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ERNESTINA MELICOFF-PORTILLO

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address6701 FANNIN
ORCID ORCID Icon0000-0001-5696-7112 Additional info
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    Collapse Biography 
    Collapse education and training
    Esc. de Medicina Ignacio A. Santos, Monterrey, MexicoMD07/2003Medicine
    Baylor College of Medicine, Houston, TX07/2010Pediatrics
    Baylor College of Medicine, Houston, TX07/2013Pediatric Pulmonology

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    Collapse Research 
    Collapse research activities and funding
    MELICO17A0     (Ernestina Melicoff)Sep 1, 2017 - Aug 31, 2021
    Cystic Fibrosis Foundation Therapeutics
    Lung Clearance Index In Pediatric Lung Transplant Patients
    Role: PI
    U01AI077810     (SWEET, STUART C)Mar 1, 2008 - Feb 28, 2018
    NIH
    B-CELL TARGETED INDUCTION TO IMPROVE OUTCOMES IN PEDIATRIC LUNG TRANSPLANTATION
    Role: Co-Investigator

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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Stephens NA, Chartan CA, Gazzaneo MC, Thomas JA, Das S, Mallory GB, Melicoff E, Vogel AM, Parker A, Hermes E, Heinle JS, McKenzie ED, Coleman RD. Use of Berlin EXCOR cannulas in both venovenous and venoarterial central extracorporeal membrane oxygenation configurations overcomes the problem of cannula instability while bridging infants and young children to lung transplant. JTCVS Tech. 2023 Apr; 18:111-120. PMID: 37096088; PMCID: PMC10122161.
      Citations:    
    2. Melicoff E, Spielberg DR, Heinle JS, McKenzie ED, Hosek KE, Schrader AL, Mallory GB. Improved Outcomes for Infants and Young Children Undergoing Lung Transplantation at Three Years of Age and Younger. Ann Am Thorac Soc. 2023 02; 20(2):254-261. PMID: 36260085.
      Citations:    Fields:    Translation:Humans
    3. O'Connor C, Munoz FM, Gazzaneo MC, Melicoff E, Das S, Lam F, Coss-Bu JA. Application of organ dysfunction assessment scores following pediatric lung transplantation. Clin Transplant. 2023 03; 37(3):e14863. PMID: 36480657.
      Citations:    Fields:    Translation:Humans
    4. Spielberg DR, Melicoff E, Heinle JS, Hosek K, Mallory GB. Differential donor management of pediatric vs adult organ donors and potential impact on pediatric lung transplantation. J Heart Lung Transplant. 2023 04; 42(4):522-532. PMID: 36564335.
      Citations:    Fields:    Translation:Humans
    5. Wattenbarger LE, Kim JJ, Melicoff E, Miyake CY, Valdes SO, Pham TDN, Adachi I, Heinle JS, Howard TS. Atrial tachyarrhythmias after lung transplantation in children: A?common occurrence. Pediatr Transplant. 2023 02; 27(1):e14410. PMID: 36314299.
      Citations: 1     Fields:    
    6. Melicoff E, Ruiz FE, Hosek K, Mallory GB. Cystic fibrosis lung transplant recipients 10 years of age or younger: Predisposing factors for end-stage disease. Pediatr Pulmonol. 2022 06; 57(6):1513-1519. PMID: 35243829.
      Citations:    Fields:    Translation:HumansCells
    7. Hayes D, Melicoff-Portillo E, Ziady AG. Selection of lung transplant candidates: A pediatric perspective on the International Society for Heart and Lung Transplantation consensus document. J Heart Lung Transplant. 2022 07; 41(7):998-999. PMID: 35317952.
      Citations:    Fields:    Translation:Humans
    8. Conrad CK, Hedlin H, Chin H, Hayes D, Heeger PS, Faro A, Goldfarb S, Melicoff-Portillo E, Thalachallour M, Odim J, Schecter M, Storch GA, Visner GA, Williams NM, Kesler K, Danziger-Isakov L, Sweet SC. Auto-inflammation and auto-immunity pathways are associated with emergence of BOS in pediatric lung transplantation. Pediatr Transplant. 2022 06; 26(4):e14247. PMID: 35146849; PMCID: PMC9086108.
