FRANK HORRIGAN

Title	Associate Professor
Institution	Baylor College of Medicine
Department	Department of Molecular Physiology & Biophysics
Address	One Baylor Plaza Houston, TX 77030
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Other Positions


Title	Associate Professor
Institution	Baylor College of Medicine
Department	Department of Neuroscience
Division	Neuroscience

Research

research activities and funding

R01NS042901 (HORRIGAN, FRANK T)Sep 30, 2001 - Mar 31, 2013 NIH Allosteric mechanisms of CA-activated K channel gating Role: Principal Investigator

R01GM105817 (HORRIGAN, FRANK T)Jun 1, 2013 - May 31, 2017 NIH Development of a Novel High-Throughput Screening Platform for BK Channel Modulato Role: Principal Investigator

R03NS101456 (HORRIGAN, FRANK T)Jan 15, 2017 - Dec 31, 2019 NIH BK Channel Inhibition by Nobiletin Role: Principal Investigator

R01GM127332 (YAN, JIUSHENG)May 1, 2018 - Apr 30, 2022 NIH Pore Gating Mechanisms of BK Channels Role: Co-Principal Investigator

R01AR072602 (HAMILTON, SUSAN L)Aug 1, 2018 - Jun 30, 2023 NIH Mechanisms of couplon-linked skeletal muscle myopathies Role: Co-Principal Investigator

Bibliographic

selected publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Tomaro-Duchesneau C, LeValley SL, Roeth D, Sun L, Horrigan FT, Kalkum M, Hyser JM, Britton RA. Discovery of a bacterial peptide as a modulator of GLP-1 and metabolic disease. Sci Rep. 2020 03 18; 10(1):4922. PMID: 32188864.

Citations: 3 Fields:
Sci Science
Translation:Humans Animals Cells
Tajhya RB, Hu X, Tanner MR, Huq R, Kongchan N, Neilson JR, Rodney GG, Horrigan FT, Timchenko LT, Beeton C. Functional KCa1.1 channels are crucial for regulating the proliferation, migration and differentiation of human primary skeletal myoblasts. Cell Death Dis. 2016 10 20; 7(10):e2426. PMID: 27763639.

Citations: 6 Fields:
Cel Cell Biology Int Internal Medicine
Translation:Humans Cells
Tanner MR, Hu X, Huq R, Tajhya RB, Sun L, Khan FS, Laragione T, Horrigan FT, Gulko PS, Beeton C. KCa1.1 inhibition attenuates fibroblast-like synoviocyte invasiveness and ameliorates disease in rat models of rheumatoid arthritis. Arthritis Rheumatol. 2015 Jan; 67(1):96-106. PMID: 25252152.

Citations: 10 Fields:
Rhe Rheumatology
Translation:Animals Cells
Li N, Chiang DY, Wang S, Wang Q, Sun L, Voigt N, Respress JL, Ather S, Skapura DG, Jordan VK, Horrigan FT, Schmitz W, Müller FU, Valderrabano M, Nattel S, Dobrev D, Wehrens XHT. Ryanodine receptor-mediated calcium leak drives progressive development of an atrial fibrillation substrate in a transgenic mouse model. Circulation. 2014 Mar 25; 129(12):1276-1285. PMID: 24398018.

Citations: 64 Fields:
Car Cardiology Vas Vascular Diseases
Translation:Animals Cells
Horrigan FT. Perspectives on: conformational coupling in ion channels: conformational coupling in BK potassium channels. J Gen Physiol. 2012 Dec; 140(6):625-34. PMID: 23183698.

Citations: 12 Fields:
Phy Physiology
Translation:Cells
Hu X, Laragione T, Sun L, Koshy S, Jones KR, Ismailov II, Yotnda P, Horrigan FT, Gulko PS, Beeton C. KCa1.1 potassium channels regulate key proinflammatory and invasive properties of fibroblast-like synoviocytes in rheumatoid arthritis. J Biol Chem. 2012 Feb 03; 287(6):4014-22. PMID: 22074915.

Citations: 19 Fields:
Bio Biochemistry
Translation:Humans Cells
Hou S, Horrigan FT, Xu R, Heinemann SH, Hoshi T. Comparative effects of H+ and Ca2+ on large-conductance Ca2+- and voltage-gated Slo1 K+ channels. Channels (Austin). 2009 Jul-Aug; 3(4):249-58. PMID: 19617704.

Citations: 10 Fields:
Bio Biochemistry
Translation:Humans Cells
Wu Y, Xiong Y, Wang S, Yi H, Li H, Pan N, Horrigan FT, Wu Y, Ding J. Intersubunit coupling in the pore of BK channels. J Biol Chem. 2009 Aug 28; 284(35):23353-63. PMID: 19561088.

Citations: 15 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
Horrigan FT, Hoshi T. Integration of an electric-metal sensory experience in the Slo1 BK channel. Nat Struct Mol Biol. 2008 Nov; 15(11):1130-2. PMID: 18985066.

Citations: 2 Fields:
Mol Molecular Biology
Translation:Animals Cells
Ma Z, Wong KY, Horrigan FT. An extracellular Cu2+ binding site in the voltage sensor of BK and Shaker potassium channels. J Gen Physiol. 2008 May; 131(5):483-502. PMID: 18443360.

Citations: 18 Fields:
Phy Physiology
Translation:Animals Cells
Horrigan FT, Ma Z. Mg2+ enhances voltage sensor/gate coupling in BK channels. J Gen Physiol. 2008 Jan; 131(1):13-32. PMID: 18166624.

Citations: 27 Fields:
Phy Physiology
Translation:Animals Cells
Hou S, Reynolds MF, Horrigan FT, Heinemann SH, Hoshi T. Reversible binding of heme to proteins in cellular signal transduction. Acc Chem Res. 2006 Dec; 39(12):918-24. PMID: 17176030.

Citations: 21 Fields:
Che Chemistry
Translation:Animals Cells
Ma Z, Lou XJ, Horrigan FT. Role of charged residues in the S1-S4 voltage sensor of BK channels. J Gen Physiol. 2006 Mar; 127(3):309-28. PMID: 16505150.

Citations: 88 Fields:
Phy Physiology
Translation:Animals Cells
Horrigan FT, Heinemann SH, Hoshi T. Heme regulates allosteric activation of the Slo1 BK channel. J Gen Physiol. 2005 Jul; 126(1):7-21. PMID: 15955873.

Citations: 51 Fields:
Phy Physiology
Translation:Humans Cells
Zhang G, Horrigan FT. Cysteine modification alters voltage- and Ca(2+)-dependent gating of large conductance (BK) potassium channels. J Gen Physiol. 2005 Feb; 125(2):213-36. PMID: 15684095.

Citations: 23 Fields:
Phy Physiology
Translation:Humans Animals Cells
Hu L, Shi J, Ma Z, Krishnamoorthy G, Sieling F, Zhang G, Horrigan FT, Cui J. Participation of the S4 voltage sensor in the Mg2+-dependent activation of large conductance (BK) K+ channels. Proc Natl Acad Sci U S A. 2003 Sep 02; 100(18):10488-93. PMID: 12925732.

Citations: 34 Fields:
Sci Science
Translation:Animals Cells
Horrigan FT, Aldrich RW. Coupling between voltage sensor activation, Ca2+ binding and channel opening in large conductance (BK) potassium channels. J Gen Physiol. 2002 Sep; 120(3):267-305. PMID: 12198087.

Citations: 260 Fields:
Phy Physiology
Translation:Humans Animals Cells