 FRANK T. HORRIGAN
| Title | Associate Professor |
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| Institution | Baylor College of Medicine |
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| Department | Department of Molecular Physiology & Biophysics |
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| Division | Molecular Physiology & Biophysics |
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| Address | One Baylor Plaza
Houston TX 77030
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| vCard | Download vCard |
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| Title | Associate Professor |
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| Institution | Baylor College of Medicine |
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| Department | Department of Neuroscience |
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| Division | Neuroscience |
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 Research R01NS042901 (HORRIGAN, FRANK T)Sep 30, 2001 - Mar 31, 2013 NIH/NINDS
Allosteric mechanisms of CA-activated K channel gating
Role: Principal Investigator |
| R01GM105817 (HORRIGAN, FRANK T)Jun 1, 2013 - May 31, 2016 NIH/NIGMS
Development of a Novel High-Throughput Screening Platform for BK Channel Modulato
Role: Principal Investigator |
| R03NS101456 (HORRIGAN, FRANK T)Jan 15, 2017 - Dec 31, 2018 NIH/NINDS
BK Channel Inhibition by Nobiletin
Role: Principal Investigator |
| R01GM127332 (YAN, JIUSHENG)May 1, 2018 - Apr 30, 2022 NIH/NIGMS
Pore Gating Mechanisms of BK Channels
Role: Co-Principal Investigator |
| R01AR072602 (HAMILTON, SUSAN L)Aug 1, 2018 - Jun 30, 2023 NIH/NIAMS
Mechanisms of couplon-linked skeletal muscle myopathies
Role: Co-Principal Investigator |
Bibliographic
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Tajhya RB, Hu X, Tanner MR, Huq R, Kongchan N, Neilson JR, Rodney GG, Horrigan FT, Timchenko LT, Beeton C. Functional KCa1.1 channels are crucial for regulating the proliferation, migration and differentiation of human primary skeletal myoblasts. Cell Death Dis. 2016 10 20; 7(10):e2426. PMID: 27763639.
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Tanner MR, Hu X, Huq R, Tajhya RB, Sun L, Khan FS, Laragione T, Horrigan FT, Gulko PS, Beeton C. KCa1.1 inhibition attenuates fibroblast-like synoviocyte invasiveness and ameliorates disease in rat models of rheumatoid arthritis. Arthritis Rheumatol. 2015 Jan; 67(1):96-106. PMID: 25252152.
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Li N, Chiang DY, Wang S, Wang Q, Sun L, Voigt N, Respress JL, Ather S, Skapura DG, Jordan VK, Horrigan FT, Schmitz W, Müller FU, Valderrabano M, Nattel S, Dobrev D, Wehrens XHT. Ryanodine receptor-mediated calcium leak drives progressive development of an atrial fibrillation substrate in a transgenic mouse model. Circulation. 2014 Mar 25; 129(12):1276-1285. PMID: 24398018.
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Horrigan FT. Perspectives on: conformational coupling in ion channels: conformational coupling in BK potassium channels. J Gen Physiol. 2012 Dec; 140(6):625-34. PMID: 23183698.
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Hu X, Laragione T, Sun L, Koshy S, Jones KR, Ismailov II, Yotnda P, Horrigan FT, Gulko PS, Beeton C. KCa1.1 potassium channels regulate key proinflammatory and invasive properties of fibroblast-like synoviocytes in rheumatoid arthritis. J Biol Chem. 2012 Feb 03; 287(6):4014-22. PMID: 22074915.
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Hou S, Horrigan FT, Xu R, Heinemann SH, Hoshi T. Comparative effects of H+ and Ca2+ on large-conductance Ca2+- and voltage-gated Slo1 K+ channels. Channels (Austin). 2009 Jul-Aug; 3(4):249-58. PMID: 19617704.
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Wu Y, Xiong Y, Wang S, Yi H, Li H, Pan N, Horrigan FT, Wu Y, Ding J. Intersubunit coupling in the pore of BK channels. J Biol Chem. 2009 Aug 28; 284(35):23353-63. PMID: 19561088.
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Horrigan FT, Hoshi T. Integration of an electric-metal sensory experience in the Slo1 BK channel. Nat Struct Mol Biol. 2008 Nov; 15(11):1130-2. PMID: 18985066.