      Citations:    Fields:    Translation:Humans
    9. Sweet SC, Armstrong B, Blatter J, Chin H, Conrad C, Goldfarb S, Hayes D, Heeger PS, Lyou V, Melicoff-Portillo E, Mohanakumar T, Odim J, Ravichandran R, Schecter M, Storch GA, Visner G, Williams NM, Danziger-Isakov L. CTOTC-08: A multicenter randomized controlled trial of rituximab induction to reduce antibody development and improve outcomes in pediatric lung transplant recipients. Am J Transplant. 2022 01; 22(1):230-244. PMID: 34599540.
      Citations: 1     Fields:    Translation:Humans
    10. Schrader A, Melicoff E, Munoz F, Mallory GB, Curry CV, Gazzaneo MC. Diagnosis and treatment of cryptococcal osteomyelitis in a pediatric lung transplant patient. Pediatr Transplant. 2022 Mar; 26(2):e14165. PMID: 34687575.
      Citations:    Fields:    Translation:Humans
    11. Stephens A, McKenzie D, Heinle J, Melicoff-Portillo E, Gazzaneo C, Coleman R, Adachi I. Central extracorporeal membrane oxygenation to lung transplantation after remote arterial switch operation. JTCVS Tech. 2021 Dec; 10:452-455. PMID: 34977782; PMCID: PMC8690869.
      Citations:    
    12. Rajan A, Weaver AM, Aloisio GM, Jelinski J, Johnson HL, Venable SF, McBride T, Aideyan L, Ye X, Melicoff-Portillo E, Yerramilli MRK, Zeng XL, Mancini MA, Stossi F, Maresso AW, Kotkar SA, Estes MK, Blutt S, Avadhanula V, Piedra PA, Piedra FA. The human nose organoid respiratory virus model: an ex-vivo human challenge model to study RSV and SARS-CoV-2 pathogenesis and evaluate therapeutics. bioRxiv. 2021 Jul 28. PMID: 34341793; PMCID: PMC8328060.
      Citations:    
    13. Duncan-Park S, Dunphy C, Becker J, D'Urso C, Annunziato R, Blatter J, Conrad C, Goldfarb SB, Hayes D, Melicoff E, Schecter M, Visner G, Armstrong B, Chin H, Kesler K, Williams NM, Odim JN, Sweet SC, Danziger-Isakov L, Shemesh E. Remote intervention engagement and outcomes in the Clinical Trials in Organ Transplantation in Children consortium multisite trial. Am J Transplant. 2021 09; 21(9):3112-3122. PMID: 33752251; PMCID: PMC8856090.
      Citations: 1     Fields:    Translation:HumansCTClinical Trials
    14. Onyearugbulem C, Coss-Bu J, Gazzaneo MC, Melicoff E, Das S, Lam F, Mallory GB, Munoz FM. Infections Within the First Month After Pediatric Lung Transplantation: Epidemiology and Impact on Outcomes. J Pediatric Infect Dis Soc. 2021 Apr 03; 10(3):245-251. PMID: 32533840.
      Citations:    Fields:    Translation:Humans
    15. Rajan A, Weaver AM, Aloisio GM, Jelinski J, Johnson HL, Venable SF, McBride T, Aideyan L, Ye X, Melicoff-Portillo E, Yerramilli MRK, Zeng XL, Mancini MA, Stossi F, Maresso AW, Kotkar SA, Estes MK, Blutt S, Avadhanula V, Piedra PA, Piedra FA. The Human Nose Organoid Respiratory Virus Model: an Ex Vivo Human Challenge Model To Study Respiratory Syncytial Virus (RSV) and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Pathogenesis and Evaluate Therapeutics. mBio. 2021 02 22; 13(1):e0351121. PMID: 35164569; PMCID: PMC8844923.
