015 - Feb 29, 2020
    NIH/NIAID
    Engineering Novel Enteroid Models for Understanding Human Enteric Disease
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Chang-Graham AL, Danhof HA, Engevik MA, Tomaro-Duchesneau C, Karandikar UC, Estes MK, Versalovic J, Britton RA, Hyser JM. Human Intestinal Enteroids With Inducible Neurogenin-3 Expression as a Novel Model of Gut Hormone Secretion. Cell Mol Gastroenterol Hepatol. 2019 Apr 25. PMID: 31029854.
      View in: PubMed
    2. Uotani T, Murakami K, Uchida T, Tanaka S, Nagashima H, Zeng XL, Akada J, Estes MK, Graham DY, Yamaoka Y. Changes of tight junction and interleukin-8 expression using a human gastroid monolayer model of Helicobacter pylori infection. Helicobacter. 2019 Jun; 24(3):e12583. PMID: 30950121.
      View in: PubMed
    3. Viskovska MA, Zhao B, Shanker S, Choi JM, Deng L, Song Y, Palzkill T, Hu L, Estes MK, Venkataram Prasad BV. GII.4 Norovirus Protease Shows pH-Sensitive Proteolysis with a Unique Arg-His Pairing in the Catalytic Site. J Virol. 2019 Mar 15; 93(6). PMID: 30626675.
      View in: PubMed
    4. Criglar JM, Anish R, Hu L, Crawford SE, Sankaran B, Prasad BVV, Estes MK. Phosphorylation cascade regulates the formation and maturation of rotaviral replication factories. Proc Natl Acad Sci U S A. 2018 12 18; 115(51):E12015-E12023. PMID: 30509975.
      View in: PubMed
    5. Ramani S, Stewart CJ, Laucirica DR, Ajami NJ, Robertson B, Autran CA, Shinge D, Rani S, Anandan S, Hu L, Ferreon JC, Kuruvilla KA, Petrosino JF, Venkataram Prasad BV, Bode L, Kang G, Estes MK. Human milk oligosaccharides, milk microbiome and infant gut microbiome modulate neonatal rotavirus infection. Nat Commun. 2018 11 27; 9(1):5010. PMID: 30479342.
      View in: PubMed
    6. Atmar RL, Ramani S, Estes MK. Human noroviruses: recent advances in a 50-year history. Curr Opin Infect Dis. 2018 10; 31(5):422-432. PMID: 30102614.
      View in: PubMed
    7. Liang H, Estes MK, Zhang H, Du G, Zhou Y. Bile acids target proteolipid nano-assemblies of EGFR and phosphatidic acid in the plasma membrane for stimulation of MAPK signaling. PLoS One. 2018; 13(8):e0198983. PMID: 30169511.
      View in: PubMed
    8. Alvarado G, Ettayebi K, Atmar RL, Bombardi RG, Kose N, Estes MK, Crowe JE. Human Monoclonal Antibodies That Neutralize Pandemic GII.4 Noroviruses. Gastroenterology. 2018 12; 155(6):1898-1907. PMID: 30170116.
      View in: PubMed
    9. Costantini V, Morantz EK, Browne H, Ettayebi K, Zeng XL, Atmar RL, Estes MK, Vinjé J. Human Norovirus Replication in Human Intestinal Enteroids as Model to Evaluate Virus Inactivation. Emerg Infect Dis. 2018 08; 24(8):1453-1464. PMID: 30014841.
      View in: PubMed
    10. Hu L, Sankaran B, Laucirica DR, Patil K, Salmen W, Ferreon ACM, Tsoi PS, Lasanajak Y, Smith DF, Ramani S, Atmar RL, Estes MK, Ferreon JC, Prasad BVV. Glycan recognition in globally dominant human rotaviruses. Nat Commun. 2018 07 06; 9(1):2631. PMID: 29980685.
      View in: PubMed
    11. Bányai K, Estes MK, Martella V, Parashar UD. Viral gastroenteritis. Lancet. 2018 07 14; 392(10142):175-186. PMID: 30025810.
