InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1100 BATES
Houston, TX 77030
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    R01CA261723     (SHEN, LANLAN)Jul 1, 2021 - Jun 30, 2026
    Epigenetically Engineered Mouse Model for Lung Cancer Therapy
    Role: Principal Investigator

    R21HD091718     (PAMMI, MOHAN)Jun 17, 2020 - May 31, 2022
    Microbiome Induced Epigenetic Changes in Intestinal Inflammation and Necrotizing Enterocolitis
    Role: Co-Principal Investigator

    R01HD100914     (SHEN, LANLAN)Feb 7, 2020 - Jan 31, 2024
    Early Environment, Developmental Epigenetics, and Adult Colonic Diseases
    Role: Principal Investigator

    R21HD101035     (SHEN, LANLAN)Dec 1, 2019 - Nov 30, 2021
    Regulation and function of developmentally programmed 3 CpG island methylation
    Role: Principal Investigator

    R01CA233472     (SHEN, LANLAN)Aug 8, 2019 - Jul 31, 2024
    Defining the Function of Age-Related Epimutation in Intestinal Tumorigenesis
    Role: Principal Investigator

    R21CA229727     (SHEN, LANLAN)May 16, 2018 - Apr 30, 2021
    Targeting aberrant promoter DNA methylation for anticancer therapy
    Role: Principal Investigator

    R21CA137689     (SHEN, LANLAN)Apr 1, 2009 - Mar 31, 2013
    Massively Parallel Sequencing Technology for Cancer Epigenome.
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Yang L, Peery RC, Farmer LM, Gao X, Zhang Y, Creighton CJ, Zhang L, Shen L. Dietary Folate and Cofactors Accelerate Age-dependent p16 Epimutation to Promote Intestinal Tumorigenesis. Cancer Res Commun. 2024 01 19; 4(1):164-169. PMID: 38259096; PMCID: PMC10798135.
      Citations:    Translation:HumansAnimals
    2. Yang L, Chen X, Lee C, Shi J, Lawrence EB, Zhang L, Li Y, Gao N, Jung SY, Creighton CJ, Li JJ, Cui Y, Arimura S, Lei Y, Li W, Shen L. Functional characterization of age-dependent p16 epimutation reveals biological drivers and therapeutic targets for colorectal cancer. J Exp Clin Cancer Res. 2023 May 04; 42(1):113. PMID: 37143122; PMCID: PMC10157929.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Shi J, Xu J, Chen YE, Li JS, Cui Y, Shen L, Li JJ, Li W. The concurrence of DNA methylation and demethylation is associated with transcription regulation. Nat Commun. 2021 09 06; 12(1):5285. PMID: 34489442; PMCID: PMC8421433.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    4. Peery RC, Pammi M, Claud E, Shen L. Epigenome - A mediator for host-microbiome crosstalk. Semin Perinatol. 2021 10; 45(6):151455. PMID: 34246487.
      Citations: 1     Fields:    Translation:Humans
    5. Deng F, Shen L, Wang H, Zhang L. Classify multicategory outcome in patients with lung adenocarcinoma using clinical, transcriptomic and clinico-transcriptomic data: machine learning versus multinomial models. Am J Cancer Res. 2020; 10(12):4624-4639. PMID: 33415023; PMCID: PMC7783755.
      Citations: 5     
    6. Deng F, Zhou H, Lin Y, Heim JA, Shen L, Li Y, Zhang L. Predict multicategory causes of death in lung cancer patients using clinicopathologic factors. Comput Biol Med. 2021 02; 129:104161. PMID: 33307409.
      Citations: 4     Fields:    Translation:Humans
    7. Iqbal NT, Syed S, Sadiq K, Khan MN, Iqbal J, Ma JZ, Umrani F, Ahmed S, Maier EA, Denson LA, Haberman Y, McNeal MM, Setchell KDR, Zhao X, Qureshi S, Shen L, Moskaluk CA, Liu TC, Yilmaz O, Brown DE, Barratt MJ, Kung VL, Gordon JI, Moore SR, Ali SA. Study of Environmental Enteropathy and Malnutrition (SEEM) in Pakistan: protocols for biopsy based biomarker discovery and validation. BMC Pediatr. 2019 07 22; 19(1):247. PMID: 31331393; PMCID: PMC6643315.
      Citations: 8     Fields:    Translation:Humans
    8. . Murine Methyl Donor Deficiency Impairs Early Growth in Association with Dysmorphic Small Intestinal Crypts and Reduced Gut Microbial Community Diversity. Curr Dev Nutr. 2019; nzy070.