      Citations: 4     Fields:    
    16. Melicoff E, Hayes D, Benden C. Lung transplantation as an intervention for pediatric pulmonary hypertension. Pediatr Pulmonol. 2021 03; 56(3):587-592. PMID: 33210834.
      Citations:    Fields:    Translation:Humans
    17. Goss MB, Ruan W, Munoz FM, Brewer ED, O'Mahony CA, Melicoff-Portillo E, Dreyer WJ, Miloh TA, Cigarroa FG, Ranch D, Yoeli D, Adams MA, Koohmaraie S, Harter DM, Rana A, Cotton RT, Carter B, Patel S, Moreno NF, Leung DH, Goss JA, Galv?n NTN. The pediatric solid organ transplant experience with COVID-19: An initial multi-center, multi-organ case series. Pediatr Transplant. 2021 05; 25(3):e13868. PMID: 32949098; PMCID: PMC7537006.
      Citations: 29     Fields:    Translation:Humans
    18. Ammerman E, Sweet SC, Storch GA, Buller RS, Mason S, Conrad C, Hayes D, Faro A, Goldfarb SB, Melicoff E, Schecter M, Visner G, Heeger PS, Mohanakumar T, Williams N, Danziger-Isakov L. Epidemiology and persistence of rhinovirus in pediatric lung transplantation. Transpl Infect Dis. 2020 Dec; 22(6):e13422. PMID: 32686323; PMCID: PMC7900771.
      Citations: 2     Fields:    Translation:HumansCells
    19. Agrusa JE, Kothari VD, Brown AL, Masand PM, Lewis GD, Teh BS, Paulino AC, Silva-Carmona MD, Melicoff E, Allen CE, Gramatges MM. Early evidence of pulmonary dysfunction in survivors of childhood Hodgkin lymphoma. Leuk Lymphoma. 2020 10; 61(10):2419-2427. PMID: 32519904; PMCID: PMC8262456.
      Citations:    Fields:    Translation:Humans
    20. Moore PE, Boyer D, Perkins R, Katz ES, Castro-Codesal ML, MacLean JE, Akil N, Esther CR, Kaslow J, Lewis TC, Krone KA, Quizon A, Simpson R, Benscoter D, Spielberg DR, Melicoff E, Kuklinski CA, Blatter JA, Dy J, Rettig JS, Horani A, Gross J. American Thoracic Society 2019 Pediatric Core Curriculum. Pediatr Pulmonol. 2019 12; 54(12):1880-1894. PMID: 31456278.
      Citations:    Fields:    Translation:Humans
    21. Sweet SC, Chin H, Conrad C, Hayes D, Heeger PS, Faro A, Goldfarb S, Melicoff-Portillo E, Mohanakumar T, Odim J, Schecter M, Storch GA, Visner G, Williams NM, Kesler K, Danziger-Isakov L. Absence of evidence that respiratory viral infections influence pediatric lung transplantation outcomes: Results of the CTOTC-03 study. Am J Transplant. 2019 12; 19(12):3284-3298. PMID: 31216376; PMCID: PMC6883118.
      Citations: 4     Fields:    Translation:HumansCells
    22. Nguyen HN, Das S, Gazzaneo MC, Melicoff E, Mallory GB, Eldin KW, Guillerman RP. Clinico-radiologic features of pleuroparenchymal fibroelastosis in children. Pediatr Radiol. 2019 08; 49(9):1163-1170. PMID: 31004186.
      Citations: 1     Fields:    Translation:Humans
    23. Onyearugbulem C, Williams L, Zhu H, Gazzaneo MC, Melicoff E, Das S, Coss-Bu J, Lam F, Mallory G, Munoz FM. Risk factors for infection after pediatric lung transplantation. Transpl Infect Dis. 2018 Dec; 20(6):e13000. PMID: 30221817.
