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FRANK HORRIGAN

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Integrative Physiology
AddressOne Baylor Plaza
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Neuroscience
    DivisionNeuroscience


    Collapse Research 
    Collapse research activities and funding
    R01AR072602     (HAMILTON, SUSAN L ;HORRIGAN, FRANK T;JUNG, SUNG YUN;RIOS, EDUARDO)Aug 1, 2018 - Jun 30, 2023
    NIH
    Mechanisms of couplon-linked skeletal muscle myopathies
    Role: Co-Principal Investigator
    R01GM127332     (YAN, JIUSHENG)May 1, 2018 - Apr 30, 2022
    NIH
    Pore Gating Mechanisms of BK Channels
    Role: Co-Principal Investigator
    R03NS101456     (HORRIGAN, FRANK T)Jan 15, 2017 - Dec 31, 2019
    NIH
    BK Channel Inhibition by Nobiletin
    Role: Principal Investigator
    R01GM105817     (HORRIGAN, FRANK T)Jun 1, 2013 - May 31, 2017
    NIH
    Development of a Novel High-Throughput Screening Platform for BK Channel Modulato
    Role: Principal Investigator
    R01NS042901     (HORRIGAN, FRANK T)Sep 30, 2001 - Mar 31, 2013
    NIH
    Allosteric mechanisms of CA-activated K channel gating
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wu H, Sun L, Huo T, Wensel TG, Horrigan FT, Wang Z. The identification of XPR1 as a voltage- and phosphate-activated phosphate-permeable ion channel. Nat Commun. 2025 May 15; 16(1):4519. PMID: 40374661; PMCID: PMC12081713.
      Citations:    Fields:    
    2. Wang Z, Wu H, Sun L, Wensel T, Horrigan F, Huo T, Wu H, Sun L, Huo T, Wensel TG, Horrigan FT, Wang Z. The identification of XPR1 as a voltage- and phosphate-activated phosphate-permeable ion channel. Res Sq. 2024 Dec 11. PMID: 39711567; PMCID: PMC11661312.
      Citations:    
    3. Xu W, Cao Y, Stephens SB, Arredondo MJ, Chen Y, Perez W, Sun L, Yu AC, Kim JJ, Lalani SR, Li N, Horrigan FT, Altamirano F, Wehrens XH, Miyake CY, Zhang L. Folate as a potential treatment for lethal ventricular arrhythmias in TANGO2-deficiency disorder. JCI Insight. 2024 Jun 10; 9(11). PMID: 38855866; PMCID: PMC11382877.
      Citations: 1     Fields:    Translation:HumansCells
    4. Wang X, Song J, Yuan Y, Li L, Abu-Taha I, Heijman J, Sun L, Dobrev S, Kamler M, Xie L, Wehrens XHT, Horrigan FT, Dobrev D, Li N. Downregulation of FKBP5 Promotes Atrial Arrhythmogenesis. Circ Res. 2023 06 23; 133(1):e1-e16. PMID: 37154033; PMCID: PMC10330339.
      Citations: 2     Fields:    Translation:AnimalsCells
    5. Kim MD, Chung S, Baumlin N, Sun L, Silswal N, Dennis JS, Yoshida M, Sabater J, Horrigan FT, Salathe M. E-cigarette aerosols of propylene glycol impair BK channel activity and parameters of mucociliary function. Am J Physiol Lung Cell Mol Physiol. 2023 04 01; 324(4):L468-L479. PMID: 36809074; PMCID: PMC10042605.
      Citations: 1     Fields:    Translation:HumansAnimals
    6. Sun L, Horrigan FT. A gating lever and molecular logic gate that couple voltage and calcium sensor activation to opening in BK potassium channels. Sci Adv. 2022 Dec 14; 8(50):eabq5772. PMID: 36516264; PMCID: PMC9750137.
      Citations: 4     Fields:    
    7. Tomaro-Duchesneau C, LeValley SL, Roeth D, Sun L, Horrigan FT, Kalkum M, Hyser JM, Britton RA. Discovery of a bacterial peptide as a modulator of GLP-1 and metabolic disease. Sci Rep. 2020 03 18; 10(1):4922. PMID: 32188864; PMCID: PMC7080827.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    8. Tajhya RB, Hu X, Tanner MR, Huq R, Kongchan N, Neilson JR, Rodney GG, Horrigan FT, Timchenko LT, Beeton C. Functional KCa1.1 channels are crucial for regulating the proliferation, migration and differentiation of human primary skeletal myoblasts. Cell Death Dis. 2016 10 20; 7(10):e2426. PMID: 27763639; PMCID: PMC5133989.
      Citations: 10     Fields:    Translation:HumansCells
    9. Tanner MR, Hu X, Huq R, Tajhya RB, Sun L, Khan FS, Laragione T, Horrigan FT, Beeton C, Gulko PS. KCa1.1 inhibition attenuates fibroblast-like synoviocyte invasiveness and ameliorates disease in rat models of rheumatoid arthritis. Arthritis Rheumatol. 2015 Jan; 67(1):96-106. PMID: 25252152; PMCID: PMC4280298.
      Citations: 14     Fields:    Translation:AnimalsCells
    10. Li N, Chiang DY, Wang S, Wang Q, Sun L, Voigt N, Respress JL, Ather S, Skapura DG, Jordan VK, Horrigan FT, Valderrabano M, Dobrev D, Wehrens XHT, Schmitz W, M?ller FU, Nattel S. Ryanodine receptor-mediated calcium leak drives progressive development of an atrial fibrillation substrate in a transgenic mouse model. Circulation. 2014 Mar 25; 129(12):1276-1285. PMID: 24398018; PMCID: PMC4026172.