    9. Schraw JM, Yiu TT, Lupo PJ, Tsavachidis S, Rau R, Bondy ML, Rabin KR, Shen L, Scheurer ME. Maternal folate genes and aberrant DNA hypermethylation in pediatric acute lymphoblastic leukemia. PLoS One. 2018; 13(5):e0197408. PMID: 29763473; PMCID: PMC5953491.
      Citations: 2     Fields:    Translation:HumansCells
    10. Parikh N, Shuck RL, Gagea M, Shen L, Donehower LA. Enhanced inflammation and attenuated tumor suppressor pathways are associated with oncogene-induced lung tumors in aged mice. Aging Cell. 2018 02; 17(1). PMID: 29047229; PMCID: PMC5771401.
      Citations: 14     Fields:    Translation:AnimalsCells
    11. Yu DH, Gadkari M, Zhou Q, Yu S, Gao N, Guan Y, Schady D, Roshan TN, Chen MH, Laritsky E, Ge Z, Wang H, Chen R, Westwater C, Bry L, Waterland RA, Moriarty C, Hwang C, Swennes AG, Moore SR, Shen L. Postnatal epigenetic regulation of intestinal stem cells requires DNA methylation and is guided by the microbiome. Genome Biol. 2015 Sep 30; 16:211. PMID: 26420038; PMCID: PMC4589031.
      Citations: 54     Fields:    Translation:AnimalsCells
    12. Fujii S, Srivastava V, Hegde A, Kondo Y, Shen L, Hoshino K, Gonzalez Y, Wang J, Sasai K, Ma X, Katayama H, Estecio MR, Hamilton SR, Wistuba I, Issa JP, Sen S. Regulation of AURKC expression by CpG island methylation in human cancer cells. Tumour Biol. 2015 Sep; 36(10):8147-58. PMID: 25990457.
      Citations: 4     Fields:    Translation:HumansCells
    13. Nosavanh L, Yu DH, Jaehnig EJ, Tong Q, Shen L, Chen MH. Cell-autonomous activation of Hedgehog signaling inhibits brown adipose tissue development. Proc Natl Acad Sci U S A. 2015 Apr 21; 112(16):5069-74. PMID: 25848030; PMCID: PMC4413261.
      Citations: 21     Fields:    Translation:AnimalsCells
    14. Yu DH, Waterland RA, Shen L. On the meaning of the word 'epimutation': a comment. Trends Genet. 2015 Jan; 31(1):1. PMID: 25480537.
      Citations:    Fields:    Translation:Animals
    15. Sakamori R, Yu S, Zhang X, Hoffman A, Sun J, Das S, Vedula P, Li G, Fu J, Walker F, Yang CS, Yi Z, Hsu W, Yu DH, Shen L, Rodriguez AJ, Taketo MM, Bonder EM, Verzi MP, Gao N. CDC42 inhibition suppresses progression of incipient intestinal tumors. Cancer Res. 2014 Oct 01; 74(19):5480-92. PMID: 25113996; PMCID: PMC4184946.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    16. Yu DH, Waterland RA, Zhang P, Schady D, Chen MH, Guan Y, Gadkari M, Shen L. Targeted p16(Ink4a) epimutation causes tumorigenesis and reduces survival in mice. J Clin Invest. 2014 Sep; 124(9):3708-12. PMID: 25061879; PMCID: PMC4151219.
      Citations: 36     Fields:    Translation:AnimalsCells
    17. Kunde-Ramamoorthy G, Coarfa C, Laritsky E, Kessler NJ, Harris RA, Xu M, Chen R, Shen L, Milosavljevic A, Waterland RA. Comparison and quantitative verification of mapping algorithms for whole-genome bisulfite sequencing. Nucleic Acids Res. 2014 Apr; 42(6):e43. PMID: 24391148; PMCID: PMC3973287.
      Citations: 29     Fields:    Translation:HumansCells
    18. Li G, Zhang W, Baker MS, Laritsky E, Mattan-Hung N, Yu D, Kunde-Ramamoorthy G, Simerly RB, Chen R, Shen L, Waterland RA. Major epigenetic development distinguishing neuronal and non-neuronal cells occurs postnatally in the murine hypothalamus. Hum Mol Genet. 2014 Mar 15; 23(6):1579-90. PMID: 24186871; PMCID: PMC3929094.