      Citations: 2     Fields:    Translation:Humans
    24. Blatter JA, Sweet SC, Conrad C, Danziger-Isakov LA, Faro A, Goldfarb SB, Hayes D, Melicoff E, Schecter M, Storch G, Visner GA, Williams NM, Wang D. Anellovirus loads are associated with outcomes in pediatric lung transplantation. Pediatr Transplant. 2018 02; 22(1). PMID: 29082660; PMCID: PMC5811341.
      Citations: 18     Fields:    Translation:HumansCells
    25. Ammerman E, Sweet SC, Fenchel M, Storch GA, Conrad C, Hayes D, Faro A, Goldfarb S, Melicoff E, Schecter M, Visner G, Williams NM, Danziger-Isakov L. Risk and outcomes of pulmonary fungal infection after pediatric lung transplantation. Clin Transplant. 2017 Nov; 31(11). PMID: 28871606; PMCID: PMC5724976.
      Citations: 2     Fields:    Translation:Humans
    26. Parrish A, Fenchel M, Storch GA, Buller R, Mason S, Williams N, Ikle D, Conrad C, Faro A, Goldfarb S, Hayes D, Melicoff-Portillo E, Schecter M, Visner G, Sweet S, Danziger-Isakov L, Clinical Trials in Organ Transplantation in Children (CTOTC-03). Epstein-Barr viral loads do not predict post-transplant lymphoproliferative disorder in pediatric lung transplant recipients: A multicenter prospective cohort study. Pediatr Transplant. 2017 Sep; 21(6). PMID: 28639398; PMCID: PMC5568922.
      Citations: 1     Fields:    Translation:HumansCells
    27. Scully BB, Goss M, Liu H, Keuht ML, Adachi I, McKenzie ED, Fraser CD, Melicoff E, Mallory GB, Heinle JS, Rana A. Waiting list outcomes in pediatric lung transplantation: Poor results for children listed in adult transplant programs. J Heart Lung Transplant. 2017 Nov; 36(11):1201-1208. PMID: 28579113.
      Citations: 1     Fields:    Translation:Humans
    28. Das S, Melicoff-Portillo E, Sockrider M. Lung Transplantation in Children. Am J Respir Crit Care Med. 2016 08 15; 194(4):P7-8. PMID: 27525467.
      Citations:    Fields:    Translation:Humans
    29. Garcia-Morales LJ, Chen NY, Weng T, Luo F, Davies J, Philip K, Volcik KA, Melicoff E, Amione-Guerra J, Bunge RR, Bruckner BA, Loebe M, Eltzschig HK, Pandit LM, Blackburn MR, Karmouty-Quintana H. Altered Hypoxic-Adenosine Axis and Metabolism in Group III Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2016 Apr; 54(4):574-83. PMID: 26414702; PMCID: PMC4821053.
      Citations: 23     Fields:    Translation:Humans
    30. Guzman-Pruneda FA, Orr Y, Trost JG, Zhang W, Das S, Melicoff E, Maddox J, Nugent M, Mery CM, Adachi I, Schecter MG, Mallory GB, Morales DL, Heinle JS, McKenzie ED. Bronchial artery revascularization and en bloc lung transplant in children. J Heart Lung Transplant. 2016 Jan; 35(1):122-129. PMID: 26508727.
      Citations: 3     Fields:    Translation:Humans
    31. Weng T, Poth JM, Karmouty-Quintana H, Garcia-Morales LJ, Melicoff E, Luo F, Chen NY, Evans CM, Bunge RR, Bruckner BA, Loebe M, Volcik KA, Eltzschig HK, Blackburn MR. Hypoxia-induced deoxycytidine kinase contributes to epithelial proliferation in pulmonary fibrosis. Am J Respir Crit Care Med. 2014 Dec 15; 190(12):1402-12. PMID: 25358054; PMCID: PMC4299646.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    32. Le TT, Karmouty-Quintana H, Melicoff E, Le TT, Weng T, Chen NY, Pedroza M, Zhou Y, Davies J, Philip K, Molina J, Luo F, George AT, Garcia-Morales LJ, Bunge RR, Bruckner BA, Loebe M, Seethamraju H, Agarwal SK, Blackburn MR. Blockade of IL-6 Trans signaling attenuates pulmonary fibrosis. J Immunol. 2014 Oct 01; 193(7):3755-68. PMID: 25172494; PMCID: PMC4169999.