      View in: PubMed
    12. Ramani S, Crawford SE, Blutt SE, Estes MK. Human organoid cultures: transformative new tools for human virus studies. Curr Opin Virol. 2018 04; 29:79-86. PMID: 29656244.
      View in: PubMed
    13. Rajan A, Vela L, Zeng XL, Yu X, Shroyer N, Blutt SE, Poole NM, Carlin LG, Nataro JP, Estes MK, Okhuysen PC, Maresso AW. Novel Segment- and Host-Specific Patterns of Enteroaggregative Escherichia coli Adherence to Human Intestinal Enteroids. MBio. 2018 02 20; 9(1). PMID: 29463660.
      View in: PubMed
    14. Zou WY, Blutt SE, Zeng XL, Chen MS, Lo YH, Castillo-Azofeifa D, Klein OD, Shroyer NF, Donowitz M, Estes MK. Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation. Cell Rep. 2018 01 23; 22(4):1003-1015. PMID: 29386123.
      View in: PubMed
    15. Blutt SE, Crawford SE, Ramani S, Zou WY, Estes MK. Engineered Human Gastrointestinal Cultures to Study the Microbiome and Infectious Diseases. Cell Mol Gastroenterol Hepatol. 2018 Mar; 5(3):241-251. PMID: 29675450.
      View in: PubMed
    16. Chen Y, Zhou W, Roh T, Estes MK, Kaplan DL. In vitro enteroid-derived three-dimensional tissue model of human small intestinal epithelium with innate immune responses. PLoS One. 2017; 12(11):e0187880. PMID: 29186150.
      View in: PubMed
    17. Crawford SE, Ramani S, Tate JE, Parashar UD, Svensson L, Hagbom M, Franco MA, Greenberg HB, O'Ryan M, Kang G, Desselberger U, Estes MK. Rotavirus infection. Nat Rev Dis Primers. 2017 Nov 09; 3:17083. PMID: 29119972.
      View in: PubMed
    18. Poole NM, Green SI, Rajan A, Vela LE, Zeng XL, Estes MK, Maresso AW. Role for FimH in Extraintestinal Pathogenic Escherichia coli Invasion and Translocation through the Intestinal Epithelium. Infect Immun. 2017 11; 85(11). PMID: 28808163.
      View in: PubMed
    19. Cortes-Penfield NW, Ramani S, Estes MK, Atmar RL. Prospects and Challenges in the Development of a Norovirus Vaccine. Clin Ther. 2017 Aug; 39(8):1537-1549. PMID: 28756066.
      View in: PubMed
    20. Sharma S, Carlsson B, Czakó R, Vene S, Haglund M, Ludvigsson J, Larson G, Hammarström L, Sosnovtsev SV, Atmar RL, Green KY, Estes MK, Svensson L. Human Sera Collected between 1979 and 2010 Possess Blocking-Antibody Titers to Pandemic GII.4 Noroviruses Isolated over Three Decades. J Virol. 2017 07 15; 91(14). PMID: 28468886.
      View in: PubMed
    21. Laucirica DR, Triantis V, Schoemaker R, Estes MK, Ramani S. Milk Oligosaccharides Inhibit Human Rotavirus Infectivity in MA104 Cells. J Nutr. 2017 09; 147(9):1709-1714. PMID: 28637685.
      View in: PubMed
    22. Shanker S, Hu L, Ramani S, Atmar RL, Estes MK, Venkataram Prasad BV. Structural features of glycan recognition among viral pathogens. Curr Opin Struct Biol. 2017 06; 44:211-218. PMID: 28591681.
      View in: PubMed
    23. Blutt SE, Broughman JR, Zou W, Zeng XL, Karandikar UC, In J, Zachos NC, Kovbasnjuk O, Donowitz M, Estes MK. Gastrointestinal microphysiological systems. Exp Biol Med (Maywood). 2017 10; 242(16):1633-1642. PMID: 28534432.
      View in: PubMed
    24. Ramani S, Neill FH, Ferreira J, Treanor JJ, Frey SE, Topham DJ, Goodwin RR, Borkowski A, Baehner F, Mendelman PM, Estes MK, Atmar RL. B-Cell Responses to Intramuscular Administration of a Bivalent Virus-Like Particle Human Norovirus Vaccine. Clin Vaccine Immunol. 2017 May; 24(5). PMID: 28249841.