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Ma Z, Wong KY, Horrigan FT. An extracellular Cu2+ binding site in the voltage sensor of BK and Shaker potassium channels. J Gen Physiol. 2008 May; 131(5):483-502. PMID: 18443360.
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Horrigan FT, Ma Z. Mg2+ enhances voltage sensor/gate coupling in BK channels. J Gen Physiol. 2008 Jan; 131(1):13-32. PMID: 18166624.
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Yang H, Hu L, Shi J, Delaloye K, Horrigan FT, Cui J. Mg2+ mediates interaction between the voltage sensor and cytosolic domain to activate BK channels. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):18270-5. PMID: 17984060.
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Hou S, Reynolds MF, Horrigan FT, Heinemann SH, Hoshi T. Reversible binding of heme to proteins in cellular signal transduction. Acc Chem Res. 2006 Dec; 39(12):918-24. PMID: 17176030.
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Ma Z, Lou XJ, Horrigan FT. Role of charged residues in the S1-S4 voltage sensor of BK channels. J Gen Physiol. 2006 Mar; 127(3):309-28. PMID: 16505150.
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Horrigan FT, Heinemann SH, Hoshi T. Heme regulates allosteric activation of the Slo1 BK channel. J Gen Physiol. 2005 Jul; 126(1):7-21. PMID: 15955873.
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Zhang G, Horrigan FT. Cysteine modification alters voltage- and Ca(2+)-dependent gating of large conductance (BK) potassium channels. J Gen Physiol. 2005 Feb; 125(2):213-36. PMID: 15684095.
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Hu L, Shi J, Ma Z, Krishnamoorthy G, Sieling F, Zhang G, Horrigan FT, Cui J. Participation of the S4 voltage sensor in the Mg2+-dependent activation of large conductance (BK) K+ channels. Proc Natl Acad Sci U S A. 2003 Sep 02; 100(18):10488-93. PMID: 12925732.
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Horrigan FT, Aldrich RW. Coupling between voltage sensor activation, Ca2+ binding and channel opening in large conductance (BK) potassium channels. J Gen Physiol. 2002 Sep; 120(3):267-305. PMID: 12198087.
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Lou XJ, Schena M, Horrigan FT, Lawn RM, Davis RW. Expression monitoring using cDNA microarrays. A general protocol. Methods Mol Biol. 2001; 175:323-40. PMID: 11462845.
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Horrigan FT, Aldrich RW. Allosteric voltage gating of potassium channels II. Mslo channel gating charge movement in the absence of Ca(2+). J Gen Physiol. 1999 Aug; 114(2):305-36. PMID: 10436004.
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Horrigan FT, Cui J, Aldrich RW. Allosteric voltage gating of potassium channels I. Mslo ionic currents in the absence of Ca(2+). J Gen Physiol. 1999 Aug; 114(2):277-304. PMID: 10436003.
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Lou XJ, Boonmark NW, Horrigan FT, Degen JL, Lawn RM. Fibrinogen deficiency reduces vascular accumulation of apolipoprotein(a) and development of atherosclerosis in apolipoprotein(a) transgenic mice. Proc Natl Acad Sci U S A. 1998 Oct 13; 95(21):12591-5. PMID: 9770530.
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Horrigan FT, Gilly WF. Methadone block of K+ current in squid giant fiber lobe neurons. J Gen Physiol. 1996 Feb; 107(2):243-60. PMID: 8833344.
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Horrigan FT, Bookman RJ. Releasable pools and the kinetics of exocytosis in adrenal chromaffin cells. Neuron. 1994 Nov; 13(5):1119-29. PMID: 7946349.
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Gilly WF, Lucero MT, Horrigan FT. Control of the spatial distribution of sodium channels in giant fiber lobe neurons of the squid. Neuron. 1990 Nov; 5(5):663-74. PMID: 2171590.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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| Year | Publications |
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| 1990 | 1 | | 1994 | 1 | | 1996 | 1 | | 1998 | 1 | | 1999 | 2 | | 2001 | 1 | | 2002 | 1 | | 2003 | 1 | | 2005 | 2 | | 2006 | 2 | | 2007 | 1 | | 2008 | 3 | | 2009 | 2 | | 2011 | 1 | | 2012 | 1 | | 2014 | 1 | | 2015 | 1 | | 2016 | 1 |
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