      Citations: 14     Fields:    Translation:AnimalsCells
    19. Yu DH, Ware C, Waterland RA, Zhang J, Chen MH, Gadkari M, Kunde-Ramamoorthy G, Nosavanh LM, Shen L. Developmentally programmed 3' CpG island methylation confers tissue- and cell-type-specific transcriptional activation. Mol Cell Biol. 2013 May; 33(9):1845-58. PMID: 23459939; PMCID: PMC3624169.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    20. Zhang Y, Shu J, Si J, Shen L, Estecio MR, Issa JP. Repetitive elements and enforced transcriptional repression co-operate to enhance DNA methylation spreading into a promoter CpG-island. Nucleic Acids Res. 2012 Aug; 40(15):7257-68. PMID: 22600741; PMCID: PMC3424568.
      Citations: 12     Fields:    Translation:HumansCells
    21. Yamazaki J, Taby R, Vasanthakumar A, Macrae T, Ostler KR, Shen L, Kantarjian HM, Estecio MR, Jelinek J, Godley LA, Issa JP. Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia. Epigenetics. 2012 Feb; 7(2):201-7. PMID: 22395470; PMCID: PMC3335912.
      Citations: 56     Fields:    Translation:HumansCells
    22. Konishi K, Watanabe Y, Shen L, Guo Y, Castoro RJ, Kondo K, Chung W, Ahmed S, Jelinek J, Boumber YA, Estecio MR, Maegawa S, Kondo Y, Itoh F, Imawari M, Hamilton SR, Issa JP. DNA methylation profiles of primary colorectal carcinoma and matched liver metastasis. PLoS One. 2011; 6(11):e27889. PMID: 22132162; PMCID: PMC3221680.
      Citations: 15     Fields:    Translation:HumansCells
    23. Watanabe Y, Castoro RJ, Kim HS, North B, Oikawa R, Hiraishi T, Ahmed SS, Chung W, Cho MY, Toyota M, Itoh F, Estecio MR, Shen L, Jelinek J, Issa JP. Frequent alteration of MLL3 frameshift mutations in microsatellite deficient colorectal cancer. PLoS One. 2011; 6(8):e23320. PMID: 21853109; PMCID: PMC3154922.
      Citations: 41     Fields:    Translation:HumansCells
    24. Waterland RA, Kellermayer R, Laritsky E, Rayco-Solon P, Harris RA, Travisano M, Zhang W, Torskaya MS, Zhang J, Shen L, Manary MJ, Prentice AM. Season of conception in rural gambia affects DNA methylation at putative human metastable epialleles. PLoS Genet. 2010 Dec 23; 6(12):e1001252. PMID: 21203497; PMCID: PMC3009670.
      Citations: 189     Fields:    Translation:HumansAnimalsCells
    25. Wallace K, Grau MV, Levine AJ, Shen L, Hamdan R, Chen X, Gui J, Haile RW, Barry EL, Ahnen D, McKeown-Eyssen G, Baron JA, Issa JP. Association between folate levels and CpG Island hypermethylation in normal colorectal mucosa. Cancer Prev Res (Phila). 2010 Dec; 3(12):1552-64. PMID: 21149331; PMCID: PMC3058541.
      Citations: 42     Fields:    Translation:HumansCells
    26. An B, Kondo Y, Okamoto Y, Shinjo K, Kanemitsu Y, Komori K, Hirai T, Sawaki A, Tajika M, Nakamura T, Yamao K, Yatabe Y, Fujii M, Murakami H, Osada H, Tani T, Matsuo K, Shen L, Issa JP, Sekido Y. Characteristic methylation profile in CpG island methylator phenotype-negative distal colorectal cancers. Int J Cancer. 2010 Nov 01; 127(9):2095-105. PMID: 20131317.
      Citations: 20     Fields:    Translation:HumansCells
    27. Gallegos J, Castoro RJ, Chung W, Maegawa S, Oki Y, Kondo Y, Jelinek J, Shen L, Hartung H, Aplan PD, Czerniak BA, Liang S, Issa JP, Est?cio MR, Vallot C. Genome architecture marked by retrotransposons modulates predisposition to DNA methylation in cancer. Genome Res. 2010 Oct; 20(10):1369-82. PMID: 20716667; PMCID: PMC2945186.
      Citations: 49     Fields:    Translation:HumansCells
    28. Stadler B, Ivanovska I, Mehta K, Song S, Nelson A, Tan Y, Mathieu J, Darby C, Blau CA, Ware C, Peters G, Miller DG, Shen L, Cleary MA, Ruohola-Baker H. Characterization of microRNAs involved in embryonic stem cell states. Stem Cells Dev. 2010 Jul; 19(7):935-50. PMID: 20128659; PMCID: PMC3128320.