      View in: PubMed
    25. Zou WY, Blutt SE, Crawford SE, Ettayebi K, Zeng XL, Saxena K, Ramani S, Karandikar UC, Zachos NC, Estes MK. Human Intestinal Enteroids: New Models to Study Gastrointestinal Virus Infections. Methods Mol Biol. 2017 Mar 31. PMID: 28361480.
      View in: PubMed
    26. Yu H, Hasan NM, In JG, Estes MK, Kovbasnjuk O, Zachos NC, Donowitz M. The Contributions of Human Mini-Intestines to the Study of Intestinal Physiology and Pathophysiology. Annu Rev Physiol. 2017 02 10; 79:291-312. PMID: 28192061.
      View in: PubMed
    27. Hurwitz AM, Huang W, Kou B, Estes MK, Atmar RL, Palzkill T. Identification and Characterization of Single-Chain Antibodies that Specifically Bind GI Noroviruses. PLoS One. 2017; 12(1):e0170162. PMID: 28095447.
      View in: PubMed
    28. Saxena K, Simon LM, Zeng XL, Blutt SE, Crawford SE, Sastri NP, Karandikar UC, Ajami NJ, Zachos NC, Kovbasnjuk O, Donowitz M, Conner ME, Shaw CA, Estes MK. A paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infection. Proc Natl Acad Sci U S A. 2017 01 24; 114(4):E570-E579. PMID: 28069942.
      View in: PubMed
    29. Hurwitz AM, Huang W, Estes MK, Atmar RL, Palzkill T. Deep sequencing of phage-displayed peptide libraries reveals sequence motif that detects norovirus. Protein Eng Des Sel. 2017 Feb; 30(2):129-139. PMID: 28035012.
      View in: PubMed
    30. Ramani S, Mamani N, Villena R, Bandyopadhyay AS, Gast C, Sato A, Laucirica D, Clemens R, Estes MK, O'Ryan ML. Rotavirus Serum IgA Immune Response in Children Receiving Rotarix Coadministered With bOPV or IPV. Pediatr Infect Dis J. 2016 10; 35(10):1137-9. PMID: 27254033.
      View in: PubMed
    31. In JG, Foulke-Abel J, Estes MK, Zachos NC, Kovbasnjuk O, Donowitz M. Human mini-guts: new insights into intestinal physiology and host-pathogen interactions. Nat Rev Gastroenterol Hepatol. 2016 Nov; 13(11):633-642. PMID: 27677718.
      View in: PubMed
    32. Shanker S, Czakó R, Sapparapu G, Alvarado G, Viskovska M, Sankaran B, Atmar RL, Crowe JE, Estes MK, Prasad BV. Structural basis for norovirus neutralization by an HBGA blocking human IgA antibody. Proc Natl Acad Sci U S A. 2016 10 04; 113(40):E5830-E5837. PMID: 27647885.
      View in: PubMed
    33. Qu L, Murakami K, Broughman JR, Lay MK, Guix S, Tenge VR, Atmar RL, Estes MK. Replication of Human Norovirus RNA in Mammalian Cells Reveals Lack of Interferon Response. J Virol. 2016 10 01; 90(19):8906-23. PMID: 27466422.
      View in: PubMed
    34. Ettayebi K, Crawford SE, Murakami K, Broughman JR, Karandikar U, Tenge VR, Neill FH, Blutt SE, Zeng XL, Qu L, Kou B, Opekun AR, Burrin D, Graham DY, Ramani S, Atmar RL, Estes MK. Replication of human noroviruses in stem cell-derived human enteroids. Science. 2016 09 23; 353(6306):1387-1393. PMID: 27562956.
      View in: PubMed
    35. Hesse S, Neill FH, Estes MK, Shanker S, Prasad BV, Ferreira J, Atmar RL. Correction for Hesse et al., Serological Responses to a Norovirus Nonstructural Fusion Protein after Vaccination and Infection. Clin Vaccine Immunol. 2016 08; 23(8):735. PMID: 27495982.
