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FRANK T. HORRIGAN

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular Physiology & Biophysics
DivisionMolecular Physiology & Biophysics
AddressOne Baylor Plaza
Houston TX 77030
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Neuroscience
    DivisionNeuroscience


    Collapse Research 
    Collapse research activities and funding
    R01NS042901     (HORRIGAN, FRANK T)Sep 30, 2001 - Mar 31, 2013
    NIH/NINDS
    Allosteric mechanisms of CA-activated K channel gating
    Role: Principal Investigator

    R01GM105817     (HORRIGAN, FRANK T)Jun 1, 2013 - May 31, 2016
    NIH/NIGMS
    Development of a Novel High-Throughput Screening Platform for BK Channel Modulato
    Role: Principal Investigator

    R03NS101456     (HORRIGAN, FRANK T)Jan 15, 2017 - Dec 31, 2018
    NIH/NINDS
    BK Channel Inhibition by Nobiletin
    Role: Principal Investigator

    R01GM127332     (YAN, JIUSHENG)May 1, 2018 - Apr 30, 2022
    NIH/NIGMS
    Pore Gating Mechanisms of BK Channels
    Role: Co-Principal Investigator

    R01AR072602     (HAMILTON, SUSAN L)Aug 1, 2018 - Jun 30, 2023
    NIH/NIAMS
    Mechanisms of couplon-linked skeletal muscle myopathies
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Tajhya RB, Hu X, Tanner MR, Huq R, Kongchan N, Neilson JR, Rodney GG, Horrigan FT, Timchenko LT, Beeton C. Functional KCa1.1 channels are crucial for regulating the proliferation, migration and differentiation of human primary skeletal myoblasts. Cell Death Dis. 2016 10 20; 7(10):e2426. PMID: 27763639.
      View in: PubMed
    2. Tanner MR, Hu X, Huq R, Tajhya RB, Sun L, Khan FS, Laragione T, Horrigan FT, Gulko PS, Beeton C. KCa1.1 inhibition attenuates fibroblast-like synoviocyte invasiveness and ameliorates disease in rat models of rheumatoid arthritis. Arthritis Rheumatol. 2015 Jan; 67(1):96-106. PMID: 25252152.
      View in: PubMed
    3. Li N, Chiang DY, Wang S, Wang Q, Sun L, Voigt N, Respress JL, Ather S, Skapura DG, Jordan VK, Horrigan FT, Schmitz W, Müller FU, Valderrabano M, Nattel S, Dobrev D, Wehrens XHT. Ryanodine receptor-mediated calcium leak drives progressive development of an atrial fibrillation substrate in a transgenic mouse model. Circulation. 2014 Mar 25; 129(12):1276-1285. PMID: 24398018.
      View in: PubMed
    4. Horrigan FT. Perspectives on: conformational coupling in ion channels: conformational coupling in BK potassium channels. J Gen Physiol. 2012 Dec; 140(6):625-34. PMID: 23183698.
      View in: PubMed
    5. Hu X, Laragione T, Sun L, Koshy S, Jones KR, Ismailov II, Yotnda P, Horrigan FT, Gulko PS, Beeton C. KCa1.1 potassium channels regulate key proinflammatory and invasive properties of fibroblast-like synoviocytes in rheumatoid arthritis. J Biol Chem. 2012 Feb 03; 287(6):4014-22. PMID: 22074915.
      View in: PubMed
    6. Hou S, Horrigan FT, Xu R, Heinemann SH, Hoshi T. Comparative effects of H+ and Ca2+ on large-conductance Ca2+- and voltage-gated Slo1 K+ channels. Channels (Austin). 2009 Jul-Aug; 3(4):249-58. PMID: 19617704.
      View in: PubMed
    7. Wu Y, Xiong Y, Wang S, Yi H, Li H, Pan N, Horrigan FT, Wu Y, Ding J. Intersubunit coupling in the pore of BK channels. J Biol Chem. 2009 Aug 28; 284(35):23353-63. PMID: 19561088.
      View in: PubMed
    8. Horrigan FT, Hoshi T. Integration of an electric-metal sensory experience in the Slo1 BK channel. Nat Struct Mol Biol. 2008 Nov; 15(11):1130-2. PMID: 18985066.
      View in: PubMed