      Citations: 83     Fields:    Translation:HumansAnimalsCells
    29. Taube JH, Allton K, Duncan SA, Shen L, Barton MC. Foxa1 functions as a pioneer transcription factor at transposable elements to activate Afp during differentiation of embryonic stem cells. J Biol Chem. 2010 May 21; 285(21):16135-44. PMID: 20348100; PMCID: PMC2871482.
      Citations: 35     Fields:    Translation:AnimalsCells
    30. Kellermayer R, Balasa A, Zhang W, Lee S, Mirza S, Chakravarty A, Szigeti R, Laritsky E, Tatevian N, Smith CW, Shen L, Waterland RA. Epigenetic maturation in colonic mucosa continues beyond infancy in mice. Hum Mol Genet. 2010 Jun 01; 19(11):2168-76. PMID: 20197410; PMCID: PMC2865374.
      Citations: 30     Fields:    Translation:AnimalsCells
    31. Maegawa S, Hinkal G, Kim HS, Shen L, Zhang L, Zhang J, Zhang N, Liang S, Donehower LA, Issa JP. Widespread and tissue specific age-related DNA methylation changes in mice. Genome Res. 2010 Mar; 20(3):332-40. PMID: 20107151; PMCID: PMC2840983.
      Citations: 224     Fields:    Translation:AnimalsCells
    32. Shen L, Kantarjian H, Guo Y, Lin E, Shan J, Huang X, Berry D, Ahmed S, Zhu W, Pierce S, Kondo Y, Oki Y, Jelinek J, Saba H, Estey E, Issa JP. DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes. J Clin Oncol. 2010 Feb 01; 28(4):605-13. PMID: 20038729; PMCID: PMC2815995.
      Citations: 121     Fields:    Translation:HumansCells
    33. Goto Y, Shinjo K, Kondo Y, Shen L, Toyota M, Suzuki H, Gao W, An B, Fujii M, Murakami H, Osada H, Taniguchi T, Usami N, Kondo M, Hasegawa Y, Shimokata K, Matsuo K, Hida T, Fujimoto N, Kishimoto T, Issa JP, Sekido Y. Epigenetic profiles distinguish malignant pleural mesothelioma from lung adenocarcinoma. Cancer Res. 2009 Dec 01; 69(23):9073-82. PMID: 19887624.
      Citations: 40     Fields:    Translation:HumansCells
    34. Konishi K, Shen L, Jelinek J, Watanabe Y, Ahmed S, Kaneko K, Kogo M, Takano T, Imawari M, Hamilton SR, Issa JP. Concordant DNA methylation in synchronous colorectal carcinomas. Cancer Prev Res (Phila). 2009 Sep; 2(9):814-22. PMID: 19737982; PMCID: PMC3544187.
      Citations: 24     Fields:    Translation:HumansCells
    35. Suzuki H, Igarashi S, Nojima M, Maruyama R, Yamamoto E, Kai M, Akashi H, Watanabe Y, Yamamoto H, Sasaki Y, Itoh F, Imai K, Sugai T, Shen L, Issa JP, Shinomura Y, Tokino T, Toyota M. IGFBP7 is a p53-responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype. Carcinogenesis. 2010 Mar; 31(3):342-9. PMID: 19638426.
      Citations: 46     Fields:    Translation:HumansCells
    36. Tellez CS, Shen L, Jelinek J, Gershenwald JE, Issa JP, Est?cio MR. CpG island methylation profiling in human melanoma cell lines. Melanoma Res. 2009 Jun; 19(3):146-55. PMID: 19441164.
      Citations: 45     Fields:    Translation:HumansCells
    37. Waterland RA, Kellermayer R, Rached MT, Tatevian N, Gomes MV, Zhang J, Zhang L, Chakravarty A, Zhu W, Laritsky E, Zhang W, Wang X, Shen L. Epigenomic profiling indicates a role for DNA methylation in early postnatal liver development. Hum Mol Genet. 2009 Aug 15; 18(16):3026-38. PMID: 19457928; PMCID: PMC2714727.
      Citations: 31     Fields:    Translation:AnimalsCells
    38. Watanabe Y, Kim HS, Castoro RJ, Chung W, Estecio MR, Kondo K, Guo Y, Ahmed SS, Toyota M, Itoh F, Suk KT, Cho MY, Shen L, Jelinek J, Issa JP. Sensitive and specific detection of early gastric cancer with DNA methylation analysis of gastric washes. Gastroenterology. 2009 Jun; 136(7):2149-58. PMID: 19375421; PMCID: PMC2722957.