      View in: PubMed
    36. Lloyd RE, Estes MK. Editorial overview: Viruses and cell metabolism. Curr Opin Virol. 2016 08; 19:vii-viii. PMID: 27619793.
      View in: PubMed
    37. Karandikar UC, Crawford SE, Ajami NJ, Murakami K, Kou B, Ettayebi K, Papanicolaou GA, Jongwutiwes U, Perales MA, Shia J, Mercer D, Finegold MJ, Vinjé J, Atmar RL, Estes MK. Detection of human norovirus in intestinal biopsies from immunocompromised transplant patients. J Gen Virol. 2016 09; 97(9):2291-300. PMID: 27412790.
      View in: PubMed
    38. Sapparapu G, Czakó R, Alvarado G, Shanker S, Prasad BV, Atmar RL, Estes MK, Crowe JE. Frequent Use of the IgA Isotype in Human B Cells Encoding Potent Norovirus-Specific Monoclonal Antibodies That Block HBGA Binding. PLoS Pathog. 2016 06; 12(6):e1005719. PMID: 27355511.
      View in: PubMed
    39. Mills M, Estes MK. Physiologically relevant human tissue models for infectious diseases. Drug Discov Today. 2016 09; 21(9):1540-1552. PMID: 27352632.
      View in: PubMed
    40. Prasad BV, Shanker S, Muhaxhiri Z, Deng L, Choi JM, Estes MK, Song Y, Palzkill T, Atmar RL. Antiviral targets of human noroviruses. Curr Opin Virol. 2016 06; 18:117-25. PMID: 27318434.
      View in: PubMed
    41. Menon VK, George S, Sarkar R, Giri S, Samuel P, Vivek R, Saravanabavan A, Liakath FB, Ramani S, Iturriza-Gomara M, Gray JJ, Brown DW, Estes MK, Kang G. Norovirus Gastroenteritis in a Birth Cohort in Southern India. PLoS One. 2016; 11(6):e0157007. PMID: 27284939.
      View in: PubMed
    42. Ramani S, Estes MK, Atmar RL. Correlates of Protection against Norovirus Infection and Disease-Where Are We Now, Where Do We Go? PLoS Pathog. 2016 04; 12(4):e1005334. PMID: 27115358.
      View in: PubMed
    43. Ramani S, Hu L, Venkataram Prasad BV, Estes MK. Diversity in Rotavirus-Host Glycan Interactions: A "Sweet" Spectrum. Cell Mol Gastroenterol Hepatol. 2016 May; 2(3):263-273. PMID: 28090561.
      View in: PubMed
    44. In J, Foulke-Abel J, Zachos NC, Hansen AM, Kaper JB, Bernstein HD, Halushka M, Blutt S, Estes MK, Donowitz M, Kovbasnjuk O. Enterohemorrhagic Escherichia coli reduce mucus and intermicrovillar bridges in human stem cell-derived colonoids. Cell Mol Gastroenterol Hepatol. 2016 Jan 01; 2(1):48-62.e3. PMID: 26855967.
      View in: PubMed
    45. Zachos NC, Kovbasnjuk O, Foulke-Abel J, In J, Blutt SE, de Jonge HR, Estes MK, Donowitz M. Human Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and Pathophysiology. J Biol Chem. 2016 Feb 19; 291(8):3759-66. PMID: 26677228.
      View in: PubMed
    46. Hesse S, Neill FH, Estes MK, Shanker S, Prasad BV, Ferreira J, Atmar RL. Serological Responses to a Norovirus Nonstructural Fusion Protein after Vaccination and Infection. Clin Vaccine Immunol. 2016 02; 23(2):181-3. PMID: 26656120.
      View in: PubMed
    47. Foulke-Abel J, In J, Yin J, Zachos NC, Kovbasnjuk O, Estes MK, de Jonge H, Donowitz M. Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology. Gastroenterology. 2016 Mar; 150(3):638-649.e8. PMID: 26677983.
      View in: PubMed
    48. Hyser JM, Estes MK. Pathophysiological Consequences of Calcium-Conducting Viroporins. Annu Rev Virol. 2015 Nov; 2(1):473-96. PMID: 26958925.