    9. Ma Z, Wong KY, Horrigan FT. An extracellular Cu2+ binding site in the voltage sensor of BK and Shaker potassium channels. J Gen Physiol. 2008 May; 131(5):483-502. PMID: 18443360.
      View in: PubMed
    10. Horrigan FT, Ma Z. Mg2+ enhances voltage sensor/gate coupling in BK channels. J Gen Physiol. 2008 Jan; 131(1):13-32. PMID: 18166624.
      View in: PubMed
    11. Yang H, Hu L, Shi J, Delaloye K, Horrigan FT, Cui J. Mg2+ mediates interaction between the voltage sensor and cytosolic domain to activate BK channels. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):18270-5. PMID: 17984060.
      View in: PubMed
    12. Hou S, Reynolds MF, Horrigan FT, Heinemann SH, Hoshi T. Reversible binding of heme to proteins in cellular signal transduction. Acc Chem Res. 2006 Dec; 39(12):918-24. PMID: 17176030.
      View in: PubMed
    13. Ma Z, Lou XJ, Horrigan FT. Role of charged residues in the S1-S4 voltage sensor of BK channels. J Gen Physiol. 2006 Mar; 127(3):309-28. PMID: 16505150.
      View in: PubMed
    14. Horrigan FT, Heinemann SH, Hoshi T. Heme regulates allosteric activation of the Slo1 BK channel. J Gen Physiol. 2005 Jul; 126(1):7-21. PMID: 15955873.
      View in: PubMed
    15. Zhang G, Horrigan FT. Cysteine modification alters voltage- and Ca(2+)-dependent gating of large conductance (BK) potassium channels. J Gen Physiol. 2005 Feb; 125(2):213-36. PMID: 15684095.
      View in: PubMed
    16. Hu L, Shi J, Ma Z, Krishnamoorthy G, Sieling F, Zhang G, Horrigan FT, Cui J. Participation of the S4 voltage sensor in the Mg2+-dependent activation of large conductance (BK) K+ channels. Proc Natl Acad Sci U S A. 2003 Sep 02; 100(18):10488-93. PMID: 12925732.
      View in: PubMed
    17. Horrigan FT, Aldrich RW. Coupling between voltage sensor activation, Ca2+ binding and channel opening in large conductance (BK) potassium channels. J Gen Physiol. 2002 Sep; 120(3):267-305. PMID: 12198087.
      View in: PubMed
    18. Lou XJ, Schena M, Horrigan FT, Lawn RM, Davis RW. Expression monitoring using cDNA microarrays. A general protocol. Methods Mol Biol. 2001; 175:323-40. PMID: 11462845.
      View in: PubMed
    19. Horrigan FT, Aldrich RW. Allosteric voltage gating of potassium channels II. Mslo channel gating charge movement in the absence of Ca(2+). J Gen Physiol. 1999 Aug; 114(2):305-36. PMID: 10436004.
      View in: PubMed
    20. Horrigan FT, Cui J, Aldrich RW. Allosteric voltage gating of potassium channels I. Mslo ionic currents in the absence of Ca(2+). J Gen Physiol. 1999 Aug; 114(2):277-304. PMID: 10436003.
      View in: PubMed
    21. Lou XJ, Boonmark NW, Horrigan FT, Degen JL, Lawn RM. Fibrinogen deficiency reduces vascular accumulation of apolipoprotein(a) and development of atherosclerosis in apolipoprotein(a) transgenic mice. Proc Natl Acad Sci U S A. 1998 Oct 13; 95(21):12591-5. PMID: 9770530.
      View in: PubMed
    22. Horrigan FT, Gilly WF. Methadone block of K+ current in squid giant fiber lobe neurons. J Gen Physiol. 1996 Feb; 107(2):243-60. PMID: 8833344.
      View in: PubMed
    23. Horrigan FT, Bookman RJ. Releasable pools and the kinetics of exocytosis in adrenal chromaffin cells. Neuron. 1994 Nov; 13(5):1119-29. PMID: 7946349.
      View in: PubMed
    24. Gilly WF, Lucero MT, Horrigan FT. Control of the spatial distribution of sodium channels in giant fiber lobe neurons of the squid. Neuron. 1990 Nov; 5(5):663-74. PMID: 2171590.
      View in: PubMed
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