      Citations: 52     Fields:    Translation:HumansCells
    39. Ware CB, Wang L, Mecham BH, Shen L, Nelson AM, Bar M, Lamba DA, Dauphin DS, Buckingham B, Askari B, Lim R, Tewari M, Gartler SM, Issa JP, Pavlidis P, Duan Z, Blau CA. Histone deacetylase inhibition elicits an evolutionarily conserved self-renewal program in embryonic stem cells. Cell Stem Cell. 2009 Apr 03; 4(4):359-69. PMID: 19341625; PMCID: PMC2719860.
      Citations: 82     Fields:    Translation:HumansAnimalsCells
    40. Figueiredo JC, Grau MV, Wallace K, Levine AJ, Shen L, Hamdan R, Chen X, Bresalier RS, McKeown-Eyssen G, Haile RW, Baron JA, Issa JP. Global DNA hypomethylation (LINE-1) in the normal colon and lifestyle characteristics and dietary and genetic factors. Cancer Epidemiol Biomarkers Prev. 2009 Apr; 18(4):1041-9. PMID: 19336559; PMCID: PMC2712652.
      Citations: 75     Fields:    Translation:HumansCells
    41. Kim MJ, White-Cross JA, Shen L, Issa JP, Rashid A. Hypomethylation of long interspersed nuclear element-1 in hepatocellular carcinomas. Mod Pathol. 2009 Mar; 22(3):442-9. PMID: 19136926.
      Citations: 20     Fields:    Translation:HumansCells
    42. Boumber YA, Kondo Y, Chen X, Shen L, Guo Y, Tellez C, Ahmed S, Issa JP, Est?cio MR. An Sp1/Sp3 binding polymorphism confers methylation protection. PLoS Genet. 2008 Aug 22; 4(8):e1000162. PMID: 18725933; PMCID: PMC2515197.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    43. Gao W, Kondo Y, Shen L, Shimizu Y, Sano T, Yamao K, Natsume A, Goto Y, Ito M, Murakami H, Osada H, Zhang J, Issa JP, Sekido Y. Variable DNA methylation patterns associated with progression of disease in hepatocellular carcinomas. Carcinogenesis. 2008 Oct; 29(10):1901-10. PMID: 18632756.
      Citations: 58     Fields:    Translation:HumansCells
    44. Kroeger H, Jelinek J, He R, Kondo K, Chung W, Zhang L, Shen L, Kantarjian HM, Bueso-Ramos CE, Issa JP, Est?cio MR. Aberrant CpG island methylation in acute myeloid leukemia is accentuated at relapse. Blood. 2008 Aug 15; 112(4):1366-73. PMID: 18523155; PMCID: PMC2515110.
      Citations: 61     Fields:    Translation:HumansCells
    45. Kondo Y, Shen L, Cheng AS, Ahmed S, Boumber Y, Charo C, Yamochi T, Urano T, Furukawa K, Kwabi-Addo B, Gold DL, Sekido Y, Huang TH, Issa JP. Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation. Nat Genet. 2008 Jun; 40(6):741-50. PMID: 18488029.
      Citations: 285     Fields:    Translation:HumansCells
    46. Majewski T, Lee S, Jeong J, Yoon DS, Kram A, Kim MS, Tuziak T, Bondaruk J, Lee S, Park WS, Tang KS, Chung W, Shen L, Ahmed SS, Johnston DA, Grossman HB, Dinney CP, Zhou JH, Harris RA, Snyder C, Filipek S, Narod SA, Watson P, Lynch HT, Gazdar A, Bar-Eli M, Wu XF, McConkey DJ, Baggerly K, Issa JP, Benedict WF, Scherer SE, Czerniak B. Understanding the development of human bladder cancer by using a whole-organ genomic mapping strategy. Lab Invest. 2008 Jul; 88(7):694-721. PMID: 18458673; PMCID: PMC2849658.
      Citations: 24     Fields:    Translation:HumansCells
    47. Suehiro Y, Wong CW, Chirieac LR, Kondo Y, Shen L, Webb CR, Chan YW, Chan AS, Chan TL, Wu TT, Rashid A, Hamanaka Y, Hinoda Y, Shannon RL, Wang X, Morris J, Issa JP, Yuen ST, Leung SY, Hamilton SR. Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma. Clin Cancer Res. 2008 May 01; 14(9):2560-9. PMID: 18451217; PMCID: PMC3544184.