      View in: PubMed
    49. Kou B, Huang W, Neill FH, Palzkill T, Estes MK, Atmar RL. Norovirus Antigen Detection with a Combination of Monoclonal and Single-Chain Antibodies. J Clin Microbiol. 2015 Dec; 53(12):3916-8. PMID: 26447115.
      View in: PubMed
    50. Saxena K, Blutt SE, Ettayebi K, Zeng XL, Broughman JR, Crawford SE, Karandikar UC, Sastri NP, Conner ME, Opekun AR, Graham DY, Qureshi W, Sherman V, Foulke-Abel J, In J, Kovbasnjuk O, Zachos NC, Donowitz M, Estes MK. Human Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and Pathophysiology. J Virol. 2016 01 01; 90(1):43-56. PMID: 26446608.
      View in: PubMed
    51. Hu L, Ramani S, Czako R, Sankaran B, Yu Y, Smith DF, Cummings RD, Estes MK, Venkataram Prasad BV. Structural basis of glycan specificity in neonate-specific bovine-human reassortant rotavirus. Nat Commun. 2015 Sep 30; 6:8346. PMID: 26420502.
      View in: PubMed
    52. Atmar RL, Bernstein DI, Lyon GM, Treanor JJ, Al-Ibrahim MS, Graham DY, Vinjé J, Jiang X, Gregoricus N, Frenck RW, Moe CL, Chen WH, Ferreira J, Barrett J, Opekun AR, Estes MK, Borkowski A, Baehner F, Goodwin R, Edmonds A, Mendelman PM. Serological Correlates of Protection against a GII.4 Norovirus. Clin Vaccine Immunol. 2015 Aug; 22(8):923-9. PMID: 26041041.
      View in: PubMed
    53. Hagström AE, Garvey G, Paterson AS, Dhamane S, Adhikari M, Estes MK, Strych U, Kourentzi K, Atmar RL, Willson RC. Sensitive detection of norovirus using phage nanoparticle reporters in lateral-flow assay. PLoS One. 2015; 10(5):e0126571. PMID: 25978622.
      View in: PubMed
    54. Ramani S, Neill FH, Opekun AR, Gilger MA, Graham DY, Estes MK, Atmar RL. Mucosal and Cellular Immune Responses to Norwalk Virus. J Infect Dis. 2015 Aug 01; 212(3):397-405. PMID: 25635121.
      View in: PubMed
    55. Czakó R, Atmar RL, Opekun AR, Gilger MA, Graham DY, Estes MK. Experimental human infection with Norwalk virus elicits a surrogate neutralizing antibody response with cross-genogroup activity. Clin Vaccine Immunol. 2015 Feb; 22(2):221-8. PMID: 25540269.
      View in: PubMed
    56. Crawford SE, Ajami N, Parker TD, Kitamoto N, Natori K, Takeda N, Tanaka T, Kou B, Atmar RL, Estes MK. Mapping broadly reactive norovirus genogroup I and II monoclonal antibodies. Clin Vaccine Immunol. 2015 Feb; 22(2):168-77. PMID: 25428246.
      View in: PubMed
    57. Kou B, Crawford SE, Ajami NJ, Czakó R, Neill FH, Tanaka TN, Kitamoto N, Palzkill TG, Estes MK, Atmar RL. Characterization of cross-reactive norovirus-specific monoclonal antibodies. Clin Vaccine Immunol. 2015 Feb; 22(2):160-7. PMID: 25428247.
      View in: PubMed
    58. Zhang B, Chassaing B, Shi Z, Uchiyama R, Zhang Z, Denning TL, Crawford SE, Pruijssers AJ, Iskarpatyoti JA, Estes MK, Dermody TS, Ouyang W, Williams IR, Vijay-Kumar M, Gewirtz AT. Viral infection. Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18. Science. 2014 Nov 14; 346(6211):861-5. PMID: 25395539.
      View in: PubMed
    59. Sastri NP, Viskovska M, Hyser JM, Tanner MR, Horton LB, Sankaran B, Prasad BV, Estes MK. Structural plasticity of the coiled-coil domain of rotavirus NSP4. J Virol. 2014 Dec; 88(23):13602-12. PMID: 25231315.