      Citations: 108     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    33. Karmouty-Quintana H, Zhong H, Acero L, Weng T, Melicoff E, West JD, Hemnes A, Grenz A, Eltzschig HK, Blackwell TS, Xia Y, Johnston RA, Zeng D, Belardinelli L, Blackburn MR. The A2B adenosine receptor modulates pulmonary hypertension associated with interstitial lung disease. FASEB J. 2012 Jun; 26(6):2546-57. PMID: 22415303; PMCID: PMC3650483.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    34. Wu XS, McNeil BD, Xu J, Fan J, Xue L, Melicoff E, Adachi R, Bai L, Wu LG. Ca(2+) and calmodulin initiate all forms of endocytosis during depolarization at a nerve terminal. Nat Neurosci. 2009 Aug; 12(8):1003-1010. PMID: 19633667; PMCID: PMC4887276.
      Citations: 121     Fields:    Translation:AnimalsCells
    35. Melicoff E, Sansores-Garcia L, Gomez A, Moreira DC, Datta P, Thakur P, Petrova Y, Siddiqi T, Murthy JN, Dickey BF, Heidelberger R, Adachi R. Synaptotagmin-2 controls regulated exocytosis but not other secretory responses of mast cells. J Biol Chem. 2009 Jul 17; 284(29):19445-51. PMID: 19473977; PMCID: PMC2740570.
      Citations: 25     Fields:    Translation:AnimalsCells
    36. He L, Xue L, Xu J, McNeil BD, Bai L, Melicoff E, Adachi R, Wu LG. Compound vesicle fusion increases quantal size and potentiates synaptic transmission. Nature. 2009 May 07; 459(7243):93-7. PMID: 19279571; PMCID: PMC2768540.
      Citations: 63     Fields:    Translation:AnimalsCells
    37. Tuvim MJ, Mospan AR, Burns KA, Chua M, Mohler PJ, Melicoff E, Adachi R, Ammar-Aouchiche Z, Davis CW, Dickey BF. Synaptotagmin 2 couples mucin granule exocytosis to Ca2+ signaling from endoplasmic reticulum. J Biol Chem. 2009 Apr 10; 284(15):9781-7. PMID: 19208631; PMCID: PMC2665099.
      Citations: 30     Fields:    Translation:AnimalsCells
    38. Clement CG, Evans SE, Evans CM, Hawke D, Kobayashi R, Reynolds PR, Moghaddam SJ, Scott BL, Melicoff E, Adachi R, Dickey BF, Tuvim MJ. Stimulation of lung innate immunity protects against lethal pneumococcal pneumonia in mice. Am J Respir Crit Care Med. 2008 Jun 15; 177(12):1322-30. PMID: 18388354; PMCID: PMC2427056.
      Citations: 64     Fields:    Translation:AnimalsCells
    39. Thakurdas SM, Melicoff E, Sansores-Garcia L, Moreira DC, Petrova Y, Stevens RL, Adachi R. The mast cell-restricted tryptase mMCP-6 has a critical immunoprotective role in bacterial infections. J Biol Chem. 2007 Jul 20; 282(29):20809-15. PMID: 17456473.
      Citations: 84     Fields:    Translation:AnimalsCells
    40. Pang ZP, Melicoff E, Padgett D, Liu Y, Teich AF, Dickey BF, Lin W, Adachi R, S?dhof TC. Synaptotagmin-2 is essential for survival and contributes to Ca2+ triggering of neurotransmitter release in central and neuromuscular synapses. J Neurosci. 2006 Dec 27; 26(52):13493-504. PMID: 17192432; PMCID: PMC6674714.
      Citations: 106     Fields:    Translation:AnimalsCells
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