      Citations: 52     Fields:    Translation:HumansCells
    48. Kondo Y, Shen L, Ahmed S, Boumber Y, Sekido Y, Haddad BR, Issa JP. Downregulation of histone H3 lysine 9 methyltransferase G9a induces centrosome disruption and chromosome instability in cancer cells. PLoS One. 2008 Apr 30; 3(4):e2037. PMID: 18446223; PMCID: PMC2323574.
      Citations: 112     Fields:    Translation:HumansCells
    49. Chung W, Kwabi-Addo B, Ittmann M, Jelinek J, Shen L, Yu Y, Issa JP. Identification of novel tumor markers in prostate, colon and breast cancer by unbiased methylation profiling. PLoS One. 2008 Apr 30; 3(4):e2079. PMID: 18446232; PMCID: PMC2323612.
      Citations: 52     Fields:    Translation:HumansCells
    50. Zuo X, Shen L, Issa JP, Moy O, Morris JS, Lippman SM, Shureiqi I. 15-Lipoxygenase-1 transcriptional silencing by DNA methyltransferase-1 independently of DNA methylation. FASEB J. 2008 Jun; 22(6):1981-92. PMID: 18198215; PMCID: PMC2410033.
      Citations: 13     Fields:    Translation:HumansCells
    51. Shen L, Kondo Y, Ahmed S, Boumber Y, Konishi K, Guo Y, Chen X, Vilaythong JN, Issa JP. Drug sensitivity prediction by CpG island methylation profile in the NCI-60 cancer cell line panel. Cancer Res. 2007 Dec 01; 67(23):11335-43. PMID: 18056460.
      Citations: 41     Fields:    Translation:HumansCells
    52. Oki Y, Jelinek J, Shen L, Kantarjian HM, Issa JP. Induction of hypomethylation and molecular response after decitabine therapy in patients with chronic myelomonocytic leukemia. Blood. 2008 Feb 15; 111(4):2382-4. PMID: 18055864; PMCID: PMC2234065.
      Citations: 32     Fields:    Translation:HumansCellsCTClinical Trials
    53. Wang J, Bhutani M, Pathak AK, Lang W, Ren H, Jelinek J, He R, Shen L, Issa JP, Mao L. Delta DNMT3B variants regulate DNA methylation in a promoter-specific manner. Cancer Res. 2007 Nov 15; 67(22):10647-52. PMID: 18006804.
      Citations: 24     Fields:    Translation:HumansCells
    54. Shen L, Toyota M, Kondo Y, Lin E, Zhang L, Guo Y, Hernandez NS, Chen X, Ahmed S, Konishi K, Hamilton SR, Issa JP. Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer. Proc Natl Acad Sci U S A. 2007 Nov 20; 104(47):18654-9. PMID: 18003927; PMCID: PMC2141832.
      Citations: 229     Fields:    Translation:HumansCells
    55. Shen L, Catalano PJ, Benson AB, O'Dwyer P, Hamilton SR, Issa JP. Association between DNA methylation and shortened survival in patients with advanced colorectal cancer treated with 5-fluorouracil based chemotherapy. Clin Cancer Res. 2007 Oct 15; 13(20):6093-8. PMID: 17947473; PMCID: PMC3575642.
      Citations: 79     Fields:    Translation:HumansCells
    56. Shen L, Kondo Y, Guo Y, Zhang J, Zhang L, Ahmed S, Shu J, Chen X, Waterland RA, Issa JP. Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters. PLoS Genet. 2007 Oct; 3(10):2023-36. PMID: 17967063; PMCID: PMC2041996.
      Citations: 163     Fields:    Translation:HumansCells
    57. Yan PS, Ibrahim AE, Tellez CS, Shen L, Huang TH, Issa JP, Est?cio MR. High-throughput methylation profiling by MCA coupled to CpG island microarray. Genome Res. 2007 Oct; 17(10):1529-36. PMID: 17785535; PMCID: PMC1987348.
      Citations: 69     Fields:    Translation:HumansCells
    58. Shen L, Waterland RA. Methods of DNA methylation analysis. Curr Opin Clin Nutr Metab Care. 2007 Sep; 10(5):576-81. PMID: 17693740.