      View in: PubMed
    60. Bernstein DI, Atmar RL, Lyon GM, Treanor JJ, Chen WH, Jiang X, Vinjé J, Gregoricus N, Frenck RW, Moe CL, Al-Ibrahim MS, Barrett J, Ferreira J, Estes MK, Graham DY, Goodwin R, Borkowski A, Clemens R, Mendelman PM. Norovirus vaccine against experimental human GII.4 virus illness: a challenge study in healthy adults. J Infect Dis. 2015 Mar 15; 211(6):870-8. PMID: 25210140.
      View in: PubMed
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    101. Baclayon M, Shoemaker GK, Uetrecht C, Crawford SE, Estes MK, Prasad BV, Heck AJ, Wuite GJ, Roos WH. Prestress strengthens the shell of Norwalk virus nanoparticles. Nano Lett. 2011 Nov 09; 11(11):4865-9. PMID: 21967663.
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    105. Pan S, Wang S, Utama B, Huang L, Blok N, Estes MK, Moremen KW, Sifers RN. Golgi localization of ERManI defines spatial separation of the mammalian glycoprotein quality control system. Mol Biol Cell. 2011 Aug 15; 22(16):2810-22. PMID: 21697506.
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    133. Banerjee I, Gladstone BP, Le Fevre AM, Ramani S, Iturriza-Gomara M, Gray JJ, Brown DW, Estes MK, Muliyil JP, Jaffar S, Kang G. Neonatal infection with G10P[11] rotavirus did not confer protection against subsequent rotavirus infection in a community cohort in Vellore, South India. J Infect Dis. 2007 Mar 01; 195(5):625-32. PMID: 17262703.
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    139. Zhang X, Buehner NA, Hutson AM, Estes MK, Mason HS. Tomato is a highly effective vehicle for expression and oral immunization with Norwalk virus capsid protein. Plant Biotechnol J. 2006 Jul; 4(4):419-32. PMID: 17177807.
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    143. Chen R, Neill JD, Estes MK, Prasad BV. X-ray structure of a native calicivirus: structural insights into antigenic diversity and host specificity. Proc Natl Acad Sci U S A. 2006 May 23; 103(21):8048-53. PMID: 16702551.
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    146. Choi NW, Estes MK, Langridge WH. Synthesis of a ricin toxin B subunit-rotavirus VP7 fusion protein in potato. Mol Biotechnol. 2006 Feb; 32(2):117-28. PMID: 16444013.
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    147. Choi NW, Estes MK, Langridge WH. Ricin toxin B subunit enhancement of rotavirus NSP4 immunogenicity in mice. Viral Immunol. 2006; 19(1):54-63. PMID: 16553550.
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    148. Tanaka T, Kitamoto N, Jiang X, Estes MK. High efficiency cross-reactive monoclonal antibody production by oral immunization with recombinant norwalk virus-like particles. Microbiol Immunol. 2006; 50(11):883-8. PMID: 17116984.
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    149. Choi NW, Estes MK, Langridge WH. Synthesis and assembly of a cholera toxin B subunit-rotavirus VP7 fusion protein in transgenic potato. Mol Biotechnol. 2005 Nov; 31(3):193-202. PMID: 16230769.
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    150. Choi NW, Estes MK, Langridge WH. Oral immunization with a shiga toxin B subunit: rotavirus NSP4(90) fusion protein protects mice against gastroenteritis. Vaccine. 2005 Oct 25; 23(44):5168-76. PMID: 16040169.
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    151. Vizzi E, Calviño E, González R, Pérez-Schael I, Ciarlet M, Kang G, Estes MK, Liprandi F, Ludert JE. Evaluation of serum antibody responses against the rotavirus nonstructural protein NSP4 in children after rhesus rotavirus tetravalent vaccination or natural infection. Clin Diagn Lab Immunol. 2005 Oct; 12(10):1157-63. PMID: 16210477.