      Citations: 83     Fields:    Translation:AnimalsCells
    11. Horrigan FT. Perspectives on: conformational coupling in ion channels: conformational coupling in BK potassium channels. J Gen Physiol. 2012 Dec; 140(6):625-34. PMID: 23183698; PMCID: PMC3514727.
      Citations: 14     Fields:    Translation:Cells
    12. Hu X, Laragione T, Sun L, Koshy S, Jones KR, Ismailov II, Yotnda P, Horrigan FT, Beeton C, Gulko PS. KCa1.1 potassium channels regulate key proinflammatory and invasive properties of fibroblast-like synoviocytes in rheumatoid arthritis. J Biol Chem. 2012 Feb 03; 287(6):4014-22. PMID: 22074915; PMCID: PMC3281680.
      Citations: 23     Fields:    Translation:HumansCells
    13. Hou S, Horrigan FT, Xu R, Heinemann SH, Hoshi T. Comparative effects of H+ and Ca2+ on large-conductance Ca2+- and voltage-gated Slo1 K+ channels. Channels (Austin). 2009 Jul-Aug; 3(4):249-58. PMID: 19617704; PMCID: PMC2824562.
      Citations: 11     Fields:    Translation:HumansCells
    14. Wu Y, Xiong Y, Wang S, Yi H, Li H, Pan N, Horrigan FT, Wu Y, Ding J. Intersubunit coupling in the pore of BK channels. J Biol Chem. 2009 Aug 28; 284(35):23353-63. PMID: 19561088; PMCID: PMC2749109.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    15. Horrigan FT, Hoshi T. Integration of an electric-metal sensory experience in the Slo1 BK channel. Nat Struct Mol Biol. 2008 Nov; 15(11):1130-2. PMID: 18985066.
      Citations: 2     Fields:    Translation:AnimalsCells
    16. Ma Z, Wong KY, Horrigan FT. An extracellular Cu2+ binding site in the voltage sensor of BK and Shaker potassium channels. J Gen Physiol. 2008 May; 131(5):483-502. PMID: 18443360; PMCID: PMC2346571.
      Citations: 19     Fields:    Translation:AnimalsCells
    17. Horrigan FT, Ma Z. Mg2+ enhances voltage sensor/gate coupling in BK channels. J Gen Physiol. 2008 Jan; 131(1):13-32. PMID: 18166624; PMCID: PMC2174156.
      Citations: 28     Fields:    Translation:AnimalsCells
    18. Yang H, Hu L, Shi J, Delaloye K, Horrigan FT, Cui J. Mg2+ mediates interaction between the voltage sensor and cytosolic domain to activate BK channels. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):18270-5. PMID: 17984060; PMCID: PMC2084332.
      Citations:    
    19. Hou S, Reynolds MF, Horrigan FT, Heinemann SH, Hoshi T. Reversible binding of heme to proteins in cellular signal transduction. Acc Chem Res. 2006 Dec; 39(12):918-24. PMID: 17176030.
      Citations: 24     Fields:    Translation:AnimalsCells
    20. Ma Z, Lou XJ, Horrigan FT. Role of charged residues in the S1-S4 voltage sensor of BK channels. J Gen Physiol. 2006 Mar; 127(3):309-28. PMID: 16505150; PMCID: PMC2151507.
      Citations: 96     Fields:    Translation:AnimalsCells
    21. Horrigan FT, Heinemann SH, Hoshi T. Heme regulates allosteric activation of the Slo1 BK channel. J Gen Physiol. 2005 Jul; 126(1):7-21. PMID: 15955873; PMCID: PMC2266614.
      Citations: 54     Fields:    Translation:HumansCells
    22. Zhang G, Horrigan FT. Cysteine modification alters voltage- and Ca(2+)-dependent gating of large conductance (BK) potassium channels. J Gen Physiol. 2005 Feb; 125(2):213-36. PMID: 15684095; PMCID: PMC2217493.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    23. Hu L, Shi J, Ma Z, Krishnamoorthy G, Sieling F, Zhang G, Horrigan FT, Cui J. Participation of the S4 voltage sensor in the Mg2+-dependent activation of large conductance (BK) K+ channels. Proc Natl Acad Sci U S A. 2003 Sep 02; 100(18):10488-93. PMID: 12925732; PMCID: PMC193588.
      Citations: 39     Fields:    Translation:AnimalsCells
    24. Horrigan FT, Aldrich RW. Coupling between voltage sensor activation, Ca2+ binding and channel opening in large conductance (BK) potassium channels. J Gen Physiol. 2002 Sep; 120(3):267-305. PMID: 12198087; PMCID: PMC2229516.
      Citations: 291     Fields:    Translation:HumansAnimalsCells
    25. Horrigan FT, Cui J, Aldrich RW. Allosteric voltage gating of potassium channels I. Mslo ionic currents in the absence of Ca(2+). J Gen Physiol. 1999 Aug; 114(2):277-304. PMID: 10436003; PMCID: PMC2230643.
      Citations: 168     Fields:    Translation:AnimalsCells
    26. Horrigan FT, Aldrich RW. Allosteric voltage gating of potassium channels II. Mslo channel gating charge movement in the absence of Ca(2+). J Gen Physiol. 1999 Aug; 114(2):305-36. PMID: 10436004; PMCID: PMC2230644.
      Citations: 130     Fields:    Translation:AnimalsCells
    27. Horrigan FT, Gilly WF. Methadone block of K+ current in squid giant fiber lobe neurons. J Gen Physiol. 1996 Feb; 107(2):243-60. PMID: 8833344; PMCID: PMC2219262.
      Citations: 4     Fields:    Translation:AnimalsCells
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