      Citations: 40     Fields:    Translation:HumansCells
    59. Lee S, Jeong J, Majewski T, Scherer SE, Kim MS, Tuziak T, Tang KS, Baggerly K, Grossman HB, Zhou JH, Shen L, Bondaruk J, Ahmed SS, Samanta S, Spiess P, Wu X, Filipek S, McConkey D, Bar-Eli M, Issa JP, Benedict WF, Czerniak B. Forerunner genes contiguous to RB1 contribute to the development of in situ neoplasia. Proc Natl Acad Sci U S A. 2007 Aug 21; 104(34):13732-7. PMID: 17702869; PMCID: PMC1949496.
      Citations: 21     Fields:    Translation:HumansCells
    60. Kwabi-Addo B, Chung W, Shen L, Ittmann M, Wheeler T, Jelinek J, Issa JP. Age-related DNA methylation changes in normal human prostate tissues. Clin Cancer Res. 2007 Jul 01; 13(13):3796-802. PMID: 17606710.
      Citations: 89     Fields:    Translation:HumansCells
    61. Kondo Y, Shen L, Suzuki S, Kurokawa T, Masuko K, Tanaka Y, Kato H, Mizuno Y, Yokoe M, Sugauchi F, Hirashima N, Orito E, Osada H, Ueda R, Guo Y, Chen X, Issa JP, Sekido Y. Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas. Hepatol Res. 2007 Nov; 37(11):974-83. PMID: 17584191.
      Citations: 71     
    62. Gharibyan V, Shen L, Ibrahim AE, Doshi K, He R, Jelinek J, Yang AS, Yan PS, Huang TH, Tajara EH, Issa JP, Est?cio MR. LINE-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability. PLoS One. 2007 May 02; 2(5):e399. PMID: 17476321; PMCID: PMC1851990.
      Citations: 131     Fields:    Translation:HumansCells
    63. Boumber YA, Kondo Y, Chen X, Shen L, Gharibyan V, Konishi K, Estey E, Kantarjian H, Garcia-Manero G, Issa JP. RIL, a LIM gene on 5q31, is silenced by methylation in cancer and sensitizes cancer cells to apoptosis. Cancer Res. 2007 Mar 01; 67(5):1997-2005. PMID: 17332327.
      Citations: 35     Fields:    Translation:HumansCells
    64. Konishi K, Shen L, Wang S, Meltzer SJ, Harpaz N, Issa JP. Rare CpG island methylator phenotype in ulcerative colitis-associated neoplasias. Gastroenterology. 2007 Apr; 132(4):1254-60. PMID: 17408633.
      Citations: 35     Fields:    Translation:HumansCells
    65. Shen L, Guo Y, Chen X, Ahmed S, Issa JP. Optimizing annealing temperature overcomes bias in bisulfite PCR methylation analysis. Biotechniques. 2007 Jan; 42(1):48, 50, 52 passim. PMID: 17269485.
      Citations: 56     Fields:    Translation:Cells
    66. Feng W, Shen L, Wen S, Rosen DG, Jelinek J, Hu X, Huan S, Huang M, Liu J, Sahin AA, Hunt KK, Bast RC, Shen Y, Issa JP, Yu Y. Correlation between CpG methylation profiles and hormone receptor status in breast cancers. Breast Cancer Res. 2007; 9(4):R57. PMID: 17764565; PMCID: PMC2206733.
      Citations: 68     Fields:    Translation:HumansCells
    67. Montero AJ, Mao L, Youssef EM, Estecio M, Shen L, Issa JP, D?az-Montero CM. Epigenetic inactivation of EGFR by CpG island hypermethylation in cancer. Cancer Biol Ther. 2006 Nov; 5(11):1494-501. PMID: 17369752.
      Citations: 29     Fields:    Translation:HumansCells
    68. Shu J, Jelinek J, Chang H, Shen L, Qin T, Chung W, Oki Y, Issa JP. Silencing of bidirectional promoters by DNA methylation in tumorigenesis. Cancer Res. 2006 May 15; 66(10):5077-84. PMID: 16707430.
      Citations: 41     Fields:    Translation:HumansCells
    69. Yang AS, Doshi KD, Choi SW, Mason JB, Mannari RK, Gharybian V, Luna R, Rashid A, Shen L, Estecio MR, Kantarjian HM, Garcia-Manero G, Issa JP. DNA methylation changes after 5-aza-2'-deoxycytidine therapy in patients with leukemia. Cancer Res. 2006 May 15; 66(10):5495-503. PMID: 16707479.