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    152. Choi NW, Estes MK, Langridge WH. Mucosal immunization with a ricin toxin B subunit-rotavirus NSP4 fusion protein stimulates a Th1 lymphocyte response. J Biotechnol. 2006 Jan 24; 121(2):272-83. PMID: 16181698.
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    153. Hutson AM, Airaud F, LePendu J, Estes MK, Atmar RL. Norwalk virus infection associates with secretor status genotyped from sera. J Med Virol. 2005 Sep; 77(1):116-20. PMID: 16032732.
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    154. Asanaka M, Atmar RL, Ruvolo V, Crawford SE, Neill FH, Estes MK. Replication and packaging of Norwalk virus RNA in cultured mammalian cells. Proc Natl Acad Sci U S A. 2005 Jul 19; 102(29):10327-32. PMID: 16002473.
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    155. Pesavento JB, Crawford SE, Roberts E, Estes MK, Prasad BV. pH-induced conformational change of the rotavirus VP4 spike: implications for cell entry and antibody neutralization. J Virol. 2005 Jul; 79(13):8572-80. PMID: 15956598.
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    156. Parker TD, Kitamoto N, Tanaka T, Hutson AM, Estes MK. Identification of Genogroup I and Genogroup II broadly reactive epitopes on the norovirus capsid. J Virol. 2005 Jun; 79(12):7402-9. PMID: 15919896.
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    157. Nurgalieva ZZ, Conner ME, Opekun AR, Zheng CQ, Elliott SN, Ernst PB, Osato M, Estes MK, Graham DY. B-cell and T-cell immune responses to experimental Helicobacter pylori infection in humans. Infect Immun. 2005 May; 73(5):2999-3006. PMID: 15845507.
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    158. Scofield VL, Montufar-Solis D, Cheng E, Estes MK, Klein JR. Intestinal TSH production is localized in crypt enterocytes and in villus 'hotblocks' and is coupled to IL-7 production: evidence for involvement of TSH during acute enteric virus infection. Immunol Lett. 2005 Jun 15; 99(1):36-44. PMID: 15894109.
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    159. Chakravarty S, Hutson AM, Estes MK, Prasad BV. Evolutionary trace residues in noroviruses: importance in receptor binding, antigenicity, virion assembly, and strain diversity. J Virol. 2005 Jan; 79(1):554-68. PMID: 15596848.
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    160. Moe CL, Sair A, Lindesmith L, Estes MK, Jaykus LA. Diagnosis of norwalk virus infection by indirect enzyme immunoassay detection of salivary antibodies to recombinant norwalk virus antigen. Clin Diagn Lab Immunol. 2004 Nov; 11(6):1028-34. PMID: 15539501.
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    161. Blutt SE, Crawford SE, Warfield KL, Lewis DE, Estes MK, Conner ME. The VP7 outer capsid protein of rotavirus induces polyclonal B-cell activation. J Virol. 2004 Jul; 78(13):6974-81. PMID: 15194774.
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    162. Huang H, Schroeder F, Estes MK, McPherson T, Ball JM. Interaction(s) of rotavirus non-structural protein 4 (NSP4) C-terminal peptides with model membranes. Biochem J. 2004 Jun 15; 380(Pt 3):723-33. PMID: 15012630.
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    163. Hutson AM, Atmar RL, Estes MK. Norovirus disease: changing epidemiology and host susceptibility factors. Trends Microbiol. 2004 Jun; 12(6):279-87. PMID: 15165606.
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    164. Chen R, Neill JD, Noel JS, Hutson AM, Glass RI, Estes MK, Prasad BV. Inter- and intragenus structural variations in caliciviruses and their functional implications. J Virol. 2004 Jun; 78(12):6469-79. PMID: 15163740.
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    165. Duizer E, Schwab KJ, Neill FH, Atmar RL, Koopmans MP, Estes MK. Laboratory efforts to cultivate noroviruses. J Gen Virol. 2004 Jan; 85(Pt 1):79-87. PMID: 14718622.
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    166. Bertolotti-Ciarlet A, Crawford SE, Hutson AM, Estes MK. The 3' end of Norwalk virus mRNA contains determinants that regulate the expression and stability of the viral capsid protein VP1: a novel function for the VP2 protein. J Virol. 2003 Nov; 77(21):11603-15. PMID: 14557646.