      Citations: 114     Fields:    Translation:HumansCells
    70. Kantarjian H, Issa JP, Rosenfeld CS, Bennett JM, Albitar M, DiPersio J, Klimek V, Slack J, de Castro C, Ravandi F, Helmer R, Shen L, Nimer SD, Leavitt R, Raza A, Saba H. Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study. Cancer. 2006 Apr 15; 106(8):1794-803. PMID: 16532500.
      Citations: 524     Fields:    Translation:HumansCellsCTClinical Trials
    71. Yang AD, Camp ER, Fan F, Shen L, Gray MJ, Liu W, Somcio R, Bauer TW, Wu Y, Hicklin DJ, Ellis LM. Vascular endothelial growth factor receptor-1 activation mediates epithelial to mesenchymal transition in human pancreatic carcinoma cells. Cancer Res. 2006 Jan 01; 66(1):46-51. PMID: 16397214.
      Citations: 101     Fields:    Translation:HumansCells
    72. Shen L, Kondo Y, Rosner GL, Xiao L, Hernandez NS, Vilaythong J, Houlihan PS, Krouse RS, Prasad AR, Einspahr JG, Buckmeier J, Alberts DS, Hamilton SR, Issa JP. MGMT promoter methylation and field defect in sporadic colorectal cancer. J Natl Cancer Inst. 2005 Sep 21; 97(18):1330-8. PMID: 16174854.
      Citations: 211     Fields:    Translation:HumansCells
    73. Issa JP, Shen L, Toyota M. CIMP, at last. Gastroenterology. 2005 Sep; 129(3):1121-4. PMID: 16143149.
      Citations: 48     Fields:    Translation:HumansCells
    74. Chirieac LR, Shen L, Catalano PJ, Issa JP, Hamilton SR. Phenotype of microsatellite-stable colorectal carcinomas with CpG island methylation. Am J Surg Pathol. 2005 Apr; 29(4):429-36. PMID: 15767794.
      Citations: 18     Fields:    Translation:HumansCells
    75. Kondo Y, Shen L, Yan PS, Huang TH, Issa JP. Chromatin immunoprecipitation microarrays for identification of genes silenced by histone H3 lysine 9 methylation. Proc Natl Acad Sci U S A. 2004 May 11; 101(19):7398-403. PMID: 15123805; PMCID: PMC409930.
      Citations: 40     Fields:    Translation:HumansCells
    76. Shen L, Kondo Y, Hamilton SR, Rashid A, Issa JP. P14 methylation in human colon cancer is associated with microsatellite instability and wild-type p53. Gastroenterology. 2003 Mar; 124(3):626-33. PMID: 12612901.
      Citations: 30     Fields:    Translation:HumansCells
    77. Shen L, Toyota M, Kondo Y, Obata T, Daniel S, Pierce S, Imai K, Kantarjian HM, Issa JP, Garcia-Manero G. Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia. Blood. 2003 May 15; 101(10):4131-6. PMID: 12586619.
      Citations: 42     Fields:    Translation:HumansCells
    78. Kondo Y, Shen L, Issa JP. Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer. Mol Cell Biol. 2003 Jan; 23(1):206-15. PMID: 12482974; PMCID: PMC140684.
      Citations: 111     Fields:    Translation:HumansCells
    79. Shen L, Kondo Y, Issa JP, Garcia-Manero G. Lack of p21(CIP1) DNA methylation in acute lymphocytic leukemia. Blood. 2002 Nov 01; 100(9):3432-3; author reply 3433-4. PMID: 12412576.
      Citations: 9     Fields:    Translation:HumansCells
    80. Shen L, Ahuja N, Shen Y, Habib NA, Toyota M, Rashid A, Issa JP. DNA methylation and environmental exposures in human hepatocellular carcinoma. J Natl Cancer Inst. 2002 May 15; 94(10):755-61. PMID: 12011226.
      Citations: 69     Fields:    Translation:HumansCellsPHPublic Health
    81. Moinova HR, Chen WD, Shen L, Smiraglia D, Olechnowicz J, Ravi L, Kasturi L, Myeroff L, Plass C, Parsons R, Minna J, Willson JK, Green SB, Issa JP, Markowitz SD. HLTF gene silencing in human colon cancer. Proc Natl Acad Sci U S A. 2002 Apr 02; 99(7):4562-7. PMID: 11904375; PMCID: PMC123687.
      Citations: 62     Fields:    Translation:HumansCells
    82. Shen L, Issa JP. Epigenetics in colorectal cancer. Curr Opin Gastroenterol. 2002 Jan; 18(1):68-73. PMID: 17031233.
      Citations: 13     Fields:    
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