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    167. Blutt SE, Kirkwood CD, Parreño V, Warfield KL, Ciarlet M, Estes MK, Bok K, Bishop RF, Conner ME. Rotavirus antigenaemia and viraemia: a common event? Lancet. 2003 Nov 01; 362(9394):1445-9. PMID: 14602437.
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    168. Bertolotti-Ciarlet A, Ciarlet M, Crawford SE, Conner ME, Estes MK. Immunogenicity and protective efficacy of rotavirus 2/6-virus-like particles produced by a dual baculovirus expression vector and administered intramuscularly, intranasally, or orally to mice. Vaccine. 2003 Sep 08; 21(25-26):3885-900. PMID: 12922123.
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    169. Tacket CO, Sztein MB, Losonsky GA, Wasserman SS, Estes MK. Humoral, mucosal, and cellular immune responses to oral Norwalk virus-like particles in volunteers. Clin Immunol. 2003 Sep; 108(3):241-7. PMID: 14499247.
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    170. Glass PJ, Zeng CQ, Estes MK. Two nonoverlapping domains on the Norwalk virus open reading frame 3 (ORF3) protein are involved in the formation of the phosphorylated 35K protein and in ORF3-capsid protein interactions. J Virol. 2003 Mar; 77(6):3569-77. PMID: 12610132.
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    171. Hutson AM, Atmar RL, Marcus DM, Estes MK. Norwalk virus-like particle hemagglutination by binding to h histo-blood group antigens. J Virol. 2003 Jan; 77(1):405-15. PMID: 12477845.
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    172. Kitamoto N, Tanaka T, Natori K, Takeda N, Nakata S, Jiang X, Estes MK. Cross-reactivity among several recombinant calicivirus virus-like particles (VLPs) with monoclonal antibodies obtained from mice immunized orally with one type of VLP. J Clin Microbiol. 2002 Jul; 40(7):2459-65. PMID: 12089262.
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    173. Casola A, Garofalo RP, Crawford SE, Estes MK, Mercurio F, Crowe SE, Brasier AR. Interleukin-8 gene regulation in intestinal epithelial cells infected with rotavirus: role of viral-induced IkappaB kinase activation. Virology. 2002 Jun 20; 298(1):8-19. PMID: 12093168.
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    174. Hutson AM, Atmar RL, Graham DY, Estes MK. Norwalk virus infection and disease is associated with ABO histo-blood group type. J Infect Dis. 2002 May 01; 185(9):1335-7. PMID: 12001052.
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    175. Bertolotti-Ciarlet A, White LJ, Chen R, Prasad BV, Estes MK. Structural requirements for the assembly of Norwalk virus-like particles. J Virol. 2002 Apr; 76(8):4044-55. PMID: 11907243.
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    176. Ciarlet M, Ludert JE, Iturriza-Gómara M, Liprandi F, Gray JJ, Desselberger U, Estes MK. Initial interaction of rotavirus strains with N-acetylneuraminic (sialic) acid residues on the cell surface correlates with VP4 genotype, not species of origin. J Virol. 2002 Apr; 76(8):4087-95. PMID: 11907248.
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    177. Ciarlet M, Hyser JM, Estes MK. Sequence analysis of the VP4, VP6, VP7, and NSP4 gene products of the bovine rotavirus WC3. Virus Genes. 2002 Mar; 24(2):107-18. PMID: 12018701.
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    178. Ciarlet M, Crawford SE, Cheng E, Blutt SE, Rice DA, Bergelson JM, Estes MK. VLA-2 (alpha2beta1) integrin promotes rotavirus entry into cells but is not necessary for rotavirus attachment. J Virol. 2002 Feb; 76(3):1109-23. PMID: 11773387.
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    179. Ciarlet M, Conner ME, Finegold MJ, Estes MK. Group A rotavirus infection and age-dependent diarrheal disease in rats: a new animal model to study the pathophysiology of rotavirus infection. J Virol. 2002 Jan; 76(1):41-57. PMID: 11739670.
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